Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3Sn.AK-Thp    (Changed: 23-FEB-07 ) Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C3H/HeSnJ Donor Strain AKR/J Generation N21 Generation Definitions

Important Note
This strain might be segregating for the recessive tufted (tf) mutation, also on Chromosome 17

Control Information

	Control
	Wild-type from the colony
	000661 C3H/HeSnJ
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of T

003879	B10;TFLe-a/a T tf/+ tf/J
000405	B10ScSn.Cg-T/J
004591	B6 x B6Ei.Cg-TWis/EiJ
000953	B6 x BALB/cBy-T4J/J
001518	B6 x STOCK T tf/th45 tf/J
000567	B6.Cg-T2J +/+ Qkqk-v/J
001015	B6.Cg-T4Or/J
001054	B6.Cg-TOrl/EiJ
000350	B6By.Cg-KitW-v MitfMi-wh T/J
016926	BTBR T+ tf-Fbxl3Ovtm/J
002282	BTBR T+ tf/J
000545	C57BL/6J-T2J/J
001199	C57BL/6J-T5J/J
001961	C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei
001814	STOCK Tc/J

View Strains carrying other alleles of T     (15 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

T^hp/T⁺

        involves: AKR/J * C57BL/Gr * CBA/Gr

• limbs/digits/tail phenotype
• abnormal tail development
  • at E12 the base of the tail is constricted; the thickness of the tail itself varies   (MGI Ref ID J:31524)
  • at E13 the tail distal to the constriction is thinned   (MGI Ref ID J:31524)
  • by E14 the tail is thinned to a filament which often drops off resulting in a blunt-ended tail or tail rudiment   (MGI Ref ID J:31524)
• kinked tail
  • varying degrees   (MGI Ref ID J:31524)
• polydactyly
  • on the hind feet of embryos inheriting the T^hp allele from their mother   (MGI Ref ID J:31524)
• short tail
  • shortened by varying amounts   (MGI Ref ID J:31524)
  • the only abnormality seen in older embryos   (MGI Ref ID J:31524)
• thick tail
  • degree of thickness varies   (MGI Ref ID J:31524)
• reproductive system phenotype
• decreased litter size
  • litters from carrier males and normal females are reduced compared to normal; litters from matings of carrier females and normal males are even smaller in size   (MGI Ref ID J:31524)
• other phenotype
• maternal effect
  • heterozygous offspring from carrier females and normal males are edematous and die before or at birth   (MGI Ref ID J:31524)
• homeostasis/metabolism phenotype
• edema
  • embryos inheriting the T^hp allele from their mother are edematous   (MGI Ref ID J:31524)
• growth/size phenotype
• slow postnatal weight gain
  • characteristic of mice inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
• embryogenesis phenotype
• abnormal neural tube morphology/development
  • at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother   (MGI Ref ID J:31524)
• • abnormal neural tube closure   (MGI Ref ID J:31524)
  • • open neural tube
      • characteristic of some E10 embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
    • • spina bifida
        • occurs at a low frequency among embryos inheriting the T^hp allele from their mother   (MGI Ref ID J:31524)
• abnormal notochord morphology
  • at E10 the notochord in the trunk is poorly differentiated and characteristic of embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
  • at E10 the notochord in the tail may be absent, swollen, or duplicated in embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
• • absent notochord
    • at E10 the tail notochord may be absent in embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
• cardiovascular system phenotype
• abnormal pericardium morphology
  • inflation of the pericardium is seen in embryos inheriting the T^hp allele from their mother   (MGI Ref ID J:31524)
• nervous system phenotype
• abnormal neural tube morphology/development
  • at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother   (MGI Ref ID J:31524)
• • abnormal neural tube closure   (MGI Ref ID J:31524)
  • • open neural tube
      • characteristic of some E10 embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
    • • spina bifida
        • occurs at a low frequency among embryos inheriting the T^hp allele from their mother   (MGI Ref ID J:31524)
• exencephaly
  • occurs in low frequency among embryos inheriting the T^hp allele from their mother   (MGI Ref ID J:31524)
• skeleton phenotype
• abnormal vertebral column morphology
  • may end abruptly before or at the level of the second sacral vertebra   (MGI Ref ID J:31524)
• • abnormal cervical vertebrae morphology
    • characteristic of embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
    • one or more may be incomplete dorsally   (MGI Ref ID J:31524)
  • • abnormal cervical atlas morphology
      • characteristic of embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
      • frequently incomplete dorsally   (MGI Ref ID J:31524)
    • abnormal cervical axis morphology
      • characteristic of embryos inheriting the T^hp allele from their father   (MGI Ref ID J:31524)
      • frequently incomplete dorsally   (MGI Ref ID J:31524)
  • abnormal sacral vertebrae morphology   (MGI Ref ID J:31524)
  • short vertebral column   (MGI Ref ID J:31524)

T^hp/T^hp

        involves: AKR/J * C57BL/Gr * CBA/Gr

• mortality/aging
• complete prenatal lethality
  • after implantation   (MGI Ref ID J:5522)

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Thp
Allele Name		hairpin tail
Allele Type		Spontaneous
Strain of Origin		AKR/J
Gene Symbol and Name		T, brachyury
Chromosome		17
Gene Common Name(s)		Bra; Low; Lr; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio;
Associated Marker Note		Affected-Count: 1Af1-Gene: MGI:97837
General Note		Because this allele arose in the AKR/J inbred strain and can only be transmitted to viable offspring via a male carrier, all T strains carry the AKR Y chromosome.
Molecular Note		Restriction length polymorphisms and simple sequence variants were used to define the breakpoints of the deletion that comprises this allele. The proximal breakpoint of the deletion maps between D17Leh66EI and D17Leh66EII and the distal breakpoint is proximal to D17Mit122 but distal to D17Leh66D. The Qk locus is included in the deletion. [MGI Ref ID J:62654]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

T^hp related

Baker J; Liu JP; Robertson EJ; Efstratiadis A. 1993. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75(1):73-82. [PubMed: 8402902]  [MGI Ref ID J:15107]

Barlow DP; Stoger R; Herrmann BG; Saito K; Schweifer N. 1991. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 349(6304):84-7. [PubMed: 1845916]  [MGI Ref ID J:10895]

Bennett D. 1978. Rescue of a lethal T/t locus genotype by chimaerism with normal embryos. Nature 272(5653):539. [PubMed: 692659]  [MGI Ref ID J:6036]

Bennett D. 1975. The T-locus of the mouse. Cell 6:441-454.  [MGI Ref ID J:11933]

Bergstrom RA; You Y; Erway LC; Lyon MF; Schimenti JC. 1998. Deletion mapping of the head tilt (het) gene in mice: a vestibular mutation causing specific absence of otoliths. Genetics 150(2):815-22. [PubMed: 9755211]  [MGI Ref ID J:50247]

Bogani D; Siggers P; Brixey R; Warr N; Beddow S; Edwards J; Williams D; Wilhelm D; Koopman P; Flavell RA; Chi H; Ostrer H; Wells S; Cheeseman M; Greenfield A. 2009. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol 7(9):e1000196. [PubMed: 19753101]  [MGI Ref ID J:153050]

Filson AJ; Louvi A; Efstratiadis A; Robertson EJ. 1993. Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes. Development 118(3):731-6. [PubMed: 8076514]  [MGI Ref ID J:13165]

Friezner Degen SJ; Bell SM; Schaefer LA; Elliott RW. 1990. Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17. Genomics 8(1):49-61. [PubMed: 2081600]  [MGI Ref ID J:11089]

Griffen AB; Frazier JE. 1965. Hairpin tail Mouse News Lett 32:43-44.  [MGI Ref ID J:85320]

Johnson DR. 1974. Further observations on the haipin-tail (Thp) mutation in the mouse. Genet Res 24(2):207-13. [PubMed: 4452482]  [MGI Ref ID J:5522]

Johnson DR. 1974. Hairpin-tail: a case of post-reductional gene action in the mouse egg. Genetics 76(4):795-805. [PubMed: 4838760]  [MGI Ref ID J:31524]

Kagami S; Nakajima H; Kumano K; Suzuki K; Suto A; Imada K; Davey HW; Saito Y; Takatsu K; Leonard WJ; Iwamoto I. 2000. Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue. Blood 95(4):1370-7. [PubMed: 10666213]  [MGI Ref ID J:106678]

McGrath J; Solter D. 1984. Maternal Thp lethality in the mouse is a nuclear, not cytoplasmic, defect. Nature 308(5959):550-1. [PubMed: 6709063]  [MGI Ref ID J:7391]

Planchart A; You Y; Schimenti JC. 2000. Physical mapping of male fertility and meiotic drive quantitative trait loci in the mouse t complex using chromosome deficiencies. Genetics 155(2):803-12. [PubMed: 10835401]  [MGI Ref ID J:62654]

Rennebeck GM; Lader E; Chen Q; Bohm RA; Cai ZS; Faust C; Magnuson T; Pease LR; Artzt K. 1995. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol 172(1):206-17. [PubMed: 7589801]  [MGI Ref ID J:29666]

Sleutels F; Zwart R; Barlow DP. 2002. The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature 415(6873):810-3. [PubMed: 11845212]  [MGI Ref ID J:77594]

Wang E; Cortopassi G. 1994. Mice with duplications and deletions at the Tme locus have altered MnSOD activity. J Biol Chem 269(36):22463-5. [PubMed: 8077189]  [MGI Ref ID J:20170]

Washburn LL; Eicher EM. 1983. Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature 303(5915):338-40. [PubMed: 6855886]  [MGI Ref ID J:7073]

Winking H; Silver LM. 1984. Characterization of a recombinant mouse T haplotype that expresses a dominant lethal maternal effect. Genetics 108(4):1013-20. [PubMed: 6510705]  [MGI Ref ID J:7679]

Wutz A; Theussl HC; Dausman J; Jaenisch R; Barlow DP; Wagner EF. 2001. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Development 128(10):1881-7. [PubMed: 11311167]  [MGI Ref ID J:68721]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Colony Maintenance

Breeding & Husbandry	Thp/+ females can not transmit Thp. Although carrier females can bear carrier pups from carrier males, the carrier pups which inherit Thp from their mother die in utero.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Wild-type from the colony
	000661 C3H/HeSnJ
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

This strain might be segregating for the recessive tufted (tf) mutation, also on Chromosome 17

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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