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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Description
Mice homozygous for the meander tail-J spontaneous mutation (meaJ) have variably shortened and kinked tails. At about 2 weeks an unsteadiness of gait, often amounting to a tremor, appears. Homozygous mutant mice are smaller and less vigorous than wiltype controls but are fertile. The anterior lobe of the cerebellum is disorganized. Purkinje cells are scattered, some cellular layers never form, and Bergmann glial processes are absent. The cytoarchitecture of the posterior lobe is normal, and the transition from normal to disorganized areas is sharply demarcated. This mutation occurred in the BKS.Cg-Leprdb +/+ m strain so it is also segregating for the diabetes (Leprdb) and misty (m) mutations. See strain description for BKS.Cg-Leprdb +/+ m (Stock No. 000642) for more information.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| 000662 C57BLKS/J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Leprdb allele
002048 B6 x C57BLKS-m Leprdb Myo15sh2-J/J 000697 B6.Cg-m +/+ Leprdb/J 000699 B6.Cg-m Leprdb/+ +/J 000642 BKS.Cg-m +/+ Leprdb/J 000700 BKS.Cg-m Leprdb/+ +/J 000707 CBA.Cg-m Leprdb/+ +/J 006654 FVB.BKS(D)-Leprdb/ChuaJ View Strains carrying Leprdb (7 strains)
002048 B6 x C57BLKS-m Leprdb Myo15sh2-J/J 000697 B6.Cg-m +/+ Leprdb/J 000699 B6.Cg-m Leprdb/+ +/J 000027 B6.D-Tyrp1b m/J 000642 BKS.Cg-m +/+ Leprdb/J 000700 BKS.Cg-m Leprdb/+ +/J 001049 BKS.Cg-mea2J m/+ +/J 000707 CBA.Cg-m Leprdb/+ +/J
000709 129P3/J-Leprdb-3J/J 008518 B6.129-Leprtm1Mgmj/J 008320 B6.129-Leprtm2(cre)Rck/J 008385 B6.129-Leprtm2Mgmj/J 008327 B6.129P2-Leprtm1Rck/J 004939 NOD/ShiLtJ-Leprdb-5J/LtJ 006846 STOCK Leprdb-9J/Jgn
001049 BKS.Cg-mea2J m/+ +/J
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Leprdb relatedDiabetes and Obesity Research
Hyperglycemia
Type 2 Diabetes (NIDDM)
m relatedDiabetes and Obesity Research
Hyperinsulinemia
Impaired Wound Healing
Insulin Resistance
Obesity With Diabetes
Endocrine Deficiency Research
Adipose Defects
Hypothalamus/Pituitary Defects
Pancreas Defects
Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects
Internal/Organ Research
Adipose Defects
Metabolism Research
Mouse/Human Gene Homologs
obesity, morbid, with hypogonadism (rare)
Reproductive Biology Research
Fertility Defects
meaJ relatedDermatology Research
Color and White Spotting Defects
Developmental Biology Research
Skeletal Defects
Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Leprdb | ||
|---|---|---|---|
| Allele Name | diabetes | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Lepdb; Lepr-; Leprdb-1J; db; leprdb; | ||
| Strain of Origin | C57BLKS/J | ||
| Gene Symbol and Name | Lepr, leptin receptor | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | CD295; Fa; LEPROT; Leprb; Modb1; OB-RGRP; OBR; db; diabetes; leptin receptor gene-related protein; obese-like; obl; | ||
| Molecular Note | A G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and a 106 nt insertion in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function. [MGI Ref ID J:31324] [MGI Ref ID J:31327] [MGI Ref ID J:31488] | ||
| Allele Symbol | m | ||
| Allele Name | misty | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | DBA/J | ||
| Allele Symbol | meaJ | ||
| Allele Name | meander tail Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C57BLKS/J-m +/+ Leprdb | ||
| Gene Symbol and Name | mea, meander tail | ||
| Chromosome | 4 | ||
| General Note | This mutation is the first remutation to meander tail found at The Jackson Laboratory (J:16313). | ||
Genotyping
Genotyping Information
Genotyping Protocols
Leprdb, PYRO, vers. 2
Leprdb, REST, vers. 1
m (Misty), STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Chen H; Charlat O; Tartaglia LA; Woolf EA; Weng X; Ellis SJ; Lakey ND; Culpepper J; Moore KJ; Breitbart RE; Duyk GM; Tepper RI; Morgenstern JP. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84(3):491-5. [PubMed: 8608603] [MGI Ref ID J:31324]
Chua SC Jr; Chung WK; Wu-Peng XS; Zhang Y; Liu SM; Tartaglia L; Leibel RL. 1996. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor [see comments] Science 271(5251):994-6. [PubMed: 8584938] [MGI Ref ID J:31419]
Hamre KM; Goldowitz D. 1996. Analysis of gene action in the meander tail mutant mouse: examination of cerebellar phenotype and mitotic activity of granule cell neuroblasts. J Comp Neurol 368(2):304-15. [PubMed: 8725309] [MGI Ref ID J:32737]
Leprdb relatedAasum E; Hafstad AD; Severson DL; Larsen TS. 2003. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 52(2):434-41. [PubMed: 12540618] [MGI Ref ID J:107138]
Adkison DL; Sundberg JP. 1991. Lipomatous hamartomas and choristomas in inbred laboratory mice. Vet Pathol 28(4):305-12. [PubMed: 1949510] [MGI Ref ID J:2714]
Ahima RS; Prabakaran D; Flier JS. 1998. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J Clin Invest 101(5):1020-7. [PubMed: 9486972] [MGI Ref ID J:118976]
Akpinar P; Kuwajima S; Krutzfeldt J; Stoffel M. 2005. Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab 2(6):385-97. [PubMed: 16330324] [MGI Ref ID J:129667]
Al-Mashat HA; Kandru S; Liu R; Behl Y; Desta T; Graves DT. 2006. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes 55(2):487-95. [PubMed: 16443785] [MGI Ref ID J:106866]
Alberts P; Nilsson C; Selen G; Engblom LO; Edling NH; Norling S; Klingstrom G; Larsson C; Forsgren M; Ashkzari M; Nilsson CE; Fiedler M; Bergqvist E; Ohman B; Bjorkstrand E; Abrahmsen LB. 2003. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 144(11):4755-62. [PubMed: 12960099] [MGI Ref ID J:87239]
Altomonte J; Cong L; Harbaran S; Richter A; Xu J; Meseck M; Dong HH. 2004. Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J Clin Invest 114(10):1493-503. [PubMed: 15546000] [MGI Ref ID J:94423]
Anzawa R; Bernard M; Tamareille S; Baetz D; Confort-Gouny S; Gascard JP; Cozzone P; Feuvray D. 2006. Intracellular sodium increase and susceptibility to ischaemia in hearts from type 2 diabetic db/db mice. Diabetologia 49(3):598-606. [PubMed: 16425033] [MGI Ref ID J:107891]
Aoki K; Saito T; Satoh S; Mukasa K; Kaneshiro M; Kawasaki S; Okamura A; Sekihara H. 1999. Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone. Diabetes 48(8):1579-85. [PubMed: 10426376] [MGI Ref ID J:56421]
Ariyasu H; Takaya K; Hosoda H; Iwakura H; Ebihara K; Mori K; Ogawa Y; Hosoda K; Akamizu T; Kojima M; Kangawa K; Nakao K. 2002. Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 143(9):3341-50. [PubMed: 12193546] [MGI Ref ID J:81463]
Asai J; Takenaka H; Kusano KF; Ii M; Luedemann C; Curry C; Eaton E; Iwakura A; Tsutsumi Y; Hamada H; Kishimoto S; Thorne T; Kishore R; Losordo DW. 2006. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 113(20):2413-24. [PubMed: 16702471] [MGI Ref ID J:122447]
Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 294(2):E284-90. [PubMed: 18029445] [MGI Ref ID J:133332]
Baba M; Wada J; Eguchi J; Hashimoto I; Okada T; Yasuhara A; Shikata K; Kanwar YS; Makino H. 2005. Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms. J Am Soc Nephrol 16(11):3222-34. [PubMed: 16177004] [MGI Ref ID J:116853]
Bagi Z; Erdei N; Toth A; Li W; Hintze TH; Koller A; Kaley G. 2005. Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins. Arterioscler Thromb Vasc Biol 25(8):1610-6. [PubMed: 15947245] [MGI Ref ID J:114331]
Bagi Z; Koller A; Kaley G. 2004. PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes. Am J Physiol Heart Circ Physiol 286(2):H742-8. [PubMed: 14551045] [MGI Ref ID J:87610]
Bahary N; Leibel RL; Joseph L; Friedman JM. 1990. Molecular mapping of the mouse db mutation. Proc Natl Acad Sci U S A 87(21):8642-6. [PubMed: 1978328] [MGI Ref ID J:10819]
Balthasar N; Coppari R; McMinn J; Liu SM; Lee CE; Tang V; Kenny CD; McGovern RA; Chua SC Jr; Elmquist JK; Lowell BB. 2004. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42(6):983-91. [PubMed: 15207242] [MGI Ref ID J:106354]
Barile GR; Pachydaki SI; Tari SR; Lee SE; Donmoyer CM; Ma W; Rong LL; Buciarelli LG; Wendt T; Horig H; Hudson BI; Qu W; Weinberg AD; Yan SF; Schmidt AM. 2005. The RAGE axis in early diabetic retinopathy. Invest Ophthalmol Vis Sci 46(8):2916-24. [PubMed: 16043866] [MGI Ref ID J:103714]
Barinaga M. 1996. Researchers nail down leptin receptor [news; comment] Science 271(5251):913. [PubMed: 8584929] [MGI Ref ID J:31488]
Barouch LA; Berkowitz DE; Harrison RW; O'Donnell CP; Hare JM. 2003. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 108(6):754-9. [PubMed: 12885755] [MGI Ref ID J:103063]
Barouch LA; Gao D; Chen L; Miller KL; Xu W; Phan AC; Kittleson MM; Minhas KM; Berkowitz DE; Wei C; Hare JM. 2006. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circ Res 98(1):119-24. [PubMed: 16339484] [MGI Ref ID J:118064]
Bates SH; Dundon TA; Seifert M; Carlson M; Maratos-Flier E; Myers MG Jr. 2004. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 53(12):3067-73. [PubMed: 15561935] [MGI Ref ID J:94585]
Bates SH; Kulkarni RN; Seifert M; Myers MG Jr. 2005. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 1(3):169-78. [PubMed: 16054060] [MGI Ref ID J:129847]
Bates SH; Stearns WH; Dundon TA; Schubert M; Tso AW; Wang Y; Banks AS; Lavery HJ; Haq AK; Maratos-Flier E; Neel BG; Schwartz MW; Myers MG Jr. 2003. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421(6925):856-9. [PubMed: 12594516] [MGI Ref ID J:82334]
Batra A; Pietsch J; Fedke I; Glauben R; Okur B; Stroh T; Zeitz M; Siegmund B. 2007. Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol 170(6):1931-41. [PubMed: 17525261] [MGI Ref ID J:122150]
Baumgart J; Wisniewski HG; Amlacher R; Zhukovskaya NV; Rentz E. 1989. Age-dependent antileukemic action and suppression of immune response by 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (ambazone) in mice. Neoplasma 36(4):393-400. [PubMed: 2770926] [MGI Ref ID J:27903]
Begin-Heick N. 1992. Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice. Am J Physiol 263(1 Pt 1):C121-9. [PubMed: 1322037] [MGI Ref ID J:2110]
Begin-Heick N. 1994. Liver beta-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes. Am J Physiol 266(6 Pt 1):C1664-72. [PubMed: 8023896] [MGI Ref ID J:18963]
Belke DD; Larsen TS; Gibbs EM; Severson DL. 2001. Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter. Am J Physiol Endocrinol Metab 280(3):E420-7. [PubMed: 11171596] [MGI Ref ID J:134584]
Belmadani S; Palen DI; Gonzalez-Villalobos RA; Boulares HA; Matrougui K. 2008. Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice. Diabetes 57(6):1629-37. [PubMed: 18319304] [MGI Ref ID J:136927]
Berk PD; Zhou S; Kiang C; Stump DD; Fan X; Bradbury MW. 1999. Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. J Biol Chem 274(40):28626-31. [PubMed: 10497230] [MGI Ref ID J:57965]
Bjorbaek C; Elmquist JK; Frantz JD; Shoelson SE; Flier JS. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1(4):619-25. [PubMed: 9660946] [MGI Ref ID J:119803]
Bodary PF; Shen Y; Ohman M; Bahrou KL; Vargas FB; Cudney SS; Wickenheiser KJ; Myers MG Jr; Eitzman DT. 2007. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol 27(1):70-6. [PubMed: 17095713] [MGI Ref ID J:135034]
Boillot D; Assan R; Dardenne M; Debray-Sachs M; Bach JF. 1986. T-lymphopenia and T-cell imbalance in diabetic db/db mice. Diabetes 35(2):198-203. [PubMed: 3510925] [MGI Ref ID J:109948]
Bouchard G; Johnson D; Carver T; Paigen B; Carey MC. 2002. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res 43(7):1105-13. [PubMed: 12091495] [MGI Ref ID J:88773]
Boudina S; Sena S; Theobald H; Sheng X; Wright JJ; Hu XX; Aziz S; Johnson JI; Bugger H; Zaha VG; Abel ED. 2007. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 56(10):2457-66. [PubMed: 17623815] [MGI Ref ID J:126567]
Brem H; Tomic-Canic M; Entero H; Hanflik AM; Wang VM; Fallon JT; Ehrlich HP. 2007. The synergism of age and db/db genotype impairs wound healing. Exp Gerontol 42(6):523-31. [PubMed: 17275236] [MGI Ref ID J:123188]
Brezniceanu ML; Liu F; Wei CC; Chenier I; Godin N; Zhang SL; Filep JG; Ingelfinger JR; Chan JS. 2008. Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes 57(2):451-9. [PubMed: 17977949] [MGI Ref ID J:132449]
Brown RL; Breeden MP; Greenhalgh DG. 1994. PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse. J Surg Res 56(6):562-70. [PubMed: 8015312] [MGI Ref ID J:19344]
Brun P; Castagliuolo I; Leo VD; Buda A; Pinzani M; Palu G; Martines D. 2007. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292(2):G518-25. [PubMed: 17023554] [MGI Ref ID J:124815]
Buettner C; Pocai A; Muse ED; Etgen AM; Myers MG Jr; Rossetti L. 2006. Critical role of STAT3 in leptin's metabolic actions. Cell Metab 4(1):49-60. [PubMed: 16814732] [MGI Ref ID J:129709]
Bunger L; Forsting J; McDonald KL; Horvat S; Duncan J; Hochscheid S; Baile CA; Hill WG; Speakman JR. 2003. Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and reception. FASEB J 17(1):85-7. [PubMed: 12424222] [MGI Ref ID J:118012]
Busso N; So A; Chobaz-Peclat V; Morard C; Martinez-Soria E; Talabot-Ayer D; Gabay C. 2002. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168(2):875-82. [PubMed: 11777985] [MGI Ref ID J:73743]
Calvert JW; Gundewar S; Jha S; Greer JJ; Bestermann WH; Tian R; Lefer DJ. 2008. Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling. Diabetes 57(3):696-705. [PubMed: 18083782] [MGI Ref ID J:132319]
Carley AN; Severson DL. 2005. Fatty acid metabolism is enhanced in type 2 diabetic hearts. Biochim Biophys Acta 1734(2):112-26. [PubMed: 15904868] [MGI Ref ID J:99066]
Chaput E; Saladin R; Silvestre M; Edgar AD. 2000. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem Biophys Res Commun 271(2):445-50. [PubMed: 10799317] [MGI Ref ID J:62209]
Chen H; Charlat O; Tartaglia LA; Woolf EA; Weng X; Ellis SJ; Lakey ND; Culpepper J; Moore KJ; Breitbart RE; Duyk GM; Tepper RI; Morgenstern JP. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84(3):491-5. [PubMed: 8608603] [MGI Ref ID J:31324]
Chen HC; Stone SJ; Zhou P; Buhman KK; Farese RV Jr. 2002. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes 51(11):3189-95. [PubMed: 12401709] [MGI Ref ID J:107180]
Cheng KK; Lam KS; Wang Y; Huang Y; Carling D; Wu D; Wong C; Xu A. 2007. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 56(5):1387-94. [PubMed: 17287464] [MGI Ref ID J:122100]
Cheung W; Yu PX; Little BM; Cone RD; Marks DL; Mak RH. 2005. Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115(6):1659-65. [PubMed: 15931394] [MGI Ref ID J:99198]
Chiellini C; Costa M; Novelli SE; Amri EZ; Benzi L; Bertacca A; Cohen P; Del Prato S; Friedman JM; Maffei M. 2003. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. J Cell Physiol 195(2):309-21. [PubMed: 12652657] [MGI Ref ID J:106181]
Chin M; Isono M; Isshiki K; Araki S; Sugimoto T; Guo B; Sato H; Haneda M; Kashiwagi A; Koya D. 2005. Estrogen and Raloxifene, a Selective Estrogen Receptor Modulator, Ameliorate Renal Damage in db/db Mice. Am J Pathol 166(6):1629-36. [PubMed: 15920148] [MGI Ref ID J:98819]
Choe SS; Choi AH; Lee JW; Kim KH; Chung JJ; Park J; Lee KM; Park KG; Lee IK; Kim JB. 2007. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes 56(6):1534-43. [PubMed: 17369526] [MGI Ref ID J:126465]
Choo HJ; Kim JH; Kwon OB; Lee CS; Mun JY; Han SS; Yoon YS; Yoon G; Choi KM; Ko YG. 2006. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia 49(4):784-91. [PubMed: 16501941] [MGI Ref ID J:107887]
Chu KY; Lau T; Carlsson PO; Leung PS. 2006. Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes. Diabetes 55(2):367-74. [PubMed: 16443769] [MGI Ref ID J:106880]
Chua S Jr; Liu SM; Li Q; Yang L; Thassanapaff VT; Fisher P. 2002. Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. Diabetologia 45(7):976-90. [PubMed: 12136396] [MGI Ref ID J:78850]
Chung WK; Belfi K; Chua M; Wiley J; Mackintosh R; Nicolson M; Boozer CN; Leibel RL. 1998. Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice. Am J Physiol 274(4 Pt 2):R985-90. [PubMed: 9575960] [MGI Ref ID J:47168]
Cinti S; Mitchell G; Barbatelli G; Murano I; Ceresi E; Faloia E; Wang S; Fortier M; Greenberg AS; Obin MS. 2005. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46(11):2347-55. [PubMed: 16150820] [MGI Ref ID J:104779]
Clapham JC; Coulthard VH; Moore GB. 2001. Concordant mRNA Expression of UCP-3, but Not UCP-2, with Mitochondrial Thioesterase-1 in Brown Adipose Tissue and Skeletal Muscle in db/db Diabetic Mice. Biochem Biophys Res Commun 287(5):1058-62. [PubMed: 11587528] [MGI Ref ID J:72433]
Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254] [MGI Ref ID J:6485]
Cleary MP; Hu X; Grossmann ME; Juneja SC; Dogan S; Grande JP; Maihle NJ. 2007. Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response? Exp Biol Med (Maywood) 232(1):70-80. [PubMed: 17202587] [MGI Ref ID J:129353]
Cleary MP; Juneja SC; Phillips FC; Hu X; Grande JP; Maihle NJ. 2004. Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med (Maywood) 229(2):182-93. [PubMed: 14734797] [MGI Ref ID J:102011]
Cohen MP; Clements RS; Cohen JA; Shearman CW. 1996. Glycated albumin promotes a generalized vasculopathy in the db/db mouse. Biochem Biophys Res Commun 218(1):72-5. [PubMed: 8573179] [MGI Ref ID J:30654]
Cohen MP; Clements RS; Cohen JA; Shearman CW. 1996. Prevention of decline in renal function in the diabetic db/db mouse. Diabetologia 39(3):270-4. [PubMed: 8721771] [MGI Ref ID J:31848]
Cohen MP; Sharma K; Guo J; Eltayeb BO; Ziyadeh FN. 1998. The renal TGF-beta system in the db/db mouse model of diabetic nephropathy. Exp Nephrol 6(3):226-33. [PubMed: 9639038] [MGI Ref ID J:49923]
Cohen MP; Sharma K; Jin Y; Hud E; Wu VY; Tomaszewski J; Ziyadeh FN. 1995. Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy. J Clin Invest 95(5):2338-45. [PubMed: 7738197] [MGI Ref ID J:24919]
Coleman DL. 1980. Acetone metabolism in mice: increased activity in mice heterozygous for obesity genes. Proc Natl Acad Sci U S A 77(1):290-3. [PubMed: 6928621] [MGI Ref ID J:6278]
Coleman DL. 1979. Obesity genes: beneficial effects in heterozygous mice. Science 203(4381):663-5. [PubMed: 760211] [MGI Ref ID J:6081]
Coleman DL. 1982. Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia 22(3):205-11. [PubMed: 7075918] [MGI Ref ID J:6756]
Coleman DL; Hummel KP. 1973. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 9(4):287-93. [PubMed: 4588246] [MGI Ref ID J:5400]
Collins S; Surwit RS. 1996. Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271(16):9437-40. [PubMed: 8621612] [MGI Ref ID J:33332]
Collins SJ; Alexander SL; Lopez-Guisa JM; Cai X; Maruvada R; Chua SC; Zhang G; Okamura DM; Matsuo S; Eddy AA. 2006. Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice. Nephron Exp Nephrol 104(1):e23-34. [PubMed: 16735799] [MGI Ref ID J:127478]
Dardenne M; Savino W; Bach JF. 1984. Autoimmune mice develop antibodies to thymic hormone: production of anti-thymulin monoclonal autoantibodies from diabetic (db/db) and B/W mice. J Immunol 133(2):740-3. [PubMed: 6539799] [MGI Ref ID J:109953]
Davis RC; Schadt EE; Cervino AC; Peterfy M; Lusis AJ. 2005. Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility. Diabetes 54(4):1191-9. [PubMed: 15793261] [MGI Ref ID J:109430]
De Rosa V; Procaccini C; Cali G; Pirozzi G; Fontana S; Zappacosta S; La Cava A; Matarese G. 2007. A Key Role of Leptin in the Control of Regulatory T Cell Proliferation. Immunity 26(2):241-255. [PubMed: 17307705] [MGI Ref ID J:118425]
DeRubertis FR; Craven PA; Melhem MF; Salah EM. 2004. Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction. Diabetes 53(3):762-8. [PubMed: 14988262] [MGI Ref ID J:88385]
Debray-Sachs M; Sai P; Boitard C; Assan R; Hamburger J. 1983. Anti-pancreatic immunity in genetically diabetic mice. Clin Exp Immunol 51(1):1-7. [PubMed: 6339122] [MGI Ref ID J:7005]
Del Rey A; Roggero E; Randolf A; Mahuad C; McCann S; Rettori V; Besedovsky HO. 2006. IL-1 resets glucose homeostasis at central levels. Proc Natl Acad Sci U S A 103(43):16039-44. [PubMed: 17035503] [MGI Ref ID J:115278]
Dentin R; Liu Y; Koo SH; Hedrick S; Vargas T; Heredia J; Yates J rd; Montminy M. 2007. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449(7160):366-9. [PubMed: 17805301] [MGI Ref ID J:126351]
Ding H; Howarth AG; Pannirselvam M; Anderson TJ; Severson DL; Wiehler WB; Triggle CR; Tuana BS. 2005. Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP. Am J Physiol Heart Circ Physiol 289(1):H206-11. [PubMed: 15764684] [MGI Ref ID J:115429]
Du K; Herzig S; Kulkarni RN; Montminy M. 2003. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300(5625):1574-7. [PubMed: 12791994] [MGI Ref ID J:113933]
Ducy P; Amling M; Takeda S; Priemel M; Schilling AF; Beil FT; Shen J; Vinson C; Rueger JM; Karsenty G. 2000. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100(2):197-207. [PubMed: 10660043] [MGI Ref ID J:60001]
Eguchi J; Wada J; Hida K; Zhang H; Matsuoka T; Baba M; Hashimoto I; Shikata K; Ogawa N; Makino H. 2005. Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. Biochem J 387(Pt 2):343-53. [PubMed: 15563274] [MGI Ref ID J:117533]
Elrod JW; Duranski MR; Langston W; Greer JJ; Tao L; Dugas TR; Kevil CG; Champion HC; Lefer DJ. 2006. eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circ Res 99(1):78-85. [PubMed: 16763164] [MGI Ref ID J:123669]
Erdei N; Bagi Z; Edes I; Kaley G; Koller A. 2007. H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice. Am J Physiol Heart Circ Physiol 292(1):H649-56. [PubMed: 16997891] [MGI Ref ID J:119955]
Faggioni R; Fantuzzi G; Gabay C; Moser A; Dinarello CA; Feingold KR ; Grunfeld C. 1999. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 276(1 Pt 2):R136-42. [PubMed: 9887187] [MGI Ref ID J:52477]
Faggioni R; Fuller J; Moser A; Feingold KR; Grunfeld C. 1997. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Am J Physiol 273(1 Pt 2):R181-6. [PubMed: 9249548] [MGI Ref ID J:41966]
Ferry G; Tellier E; Try A; Gres S; Naime I; Simon MF; Rodriguez M; Boucher J; Tack I; Gesta S; Chomarat P; Dieu M; Raes M; Galizzi JP; Valet P; Boutin JA; Saulnier-Blache JS. 2003. Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J Biol Chem 278(20):18162-9. [PubMed: 12642576] [MGI Ref ID J:83593]
Finck BN; Gropler MC; Chen Z; Leone TC; Croce MA; Harris TE; Lawrence JC Jr; Kelly DP. 2006. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab 4(3):199-210. [PubMed: 16950137] [MGI Ref ID J:129744]
Friedman JE; Sun Y; Ishizuka T; Farrell CJ; McCormack SE; Herron LM; Hakimi P; Lechner P; Yun JS. 1997. Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice. J Biol Chem 272(50):31475-81. [PubMed: 9395482] [MGI Ref ID J:44631]
Fulton S; Pissios P; Manchon RP; Stiles L; Frank L; Pothos EN; Maratos-Flier E; Flier JS. 2006. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51(6):811-22. [PubMed: 16982425] [MGI Ref ID J:113646]
Gao Q; Wolfgang MJ; Neschen S; Morino K; Horvath TL; Shulman GI; Fu XY. 2004. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 101(13):4661-6. [PubMed: 15070774] [MGI Ref ID J:89242]
Gao X; Belmadani S; Picchi A; Xu X; Potter BJ; Tewari-Singh N; Capobianco S; Chilian WM; Zhang C. 2007. Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115(2):245-54. [PubMed: 17200442] [MGI Ref ID J:129770]
Gao X; Zhang H; Schmidt AM; Zhang C. 2008. AGE/RAGE produces endothelial dysfunction in coronary arterioles in Type 2 diabetic mice. Am J Physiol Heart Circ Physiol 295(2):H491-8. [PubMed: 18539754] [MGI Ref ID J:138204]
Garcia-Vicente S; Yraola F; Marti L; Gonzalez-Munoz E; Garcia-Barrado MJ; Canto C; Abella A; Bour S; Artuch R; Sierra C; Brandi N; Carpene C; Moratinos J; Camps M; Palacin M; Testar X; Guma A; Albericio F; Royo M; Mian A; Zorzano A. 2007. Oral insulin-mimetic compounds that act independently of insulin. Diabetes 56(2):486-93. [PubMed: 17259395] [MGI Ref ID J:121956]
Garris DR. 1995. Developmental and regional changes in brain norepinephrine levels in diabetic C57BL/KsJ mice: effects of estradiol and progesterone. Brain Res Dev Brain Res 89(2):314-9. [PubMed: 8612335] [MGI Ref ID J:29832]
Garris DR. 2004. Ultrastructural analysis of progressive endometrial hypercytolipidemia induced by obese (ob/ob) and diabetes (db/db) genotype mutations: structural basis of female reproductive tract involution. Tissue Cell 36(1):19-28. [PubMed: 14729450] [MGI Ref ID J:102445]
Garris DR; Garris BL. 2003. Diabetes (db/db) mutation-induced ovarian involution: progressive hypercytolipidemia. Exp Biol Med (Maywood) 228(9):1040-50. [PubMed: 14530513] [MGI Ref ID J:103053]
Garris DR; Garris BL. 2003. Diabetes-induced, progressive endometrial involution characterization of periluminal epithelial lipoatrophy. Diabetes 52(1):51-8. [PubMed: 12502493] [MGI Ref ID J:80996]
Garris DR; Garris BL. 2004. Genomic modulation of diabetes (db/db) and obese (ob/ob) mutation-induced hypercytolipidemia: cytochemical basis of female reproductive tract involution. Cell Tissue Res 316(2):233-41. [PubMed: 15024641] [MGI Ref ID J:105101]
Garris DR; Garris BL; Novikova L; Lau YS. 2005. Structural, metabolic and endocrine analysis of the diabetes (db/db) hypogonadal syndrome: relationship to hypophyseal hypercytolipidemia. Cell Tissue Res 319(3):501-12. [PubMed: 15672265] [MGI Ref ID J:105149]
Giacomelli F; Wiener J. 1979. Primary myocardial disease in the diabetic mouse. An ultrastructural study. Lab Invest 40(4):460-73. [PubMed: 431046] [MGI Ref ID J:6115]
Gibbs EM; Stock JL; McCoid SC; Stukenbrok HA; Pessin JE; Stevenson RW; Milici AJ; McNeish JD. 1995. Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest 95(4):1512-8. [PubMed: 7706456] [MGI Ref ID J:109916]
Gibran NS; Jang YC; Isik FF; Greenhalgh DG; Muffley LA; Underwood RA; Usui ML; Larsen J; Smith DG; Bunnett N; Ansel JC; Olerud JE. 2002. Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. J Surg Res 108(1):122-8. [PubMed: 12443724] [MGI Ref ID J:102980]
Gimeno RE; Dembski M; Weng X; Deng N; Shyjan AW; Gimeno CJ; Iris F; Ellis SJ; Woolf EA; Tartaglia LA. 1997. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46(5):900-6. [PubMed: 9133562] [MGI Ref ID J:40062]
Gloaguen I; Costa P; Demartis A; Lazzaro D; Di Marco A; Graziani R ; Paonessa G ; Chen F ; Rosenblum CI ; Van der Ploeg LH ; Cortese R ; Ciliberto G ; Laufer R. 1997. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A 94(12):6456-61. [PubMed: 9177239] [MGI Ref ID J:40976]
Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466] [MGI Ref ID J:109860]
Graewin SJ; Lee KH; Tran KQ; Goldblatt MI; Svatek CL; Nakeeb A; Pitt HA. 2004. Leptin-resistant obese mice do not form biliary crystals on a high cholesterol diet. J Surg Res 122(2):145-9. [PubMed: 15555610] [MGI Ref ID J:101794]
Graves DT; Naguib G; Lu H; Leone C; Hsue H; Krall E. 2005. Inflammation is more persistent in type 1 diabetic mice. J Dent Res 84(4):324-8. [PubMed: 15790737] [MGI Ref ID J:112485]
Greer JJ; Ware DP; Lefer DJ. 2006. Myocardial infarction and heart failure in the db/db diabetic mouse. Am J Physiol Heart Circ Physiol 290(1):H146-53. [PubMed: 16113078] [MGI Ref ID J:104790]
Gruen ML; Hao M; Piston DW; Hasty AH. 2007. Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol 293(5):C1481-8. [PubMed: 17728393] [MGI Ref ID J:128699]
Gruen ML; Plummer MR; Zhang W; Posey KA; Linton M; Fazio S; Hasty AH. 2005. Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 46(9):2007-14. [PubMed: 15995171] [MGI Ref ID J:100492]
Gundewar S; Calvert JW; Elrod JW; Lefer DJ. 2007. Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes. Am J Physiol Heart Circ Physiol 293(4):H2462-71. [PubMed: 17630348] [MGI Ref ID J:126117]
Guo M; Ricardo SD; Deane JA; Shi M; Cullen-McEwen L; Bertram JF. 2005. A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy. J Anat 207(6):813-21. [PubMed: 16367807] [MGI Ref ID J:112821]
Guo Z; Su W; Allen S; Pang H; Daugherty A; Smart E; Gong MC. 2005. COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Cardiovasc Res 67(4):723-35. [PubMed: 15885672] [MGI Ref ID J:106597]
Ha TS; Barnes JL; Stewart JL; Ko CW; Miner JH; Abrahamson DR; Sanes JR; Kasinath BS. 1999. Regulation of renal laminin in mice with type II diabetes. J Am Soc Nephrol 10(9):1931-9. [PubMed: 10477145] [MGI Ref ID J:103217]
Hafstad AD; Khalid AM; How OJ; Larsen TS; Aasum E. 2007. Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice. Am J Physiol Endocrinol Metab 292(5):E1288-94. [PubMed: 17213470] [MGI Ref ID J:121240]
Hafstad AD; Solevag GH; Severson DL; Larsen TS; Aasum E. 2006. Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. Am J Physiol Heart Circ Physiol 290(5):H1763-9. [PubMed: 16327015] [MGI Ref ID J:108594]
Halaas JL; Gajiwala KS; Maffei M; Cohen SL; Chait BT; Rabinowitz D; Lallone RL; Burley SK; Friedman JM. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene [see comments] Science 269(5223):543-6. [PubMed: 7624777] [MGI Ref ID J:29161]
Han KL; Choi JS; Lee JY; Song J; Joe MK; Jung MH; Hwang JK. 2008. Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes 57(3):737-45. [PubMed: 18065517] [MGI Ref ID J:132456]
Harris RB. 1999. Parabiosis between db/db and ob/ob or db/+ mice. Endocrinology 140(1):138-45. [PubMed: 9886818] [MGI Ref ID J:114258]
Harris RB; Mitchell TD; Yan X; Simpson JS; Redmann SM Jr. 2001. Metabolic responses to leptin in obese db/db mice are strain dependent. Am J Physiol Regul Integr Comp Physiol 281(1):R115-32. [PubMed: 11404285] [MGI Ref ID J:70291]
He H; Liu R; Desta T; Leone C; Gerstenfeld LC; Graves DT. 2004. Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss. Endocrinology 145(1):447-52. [PubMed: 14525917] [MGI Ref ID J:87439]
Herberg L; Coleman DL. 1977. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26(1):59-99. [PubMed: 834144] [MGI Ref ID J:5759]
Hileman SM; Pierroz DD; Masuzaki H; Bjorbaek C; El-Haschimi K; Banks WA; Flier JS. 2002. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 143(3):775-83. [PubMed: 11861497] [MGI Ref ID J:109736]
Hirose Y; Hata K; Kuno T; Yoshida K; Sakata K; Yamada Y; Tanaka T; Reddy BS; Mori H. 2004. Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice. Carcinogenesis 25(5):821-5. [PubMed: 14729596] [MGI Ref ID J:89550]
How OJ; Aasum E; Severson DL; Chan WY; Essop MF; Larsen TS. 2006. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 55(2):466-73. [PubMed: 16443782] [MGI Ref ID J:106871]
Hu Z; Lee IH; Wang X; Sheng H; Zhang L; Du J; Mitch WE. 2007. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes 56(10):2449-56. [PubMed: 17623817] [MGI Ref ID J:126566]
Hummel KP; Chapman DB. 1970. Location of diabetes (db) in Linkage Group VIII. Mouse News Lett 42:29. [MGI Ref ID J:13504]
Hummel KP; Dickie MM; Coleman DL. 1966. Diabetes, a new mutation in the mouse. Science 153(740):1127-8. [PubMed: 5918576] [MGI Ref ID J:5010]
Ichinose K; Maeshima Y; Yamamoto Y; Kinomura M; Hirokoshi K; Kitayama H; Takazawa Y; Sugiyama H; Yamasaki Y; Agata N; Makino H. 2006. 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice. Diabetes 55(5):1232-42. [PubMed: 16644677] [MGI Ref ID J:108664]
Ii M; Nishimura H; Kusano KF; Qin G; Yoon YS; Wecker A; Asahara T; Losordo DW. 2005. Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy. Circulation 112(1):93-102. [PubMed: 15983249] [MGI Ref ID J:116383]
Ikejima S; Sasaki S; Sashinami H; Mori F; Ogawa Y; Nakamura T; Abe Y; Wakabayashi K; Suda T; Nakane A. 2005. Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice. Diabetes 54(1):182-9. [PubMed: 15616027] [MGI Ref ID J:105107]
Itateyama E; Chiba S; Sakata T; Yoshimatsu H. 2003. Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain. Exp Biol Med (Maywood) 228(10):1132-7. [PubMed: 14610251] [MGI Ref ID J:103056]
Iwakura H; Akamizu T; Ariyasu H; Irako T; Hosoda K; Nakao K; Kangawa K. 2007. Effects of ghrelin administration on decreased growth hormone status in obese animals. Am J Physiol Endocrinol Metab 293(3):E819-25. [PubMed: 17595213] [MGI Ref ID J:125421]
James AN; Ryan JP; Crowell MD; Parkman HP. 2004. Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation. Am J Physiol Gastrointest Liver Physiol 287(3):G612-9. [PubMed: 15107299] [MGI Ref ID J:96077]
Jiang T; Wang XX; Scherzer P; Wilson P; Tallman J; Takahashi H; Li J; Iwahashi M; Sutherland E; Arend L; Levi M. 2007. Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy. Diabetes 56(10):2485-93. [PubMed: 17660268] [MGI Ref ID J:126553]
Johnson DR; O'Connor JC; Hartman ME; Tapping RI; Freund GG. 2007. Acute hypoxia activates the neuroimmune system, which diabetes exacerbates. J Neurosci 27(5):1161-6. [PubMed: 17267571] [MGI Ref ID J:117904]
Johnson LM; Sidman RL. 1979. A reproductive endocrine profile in the diabetes (db) mutant mouse. Biol Reprod 20(3):552-9. [PubMed: 378276] [MGI Ref ID J:6157]
Jones SP; Girod WG; Granger DN; Palazzo AJ; Lefer DJ. 1999. Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart. Am J Physiol 277(2 Pt 2):H763-9. [PubMed: 10444504] [MGI Ref ID J:56871]
Kamagate A; Qu S; Perdomo G; Su D; Kim DH; Slusher S; Meseck M; Dong HH. 2008. FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest 118(6):2347-64. [PubMed: 18497885] [MGI Ref ID J:137715]
Kampfer H; Paulukat J; Muhl H; Wetzler C; Pfeilschifter J; Frank S. 2000. Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing. Mol Med 6(12):1016-27. [PubMed: 11474118] [MGI Ref ID J:109870]
Kampfer H; Pfeilschifter J; Frank S. 2003. Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair. J Invest Dermatol 121(6):1544-51. [PubMed: 14675208] [MGI Ref ID J:120040]
Kanda H; Tateya S; Tamori Y; Kotani K; Hiasa K; Kitazawa R; Kitazawa S; Miyachi H; Maeda S; Egashira K; Kasuga M. 2006. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116(6):1494-505. [PubMed: 16691291] [MGI Ref ID J:110277]
Kharitonenkov A; Shiyanova TL; Koester A; Ford AM; Micanovic R; Galbreath EJ; Sandusky GE; Hammond LJ; Moyers JS; Owens RA; Gromada J; Brozinick JT; Hawkins ED; Wroblewski VJ; Li DS; Mehrbod F; Jaskunas SR; Shanafelt AB. 2005. FGF-21 as a novel metabolic regulator. J Clin Invest 115(6):1627-35. [PubMed: 15902306] [MGI Ref ID J:99202]
Kim JG; Baggio LL; Bridon DP; Castaigne JP; Robitaille MF; Jette L; Benquet C; Drucker DJ. 2003. Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo. Diabetes 52(3):751-9. [PubMed: 12606517] [MGI Ref ID J:82421]
Kobayashi K; Forte TM; Taniguchi S; Ishida BY; Oka K; Chan L. 2000. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 49(1):22-31. [PubMed: 10647060] [MGI Ref ID J:59345]
Koh EH; Park JY; Park HS; Jeon MJ; Ryu JW; Kim M; Kim SY; Kim MS; Kim SW; Park IS; Youn JH; Lee KU. 2007. Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes 56(12):2973-81. [PubMed: 17827403] [MGI Ref ID J:132424]
Koo SH; Flechner L; Qi L; Zhang X; Screaton RA; Jeffries S; Hedrick S; Xu W; Boussouar F; Brindle P; Takemori H; Montminy M. 2005. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437(7062):1109-11. [PubMed: 16148943] [MGI Ref ID J:102116]
Koya D; Haneda M; Nakagawa H; Isshiki K; Sato H; Maeda S; Sugimoto T; Yasuda H; Kashiwagi A; Ways DK; King GL; Kikkawa R. 2000. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 14(3):439-47. [PubMed: 10698958] [MGI Ref ID J:60932]
Kudo T; Akiyama M; Kuriyama K; Sudo M; Moriya T; Shibata S. 2004. Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. Diabetologia 47(8):1425-36. [PubMed: 15309293] [MGI Ref ID J:91813]
Kulkarni RN; Wang ZL; Wang RM; Hurley JD; Smith DM; Ghatei MA ; Withers DJ ; Gardiner JV ; Bailey CJ ; Bloom SR. 1997. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 100(11):2729-36. [PubMed: 9389736] [MGI Ref ID J:45259]
Lam QL; Liu S; Cao X; Lu L. 2006. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol 36(12):3118-30. [PubMed: 17125143] [MGI Ref ID J:117089]
Lambin S; van Bree R; Caluwaerts S; Vercruysse L; Vergote I; Verhaeghe J. 2007. Adipose tissue in offspring of Lepr(db/+) mice: early-life environment vs. genotype. Am J Physiol Endocrinol Metab 292(1):E262-71. [PubMed: 16954332] [MGI Ref ID J:116980]
Laybutt DR; Preston AM; Akerfeldt MC; Kench JG; Busch AK; Biankin AV; Biden TJ. 2007. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50(4):752-763. [PubMed: 17268797] [MGI Ref ID J:119770]
Lee CH; Olson P; Hevener A; Mehl I; Chong LW; Olefsky JM; Gonzalez FJ; Ham J; Kang H; Peters JM; Evans RM. 2006. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A 103(9):3444-9. [PubMed: 16492734] [MGI Ref ID J:107250]
Lee CH; Reifsnyder PC; Naggert JK; Wasserfall C; Atkinson MA; Chen J; Leiter EH. 2005. Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis. Diabetes 54(9):2525-32. [PubMed: 16123339] [MGI Ref ID J:118305]
Lee GH; Proenca R; Montez JM; Carroll KM; Darvishzadeh JG; Lee JI; Friedman JM. 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379(6566):632-5. [PubMed: 8628397] [MGI Ref ID J:31327]
Leibowitz MD; Fievet C; Hennuyer N; Peinado-Onsurbe J; Duez H; Bergera J; Cullinan CA; Sparrow CP; Baffic J; Berger GD; Santini C; Marquis RW; Tolman RL; Smith RG; Moller DE; Auwerx J. 2000. Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett 473(3):333-6. [PubMed: 10818235] [MGI Ref ID J:115317]
Leiter EH. 1981. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse IV. Male lethal syndrome in CBA/Lt mice. Diabetes 30(12):1035-44. [PubMed: 7030829] [MGI Ref ID J:109958]
Leiter EH; Chapman HD. 1994. Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest 93(5):2007-13. [PubMed: 8182132] [MGI Ref ID J:17991]
Leiter EH; Chapman HD; Coleman DL. 1989. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Endocrinology 124(2):912-22. [PubMed: 2912706] [MGI Ref ID J:26013]
Leiter EH; Coleman DL; Eppig JJ. 1979. Endocrine pancreatic cells of postnatal diabetes (db) mice in cell culture. In Vitro 15(7):507-21. [PubMed: 393618] [MGI Ref ID J:6264]
Leiter EH; Coleman DL; Ingram DK; Reynolds MA. 1983. Influence of dietary carbohydrate on the induction of diabetes in C57BL/KsJ-db/db diabetes mice. J Nutr 113(1):184-95. [PubMed: 6337242] [MGI Ref ID J:109957]
Leiter EH; Kuff EL. 1984. Intracisternal Type A particles in murine pancreatic B cells. Immunocytochemical demonstration of increased antigen (p73) in genetically diabetic mice. Am J Pathol 114(1):46-55. [PubMed: 6362424] [MGI Ref ID J:7287]
Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. [PubMed: 3553324] [MGI Ref ID J:32752]
Lemke U; Krones-Herzig A; Diaz MB; Narvekar P; Ziegler A; Vegiopoulos A; Cato AC; Bohl S; Klingmuller U; Screaton RA; Muller-Decker K; Kersten S; Herzig S. 2008. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab 8(3):212-23. [PubMed: 18762022] [MGI Ref ID J:139669]
Levine DZ; Iacovitti M. 2006. Real-time measurement of kidney tubule fluid nitric oxide concentrations in early diabetes: disparate changes in different rodent models. Nitric Oxide 15(1):87-92. [PubMed: 16510300] [MGI Ref ID J:112767]
Levine DZ; Iacovitti M; Robertson SJ. 2008. Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. II. Effects of renal mass reduction. Am J Physiol Regul Integr Comp Physiol 294(6):R1840-6. [PubMed: 18417648] [MGI Ref ID J:137624]
Levine DZ; Iacovitti M; Robertson SJ; Mokhtar GA. 2006. Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol 290(4):R975-81. [PubMed: 16339386] [MGI Ref ID J:128685]
Li SL; Reddy MA; Cai Q; Meng L; Yuan H; Lanting L; Natarajan R. 2006. Enhanced proatherogenic responses in macrophages and vascular smooth muscle cells derived from diabetic db/db mice. Diabetes 55(9):2611-9. [PubMed: 16936211] [MGI Ref ID J:116589]
Li X; Grundy SM; Patel SB. 1997. Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100. J Lipid Res 38(7):1277-88. [PubMed: 9254055] [MGI Ref ID J:41954]
Li XL; Aou S; Oomura Y; Hori N; Fukunaga K; Hori T. 2002. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 113(3):607-15. [PubMed: 12150780] [MGI Ref ID J:109401]
Liao YJ; Ueno M; Nakagawa T; Huang C; Kanenishi K; Onodera M; Sakamoto H. 2005. Oxidative damage in cerebral vessels of diabetic db/db mice. Diabetes Metab Res Rev 21(6):554-9. [PubMed: 16021652] [MGI Ref ID J:106606]
Like AA; Lavine RL; Poffenbarger PL; Chick WL. 1972. Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria. Am J Pathol 66(2):193-224. [PubMed: 5009970] [MGI Ref ID J:5257]
Liu R; Bal HS; Desta T; Behl Y; Graves DT. 2006. Tumor necrosis factor-alpha mediates diabetes-enhanced apoptosis of matrix-producing cells and impairs diabetic healing. Am J Pathol 168(3):757-64. [PubMed: 16507891] [MGI Ref ID J:106478]
Liu Y; Nakagawa Y; Wang Y; Sakurai R; Tripathi PV; Lutfy K; Friedman TC. 2005. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes 54(1):32-40. [PubMed: 15616008] [MGI Ref ID J:105084]
Liu Z; Tanabe K; Bernal-Mizrachi E; Permutt MA. 2008. Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation. Diabetologia 51(4):623-31. [PubMed: 18219478] [MGI Ref ID J:137936]
Loffreda S; Yang SQ; Lin HZ; Karp CL; Brengman ML; Wang DJ; Klein AS; Bulkley GB; Bao C; Noble PW; Lane MD; Diehl AM. 1998. Leptin regulates proinflammatory immune responses. FASEB J 12(1):57-65. [PubMed: 9438411] [MGI Ref ID J:115105]
Lord GM; Matarese G; Howard JK; Baker RJ; Bloom SR; Lechler RI. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394(6696):897-901. [PubMed: 9732873] [MGI Ref ID J:49623]
Lu FL; Johnston RA; Flynt L; Theman TA; Terry RD; Schwartzman IN; Lee A; Shore SA. 2006. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol 290(5):L856-65. [PubMed: 16373670] [MGI Ref ID J:115772]
Lu H; Raptis M; Black E; Stan M; Amar S; Graves DT. 2004. Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology 145(11):4934-9. [PubMed: 15284196] [MGI Ref ID J:105615]
Luo N; Liu SM; Liu H; Li Q; Xu Q; Sun X; Davis B; Li J; Chua S Jr. 2006. Allelic variation on chromosome 5 controls beta-cell mass expansion during hyperglycemia in leptin receptor-deficient diabetes mice. Endocrinology 147(5):2287-95. [PubMed: 16484328] [MGI Ref ID J:129660]
Luttrell IP; Swee M; Starcher B; Parks WC; Chitaley K. 2008. Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix. Am J Physiol Heart Circ Physiol 294(5):H2204-11. [PubMed: 18326798] [MGI Ref ID J:135785]
MacLean PS; Bower JF; Vadlamudi S; Osborne JN; Bradfield JF; Burden HW; Bensch WH; Kauffman RF; Barakat HA. 2003. Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice. Arterioscler Thromb Vasc Biol 23(8):1412-5. [PubMed: 12791674] [MGI Ref ID J:109846]
Madiehe AM; Mitchell TD; Harris RB. 2003. Hyperleptinemia and reduced TNF-alpha secretion cause resistance of db/db mice to endotoxin. Am J Physiol Regul Integr Comp Physiol 284(3):R763-70. [PubMed: 12571077] [MGI Ref ID J:82497]
Maffei M; Fei H; Lee GH; Dani C; Leroy P; Zhang Y; Proenca R; Negrel R; Ailhaud G; Friedman JM. 1995. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci U S A 92(15):6957-60. [PubMed: 7624352] [MGI Ref ID J:27422]
Makino H; Miyamoto Y; Sawai K; Mori K; Mukoyama M; Nakao K; Yoshimasa Y; Suga S. 2006. Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes 55(10):2747-56. [PubMed: 17003339] [MGI Ref ID J:116575]
Mandel MA; Mahmoud AA. 1978. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J Immunol 120(4):1375-7. [PubMed: 347001] [MGI Ref ID J:109964]
Maness LM; Banks WA; Kastin AJ. 2000. Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice Brain Res 873(1):165-7. [PubMed: 10915826] [MGI Ref ID J:63732]
Manodori AB; Kuypers FA. 2002. Altered red cell turnover in diabetic mice. J Lab Clin Med 140(3):161-5. [PubMed: 12271273] [MGI Ref ID J:79265]
Mao HZ; Roussos ET; Peterfy M. 2006. Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains. Biochim Biophys Acta 1762(4):440-6. [PubMed: 16481151] [MGI Ref ID J:108762]
Maruyama K; Asai J; Ii M; Thorne T; Losordo DW; D'Amore PA. 2007. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 170(4):1178-91. [PubMed: 17392158] [MGI Ref ID J:120123]
Masaki T; Yoshimatsu H; Chiba S; Sakata T. 2000. Impaired response of UCP family to cold exposure in diabetic (db/db) mice Am J Physiol Regul Integr Comp Physiol 279(4):R1305-9. [PubMed: 11003997] [MGI Ref ID J:65231]
Mathew R; Futterweit S; Valderrama E; Tarectecan AA; Bylander JE; Bond JS; Trachtman H. 2005. Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis. Am J Physiol Renal Physiol 289(4):F911-21. [PubMed: 15942051] [MGI Ref ID J:101223]
Matsunuma A; Horiuchi N. 2007. Leptin attenuates gene expression for renal 25-hydroxyvitamin D3-1alpha-hydroxylase in mice via the long form of the leptin receptor. Arch Biochem Biophys 463(1):118-27. [PubMed: 17400175] [MGI Ref ID J:123347]
Mauer SM; Steffes MW; Michael AF; Brown DM. 1976. Studies of diabetic nephropathy in animals and man. Diabetes 25(2 SUPPL):850-7. [PubMed: 823065] [MGI Ref ID J:30970]
Mauldin JP; Srinivasan S; Mulya A; Gebre A; Parks JS; Daugherty A; Hedrick CC. 2006. Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation. J Biol Chem 281(30):21216-24. [PubMed: 16723355] [MGI Ref ID J:116456]
McMurtry AL; Cho K; Young LJ; Nelson CF; Greenhalgh DG. 1999. Expression of HSP70 in healing wounds of diabetic and nondiabetic mice. J Surg Res 86(1):36-41. [PubMed: 10452866] [MGI Ref ID J:58046]
Memon RA; Grunfeld C; Moser AH; Feingold KR. 1994. Fatty acid synthesis in obese insulin resistant diabetic mice. Horm Metab Res 26(2):85-7. [PubMed: 8200619] [MGI Ref ID J:17499]
Memon RA; Tecott LH; Nonogaki K; Beigneux A; Moser AH; Grunfeld C; Feingold KR. 2000. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice [In Process Citation] Endocrinology 141(11):4021-31. [PubMed: 11089532] [MGI Ref ID J:65569]
Mima A; Arai H; Matsubara T; Abe H; Nagai K; Tamura Y; Torikoshi K; Araki M; Kanamori H; Takahashi T; Tominaga T; Matsuura M; Iehara N; Fukatsu A; Kita T; Doi T. 2008. Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy. Diabetes 57(6):1712-22. [PubMed: 18285555] [MGI Ref ID J:136929]
Mishra R; Emancipator SN; Kern TS; Simonson MS. 2006. Association between endothelin-1 and collagen deposition in db/db diabetic mouse kidneys. Biochem Biophys Res Commun 339(1):65-70. [PubMed: 16297859] [MGI Ref ID J:103793]
Mishra R; Emancipator SN; Miller C; Kern T; Simonson MS. 2004. Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney. Am J Physiol Renal Physiol 286(5):F913-21. [PubMed: 15075187] [MGI Ref ID J:113762]
Miyazawa-Hoshimoto S; Takahashi K; Bujo H; Hashimoto N; Yagui K; Saito Y. 2005. Roles of degree of fat deposition and its localization on VEGF expression in adipocytes. Am J Physiol Endocrinol Metab 288(6):E1128-36. [PubMed: 15613686] [MGI Ref ID J:115460]
Mizuno TM; Kleopoulos SP; Bergen HT; Roberts JL; Priest CA; Mobbs CV. 1998. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47(2):294-7. [PubMed: 9519731] [MGI Ref ID J:45531]
Mohan S; Reddick RL; Musi N; Horn DA; Yan B; Prihoda TJ; Natarajan M; Abboud-Werner SL. 2008. Diabetic eNOS knockout mice develop distinct macro- and microvascular complications. Lab Invest 88(5):515-28. [PubMed: 18391994] [MGI Ref ID J:134351]
Moien-Afshari F; Ghosh S; Elmi S; Khazaei M; Rahman MM; Sallam N; Laher I. 2008. Exercise restores coronary vascular function independent of myogenic tone or hyperglycemic status in db/db mice. Am J Physiol Heart Circ Physiol 295(4):H1470-80. [PubMed: 18641279] [MGI Ref ID J:141281]
Moien-Afshari F; Ghosh S; Khazaei M; Kieffer TJ; Brownsey RW; Laher I. 2008. Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Diabetologia 51(7):1327-37. [PubMed: 18437348] [MGI Ref ID J:137918]
Mori A; Sakurai H; Choo MK; Obi R; Koizumi K; Yoshida C; Shimada Y; Saiki I. 2006. Severe pulmonary metastasis in obese and diabetic mice. Int J Cancer 119(12):2760-7. [PubMed: 16998795] [MGI Ref ID J:117826]
Moritani M; Togawa K; Yaguchi H; Fujita Y; Yamaguchi Y; Inoue H; Kamatani N; Itakura M. 2006. Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping. Genomics 88(6):719-30. [PubMed: 16919419] [MGI Ref ID J:116038]
Muller KA; Ryals JM; Feldman EL; Wright DE. 2008. Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice. Diabetes 57(6):1693-701. [PubMed: 18362211] [MGI Ref ID J:136902]
Munzberg H; Jobst EE; Bates SH; Jones J; Villanueva E; Leshan R; Bjornholm M; Elmquist J; Sleeman M; Cowley MA; Myers MG Jr. 2007. Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci 27(1):69-74. [PubMed: 17202473] [MGI Ref ID J:117213]
Murano I; Barbatelli G; Parisani V; Latini C; Muzzonigro G; Castellucci M; Cinti S. 2008. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 49(7):1562-8. [PubMed: 18390487] [MGI Ref ID J:138458]
Nakagawa T; Tsuchida A; Itakura Y; Nonomura T; Ono M; Hirota F; Inoue T; Nakayama C; Taiji M; Noguchi H. 2000. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 49(3):436-44. [PubMed: 10868966] [MGI Ref ID J:60912]
Nakagawa Y; Shimano H; Yoshikawa T; Ide T; Tamura M; Furusawa M; Yamamoto T; Inoue N; Matsuzaka T; Takahashi A; Hasty AH; Suzuki H; Sone H; Toyoshima H; Yahagi N; Yamada N. 2006. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nat Med 12(1):107-113. [PubMed: 16327801] [MGI Ref ID J:104468]
Nakamura Y; Kaneto H; Miyatsuka T; Matsuoka TA; Matsuhisa M; Node K; Hori M; Yamasaki Y. 2006. Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway. Biochem Biophys Res Commun 350(1):68-73. [PubMed: 16996478] [MGI Ref ID J:114522]
Nakatani Y; Kaneto H; Kawamori D; Hatazaki M; Miyatsuka T; Matsuoka TA; Kajimoto Y; Matsuhisa M; Yamasaki Y; Hori M. 2004. Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem 279(44):45803-9. [PubMed: 15331609] [MGI Ref ID J:119058]
Nakayama M; Inoguchi T; Sonta T; Maeda Y; Sasaki S; Sawada F; Tsubouchi H; Sonoda N; Kobayashi K; Sumimoto H; Nawata H. 2005. Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist. Biochem Biophys Res Commun 332(4):927-33. [PubMed: 15922295] [MGI Ref ID J:99119]
Nayak B; Xie P; Akagi S; Yang Q; Sun L; Wada J; Thakur A; Danesh FR; Chugh SS; Kanwar YS. 2005. Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience. Proc Natl Acad Sci U S A 102(50):17952-7. [PubMed: 16330753] [MGI Ref ID J:104390]
Ninichuk V; Khandoga AG; Segerer S; Loetscher P; Schlapbach A; Revesz L; Feifel R; Khandoga A; Krombach F; Nelson PJ; Schlondorff D; Anders HJ. 2007. The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice. Am J Pathol 170(4):1267-76. [PubMed: 17392166] [MGI Ref ID J:120121]
Nishimura S; Manabe I; Nagasaki M; Hosoya Y; Yamashita H; Fujita H; Ohsugi M; Tobe K; Kadowaki T; Nagai R; Sugiura S. 2007. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 56(6):1517-26. [PubMed: 17389330] [MGI Ref ID J:126464]
Nishina PM; Lowe S; Wang J; Paigen B. 1994. Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43(5):549-53. [PubMed: 8177042] [MGI Ref ID J:18161]
Nishina PM; Naggert JK; Verstuyft J; Paigen B. 1994. Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43(5):554-8. [PubMed: 8177043] [MGI Ref ID J:19043]
Nonogaki K; Nozue K; Oka Y. 2007. Social isolation affects the development of obesity and type 2 diabetes in mice. Endocrinology 148(10):4658-66. [PubMed: 17640995] [MGI Ref ID J:129468]
Nonogaki K; Ohba Y; Sumii M; Oka Y. 2008. Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Biochem Biophys Res Commun 372(1):186-90. [PubMed: 18477467] [MGI Ref ID J:136954]
O'Connor JC; Satpathy A; Hartman ME; Horvath EM; Kelley KW; Dantzer R; Johnson RW; Freund GG. 2005. IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J Immunol 174(8):4991-7. [PubMed: 15814729] [MGI Ref ID J:98153]
Oakes ND; Thalen P; Aasum E; Edgley A; Larsen T; Furler SM; Ljung B; Severson D. 2006. Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes. Am J Physiol Endocrinol Metab 290(5):E870-81. [PubMed: 16352676] [MGI Ref ID J:108411]
Oh KS; Kim M; Lee J; Kim MJ; Nam YS; Ham JE; Shin SS; Lee CM; Yoon M. 2006. Liver PPARalpha and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice. Biochem Biophys Res Commun 345(3):1232-1239. [PubMed: 16716264] [MGI Ref ID J:109651]
Ohta R; Shigemura N; Sasamoto K; Koyano K; Ninomiya Y. 2003. Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. Neurobiol Learn Mem 80(2):105-12. [PubMed: 12932425] [MGI Ref ID J:85127]
Okamoto K; Kakuma T; Fukuchi S; Masaki T; Sakata T; Yoshimatsu H. 2006. Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes. Brain Res 1081(1):19-27. [PubMed: 16554040] [MGI Ref ID J:108103]
Ono M; Ichihara J; Nonomura T; Itakura Y; Taiji M; Nakayama C ; Noguchi H. 1997. Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238(2):633-7. [PubMed: 9299565] [MGI Ref ID J:43162]
Pagel-Langenickel I; Bao J; Joseph JJ; Schwartz DR; Mantell BS; Xu X; Raghavachari N; Sack MN. 2008. PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J Biol Chem 283(33):22464-72. [PubMed: 18579525] [MGI Ref ID J:139876]
Palmer G; Aurrand-Lions M; Contassot E; Talabot-Ayer D; Ducrest-Gay D; Vesin C; Chobaz-Peclat V; Busso N; Gabay C. 2006. Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol 177(5):2899-907. [PubMed: 16920925] [MGI Ref ID J:139552]
Papathanassoglou E; El-Haschimi K; Li XC; Matarese G; Strom T; Mantzoros C. 2006. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 176(12):7745-52. [PubMed: 16751422] [MGI Ref ID J:132347]
Park J; Rho HK; Kim KH; Choe SS; Lee YS; Kim JB. 2005. Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Mol Cell Biol 25(12):5146-57. [PubMed: 15923630] [MGI Ref ID J:99224]
Park KW; Waki H; Villanueva CJ; Monticelli LA; Hong C; Kang S; Macdougald OA; Goldrath AW; Tontonoz P. 2008. Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-{gamma} Expression and Adipocyte Differentiation. Mol Endocrinol 22(9):2038-48. [PubMed: 18562627] [MGI Ref ID J:138276]
Park S; Bivona BJ; Feng Y; Lazartigues E; Harrison-Bernard LM. 2008. Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice. Am J Physiol Renal Physiol 295(5):F1504-11. [PubMed: 18753291] [MGI Ref ID J:140999]
Pasko KL; Salvin SB; Winkelstein A. 1981. Mechanisms in the in vivo release of lymphokines. V. Responses in alloxan-treated and genetically diabetic mice. Cell Immunol 62(1):205-19. [PubMed: 7261069] [MGI Ref ID J:109959]
Peppa M; Brem H; Ehrlich P; Zhang JG; Cai W; Li Z; Croitoru A; Thung S; Vlassara H. 2003. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes 52(11):2805-13. [PubMed: 14578300] [MGI Ref ID J:86304]
Pereira L; Matthes J; Schuster I; Valdivia HH; Herzig S; Richard S; Gomez AM. 2006. Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice. Diabetes 55(3):608-15. [PubMed: 16505222] [MGI Ref ID J:106859]
Petrolonis AJ; Yang Q; Tummino PJ; Fish SM; Prack AE; Jain S; Parsons TF; Li P; Dales NA; Ge L; Langston SP; Schuller AG; An WF; Tartaglia LA; Chen H; Hong SB. 2004. Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP). J Biol Chem 27