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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names SWXJ-9/BmJ (Changed: 15-DEC-04 ) Type Recombinant Inbred (Ri); Additional information on Recombinant Inbred Mice. Species laboratory mouse RI progenitor SWR/Bm SJL/Bm H2 Haplotype q Generation F65p Description
SWXJ-9 female mice develop ovarian granulosa cell carcinomas with an incidence of approximately 12% and a latency of 4-6 weeks. Tumor incidence can be increased to approximately 40% by treatment with dehydroepiandrosterone (DHEA) or testosterone immediately after weaning. Treatment with estradiol during this period completely suppresses tumorigenesis. Neoplasias are first observed as hemorrhagic follicles in which the antrum is blood-filled and lined with irregular masses of proliferating granulosa cells. By 6-10 weeks of age, the primary tumor encompasses the entire ovary. Metastases to lung, renal node, and liver are common by 6 to 9 months of age, with other sites occasionally affected. Susceptibility to granulosa cell carcinomas is controlled by a small number of genes, including a major susceptibility locus on Chromosome 4 and a major modifier locus on the X chromosome.
Related Strains
SWXJ Strains
001080 SWXJ10/BmJ 001081 SWXJ11/BmJ 001082 SWXJ12/BmJ 001083 SWXJ13/BmJ 001084 SWXJ14/BmJ 001072 SWXJ2/BmJ 001073 SWXJ3/BmJ 001074 SWXJ4/BmJ 001075 SWXJ5/BmJ 001076 SWXJ6/BmJ 001077 SWXJ7/BmJ 001078 SWXJ8/BmJ View SWXJ Strains (12 strains)
Phenotype
Phenotype Information
Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for SWXJ RI Line
This mouse can be used to support research in many areas including:
Cancer Research
Increased Tumor Incidence (Gonadal Tumors: testicular teratomas)
Reproductive Biology Research
Gonadal Tumors (granulosa cell tumors)
Research Tools
Cancer Research (genes regulating granulosa cell tumorigenesis)
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)
Genes & Alleles
Gene & Allele Information
Currently there are no related genes or alleles for this strain.Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Beamer WG; Shultz KL; Tennent BJ; Nadeau JH; Churchill GA; Eicher EM. 1998. Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res 58(16):3694-9. [PubMed: 9721880] [MGI Ref ID J:49710]
Tennent BJ; Shultz KL; Beamer WG. 1993. Genetic susceptibility for C19 androgen induction of ovarian granulosa cell tumorigenesis in SWXJ strains of mice. Cancer Res 53(5):1059-63. [PubMed: 8439952] [MGI Ref ID J:4202]
Tennent BJ; Shultz KL; Sundberg JP; Beamer WG. 1990. Ovarian granulosa cell tumorigenesis in SWR-derived F1 hybrid mice: preneoplastic follicular abnormality and malignant disease progression. Am J Obstet Gynecol 163(2):625-34. [PubMed: 2386155] [MGI Ref ID J:48590]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Individual Mouse Price $60.90 Female or Male
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Individual Mouse Price $79.20 Female or Male
Additional Supply Details
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Supply Details
| Standard Supply | Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain. |
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General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact Information
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Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
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| fax: | 207-288-6655 |
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