Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Breeding Considerations This strain is a good breeder. Species laboratory mouse H2 Haplotype z Generation F98 (17-SEP-12) Generation Definitions

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Appearance
albino
Related Genotype: Tyrp1^b/Tyrp1^b Oca2^p Tyr^c/Oca2^p Tyr^c A/A

Description
NZW mice have a normal lifespan but do develop anti-DNA antibodies, high serum levels of retroviral gp70 antigen, and nephritis later in life. F1 hybrids of NZB/BlNJ and NZW/LacJ (Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus.

Development
The New Zealand White inbred strain (NZW) was produced by WH Hall in 1952 by inbreeding an outbred mouse colony and selection for white coat color. Dr. SE Bernstein at The Jackson Laboratory obtained NZW mice from the Laboratory Animal Center, Carshalton, Surrey (Lac) in 1981 and were subsequently transferred to the production colony. The current generation of inbreeding of NZW/LacJ mice is F48+.

Related Strains

NZW Strains

003560

NZW/OsuJ

View NZW Strains     (1 strain)

Strains carrying   Pctp^R120H allele

000684	NZB/BlNJ
002105	NZO/HlLtJ

View Strains carrying   Pctp^R120H     (2 strains)

Strains carrying other alleles of Pctp

006607

B6.129-Pctptm1Bor/J

View Strains carrying other alleles of Pctp     (1 strain)

Additional Web Information

JAX^® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX^® NOTES, Winter 2006; 504. JAX^® Mice: the Gold Standard Just Got Better.
Mouse Phenome Database / SNP Facility

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: NZW

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Hematological Research
Anemia, Iron Deficiency and Transport Defects
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      experimental allergic encephalomyelitis (EAE)
      hemolytic anemia

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		PctpR120H
Allele Name		R120H
Allele Type		Spontaneous
Strain of Origin		NZO
Gene Symbol and Name		Pctp, phosphatidylcholine transfer protein
Chromosome		11
Gene Common Name(s)		PC-TP; STARD2;
Molecular Note		A G to A transition in exon 4 resulted in the arginine to histidine substitution at amino acid 120 in NZO, NZB/BINJ and NZW/LacJ strains. This mutation rendered the protein was inactive. [MGI Ref ID J:114974]

Genotyping

Genotyping Information

Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Haskell BD; Flurkey K; Duffy TM; Sargent EE; Leiter EH. 2002. The diabetes-prone NZO/HlLt strain. I. Immunophenotypic comparison to the related NZB/BlNJ and NZW/LacJ strains. Lab Invest 82(7):833-42. [PubMed: 12118085]  [MGI Ref ID J:77828]

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Additional References

Kumar V; Sercarz E. 1994. Holes in the T cell repertoire to myelin basic protein owing to the absence of the D beta 2-J beta 2 gene cluster: implications for T cell receptor recognition and autoimmunity. J Exp Med 179(5):1637-43. [PubMed: 7513012]  [MGI Ref ID J:18398]

Rigby RJ; Rozzo SJ; Gill H; Fernandez-Hart T; Morley BJ; Izui S; Kotzin BL; Vyse TJ. 2004. A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c. J Immunol 172(8):5078-85. [PubMed: 15067091]  [MGI Ref ID J:89134]

Pctp^R120H related

Pan HJ; Agate DS; King BL; Wu MK; Roderick SL; Leiter EH; Cohen DE. 2006. A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. FEBS Lett 580(25):5953-8. [PubMed: 17046758]  [MGI Ref ID J:114974]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           MP16

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations	This strain is a good breeder.
Diet Information	LabDiet® 5K54

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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