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Type Inbred Strain; Additional information on Inbred Strains. Type Wild-Derived; Additional information on Wild-Derived Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species M. spretus (Spain) Generation F86 (30-OCT-09) Geographic Origin Puerto Real, Cadiz Province, Spain Appearance
white-bellied agouti
Related Genotype: Aw/AwDescription
The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases.
Strains carrying Ahrb-3 allele
002920 B6(D2N).Spretus-Ahrb-3/J 000926 CAROLI/EiJ 000550 MOLF/EiJ View Strains carrying Ahrb-3 (3 strains)
Strains carrying other alleles of Ahr
000645 A/HeJ 000646 A/J 000648 AKR/J 006203 B6.129(FVB)-Ahrtm3.1Bra/J 002831 B6.129-Ahrtm1Bra/J 000130 B6.C-H17c/(HW14)ByJ 000136 B6.C-H34c/(HW22)ByJ 000370 B6.C-H38c/(HW119)ByJ 002921 B6.D2N-Ahrd/J 002727 B6;129-Ahrtm1Bra/J 001026 BALB/cByJ 000659 C3H/HeJ 000664 C57BL/6J 000669 C58/J 000351 CXB1/ByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000356 CXB6/ByJ 000357 CXB7/ByJ 002937 D2.B6-Ahrb-1/J 000671 DBA/2J 000677 MA/MyJ View Strains carrying other alleles of Ahr (24 strains)
Genetic Quality Control Annual Report
JAX® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.
View Phenotypic Data
Phenotypic Data
Mouse Phenome Database
Mouse Phenome Database / SNP Facility
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
Ahrb-3/Ahrb-3
M. spretus
- no phenotypic analysis
- *normal* no phenotypic analysis (MGI Ref ID J:34840)
- no phenotypic analysis on this allele is currently available
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Ahrb-3 relatedImmunology and Inflammation Research
Inflammation
Reproductive Biology Research
Fertility Defects
male progeny from outcrosses to inbred are sterile
Research Tools
Genetics Research
Evolution and Systematics Research
Gene Mapping: Polymorphisms
Metabolism Research
Research Tools
Toxicology Research
| Allele Symbol | Ahrb-3 | ||
|---|---|---|---|
| Allele Name | b-3 variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | Ahb-3; | ||
| Strain of Origin | M. spretus | ||
| Gene Symbol and Name | Ahr, aryl-hydrocarbon receptor | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity; | ||
| General Note |
C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460). Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains | ||
| Molecular Note | This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele. [MGI Ref ID J:22144] | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. [PubMed: 10749765] [MGI Ref ID J:61602]
Staelens J; Puimege L; Mahieu T; Pynaert G; Hochepied T; Vandenabeele A; Grooten J; Kontoyiannis D; Van Roy F; Kollias G; Libert C. 2004. Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders. Mamm Genome 15(7):537-43. [PubMed: 15366373] [MGI Ref ID J:92307]
Staelens J; Wielockx B; Puimege L; Van Roy F; Guenet JL; Libert C. 2002. Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci U S A 99(14):9340-5. [PubMed: 12089334] [MGI Ref ID J:77727]
Ahrb-3 relatedChang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. [PubMed: 8148872] [MGI Ref ID J:17460]
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. [PubMed: 4114109] [MGI Ref ID J:5282]
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579] [MGI Ref ID J:34840]
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. [PubMed: 2823093] [MGI Ref ID J:8895]
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. [PubMed: 7969080] [MGI Ref ID J:22144]
Animal Health Reports
Room Number A2A
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Individual Mouse $127.30 Female or Male
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Individual Mouse $165.50 Female or Male
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Purchasing Information
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Contact Information
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