| |||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names C.B-17 (Changed: 15-DEC-04 ) C.BKa-Ighb/IcrSmn (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain BALB/c Donor Strain C57BL/Ka Generation F79 (19-AUG-11)
Generation DefinitionsAppearance
albino
Related Genotype: Tyrp1b/Tyrp1b Tyrc/TyrcDescription
C.BKa-Igh b/IcrSmn mice express the immunoglobulin heavy-chain repertoire (Ighb) of C57BL/Ka. This is a congenic strain arising from a backcross of BALB/cxC57BL/Ka-Igh a/Igh b to BALB/c from which progeny were intercrossed to obtain mice homozygous for Igh b. Initial reports indicated that these mice occasionally expressed IgG2a, but this phenomenon was transient and unpredictable. The C.BKa-Igh b/IcrSmn (commonly referred to as C.B-17) is the background strain in which the Prkdc scid mutation arose. It is primarily used as a coisogenic control strain for C.B17/Icr-scid. Characteristics of C.BKa-Igh b/IcrSmn are essentially those of BALB/c.Development
This is a congenic strain carrying a varient of the immunoglobulin heavy chain complex allele from the C57BL/Ka strain. The BALB/c-Ighb/Smn strain (commonly referred to as C.B-17) is the background strain in which the Prkdcscid mutation arose.
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Igh
012642 B6.129P2(C)-Ightm2Cgn/J 007776 B6.129P2-Ightm2Mnz/J 007594 B6.129P2-Ptrpca Ightm1Mnz/J 001317 B6.Cg-Igha Thy1a Gpi1a/J 017574 B6;C3-Tg(Igh-V186.2-TCL1A)3Cro/J 011074 C.129P2(B6)-Igktm1Rsky Ightm2Rsky/PldJ 012235 C.129P2(B6)-Igktm2Rsky Ightm2Rsky/J 008332 C.129S1-Ightm1(Myc)Janz/J 001109 C.AL-Igho/SmnJ 004126 C.Cg-Cd19tm1(cre)Cgn Ighb/J 007775 CBy.129P2(B6)-Ightm1Mnz/J View Strains carrying other alleles of Igh (11 strains)
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Research Tools
Genetics Research
Tissue/Cell Markers
Genes & Alleles
Gene & Allele Information provided by MGI
| Gene Symbol and Name | Igh, immunoglobulin heavy chain complex | ||
|---|---|---|---|
| Chromosome | 12 | ||
References
References provided by MGI
Additional References
Bosma GC; Custer RP; Bosma MJ. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301(5900):527-30. [PubMed: 6823332] [MGI Ref ID J:6958]
Li H; Jiang Y; Cao H; Radic M; Prak EL; Weigert M. 2003. Regulation of anti-phosphatidylserine antibodies. Immunity 18(2):185-92. [PubMed: 12594946] [MGI Ref ID J:82329]
Schreier PH; Quester S; Bothwell A. 1986. Allotypic differences in murine mu genes. Nucleic Acids Res 14(5):2381-9. [PubMed: 3083402] [MGI Ref ID J:8246]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
 |
Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $125.00 Female or Male Homozygous for Ighb Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
|
Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $162.50 Female or Male Homozygous for Ighb Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiriesContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.