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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B10.A-H2h4 (4R)/SgDvEg (Changed: 15-DEC-04 ) B10.A-H2h4(4R)/SgDvEg (Changed: 15-DEC-04 ) B10.A-H2h4/(4R)SgDvEg (Changed: 15-DEC-04 ) Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Background Strain C57BL/10SnSg Donor Strain A/WySn Generation F54 Appearance
black
Related Genotype: a/a
Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2h4 allele
004447 NOD.Cg-H2h4/DilTacUmmJ View Strains carrying H2h4 (1 strain)
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Allele Symbol | H2h4 | ||
|---|---|---|---|
| Allele Name | h4 variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | H-2h4; | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | This variant has been observed in the following strains: B10.A(4R) | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189] [MGI Ref ID J:109945]
Miyashita N; Moriwaki K; Migita S. 1989. The H-2 class II genes and the susceptibility to the development of pulmonary adenoma in mice. Immunogenetics 29(1):14-8. [PubMed: 2783252] [MGI Ref ID J:32504]
STIMPFLING JH; RICHARDSON A. 1965. RECOMBINATION WITHIN THE HISTOCOMPATIBILITY LOCUS OF THE MOUSE. Genetics 51:831-46. [PubMed: 14326057] [MGI Ref ID J:109971]
Additional References
H2h4 relatedBraley-Mullen H; Sharp GC; Medling B; Tang H. 1999. Spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J Autoimmun 12(3):157-65. [PubMed: 10222025] [MGI Ref ID J:54563]
Braley-Mullen H; Yu S. 2000. Early requirement for B cells for development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice J Immunol 165(12):7262-9. [PubMed: 11120860] [MGI Ref ID J:66106]
Fang Y; Sharp GC; Braley-Mullen H. 2008. Interleukin-10 promotes resolution of granulomatous experimental autoimmune thyroiditis. Am J Pathol 172(6):1591-602. [PubMed: 18467701] [MGI Ref ID J:136188]
Hutchings PR; Verma S; Phillips JM; Harach SZ; Howlett S; Cooke A. 1999. Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice. Cell Immunol 192(2):113-21. [PubMed: 10087179] [MGI Ref ID J:54320]
Levisetti MG; Lewis DM; Suri A; Unanue ER. 2008. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57(7):1852-60. [PubMed: 18398138] [MGI Ref ID J:138230]
Nagayama Y; Horie I; Saitoh O; Nakahara M; Abiru N. 2007. CD4(+)CD25(+) naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune thyroiditis in NOD-H2(h4) mice. J Autoimmun 29(2-3):195-202. [PubMed: 17826032] [MGI Ref ID J:125178]
Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054] [MGI Ref ID J:14178]
Sharma R; Traore K; Trush MA; Rose NR; Burek CL. 2008. Intracellular adhesion molecule-1 up-regulation on thyrocytes by iodine of non-obese diabetic.H2(h4) mice is reactive oxygen species-dependent. Clin Exp Immunol 152(1):13-20. [PubMed: 18241232] [MGI Ref ID J:133583]
Yu S; Sharp GC; Braley-Mullen H. 2008. TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice. J Immunol 181(3):2238-45. [PubMed: 18641364] [MGI Ref ID J:139224]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000666 C57BL/10SnJ | (approximate) | |
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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| fax: | 207-288-6655 |
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