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Genes & Alleles

m;   mea;   mea2J;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Generation F40+3N1p

Strain Description
Mice homozygous for the meander tail 2J spontaneous mutation (mea^2J) have a phenotype that is very similar to the original meander tail (mea) and meander tail J mice (mea^J). Homozygous mutant mice have variably shortened and kinked tails. At about 2 weeks an unsteadiness of gait, often amounting to a tremor, appears. Homozygotes are smaller and less vigorous than wiltype controls but are fertile. The anterior lobe of the cerebellum is disorganized. Purkinje cells are scattered, some cellular layers never form, and Bergmann glial processes are absent. The cytoarchitecture of the posterior lobe is normal, and the transition from normal to disorganized areas is sharply demarcated. This strain is maintained in linkage with the misty coat color mutation (m).

Gene & Allele Details

Allele Symbol		m
Allele Name		misty
Strain of Origin		DBA/J
Allele Symbol		mea2J
Allele Name		meander tail 2 Jackson
Strain of Origin		C57BLKS-m Myo5ad Papss2bm on Rab38cht
Gene Symbol and Name		mea, meander tail
Chromosome		4
General Note		This mutation is the second remutation to meander tail found at The Jackson Laboratory (J:16313).

Control Information

	Control
	Heterozygote from the colony
	000662 C57BLKS/J
Considerations for Choosing Controls

Genotyping Protocols

m (Misty)

Related Strains

Strains carrying   m allele

002048	B6 x C57BLKS-m Leprdb Myo15sh2-J/J
000697	B6.Cg-m +/+ Leprdb/J
000699	B6.Cg-m Leprdb/+ +/J
000027	B6.D-Tyrp1b m/J
000642	BKS.Cg-m +/+ Leprdb/J
000700	BKS.Cg-m Leprdb/+ +/J
001192	BKS.Cg-meaJ Leprdb +/+ + m/J
000707	CBA.Cg-m Leprdb/+ +/J

View Strains carrying   m     (8 strains)

Strains carrying other alleles of mea

001192

BKS.Cg-meaJ Leprdb +/+ + m/J

View Strains carrying other alleles of mea     (1 strain)

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

m related

Dermatology Research
Color and White Spotting Defects

mea^2J related

Developmental Biology Research
Skeletal Defects

Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects

References

Additional References

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Price and Supply Information

Strain Name:	BKS.Cg-mea2J m/+ +/J
Stock Number:	001049

Price Details

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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