Strain Name:


Stock Number:



On Hold

Register Interest
The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei may be useful for studies relating to inflammatory disorders.


Strain Information

Type Inbred Strain;
Additional information on Inbred Strains.
Type Wild-Derived;
Additional information on Wild-Derived Mice.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
SpeciesM. spretus (Spain)
GenerationF86 (30-OCT-09)
Generation Definitions
Geographic OriginPuerto Real, Cadiz Province, Spain

white-bellied agouti
Related Genotype: Aw/Aw

The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases.

SPRET was derived from wild mice trapped by RD Sage in 1978 in Puerto Real, Cadiz Province, Spain. Mice were sent to Dr Mike Potter at The National Cancer Institute who subsequently transferred mice to Dr Eva Eicher at The Jackson Laboratory in 1983.

Related Strains

Strains carrying   Ahrb-3 allele
002920   B6(D2N).Spretus-Ahrb-3/J
000926   CAROLI/EiJ
000550   MOLF/EiJ
View Strains carrying   Ahrb-3     (3 strains)

Strains carrying other alleles of Ahr
000690   129P3/J
000645   A/HeJ
000646   A/J
000648   AKR/J
002831   B6.129-Ahrtm1Bra/J
000130   B6.C-H17c/(HW14)ByJ
000136   B6.C-H34c/(HW22)ByJ
000370   B6.C-H38c/(HW119)ByJ
008599   B6.Cg-Del(9Cyp1a2-Cyp1a1)1Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ
002921   B6.D2N-Ahrd/J
002727   B6;129-Ahrtm1Bra/J
001026   BALB/cByJ
000652   BDP/J
000653   BUB/BnJ
000659   C3H/HeJ
000663   C57BL/6By
001139   C57BL/6ByJ
000664   C57BL/6J
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
000928   CAST/EiJ
000656   CBA/J
000657   CE/J
000351   CXB1/ByJ
000352   CXB2/ByJ
000353   CXB3/ByJ
000354   CXB4/ByJ
000355   CXB5/ByJ
000356   CXB6/ByJ
000357   CXB7/ByJ
002937   D2.B6-Ahrb-1/J
000671   DBA/2J
000673   HRS/J
000674   I/LnJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
000684   NZB/BlNJ
000679   P/J
000930   PERA/EiJ
000726   RBF/DnJ
000682   RF/J
000644   SEA/GnJ
000280   SF/CamEiJ
000686   SJL/J
000688   ST/bJ
006203   STOCK Ahrtm3.1Bra/J
000689   SWR/J
000693   WC/ReJ KitlSl/J
000933   YBR/EiJ
View Strains carrying other alleles of Ahr     (52 strains)

Additional Web Information

JAX® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.
Mouse Phenome Database / SNP Facility
Sequence data is available from the Mouse Genomes Project at the Wellcome Trust Sanger Institute


Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


        M. spretus
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype   (MGI Ref ID J:22144)
    • mice are not susceptible to the pathological effects of polycyclic aromatic hydrocarbons   (MGI Ref ID J:34840)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research

Reproductive Biology Research
Fertility Defects
      male progeny from outcrosses to inbred are sterile

Research Tools
Genetics Research
      Evolution and Systematics Research
      Gene Mapping
      Gene Mapping: Polymorphisms

Ahrb-3 related

Metabolism Research

Research Tools
Toxicology Research

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Ahrb-3
Allele Name b-3 variant
Allele Type Not Applicable
Common Name(s) Ahb-3;
Strain of OriginM. spretus
Gene Symbol and Name Ahr, aryl-hydrocarbon receptor
Chromosome 12
Gene Common Name(s) Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity;
General Note

Strain of origin - this allele was found in M. caroli, M. spretus, MOLF/Ei strains

Molecular Note This allele encodes a high affinity, 105 kDa receptor with slightly more heat stability than the receptor encoded by the BALB/cBy allele. [MGI Ref ID J:22144]


Genotyping Information

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Additional References

Ideraabdullah FY; de la Casa-Esperon E; Bell TA; Detwiler DA; Magnuson T; Sapienza C; de Villena FP. 2004. Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res 14(10A):1880-7. [PubMed: 15466288]  [MGI Ref ID J:193384]

Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94. [PubMed: 21921910]  [MGI Ref ID J:177037]

Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. [PubMed: 10749765]  [MGI Ref ID J:61602]

Staelens J; Puimege L; Mahieu T; Pynaert G; Hochepied T; Vandenabeele A; Grooten J; Kontoyiannis D; Van Roy F; Kollias G; Libert C. 2004. Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders. Mamm Genome 15(7):537-43. [PubMed: 15366373]  [MGI Ref ID J:92307]

Staelens J; Wielockx B; Puimege L; Van Roy F; Guenet JL; Libert C. 2002. Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci U S A 99(14):9340-5. [PubMed: 12089334]  [MGI Ref ID J:77727]

Ahrb-3 related

Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579]  [MGI Ref ID J:34840]

Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. [PubMed: 7969080]  [MGI Ref ID J:22144]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A2A

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


This strain is currently On Hold.
Register Interest

To request more information use the Customer Support Contact Form or call 1-800-422-6423 or 1-207-288-5845

View All Strains Awaiting Transfer from the Donor, In Progress and On Hold

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $199.90Female or Male  

Standard Supply

This strain is currently on HOLD - Contact Customer Service for more information.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $259.90Female or Male  

Standard Supply

This strain is currently on HOLD - Contact Customer Service for more information.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

This strain is currently on HOLD - Contact Customer Service for more information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
  • 5/18/15 Stock 001146 is on hold due to breeding performance difficulties in the colony. It is unknown when this on hold status will be lifted.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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