Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3Sn.AK-Thp    (Changed: 23-FEB-07 ) Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C3H/HeSnJ Donor Strain AKR/J Generation N21

Important Note
This strain might be segregating for the recessive tufted (tf) mutation, also on Chromosome 17

Control Information

	Control
	Wild-type from the colony
	000661 C3H/HeSnJ
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of T

003879	B10;TFLe-a/a T tf/+ tf/J
000405	B10ScSn.Cg-T/J
004591	B6 x B6Ei.Cg-TWis/EiJ
000953	B6 x BALB/cBy-T4J/J
001518	B6 x STOCK T tf/th45 tf/J
000567	B6.Cg-T2J +/+ Qkqk/J
001015	B6.Cg-T4Or/J
001054	B6.Cg-TOrl/EiJ
000350	B6By.Cg-KitW-v MitfMi-wh T/J
002282	BTBR T+ tf/J
000545	C57BL/6J-T2J/J
001199	C57BL/6J-T5J/J
001961	C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei
001814	STOCK Tc/J

View Strains carrying other alleles of T     (14 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

T^hp/T⁺

        involves: AKR/J * C57BL/Gr * CBA/Gr

• limbs/digits/tail phenotype
• abnormal tail development (MGI Ref ID J:31524)
  • at E12 the base of the tail is constricted; the thickness of the tail itself varies
  • at E13 the tail distal to the constriction is thinned
  • by E14 the tail is thinned to a filament which often drops off resulting in a blunt-ended tail or tail rudiment
• kinked tail (MGI Ref ID J:31524)
  • varying degrees
• polydactyly (MGI Ref ID J:31524)
  • on the hind feet of embryos inheriting the T^hp allele from their mother
• short tail (MGI Ref ID J:31524)
  • shortened by varying amounts
  • the only abnormality seen in older embryos
• thick tail (MGI Ref ID J:31524)
  • degree of thickness varies
• reproductive system phenotype
• decreased litter size (MGI Ref ID J:31524)
  • litters from carrier males and normal females are reduced compared to normal; litters from matings of carrier females and normal males are even smaller in size
• other phenotype
• maternal effect (MGI Ref ID J:31524)
  • heterozygous offspring from carrier females and normal males are edematous and die before or at birth
• homeostasis/metabolism phenotype
• edema (MGI Ref ID J:31524)
  • embryos inheriting the T^hp allele from their mother are edematous
• growth/size phenotype
• postnatal slow weight gain (MGI Ref ID J:31524)
  • characteristic of mice inheriting the T^hp allele from their father
• embryogenesis phenotype
• abnormal neural tube morphology/development (MGI Ref ID J:31524)
  • at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother
• abnormal neural tube closure (MGI Ref ID J:31524)
• open neural tube (MGI Ref ID J:31524)
  • characteristic of some E10 embryos inheriting the T^hp allele from their father
• spina bifida (MGI Ref ID J:31524)
  • occurs at a low frequency among embryos inheriting the T^hp allele from their mother
• abnormal notochord morphology (MGI Ref ID J:31524)
  • at E10 the notochord in the trunk is poorly differentiated and characteristic of embryos inheriting the T^hp allele from their father
  • at E10 the notochord in the tail may be absent, swollen, or duplicated in embryos inheriting the T^hp allele from their father
• absent notochord (MGI Ref ID J:31524)
  • at E10 the tail notochord may be absent in embryos inheriting the T^hp allele from their father
• cardiovascular system phenotype
• abnormal pericardium morphology (MGI Ref ID J:31524)
  • inflation of the pericardium is seen in embryos inheriting the T^hp allele from their mother
• nervous system phenotype
• abnormal neural tube morphology/development (MGI Ref ID J:31524)
  • at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother
• abnormal neural tube closure (MGI Ref ID J:31524)
• open neural tube (MGI Ref ID J:31524)
  • characteristic of some E10 embryos inheriting the T^hp allele from their father
• spina bifida (MGI Ref ID J:31524)
  • occurs at a low frequency among embryos inheriting the T^hp allele from their mother
• exencephaly (MGI Ref ID J:31524)
  • occurs in low frequency among embryos inheriting the T^hp allele from their mother
• skeleton phenotype
• abnormal vertebral column (MGI Ref ID J:31524)
  • may end abruptly before or at the level of the second sacral vertebra
• abnormal cervical vertebrae morphology (MGI Ref ID J:31524)
  • characteristic of embryos inheriting the T^hp allele from their father
  • one or more may be incomplete dorsally
• abnormal cervical atlas morphology (MGI Ref ID J:31524)
  • characteristic of embryos inheriting the T^hp allele from their father
  • frequently incomplete dorsally
• abnormal cervical axis morphology (MGI Ref ID J:31524)
  • characteristic of embryos inheriting the T^hp allele from their father
  • frequently incomplete dorsally
• abnormal sacral vertebrae morphology (MGI Ref ID J:31524)
• short vertebral column (MGI Ref ID J:31524)

T^hp/T^hp

        involves: AKR/J * C57BL/Gr * CBA/Gr

• lethality-prenatal/perinatal
• embryonic lethality (MGI Ref ID J:5522)
  • after implantation

Genes & Alleles

Gene & Allele Information

Allele Symbol		Thp
Allele Name		hairpin tail
Allele Type		Spontaneous
Strain of Origin		AKR/J
Gene Symbol and Name		T, brachyury
Chromosome		17
Gene Common Name(s)		Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75;
General Note		Because this allele arose in the AKR/J inbred strain and can only be transmitted to viable offspring via a male carrier, all T strains carry the AKR Y chromosome.
Molecular Note		Restriction length polymorphisms and simple sequence variants were used to define the breakpoints of the deletion that comprises this allele. The proximal breakpoint of the deletion maps between D17Leh66EI and D17Leh66EII and the distal breakpoint is proximal to D17Mit122 but distal to D17Leh66D. The Qk locus is included in the deletion. [MGI Ref ID J:62654]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

T^hp related

Baker J; Liu JP; Robertson EJ; Efstratiadis A. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75(1):73-82. [PubMed: 8402902]  [MGI Ref ID J:15107]

Barlow DP; Stoger R; Herrmann BG; Saito K; Schweifer N. 1991. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 349(6304):84-7. [PubMed: 1845916]  [MGI Ref ID J:10895]

Bennett D. 1978. Rescue of a lethal T/t locus genotype by chimaerism with normal embryos. Nature 272(5653):539. [PubMed: 692659]  [MGI Ref ID J:6036]

Bennett D. 1975. The T-locus of the mouse. Cell 6:441-454.  [MGI Ref ID J:11933]

Bergstrom RA; You Y; Erway LC; Lyon MF; Schimenti JC. 1998. Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths. Genetics 150(2):815-22. [PubMed: 9755211]  [MGI Ref ID J:50247]

Bogani D; Siggers P; Brixey R; Warr N; Beddow S; Edwards J; Williams D; Wilhelm D; Koopman P; Flavell RA; Chi H; Ostrer H; Wells S; Cheeseman M; Greenfield A. 2009. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol 7(9):e1000196. [PubMed: 19753101]  [MGI Ref ID J:153050]

Filson AJ; Louvi A; Efstratiadis A; Robertson EJ. 1993. Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes. Development 118(3):731-6. [PubMed: 8076514]  [MGI Ref ID J:13165]

Friezner Degen SJ; Bell SM; Schaefer LA; Elliott RW. 1990. Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17. Genomics 8(1):49-61. [PubMed: 2081600]  [MGI Ref ID J:11089]

Griffen AB; Frazier JE. 1965. Hairpin tail Mouse News Lett 32:43-44.  [MGI Ref ID J:85320]

Johnson DR. 1974. Further observations on the haipin-tail (Thp) mutation in the mouse. Genet Res 24(2):207-13. [PubMed: 4452482]  [MGI Ref ID J:5522]

Johnson DR. 1974. Hairpin-tail: a case of post-reductional gene action in the mouse egg. Genetics 76(4):795-805. [PubMed: 4838760]  [MGI Ref ID J:31524]

Kagami S; Nakajima H; Kumano K; Suzuki K; Suto A; Imada K; Davey HW; Saito Y; Takatsu K; Leonard WJ; Iwamoto I. 2000. Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue. Blood 95(4):1370-7. [PubMed: 10666213]  [MGI Ref ID J:106678]

McGrath J; Solter D. 1984. Maternal Thp lethality in the mouse is a nuclear, not cytoplasmic, defect. Nature 308(5959):550-1. [PubMed: 6709063]  [MGI Ref ID J:7391]

Planchart A; You Y; Schimenti JC. 2000. Physical mapping of male fertility and meiotic drive quantitative trait loci in the mouse t complex using chromosome deficiencies. Genetics 155(2):803-12. [PubMed: 10835401]  [MGI Ref ID J:62654]

Rennebeck GM; Lader E; Chen Q; Bohm RA; Cai ZS; Faust C; Magnuson T; Pease LR; Artzt K. 1995. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol 172(1):206-17. [PubMed: 7589801]  [MGI Ref ID J:29666]

Sleutels F; Zwart R; Barlow DP. 2002. The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature 415(6873):810-3. [PubMed: 11845212]  [MGI Ref ID J:77594]

Wang E; Cortopassi G. 1994. Mice with duplications and deletions at the Tme locus have altered MnSOD activity. J Biol Chem 269(36):22463-5. [PubMed: 8077189]  [MGI Ref ID J:20170]

Washburn LL; Eicher EM. 1983. Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature 303(5915):338-40. [PubMed: 6855886]  [MGI Ref ID J:7073]

Winking H; Silver LM. 1984. Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect. Genetics 108(4):1013-20. [PubMed: 6510705]  [MGI Ref ID J:7679]

Wutz A; Theussl HC; Dausman J; Jaenisch R; Barlow DP; Wagner EF. 2001. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Development 128(10):1881-7. [PubMed: 11311167]  [MGI Ref ID J:68721]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Colony Maintenance

Breeding & Husbandry	Thp/+ females can not transmit Thp. Although carrier females can bear carrier pups from carrier males, the carrier pups which inherit Thp from their mother die in utero.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain might be segregating for the recessive tufted (tf) mutation, also on Chromosome 17

Control Information

	Control
	Wild-type from the colony
	000661 C3H/HeSnJ
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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