Strain Name: |
NZW/LacJ |
|---|---|
Stock Number: |
001058 |
Availability: | Level 4 |
Price and Supply Information | |
General Terms and Conditions |
| Strain Common Names | New Zealand White; |
| Genes & Alleles | Pctp; PctpR120H; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype z Generation F84 (03-JAN-08) Appearance
albino
Related Genotype: Tyrp1b/Tyrp1b Oca2p Tyrc/Oca2p TyrcStrain Description
NZW mice have a normal lifespan but do develop anti-DNA antibodies, high serum levels of retroviral gp70 antigen, and nephritis later in life. F1 hybrids of NZB/BlNJ and NZW/LacJ (Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus.Strain Development
The New Zealand White inbred strain (NZW) was produced by WH Hall in 1952 by inbreeding an outbred mouse colony and selection for white coat color. Dr. SE Bernstein at The Jackson Laboratory obtained NZW mice from the Laboratory Animal Center, Carshalton, Surrey (Lac) in 1981 and were subsequently transferred to the production colony. The current generation of inbreeding of NZW/LacJ mice is F48+.
Gene & Allele Details
| Allele Symbol | PctpR120H | ||
|---|---|---|---|
| Allele Name | R120H | ||
| Strain of Origin | NZO | ||
| Gene Symbol and Name | Pctp, phosphatidylcholine transfer protein | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | PC-TP; STARD2; | ||
| Molecular Note | A G to A transition in exon 4 resulted in the arginine to histidine substitution at amino acid 120 in NZO, NZB/BINJ and NZW/LacJ strains. This mutation rendered the protein was inactive. [MGI Ref ID J:114974] | ||
Colony Maintenance
| Diet Information | LabDiet® 5K54 |
|---|
Related Strains
NZW Strains
003560 NZW/Osu View NZW Strains (1 strain)
006607 B6.129-Pctptm1Bor/J
Phenotypic Data
Mouse Phenome Database
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: NZW
Additional Web Information
Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
Animal Health Reports
Room Number MP16
Research Applications
This mouse can be used to support research in many areas including:
Hematological Research
Anemia, Iron Deficiency and Transport Defects
Immunological Defects
Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
Autoimmunity (hemolytic anemia)
References
Selected Reference(s)
Additional ReferencesHaskell BD; Flurkey K; Duffy TM; Sargent EE; Leiter EH. 2002. The diabetes-prone NZO/HlLt strain. I. Immunophenotypic comparison to the related NZB/BlNJ and NZW/LacJ strains. Lab Invest 82(7):833-42. [PubMed: 12118085] [MGI Ref ID J:77828]
Price and Supply Information
| Strain Name: | NZW/LacJ |
| Stock Number: | 001058 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
USA, Canada and Mexico
| Price(s) in US dollars ($) | Genotype(s) Provided | ||||
|---|---|---|---|---|---|
| 3-5 weeks | $20.00 | Female | |||
| 6 weeks | $21.90 | Female | |||
| 7 weeks | $23.80 | Female | |||
| 8 weeks | $25.70 | Female | |||
| 3-5 weeks | $20.00 | Male | |||
| 6 weeks | $21.90 | Male | |||
| 7 weeks | $23.80 | Male | |||
| 8 weeks | $25.70 | Male | |||
Supply Details
| Standard Supply | Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months. |
|---|---|
| Supply Notes |
Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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