Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Type Wild-Derived; Additional information on Wild-Derived Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male) Species M. spretus (Spain) Generation F81 (12-JAN-09) Geographic Origin Puerto Real, Cadiz Province, Spain

Appearance
white-bellied agouti
Related Genotype: A^w/A^w

Description
The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases.

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Mouse Phenome Database / SNP Facility

Genes & Alleles

Gene & Allele Information

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. [PubMed: 10749765]  [MGI Ref ID J:61602]

Staelens J; Puimege L; Mahieu T; Pynaert G; Hochepied T; Vandenabeele A; Grooten J; Kontoyiannis D; Van Roy F; Kollias G; Libert C. 2004. Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders. Mamm Genome 15(7):537-43. [PubMed: 15366373]  [MGI Ref ID J:92307]

Staelens J; Wielockx B; Puimege L; Van Roy F; Guenet JL; Libert C. 2002. Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci U S A 99(14):9340-5. [PubMed: 12089334]  [MGI Ref ID J:77727]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A2A
Room Number           MGL375/MGL377

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

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