Strain Name:

CBA/CaHN-Btkxid/J

Stock Number:

001011

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Availability:

Level 2

CBA/CaHN-Btkxid/J mice have a mutation in the Bruton's tyrosine kinase gene (Btk), and are a model of human X-linked immunodeficiency. They have a B-lymphocyte-specific defect that results in an inability to launch an antibody response to thymus-independent type II antigens, although they do produce normal amounts of antibody in response to some protein antigens. They have low serum IgM and IgG3 and a reduced number of B-cells. Moreover, the B-cells that are present have a reduced surface IgM to IgD ratio, which suggests a disorder in B-cell maturation.

Description

Strain Information

Former Names CBA/NJ    (Changed: 15-DEC-04 )
Type Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Hemizygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
H2 Haplotypek
GenerationF108 (05-AUG-14)
Generation Definitions

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Appearance
agouti
Related Genotype: A/A

Description
CBA/CaHN-Btkxid/J mice have a mutation in the Bruton's tyrosine kinase gene (Btk), and are a model of human X-linked immunodeficiency. They have a B-lymphocyte-specific defect that results in an inability to launch an antibody response to thymus-independent type II antigens, although they do produce normal amounts of antibody in response to some protein antigens. They have low serum IgM and IgG3 and a reduced number of B-cells. Moreover, the B-cells that are present have a reduced surface IgM to IgD ratio, which suggests a disorder in B-cell maturation.

Control Information

  Control
   000654 CBA/CaJ (approximate) The mating scheme, homozygote x hemizygote, does not generate a wild-type control. 000654 may be used as an approximate control whose degree of relationship to CBA/CaHN is uncertain.
 
  Considerations for Choosing Controls

Related Strains

CBA Strains
001143   CBA/CaGnLeJ
000655   CBA/CaH-T(14;15)6Ca/J
000654   CBA/CaJ
000656   CBA/J
View CBA Strains     (4 strains)

Strains carrying   Btkxid allele
009361   B6.CBA-Btkxid/AllmJ
View Strains carrying   Btkxid     (1 strain)

Strains carrying other alleles of Btk
002536   B6;129S-Btktm1Wk/J
View Strains carrying other alleles of Btk     (1 strain)

Phenotype

Phenotype Information

View Phenotypic Data

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Agammaglobulinemia, X-Linked; XLA
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Isolated Growth Hormone Deficiency, Type III; IGHD3   (BTK)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Btkxid/Btkxid

        CBA/CaHN-Btkxid/J
  • immune system phenotype
  • abnormal macrophage physiology
    • macrophages (adherent peritoneal exudates cells, PECs) stimulated with LPS show a reduced induction of ROIs than wild-type macrophages at all LPS concentrations   (MGI Ref ID J:92639)
  • abnormal neutrophil physiology
    • mutant polymorphonuclear leukocytes (PMNs) show poorer induction of reactive oxygen intermediates (ROIs) upon LPS stimulation compared to wild-type; NO production is significantly less in mutant PMNs   (MGI Ref ID J:92639)
    • impaired neutrophil phagocytosis
      • phagocytic ability of PMNs is somewhat lower, but not significantly, compared to wild-type   (MGI Ref ID J:92639)
  • decreased acute inflammation
    • peak footpad swelling in response to carrageenan injection is reduced compared to wild-type mice   (MGI Ref ID J:92639)
  • decreased follicular B cell number
    • decrease in IgDhi IgMlo mature follicular B cells   (MGI Ref ID J:69477)
  • decreased neutrophil cell number
    • total leukocyte numbers are not significantly altered compared to wild-type, but significantly reduced peripheral PMN frequency in blood is observed in mutants   (MGI Ref ID J:92639)
  • decreased susceptibility to experimental autoimmune encephalomyelitis
    • mice show slower induction of experimental autoimmune encephalomyelitis (EAE) and milder clinical disease than wild-type mice   (MGI Ref ID J:92639)
  • impaired myelopoiesis
    • number of monocytic and granulocytic-lineage cells is significantly reduced in mutant bone marrow   (MGI Ref ID J:92639)
    • frequency of monocytic/granulocytic precursors (myeloid CFUs) is significantly reduced compared to wild-type bone marrow   (MGI Ref ID J:92639)
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • in Salmonella typhimurium-infected mice   (MGI Ref ID J:128518)
  • increased susceptibility to induced colitis
    • dextran sulfate sodium-induced colitis results in significant weight loss in wild-type mice by day 10 of DSS treatment while mutants do not exhibit any weight loss at that time   (MGI Ref ID J:92639)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • macrophages (adherent peritoneal exudates cells, PECs) stimulated with LPS show a reduced induction of ROIs than wild-type macrophages at all LPS concentrations   (MGI Ref ID J:92639)
  • abnormal neutrophil physiology
    • mutant polymorphonuclear leukocytes (PMNs) show poorer induction of reactive oxygen intermediates (ROIs) upon LPS stimulation compared to wild-type; NO production is significantly less in mutant PMNs   (MGI Ref ID J:92639)
    • impaired neutrophil phagocytosis
      • phagocytic ability of PMNs is somewhat lower, but not significantly, compared to wild-type   (MGI Ref ID J:92639)
  • decreased follicular B cell number
    • decrease in IgDhi IgMlo mature follicular B cells   (MGI Ref ID J:69477)
  • decreased neutrophil cell number
    • total leukocyte numbers are not significantly altered compared to wild-type, but significantly reduced peripheral PMN frequency in blood is observed in mutants   (MGI Ref ID J:92639)
  • impaired myelopoiesis
    • number of monocytic and granulocytic-lineage cells is significantly reduced in mutant bone marrow   (MGI Ref ID J:92639)
    • frequency of monocytic/granulocytic precursors (myeloid CFUs) is significantly reduced compared to wild-type bone marrow   (MGI Ref ID J:92639)
  • digestive/alimentary phenotype
  • increased susceptibility to induced colitis
    • dextran sulfate sodium-induced colitis results in significant weight loss in wild-type mice by day 10 of DSS treatment while mutants do not exhibit any weight loss at that time   (MGI Ref ID J:92639)
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • in Salmonella typhimurium-infected mice   (MGI Ref ID J:128518)

Btkxid/Btkxid

        CBA/HN-Btkxid
  • immune system phenotype
  • abnormal lymphopoiesis
    • incidence of small lymphocytes is slightly lower, but absolute population is not, compared to controls   (MGI Ref ID J:7981)
    • decreased B cell proliferation
      • cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells   (MGI Ref ID J:81429)
      • proliferative response in B cells from females is drastically lower than in cells from female mutants on CBA/HN * DBA/2N background   (MGI Ref ID J:81429)
  • abnormal pre-B cell morphology
    • incidence of pre-B cells is slightly reduced, but absolute population is comparable to controls   (MGI Ref ID J:7981)
  • autoimmune response
    • mice do not develop autoantibodies (anti-dsDNA or any IgG antinuclear autoantibodies)   (MGI Ref ID J:125114)
  • decreased B cell number
    • spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
    • numbers (22%) are less than female mutants on CBA/HN * DBA/2N background (40%)   (MGI Ref ID J:81429)
    • incidence of B lymphocytes is slightly lower, but absolute population is not, compared to controls   (MGI Ref ID J:81429)
  • decreased splenocyte number
    • number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)
    • females have significantly less than females on the CBA/HN * DBA/2N background which have (~90 x 106/spleen)   (MGI Ref ID J:81429)
  • hematopoietic system phenotype
  • abnormal bone marrow cell number
    • number of nucleated cells is higher in mutants than in controls   (MGI Ref ID J:7981)
  • abnormal lymphopoiesis
    • incidence of small lymphocytes is slightly lower, but absolute population is not, compared to controls   (MGI Ref ID J:7981)
    • decreased B cell proliferation
      • cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells   (MGI Ref ID J:81429)
      • proliferative response in B cells from females is drastically lower than in cells from female mutants on CBA/HN * DBA/2N background   (MGI Ref ID J:81429)
  • abnormal pre-B cell morphology
    • incidence of pre-B cells is slightly reduced, but absolute population is comparable to controls   (MGI Ref ID J:7981)
  • decreased B cell number
    • spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
    • numbers (22%) are less than female mutants on CBA/HN * DBA/2N background (40%)   (MGI Ref ID J:81429)
    • incidence of B lymphocytes is slightly lower, but absolute population is not, compared to controls   (MGI Ref ID J:81429)
  • decreased splenocyte number
    • number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)
    • females have significantly less than females on the CBA/HN * DBA/2N background which have (~90 x 106/spleen)   (MGI Ref ID J:81429)

Btkxid/Y

        CBA/HN-Btkxid
  • immune system phenotype
  • decreased B cell number
    • spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
  • decreased B cell proliferation
    • cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells   (MGI Ref ID J:81429)
  • decreased splenocyte number
    • number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)
  • hematopoietic system phenotype
  • decreased B cell number
    • spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
  • decreased B cell proliferation
    • cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells   (MGI Ref ID J:81429)
  • decreased splenocyte number
    • number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Btkxid/Btkxid

        involves: CBA/HN * DBA/2N
  • hematopoietic system phenotype
  • abnormal B cell physiology
    • spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males   (MGI Ref ID J:81429)
    • abnormal B cell proliferation
      • B cells show response to LPS and poly I:C similar to wild-type cells   (MGI Ref ID J:81429)
      • proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background   (MGI Ref ID J:81429)
  • decreased B cell number
    • spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
    • numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%)   (MGI Ref ID J:81429)
  • spleen hypoplasia
    • number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)
    • females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen)   (MGI Ref ID J:81429)
  • immune system phenotype
  • abnormal B cell physiology
    • spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males   (MGI Ref ID J:81429)
    • abnormal B cell proliferation
      • B cells show response to LPS and poly I:C similar to wild-type cells   (MGI Ref ID J:81429)
      • proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background   (MGI Ref ID J:81429)
  • decreased B cell number
    • spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
    • numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%)   (MGI Ref ID J:81429)
  • spleen hypoplasia
    • number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)
    • females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen)   (MGI Ref ID J:81429)

Btkxid/Btkxid

        involves: C57BL/6 * CBA
  • immune system phenotype
  • *normal* immune system phenotype
    • mucosal-associated invariant T cells (MAIT) that are not found in mice lacking all B cells are found in normal amounts in these mice (i.e. MAIT cells are not dependent on B1 B cells)   (MGI Ref ID J:113083)

Btkxid/Btkxid

        B6.CBA-Btkxid
  • immune system phenotype
  • decreased transitional stage B cell number
    • homozygous female mice exhibit a 2-3 fold decrease in CD23+ AA4+ bone marrow B cells (T2, T3), numbers of CD23- AA4+ cells are consistent with control   (MGI Ref ID J:145687)
    • CD23+ AA4+ splenic B cell numbers are similar to control   (MGI Ref ID J:145687)
  • hematopoietic system phenotype
  • decreased transitional stage B cell number
    • homozygous female mice exhibit a 2-3 fold decrease in CD23+ AA4+ bone marrow B cells (T2, T3), numbers of CD23- AA4+ cells are consistent with control   (MGI Ref ID J:145687)
    • CD23+ AA4+ splenic B cell numbers are similar to control   (MGI Ref ID J:145687)

Btkxid/Y

        involves: CBA/HN * DBA/2N
  • hematopoietic system phenotype
  • decreased B cell number
    • spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
  • decreased B cell proliferation
    • cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells   (MGI Ref ID J:81429)
    • proliferative response occurs slightly later and is much lower in males than in females   (MGI Ref ID J:81429)
  • spleen hypoplasia
    • number of nucleated spleen cells (~50 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)
  • immune system phenotype
  • decreased B cell number
    • spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls   (MGI Ref ID J:81429)
  • decreased B cell proliferation
    • cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells   (MGI Ref ID J:81429)
    • proliferative response occurs slightly later and is much lower in males than in females   (MGI Ref ID J:81429)
  • spleen hypoplasia
    • number of nucleated spleen cells (~50 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)   (MGI Ref ID J:81429)

Btkxid/Y

        involves: BALB/c * CBA/N
  • immune system phenotype
  • decreased B cell proliferation
    • no increase in proliferation is seen after BCR cross-linking   (MGI Ref ID J:108696)
  • decreased IgG3 level   (MGI Ref ID J:108696)
  • decreased IgM level
    • serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls   (MGI Ref ID J:108696)
    • basal serum IgM levels are decreased compared to wild-type controls   (MGI Ref ID J:108696)
  • decreased mature B cell number
    • the frequency and number of B cells are reduced in the spleen   (MGI Ref ID J:108696)
    • decreased B-1 B cell number
      • drastic reduction in the percentage of CD5+B220+ cells in the peritoneum   (MGI Ref ID J:108696)
  • hematopoietic system phenotype
  • decreased B cell proliferation
    • no increase in proliferation is seen after BCR cross-linking   (MGI Ref ID J:108696)
  • decreased IgG3 level   (MGI Ref ID J:108696)
  • decreased IgM level
    • serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls   (MGI Ref ID J:108696)
    • basal serum IgM levels are decreased compared to wild-type controls   (MGI Ref ID J:108696)
  • decreased mature B cell number
    • the frequency and number of B cells are reduced in the spleen   (MGI Ref ID J:108696)
    • decreased B-1 B cell number
      • drastic reduction in the percentage of CD5+B220+ cells in the peritoneum   (MGI Ref ID J:108696)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Btkxid related

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      B cell defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      B cell deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Btkxid
Allele Name X linked immune deficiency
Allele Type Spontaneous
Common Name(s) xid;
Strain of OriginCBA/HN
Gene Symbol and Name Btk, Bruton agammaglobulinemia tyrosine kinase
Chromosome X
Gene Common Name(s) AGMX1; AI528679; AT; ATK; BPK; Bruton's tyrosine kinase; IMD1; PSCTK1; X-linked immune deficiency; XLA; expressed sequence AI528679; xid;
Molecular Note The C to T transition point mutation at position 219 is predicted to change amino acid 28 from an arginine to a cysteine in the encoded protein. [MGI Ref ID J:13209]

Genotyping

Genotyping Information

Genotyping Protocols

BtkxidEnd Point, End Point Analysis
Btkxid, Pyrosequencing

The Jackson Laboratory does not have a PCR genotyping assay for the Btkxid mutation. The point mutation is a C to T transition at point 219 (Rawlings DJ et al. Science 1993; 261(5119):358-61 [PMID: 8332901]).

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Amsbaugh DF; Hansen CT; Prescott B; Stashak PW; Barthold DR; Baker PJ. 1972. Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness. J Exp Med 136(4):931-49. [PubMed: 4403476]  [MGI Ref ID J:109969]

Berning AK; Eicher EM; Paul WE; Scher I. 1980. Mapping of the X-linked immune deficiency mutation (xid) of CBA/N mice. J Immunol 124(4):1875-7. [PubMed: 7365241]  [MGI Ref ID J:6296]

Cancro MP; Sah AP; Levy SL; Allman DM; Schmidt MR; Woodland RT. 2001. xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development. Int Immunol 13(12):1501-14. [PubMed: 11717191]  [MGI Ref ID J:109858]

Additional References

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Wilson EL; Sherwood EM; King AM; Riley RL. 2003. A phenotypically distinct subset of immature B cells exhibits partial activation, increased survival, and preferential expression of VhS107. Eur J Immunol 33(12):3398-408. [PubMed: 14635049]  [MGI Ref ID J:90001]

Btkxid related

Abraham D; Leon O; Schnyder-Candrian S; Wang CC; Galioto AM; Kerepesi LA; Lee JJ; Lustigman S. 2004. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect Immun 72(2):810-7. [PubMed: 14742524]  [MGI Ref ID J:87861]

Ahmad A; Mond JJ. 1986. Restoration of in vitro responsiveness of xid B cells to TNP-Ficoll by 8-mercaptoguanosine. J Immunol 136(4):1223-6. [PubMed: 3511143]  [MGI Ref ID J:8173]

Akiyama K; Chen C; Wang D; Xu X; Qu C; Yamaza T; Cai T; Chen W; Sun L; Shi S. 2012. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10(5):544-55. [PubMed: 22542159]  [MGI Ref ID J:185809]

Alugupalli KR; Akira S; Lien E; Leong JM. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 178(6):3740-9. [PubMed: 17339472]  [MGI Ref ID J:144277]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Aprahamian T; Bonegio RG; Richez C; Yasuda K; Chiang LK; Sato K; Walsh K; Rifkin IR. 2009. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182(1):340-6. [PubMed: 19109165]  [MGI Ref ID J:142895]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291]  [MGI Ref ID J:119381]

Baba M; Kikuchi Y; Mori S; Kimoto H; Inui S; Sakaguchi N; Inoue J; Yamamoto T; Takemori T; Howard M; Takatsu K. 1997. Mouse germinal center B cells with the xid mutation retain responsiveness to antimouse CD40 antibodies but diminish IL-5 responsiveness. Int Immunol 9(10):1463-73. [PubMed: 9352351]  [MGI Ref ID J:43617]

Babai B; Louzir H; Cazenave PA; Dellagi K. 1999. Depletion of peritoneal CD5+ B cells has no effect on the course of Leishmania major infection in susceptible and resistant mice. Clin Exp Immunol 117(1):123-9. [PubMed: 10403925]  [MGI Ref ID J:114220]

Blair D; Dufort FJ; Chiles TC. 2012. Protein kinase Cbeta is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement. Biochem J 448(1):165-9. [PubMed: 22994860]  [MGI Ref ID J:191267]

Brorson K; Brunswick M; Ezhevsky S; Wei DG; Berg R; Scott D; Stein KE. 1997. xid affects events leading to B cell cycle entry. J Immunol 159(1):135-43. [PubMed: 9200448]  [MGI Ref ID J:110701]

Brorson KA; Krasnokutsky MV; Stein KE. 1995. Immunoglobulin isotype switching in xid mice. Mol Immunol 32(7):487-94. [PubMed: 7783751]  [MGI Ref ID J:26121]

Bruhl H; Cihak J; Goebel N; Talke Y; Renner K; Hermann F; Rodriguez-Gomez M; Reich B; Plachy J; Stangassinger M; Mack M. 2014. Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses. J Leukoc Biol 96(1):65-72. [PubMed: 24555985]  [MGI Ref ID J:212031]

Cariappa A; Kim TJ; Pillai S. 1999. Accelerated emigration of B lymphocytes in the Xid mouse. J Immunol 162(8):4417-23. [PubMed: 10201977]  [MGI Ref ID J:54343]

Cariappa A; Tang M; Parng C; Nebelitskiy E; Carroll M; Georgopoulos K; Pillai S. 2001. The Follicular versus Marginal Zone B Lymphocyte Cell Fate Decision Is Regulated by Aiolos, Btk, and CD21. Immunity 14(5):603-15. [PubMed: 11371362]  [MGI Ref ID J:69477]

Chow DA. 1995. Reduced tumorigenicity of threshold syngeneic tumor inocula in xid-bearing mice treated with natural antibodies. Int J Cancer 60(6):848-53. [PubMed: 7896457]  [MGI Ref ID J:23908]

Chung HY; Dong Z; Wortis HH. 1992. B cell deficiency progresses with lineage maturation in nude. X-linked immunodeficient mice B cell deficiency progresses with lineage maturation. J Immunol 149(11):3456-62. [PubMed: 1385525]  [MGI Ref ID J:3232]

Clark R; Krishnan V; Schoof M; Rodriguez I; Theriault B; Chekmareva M; Rinker-Schaeffer C. 2013. Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models. Am J Pathol 183(2):576-91. [PubMed: 23885715]  [MGI Ref ID J:199289]

Clarke SH; Arnold LW. 1998. B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation. J Exp Med 187(8):1325-34. [PubMed: 9547343]  [MGI Ref ID J:111386]

Clayberger C; DeKruyff RH; Fay R; Huber B; Cantor H. 1985. Evidence for defects in accessory and T cell subsets in mice expressing the xid defect. J Mol Cell Immunol 2(2):61-9. [PubMed: 3916931]  [MGI Ref ID J:9986]

Cohen DI; Steinberg AD; Paul WE; Davis MM. 1985. Expression of an X-linked gene family (XLR) in late-stage B cells and its alteration by the xid mutation. Nature 314(6009):372-4. [PubMed: 3872416]  [MGI Ref ID J:7793]

Cordeiro da Silva A; Lima EC; Vicentelli MH; Minoprio P. 1996. V beta 6-bearing T cells are involved in resistance to Trypanosoma cruzi infection in XID mice. Int Immunol 8(8):1213-9. [PubMed: 8918690]  [MGI Ref ID J:35051]

Crane DD; Griffin AJ; Wehrly TD; Bosio CM. 2013. B1a Cells Enhance Susceptibility to Infection with Virulent Francisella tularensis via Modulation of NK/NKT Cell Responses. J Immunol 190(6):2756-66. [PubMed: 23378429]  [MGI Ref ID J:193615]

Defosse DL; Duray PH; Johnson RC. 1992. The NIH-3 immunodeficient mouse is a model for Lyme borreliosis myositis and carditis. Am J Pathol 141(1):3-10. [PubMed: 1632468]  [MGI Ref ID J:1423]

Donahue AC; Hess KL; Ng KL; Fruman DA. 2004. Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85{alpha} Int Immunol 16(12):1789-1798. [PubMed: 15520044]  [MGI Ref ID J:94022]

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Thies FG; Laurindo MF; Perez EC; Novaes e Brito RR; Mariano M; Popi AF. 2013. Cross talk between peritoneal macrophages and B-1 cells in vitro. PLoS One 8(5):e62805. [PubMed: 23667522]  [MGI Ref ID J:200534]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           MP13

Colony Maintenance

Mating SystemHomozygote x Hemizygote         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $65.80MaleHemizygous for Btkxid  
4 weeks $65.80MaleHemizygous for Btkxid  
5 weeks $65.80MaleHemizygous for Btkxid  
6 weeks $68.45MaleHemizygous for Btkxid  
7 weeks $71.10MaleHemizygous for Btkxid  
8 weeks $73.75MaleHemizygous for Btkxid  
9 weeks $76.40FemaleHemizygous for Btkxid  
3 weeks $65.80FemaleHomozygous for Btkxid  
4 weeks $65.80FemaleHomozygous for Btkxid  
5 weeks $65.80FemaleHomozygous for Btkxid  
6 weeks $68.45FemaleHomozygous for Btkxid  
7 weeks $71.10FemaleHomozygous for Btkxid  
8 weeks $73.75FemaleHomozygous for Btkxid  
9 weeks $76.40FemaleHomozygous for Btkxid  

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $85.60MaleHemizygous for Btkxid  
4 weeks $85.60MaleHemizygous for Btkxid  
5 weeks $85.60MaleHemizygous for Btkxid  
6 weeks $89.00MaleHemizygous for Btkxid  
7 weeks $92.50MaleHemizygous for Btkxid  
8 weeks $95.90MaleHemizygous for Btkxid  
9 weeks $99.40FemaleHemizygous for Btkxid  
3 weeks $85.60FemaleHomozygous for Btkxid  
4 weeks $85.60FemaleHomozygous for Btkxid  
5 weeks $85.60FemaleHomozygous for Btkxid  
6 weeks $89.00FemaleHomozygous for Btkxid  
7 weeks $92.50FemaleHomozygous for Btkxid  
8 weeks $95.90FemaleHomozygous for Btkxid  
9 weeks $99.40FemaleHomozygous for Btkxid  

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Control Information

  Control
   000654 CBA/CaJ (approximate) The mating scheme, homozygote x hemizygote, does not generate a wild-type control. 000654 may be used as an approximate control whose degree of relationship to CBA/CaHN is uncertain.
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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