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Former Names B6C3HFe a/a-tip/J (Changed: 02-SEP-08 ) Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N32 Description
Mice homozygous for the tippy spontaneous mutation (tip) are small, hyperactive, cannot stand or walk without falling over, and die by 20 to 25 days of age.Development
The tippy (tip) mutation arose spontaneously in 1977 at The Jackson Laboratory in the progeny of a B6C3Fe a/a-Csf1op/+ female and a Tbx15de-H homozygous male. The tip mutation was bred away from the other mutation through four crosses to B6C3Fe-a/a and then maintained by ovarian transplant cross-intercross using B6C3Fe-a/a for the cross. In 1991 heterozygotes at approximately generation N20 were intercrossed to generate embryos for cryopreservation and in 1995 heterozygotes at approximately generation N31 were intercrossed to generate more embryos for cryopreservation.
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| Untyped from the colony | ||
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Strains carrying a allele
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Strains carrying other alleles of a
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View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
tip/tip
B6C3Fe a/a-tip/J
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:24235)
- rarely do mutant mice live beyond 28 days of age
- growth/size phenotype
- decreased body size (MGI Ref ID J:24235)
- noticeable by 12-14 days of age
- behavior/neurological phenotype
- ataxia (MGI Ref ID J:24235)
- mice fall backwards or sideways frequently
- hyperactivity (MGI Ref ID J:24235)
- noticeable by 12-14 days of age
- is not accompanied by tremor
- induced hyperactivity (MGI Ref ID J:24235)
- sudden sounds stimulate bursts of activity
- nervous system phenotype
- *normal* nervous system phenotype (MGI Ref ID J:43719)
- the number and distribution of oligodendrocytes in the spinal cord and brain appears normal, electron microscopy of semithin sections at 16 days of age fails to detect any abnormal myelination in the optic nerve, cerebellum, or spinal cord, and myelin appears normal at the ultrastructural level in spinal cord and optic nerve
- optic nerve degeneration (MGI Ref ID J:43719)
- occasional degenerating axons are observed in P16 optic nerve
- vision/eye phenotype
- optic nerve degeneration (MGI Ref ID J:43719)
- occasional degenerating axons are observed in P16 optic nerve
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:tip related
Neurobiology Research
Ataxia (Movement) Defects
| Allele Symbol | a | ||
|---|---|---|---|
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Allele Symbol | tip | ||
| Allele Name | tippy | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | STOCK Csf1op x Tbx15de-H | ||
| Gene Symbol and Name | tip, tippy | ||
| Chromosome | 9 | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
tip relatedFormstone CJ; Barclay J; Rees M; Little PF. 2000. Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9. Mamm Genome 11(5):392-4. [PubMed: 10790539] [MGI Ref ID J:61652]
Holz A; Frank M; Copeland NG; Gilbert DJ; Jenkins NA; Schwab ME. 1997. Chromosomal localization of the myelin-associated oligodendrocytic basic protein and expression in the genetically linked neurological mouse mutants ducky and tippy. J Neurochem 69(5):1801-9. [PubMed: 9349522] [MGI Ref ID J:43719]
Lane PW. 1984. Tippy (tip) Mouse News Lett 71:31. [MGI Ref ID J:13985]
Lane PW; Bronson RT. 1995. Tippy (tip) a lethal mutation on Chromosome 9 in the mouse. Mouse Genome 93(1):158-160. [MGI Ref ID J:24235]
Porter BE; Justice MJ; Copeland NG; Jenkins NA; Hunter DD; Merlie JP; Sanes JR. 1993. S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and ducky. Genomics 16(1):278-81. [PubMed: 8486374] [MGI Ref ID J:4399]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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