Strain Name: |
BALB/cByJ |
|---|---|
Stock Number: |
001026 |
Availability: | Level 1 |
Price and Supply Information | |
General Terms and Conditions |
| Strain Common Names | CBy; BALB Bailey; BALB/c Bailey J; |
| Genes & Alleles | Acads; Acadsdel-J; Cdh23; Cdh23ahl; Hld; Mdmg1; ; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype d Generation F243 (03-JAN-08) Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/TyrcImportant Note
This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.Strain Description
BALB/c mice are particularly well known for the production of plasmacytomas following injection with mineral oil, forming the basis for the production of monoclonal antibodies. Although not all BALB/c substrains have been examined for plasmacytoma induction, substrains derived from the Andervont (An) lineage (which includes BALB/cByJ) typically are susceptible, while those descended from BALB/cJ are resistant (see: Potter M ,1985). Mammary tumor incidence is normally low, but infection with mammary tumor virus by fostering to MMTV+ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life including reticular neoplasms, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains. BALB/cByJ has a deletion in the Qa2 subregion of the murine MHC.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Acadsdel-J | ||
|---|---|---|---|
| Allele Name | deletion, Jackson | ||
| Common Name(s) | Bcd-1c; | ||
| Strain of Origin | BALB/cByJ | ||
| Gene Symbol and Name | Acads, acyl-Coenzyme A dehydrogenase, short chain | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | ACAD3; AI196007; Bcd-1; Bcd1; SCAD; butyryl CoA dehydrogenase 1; expressed sequence AI196007; | ||
| General Note | Mice with a combination of this allele and the sparse fur mutation at the ornithine transcarbamylase locus (Otcspf) have been proposed as a model to study ammonia: fatty acid acyl CoA synergism. The combination increases the elevation in urinary butyrylglycine, but not in ethylmalonate or methylsuccinate present in the Acads mutants; it decreases the elevation of orotic acid found in the sparse fur mutant (J:4165). | ||
| Molecular Note | A 278bp deletion occurs which starts in intron "A" and includes exon "B" and the first 78bp of exon "C". As a result of this deletion, mRNA transcription is reduced to about 35% of normal and includes two forms, a longer normal length transcript and a shorter misspliced form. If these mRNAs were translated they both would result in truncated products. Protein product is undetectable immunologically and there is a total absence of enzyme activity. [MGI Ref ID J:12776] | ||
| Allele Symbol | Cdh23ahl | ||
| Allele Name | age related hearing loss 1 | ||
| Common Name(s) | Cdh23753A; mdfw; | ||
| Strain of Origin | multiple strains | ||
| Gene Symbol and Name | Cdh23, cadherin 23 (otocadherin) | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | 4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; v; waltzer; | ||
| Molecular Note | Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LyJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ. [MGI Ref ID J:86905] | ||
| Allele Symbol | Hld | ||
| Allele Name | hippocampal lamination defect | ||
| Strain of Origin | BALB/cJ | ||
| General Note | Abnormal laminar organization of the pyramidal layer of the cerebellum, particularly in the proximal segment of the layer, occurs in the BALB/cJ strain (J:5787). A single gene, Hld for hippocampal lamination defect, was shown to cause this abnormality in a cross of BALB/c with C57BL/6 and in the CXB recombinant inbred strains (J:13989). In normal strains, the latest formed or youngest neurons migrate past the earlier formed or older neurons to a position in the pyramidal layer that is superficial to that of the older cells. In BALB/cJ, the positions are reversed, with the older cells lying superior to the younger ones (J:5787). Since mossy fibers form synapses primarily with the older cells, this aberrant pattern of cell migration in BALB/c leads to adifferent pattern of mossy-fiber synapses, easily visualized with Timm's stain (J:5486). The dendritic excrescences induced by contact with mossy fibers on late-generated pyramidal cells in +/+ mice occur at sites on both the apical and basal dendrites; in Hld/Hld mice, they occur in two sites on the apical dendrites only (J:12029). | ||
| Gene Symbol and Name | Mdmg1, mandibular morphogenesis 1 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Mdmg-1; | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
BALB Strains
000650 BALB/cBy 001905 BALB/cGaJ 000921 BALB/cGrRkJ 000651 BALB/cJ 001311 BALB/cWtEiJ View BALB Strains (5 strains)
001137 129P1/ReJ 000690 129P3/J 002065 129T2/SvEmsJ 000691 129X1/SvJ 000646 A/J 000647 A/WySnJ 003070 ALR/LtJ 003072 ALS/LtJ 004502 B6;AKR-Lxl2/J 000653 BUB/BnJ 005494 C3.129S1(B6)-Grm1rcw/J 000664 C57BL/6J 004764 C57BL/6J-Cdh23v-8J/J 003129 C57BL/6J-Epha4rb-2J/J 004820 C57BL/6J-Kcne12J/J 004703 C57BL/6J-Kcnq2Nmf134/J 004811 C57BL/6J-nmf110/J 004812 C57BL/6J-nmf111/J 004747 C57BL/6J-nmf118/J 004656 C57BL/6J-nmf88/J 004391 C57BL/6J-Chr 13A/J/NaJ 004385 C57BL/6J-Chr 7A/J/NaJ 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000657 CE/J 000670 DBA/1J 001140 DBA/1LacJ 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 002106 KK/HlJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 001976 NOD/ShiLtJ 002050 NOR/LtJ 000679 P/J 002747 SENCARB/PtJ 002335 SKH2/J 003392 STOCK Crb1rd8/J
000651 BALB/cJ 000351 CXB1/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000357 CXB7/ByJ
Phenotypic Data
Body Weight Information - JAX® Mice Strain BALB/cByJ (001026)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - MHC H2 haplotype
Mouse Phenome Database - body weight
Mouse Phenome Database - exploratory behavior
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database - reproductive performance
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: BALB/c
JAX® Physiological Data Summary [pdf]
JAX® Physiological Data Protocol [pdf]
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Fall 1990; 443. A Brief History of the Two Substrains of BALB/c, BALB/cJ, and BALB/cByJ Available from Animal Resources.
JAX® NOTES, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
JAX® NOTES, July 1987; 430. BALB/cJ vs. BALB/cByJ.
JAX® NOTES, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX® NOTES, Summer 1992; 450. Myoepitheliomas in Inbred Laboratory Mice.
JAX® NOTES, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
JAX® NOTES, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
JAX® Physiological Data Protocol [pdf]
JAX® Physiological Data Summary [pdf]
Animal Health Reports
Room Number AX3
Room Number MP14
Room Number MP15
Research Applications
This mouse can be used to support research in many areas including:
Cdh23ahl relatedCancer Research
Increased Tumor Incidence (Mammary Gland Tumors: late onset)
Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
Neurobiology Research
Neurodevelopmental Defects (callosal agenesis, incomplete penetrance)
Vestibular and Hearing Defects (Age related hearing loss)
Research Tools
Cancer Research (monoclonal antibodies, myeloma and hybridoma production)
General Purpose
Immunology and Inflammation Research (background strain for histocompatibility congenics)
Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)
Neurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)
Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)
References
Selected Reference(s)
Additional ReferencesBentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A 67(1):377-84. [PubMed: 4318784] [MGI Ref ID J:24803]
Champy MF; Selloum M; Zeitler V; Caradec C; Jung B; Rousseau S; Pouilly L; Sorg T; Auwerx J. 2008. Genetic background determines metabolic phenotypes in the mouse. Mamm Genome 19(5):318-31. [PubMed: 18392653] [MGI Ref ID J:137669]
Ebbesen P. 1971. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. J Natl Cancer Inst 47(6):1241-5. [PubMed: 4941118] [MGI Ref ID J:24297]
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8. [PubMed: 4322934] [MGI Ref ID J:24674]
Hinsdale ME; Kelly CL; Wood PA. 1993. Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA. Genomics 16(3):605-11. [PubMed: 8325633] [MGI Ref ID J:12776]
Smith Richards BK; Belton BN; York B; Volaufova J. 2004. Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat. Am J Physiol Regul Integr Comp Physiol 286(2):R311-9. [PubMed: 14592933] [MGI Ref ID J:87779]
Sundberg JP; Hanson CA; Roop DR; Brown KS; Bedigian HG. 1991. Myoepitheliomas in inbred laboratory mice. Vet Pathol 28(4):313-23. [PubMed: 1719689] [MGI Ref ID J:22767]
Wood PA; Amendt BA; Rhead WJ; Millington DS; Inoue F; Armstrong D. 1989. Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. Pediatr Res 25(1):38-43. [PubMed: 2919115] [MGI Ref ID J:14707]
Wood PA; Hinsdale ME; Kelly CL. 1993. Molecular detection of the Bcd-1 null allele in BALB/cByJ mice by polymerase chain reaction: a simple assay for genetic monitoring Mouse Genome 91(2):342-44. [MGI Ref ID J:12812]
Price and Supply Information
| Strain Name: | BALB/cByJ |
| Stock Number: | 001026 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
USA, Canada and Mexico
| Price(s) in US dollars ($) | Genotype(s) Provided | ||||
|---|---|---|---|---|---|
| 3 weeks | $14.20 | Female | |||
| 4 weeks | $14.20 | Female | |||
| 5 weeks | $14.20 | Female | |||
| 6 weeks | $15.70 | Female | |||
| 7 weeks | $18.00 | Female | |||
| 8 weeks | $19.50 | Female | |||
| 9 weeks | $21.60 | Female | |||
| 10 weeks | $23.88 | Female | |||
| 11 weeks | $23.88 | Female | |||
| 12 weeks | $23.88 | Female | |||
| 3 weeks | $13.05 | Male | |||
| 4 weeks | $13.05 | Male | |||
| 5 weeks | $13.05 | Male | |||
| 6 weeks | $14.80 | Male | |||
| 7 weeks | $16.85 | Male | |||
| 8 weeks | $18.80 | Male | |||
| 9 weeks | $21.00 | Male | |||
| 10 weeks | $22.75 | Male | |||
| 11 weeks | $22.75 | Male | |||
| 12 weeks | $22.75 | Male | |||
Supply Details
| Standard Supply | JAX Ready Strain® (Level 1). Most popular strains. Readily available in any quantity you need. |
|---|---|
| Supply Notes |
Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. This strain is available from some international Charles River Laboratories (CRL) breeding facilities in Japan and/or Europe. For more information, see the Worldwide Distributor List for JAX® Mice. Timed pregnant females are available from the Bar Harbor facility. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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