JAX Mice Database - 001017 AKXD10/TyJ

Strain Name:	AKXD10/TyJ
Stock Number:	001017
Availability:	Repository-Cryopreserved

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Former Names AKXD-10/TyJ (Changed: 15-DEC-04 )

Type Recombinant Inbred (Ri);
Additional information on Recombinant Inbred Mice.

Species laboratory mouse

RI progenitor AKR/J DBA/2J

H2 Haplotype k

Generation F95

Appearance
albino
Related Genotype: Tyr^c/Tyr^c

Related Strains

AKXD Strains

001005 AKXD1/TyJ

001003 AKXD11/TyJ

000765 AKXD13/TyJ

000779 AKXD14/TyJ

000954 AKXD15/TyJ

000958 AKXD16/TyJ

001093 AKXD18/TyJ

000776 AKXD2/TyJ

001001 AKXD20/TyJ

001062 AKXD21/TyJ

000947 AKXD22/TyJ

000780 AKXD23/TyJ

000969 AKXD24/TyJ

000949 AKXD25/TyJ

000764 AKXD27/TyJ

000957 AKXD28/TyJ

000959 AKXD3/TyJ

000777 AKXD6/TyJ

000763 AKXD9/TyJ

View AKXD Strains (19 strains)

Strains carrying Tyr^c allele

000765 AKXD13/TyJ

000954 AKXD15/TyJ

000958 AKXD16/TyJ

001093 AKXD18/TyJ

001062 AKXD21/TyJ

000947 AKXD22/TyJ

000969 AKXD24/TyJ

000777 AKXD6/TyJ

000763 AKXD9/TyJ

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

001759 STOCK A Tyr^c Sha/J

000006 STOCK Hk Tyr^c/J

View Strains carrying Tyr^c (15 strains)

Strains carrying other alleles of Tyr

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

005445 A.B6 Tyr⁺-Cyba^nmf333/J

005012 A.B6 Tyr⁺-Myo5a^d-l31J/J

002565 A.B6-Tyr⁺/J

000580 B10.D2/nSn-Tyr^c-4J/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000058 B6(Cg)-Tyr^c-2J/J

007484 B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000035 B6.Cg-Tyr^c-J/J

000104 B6.Cg-Tyr^c-h/J

000054 B6.D2-Tyr^c-p/J

000899 C.B6-Tyr⁺ Hbb^s/J

000339 C3H/HeJ-Tyr^c-9J/J

001294 C3H/HeJ-Tyr^c-a/J

001002 C57BL/10SnJ-Tyr^c-11J/J

001006 CBA/J-Tyr^c-10J/J

000657 CE/J

000619 FS/EiJ

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

002281 NFS.C58-Tyr⁺/J

004304 NOD.CBALs-Tyr⁺/LtJ

005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ

005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ

000271 SH1/LeJ

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

000206 STOCK a/a Tyr^c-h/J

View Strains carrying other alleles of Tyr (31 strains)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for AKXD RI Line

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cancer Research (genes regulating lymphoma development)
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)

Tyr^c related

Dermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)

Mouse/Human Gene Homologs
albinism, tyrosine negative

Genes & Alleles

Gene & Allele Information

Allele Symbol		Tyr^c
Allele Name		albino
Allele Type		Spontaneous
Common Name(s)		c;
Strain of Origin		old mutant of the mouse fancy
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
General Note		Tyr^c, albino. This very old mutant was already known in Greek and Roman times. Hair and eyes are completely devoid of pigment (J:5436, J:5001, J:30725). The albino mutation affects the amount of tyrosinase, and thus of melanin, in pigment cells, but does not interfere with the production of pigment cells themselves (J:12173, J:13092). Melanocytes with melanosomes showing normal fine structure occur in the retina and hair follicles. Pigment granules are smaller and fewer than normal and completely lack melanin (J:5346, J:5001, J:30725). Tyrosinase is almost absent (J:12173).Although Tyr is the structural gene for tyrosinase, some albino mutations may affect tyrosinase enzyme regulation rather than structure (J:6611), suggesting that these mutations affect tyrosinase inhibition (J:5346), presumably via control regions of the gene. All the mutant alleles are recessive to wild-type in phenotype, but heterozygotes with wild-type produce intermediate amounts of tyrosinase (J:12173).Albino-locus mutants with lightly pigmented eyes have a reduced number of fibers of the optic nerve going to the ipsilateral lateral geniculate nucleus of the brain. This is probably a secondary effect of reduced tyrosinase activity or amount of pigment in the pigmentepithelium, since genes at other loci that reduce eye pigmentation also cause the same anomaly (J:5436, J:6064).Abnormal retinal pathways disrupted at the optic chiasm that occur in albinism can be corrected with a Tyr normal transgene (J:22320).Lipofuscin is a terminal oxidation product pigment that accumulates with age. In a cross of C57BL/6J and BALB/cJ, which differ in cardiac deposition of the pigment, this trait segregated with albinism, and is controlled by the Tyr locus (J:15460).Tyrc homozygotes do not perform as well as normal in a number of behavioral tests. It is likely that this effect is mediated, at least in part, by defective vision resulting from lack of retinal pigment (J:5470, J:5360, J:5378).
Molecular Note		The specific mutation in the albino allele is a G to C transversion causing an amino acid change from cysteine to serine. This mutation introduces a DdeI enzyme restriction site. [MGI Ref ID J:10889] [MGI Ref ID J:40223]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

Additional References

Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1981. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature 293(5831):370-4. [PubMed: 6268990] [MGI Ref ID J:6587]
Tyr^c related

Bharti K; Liu W; Csermely T; Bertuzzi S; Arnheiter H. 2008. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135(6):1169-78. [PubMed: 18272592] [MGI Ref ID J:132153]

Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. [PubMed: 16261419] [MGI Ref ID J:102639]

Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. [PubMed: 13880466] [MGI Ref ID J:12173]

Detlefsen JA. 1921. A new mutation in the house mouse Am Naturalist 55:469-73. [MGI Ref ID J:34484]

Guillery RW. 1974. Visual pathways in albinos. Sci Am 230(5):44-54. [PubMed: 4822986] [MGI Ref ID J:5436]

Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048] [MGI Ref ID J:5346]

Hegmann JP; Kieso RA; Hartman HB. 1974. Gene differences influencing visual system function and behavior. Behav Genet 4(2):165-70. [PubMed: 4842093] [MGI Ref ID J:5470]

Jackson IJ; Bennett DC. 1990. Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant. Proc Natl Acad Sci U S A 87(18):7010-4. [PubMed: 2119500] [MGI Ref ID J:40223]

Jeffery G; Schutz G; Montoliu L. 1994. Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice. Dev Biol 166(2):460-4. [PubMed: 7813769] [MGI Ref ID J:22320]

Mouse Genome Informatics (MGI). 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN (http://bio.lsd.ornl.gov/mouse/) :. [MGI Ref ID J:100221]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512] [MGI Ref ID J:5001]

Qiao JH; Welch CL; Xie PZ; Fishbein MC; Lusis AJ. 1993. Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development. J Clin Invest 92(5):2386-93. [PubMed: 8227355] [MGI Ref ID J:15460]

Rios M; Habecker B; Sasaoka T; Eisenhofer G; Tian H; Landis S ; Chikaraishi D ; Roffler-Tarlov S. 1999. Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci 19(9):3519-26. [PubMed: 10212311] [MGI Ref ID J:54692]

SILVERS WK. 1958. Origin and identity of clear cells found in hair bulbs of albino mice. Anat Rec 130(2):135-44. [PubMed: 13545569] [MGI Ref ID J:30725]

Silvers WK. 1956. Pigment cells: occurrence in hair follicles. J Morphol 99:41-55. [MGI Ref ID J:13092]

Thiessen DD; Lindzey G; Owen K. 1970. Behavior and allelic variations in enzyme activity and coat color at the C locus of the mouse. Behav Genet 1(3):257-67. [PubMed: 5005683] [MGI Ref ID J:5360]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688] [MGI Ref ID J:6611]

Tyler PA. 1970. Coat color differences and runway learning in mice. Behav Genet 1(2):149-55. [PubMed: 5527659] [MGI Ref ID J:5378]

Yokoyama T; Silversides DW; Waymire KG; Kwon BS; Takeuchi T; Overbeek PA. 1990. Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res 18(24):7293-8. [PubMed: 2124349] [MGI Ref ID J:10889]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age Price* Gender

Cryorecovery Fee $1900.00

*Price(s) in US dollars ($)

Weeks of Age	Price*	Gender
Cryorecovery Fee	$1900.00

Additional Supply Details

Pricing for International shipping destinations

Weeks of Age Price* Gender

Cryorecovery Fee $2470.00

*Price(s) in US dollars ($)

Weeks of Age	Price*	Gender
Cryorecovery Fee	$2470.00

Additional Supply Details

Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice.* One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 or 1-207-288-5845. Genomic DNA is available for this strain from the Mouse DNA Resource.

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 or 1-207-288-5845.
Genomic DNA is available for this strain from the Mouse DNA Resource.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

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Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

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Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.

001005	AKXD1/TyJ
001003	AKXD11/TyJ
000765	AKXD13/TyJ
000779	AKXD14/TyJ
000954	AKXD15/TyJ
000958	AKXD16/TyJ
001093	AKXD18/TyJ
000776	AKXD2/TyJ
001001	AKXD20/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000780	AKXD23/TyJ
000969	AKXD24/TyJ
000949	AKXD25/TyJ
000764	AKXD27/TyJ
000957	AKXD28/TyJ
000959	AKXD3/TyJ
000777	AKXD6/TyJ
000763	AKXD9/TyJ

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
005445	A.B6 Tyr⁺-Cyba^nmf333/J
005012	A.B6 Tyr⁺-Myo5a^d-l31J/J
002565	A.B6-Tyr⁺/J
000580	B10.D2/nSn-Tyr^c-4J/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
000578	B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J
000058	B6(Cg)-Tyr^c-2J/J
007484	B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035	B6.Cg-Tyr^c-J/J
000104	B6.Cg-Tyr^c-h/J
000054	B6.D2-Tyr^c-p/J
000899	C.B6-Tyr⁺ Hbb^s/J
000339	C3H/HeJ-Tyr^c-9J/J
001294	C3H/HeJ-Tyr^c-a/J
001002	C57BL/10SnJ-Tyr^c-11J/J
001006	CBA/J-Tyr^c-10J/J
000657	CE/J
000619	FS/EiJ
004828	FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
002281	NFS.C58-Tyr⁺/J
004304	NOD.CBALs-Tyr⁺/LtJ
005115	NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ
005114	NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ
000271	SH1/LeJ
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J
000206	STOCK a/a Tyr^c-h/J

Strain Name:

AKXD10/TyJ

Stock Number:

001017

Availability:

Repository-Cryopreserved

Strain Information

Related Strains

Phenotype Information

Gene & Allele Information

Genotyping Information

Helpful Links

References

Additional References

Health & Colony Maintenance Information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice & Services Conditions of Use

No Warranty

No Liability

JAX^® Mice & Services Conditions of Use