|The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei may be useful for studies relating to inflammatory disorders.|
Type Inbred Strain; Additional information on Inbred Strains. Type Wild-Derived; Additional information on Wild-Derived Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species M. spretus (Spain) Generation F86 (30-OCT-09)
Geographic Origin Puerto Real, Cadiz Province, Spain
Related Genotype: Aw/Aw
The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases.
SPRET was derived from wild mice trapped by RD Sage in 1978 in Puerto Real, Cadiz Province, Spain. Mice were sent to Dr Mike Potter at The National Cancer Institute who subsequently transferred mice to Dr Eva Eicher at The Jackson Laboratory in 1983.
View Strains carrying Ahrb-3 (3 strains)Strains carrying other alleles of Ahr
000690 129P3/J 000645 A/HeJ 000646 A/J 000648 AKR/J 002831 B6.129-Ahrtm1Bra/J 000130 B6.C-H17c/(HW14)ByJ 000136 B6.C-H34c/(HW22)ByJ 000370 B6.C-H38c/(HW119)ByJ 008599 B6.Cg-Del(9Cyp1a2-Cyp1a1)1Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ 002921 B6.D2N-Ahrd/J 002727 B6;129-Ahrtm1Bra/J 001026 BALB/cByJ 000652 BDP/J 000653 BUB/BnJ 000659 C3H/HeJ 000663 C57BL/6By 001139 C57BL/6ByJ 000664 C57BL/6J 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000928 CAST/EiJ 000656 CBA/J 000657 CE/J 000351 CXB1/ByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000356 CXB6/ByJ 000357 CXB7/ByJ 002937 D2.B6-Ahrb-1/J 000671 DBA/2J 000673 HRS/J 000674 I/LnJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 000684 NZB/BlNJ 000679 P/J 000930 PERA/EiJ 000726 RBF/DnJ 000682 RF/J 000644 SEA/GnJ 000280 SF/CamEiJ 000686 SJL/J 000688 ST/bJ 006203 STOCK Ahrtm3.1Bra/J 000689 SWR/J 000693 WC/ReJ KitlSl/J 000933 YBR/EiJView Strains carrying other alleles of Ahr (52 strains)
View Phenotypic DataPhenotypic DataView Mammalian Phenotype TermsMammalian Phenotype Terms provided by MGIassigned by genotype
Ahrb-3/Ahrb-3M. spretusView Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Immunology, Inflammation and Autoimmunity Research
Reproductive Biology Research
male progeny from outcrosses to inbred are sterile
Evolution and Systematics Research
Gene Mapping: Polymorphisms
|Allele Name||b-3 variant|
|Allele Type||Not Applicable|
|Strain of Origin||M. spretus|
|Gene Symbol and Name||Ahr, aryl-hydrocarbon receptor|
|Gene Common Name(s)||Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity;|
Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains
|Molecular Note||This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele. [MGI Ref ID J:22144]|
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119] [MGI Ref ID J:89298]
Ideraabdullah FY; de la Casa-Esperon E; Bell TA; Detwiler DA; Magnuson T; Sapienza C; de Villena FP. 2004. Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res 14(10A):1880-7. [PubMed: 15466288] [MGI Ref ID J:193384]
Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94. [PubMed: 21921910] [MGI Ref ID J:177037]
Staelens J; Puimege L; Mahieu T; Pynaert G; Hochepied T; Vandenabeele A; Grooten J; Kontoyiannis D; Van Roy F; Kollias G; Libert C. 2004. Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders. Mamm Genome 15(7):537-43. [PubMed: 15366373] [MGI Ref ID J:92307]
Staelens J; Wielockx B; Puimege L; Van Roy F; Guenet JL; Libert C. 2002. Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci U S A 99(14):9340-5. [PubMed: 12089334] [MGI Ref ID J:77727]Ahrb-3 related
Animal Health ReportsRoom Number A2A
Mating System Sibling x Sibling (Female x Male) 01-MAR-06
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Price per mouse (US dollars $) Gender Individual Mouse $199.90 Female or Male
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Price per mouse (US dollars $) Gender Individual Mouse $259.90 Female or Male
This strain is currently on HOLD - Contact Customer Service for more information.
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