Description

Strain Information

Former Names CZECHII/Ei    (Changed: 15-DEC-04 ) Type Inbred Strain; Additional information on Inbred Strains. Type Wild-Derived; Additional information on Wild-Derived Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species M. m. musculus (Czech) Generation F16+77 (06-DEC-12) Generation Definitions Geographic Origin Czechoslovakia

Appearance
white-bellied agouti
Related Genotype: A^w/A^w

Description
CZECHII/EiJ was derived from wild mice trapped in Slovakia (formerly Czechoslovakia). Unique among the thirty inbred strains tested, Velupillai et. al. reported that CZECH mice inoculated with mouse polyoma virus (Py) develop metastatic lesions in the lung derived from osteosarcomas. As such, CZECH may serve as a model for metastatic osteosarcoma in the presence of functional TRP53. Stephan et. al. reported that wild-derived strains, CZECH, MOLF (Stock No. 000550) and MSM (Stock No. 003719), exhibit decreased secretion of TNF in response to stimulation by poly(I:C) (a synthetic analog of double-stranded RNA), the result of a P369L substitution in Tlr3. Response to Tlr2, Tlr4 and Tlr7-agonists is normal. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development
Founder mice were trapped outside East Bratislava, Slovakia (formerly Czechoslovakia) by M. Kuiniack for Dr. Richard Sage in 1978. Sage sent mice to M. Potter in 1981, and, from there, mice were sent to EM Eicher at The Jackson Laboratory in 1986.

Additional Web Information

JAX^® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.
Mouse Phenome Database / SNP Facility

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Other Tissues/Organs: osteosarcoma

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Tlr deficiency

Research Tools
Genetics Research
      Evolution and Systematics Research
      Gene Mapping
      Gene Mapping: Polymorphisms

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Scott CL; Potter M. 1984. Variation in V lambda genes in the genus Mus. J Immunol 132(5):2638-43. [PubMed: 6325542]  [MGI Ref ID J:109954]

Scott CL; Potter M. 1984. Polymorphism of C lambda genes and units of duplication in the genus Mus. J Immunol 132(5):2630-7. [PubMed: 6325541]  [MGI Ref ID J:109955]

Stephan K; Smirnova I; Jacque B; Poltorak A. 2007. Genetic analysis of the innate immune responses in wild-derived inbred strains of mice. Eur J Immunol 37(1):212-23. [PubMed: 17163447]  [MGI Ref ID J:117078]

Velupillai P; Sung CK; Tian Y; Dahl J; Carroll J; Bronson R; Benjamin T. 2010. Polyoma virus-induced osteosarcomas in inbred strains of mice: host determinants of metastasis. PLoS Pathog 6(1):e1000733. [PubMed: 20107604]  [MGI Ref ID J:193164]

Additional References

Ideraabdullah FY; de la Casa-Esperon E; Bell TA; Detwiler DA; Magnuson T; Sapienza C; de Villena FP. 2004. Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res 14(10A):1880-7. [PubMed: 15466288]  [MGI Ref ID J:193384]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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