Description

Strain Information

Type Mutant Stock; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation N1p

Description
Mutations at the Mitf locus affect eye size, pigmentation, and the capacity for secondary bone resorption. MIce homozygous for the white allele (Mitf^Mi-wh) display an overall absence of pigment cells with the exception of the retina which expresses a few giving the eye a small amount of pigment. Homozygotes show slight microphthalmia but a normal skeleton. Heterozygotes (Mitf^Mi-wh/+) have a diluted coat color, light ears, a white belly spot, and in rare cases a dorsal spot. In addition, they display abnormalitites of both the cochlear and vestibular portions of the inner ear. Mice homozygous for the postaxial hemimelia spontaneous mutation (Wnt7a^px) have skeletal defects of the forelimbs. Digits 5, 4, and sometimes 3, are missing and there is a reduction or absence of the ulna. There is always a large oval foramen in the scapula. The hindlimbs are usually unaffected, but digit 5 may be absent, and occasionally the fibula is reduced. Severely affected mice tend to have an extra pair of ribs and a slight reduction in the number of presacral vertebrae. Both sexes are sterile and show anomalies of the Mullerian ducts.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying   Mitf^Mi-wh allele

000593	B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000158	B6.Cg-MitfMi-wh/MitfMi/J
000184	B6.Cg-MitfMi-wh/Mitfmi-rw/J
000157	B6.Cg-MitfMi-wh/Mitfmi-sp/J
000057	B6.Cg-MitfMi-wh/J
000350	B6By.Cg-KitW-v MitfMi-wh T/J
000302	STOCK a/a MitfMi-wh +/+ Itpr1opt/J

View Strains carrying   Mitf^Mi-wh     (7 strains)

Strains carrying other alleles of Mitf

003046	B6(FVB)-MitfMi-Mee/J
000158	B6.Cg-MitfMi-wh/MitfMi/J
000184	B6.Cg-MitfMi-wh/Mitfmi-rw/J
000157	B6.Cg-MitfMi-wh/Mitfmi-sp/J
001573	B6C3Fe a/a-MitfMi/J
000956	B6CB-Mitfmi-rw/J
002611	C57BL/6J-Mitfmi-bws/J
002134	C57BL/6J-Mitfmi-vit/J

View Strains carrying other alleles of Mitf     (8 strains)

Strains carrying other alleles of Wnt7a

004715

B6;129S1-Wnt7atm1Amc/J

View Strains carrying other alleles of Wnt7a     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms

	Albinism, Ocular, with Sensorineural Deafness - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
	Tietz Syndrome - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
	Waardenburg Syndrome, Type IIA; WS2A - Models with phenotypic similarity to human disease where etiologies involve orthologs.1

1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Mitf^Mi-wh/Mitf⁺

        involves: C57BL/6 * DBA

• pigmentation phenotype
• abnormal skin pigmentation (MGI Ref ID J:13058)
  • reduced foot pigmentation
• abnormal tail pigmentation (MGI Ref ID J:13058)
  • reduced tail pigmentation
• diluted coat color (MGI Ref ID J:13058)
  • coat color is gray and somewhat lighter than that of Myo5a^d homozygotes
  • coat color darkens slightly with age
• reduced eye pigmentation (MGI Ref ID J:13058)
  • eyes are a very dark ruby color
• skin/coat/nails phenotype
• abnormal skin pigmentation (MGI Ref ID J:13058)
  • reduced foot pigmentation
• abnormal tail pigmentation (MGI Ref ID J:13058)
  • reduced tail pigmentation
• diluted coat color (MGI Ref ID J:13058)
  • coat color is gray and somewhat lighter than that of Myo5a^d homozygotes
  • coat color darkens slightly with age
• limbs/digits/tail phenotype
• abnormal tail pigmentation (MGI Ref ID J:13058)
  • reduced tail pigmentation
• vision/eye phenotype
• reduced eye pigmentation (MGI Ref ID J:13058)
  • eyes are a very dark ruby color

Mitf^Mi-wh/Mitf^Mi-wh

        involves: C57BL/6 * DBA

• pigmentation phenotype
• absent coat pigmentation (MGI Ref ID J:13058)
  • coat color is indistinguishable from that of Tyr^c homozygotes
• ocular albinism (MGI Ref ID J:13058)
  • eyes are pink and pigmentless
• vision/eye phenotype
• microphthalmia (MGI Ref ID J:13058)
  • eye size appears reduced compared to f Tyr^c homozygotes
• ocular albinism (MGI Ref ID J:13058)
  • eyes are pink and pigmentless
• growth/size phenotype
• decreased body size (MGI Ref ID J:13058)
  • reduced body size compared to f Tyr^c homozygotes
• reproductive system phenotype
• decreased litter size (MGI Ref ID J:13058)
  • litter size is reduced in homozygous female to homozygous male crosses
• skin/coat/nails phenotype
• absent coat pigmentation (MGI Ref ID J:13058)
  • coat color is indistinguishable from that of Tyr^c homozygotes

Mitf^Mi-wh/Mitf^Mi-wh

        B6.Cg-Mitf^Mi-wh

• pigmentation phenotype
• abnormal retinal pigment epithelium morphology (MGI Ref ID J:5046)
  • pigment granules are absent at E11
  • at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
  • after E12 in some area the cells are columnar rather than cuboidal
  • at all stages the number of mitoses is increased compared to control pigment layers
• abnormal retinal pigmentation (MGI Ref ID J:5046)
  • pigment granules are absent from the pigment layer at E11
  • after E12, a few pigment granules may be found in the front edge of the pigment layer
  • at birth a few pigment granules are present near the iris
• vision/eye phenotype
• abnormal eye development (MGI Ref ID J:5046)
  • at E12 the choroid fissure is mostly closed but the joining of the retinal nervous layer is not smooth and a large retinal eversion is present at the rear of the optic cup where the fissure fails to close
  • in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
• abnormal optic cup morphology (MGI Ref ID J:5046)
  • slightly reduced in size from E13 onwards
  • irregularly formed surrounding less than half of the spherical lens
• abnormal optic stalk morphology (MGI Ref ID J:5046)
  • slight increase in diameter at E11
  • shorter and somewhat greater in diameter at E11.5 and E12
• abnormal posterior eye segment morphology (MGI Ref ID J:5046)
  • the lens fills the space normally occupied by the vitreous body
• abnormal choroid morphology (MGI Ref ID J:5046)
  • at birth the choroid fissure is irregularly closed in the anterior eye and open from the posterior part of the lens to the rear of the optic cup
  • in newborns the retinal eversion remains obvious in the unclosed portions of the choroid fissure
• abnormal retinal neuronal layer morphology (MGI Ref ID J:5046)
  • at birth, the layers are less clearly defined
• abnormal retinal pigment epithelium morphology (MGI Ref ID J:5046)
  • pigment granules are absent at E11
  • at E11.5 and E12, the pigment layer is irregullar, mainly in the dorsal region
  • after E12 in some area the cells are columnar rather than cuboidal
  • at all stages the number of mitoses is increased compared to control pigment layers
• abnormal retinal pigmentation (MGI Ref ID J:5046)
  • pigment granules are absent from the pigment layer at E11
  • after E12, a few pigment granules may be found in the front edge of the pigment layer
  • at birth a few pigment granules are present near the iris
• microphthalmia (MGI Ref ID J:5046)
  • slightly smaller at birth
• skeleton phenotype
• *normal* skeleton phenotype (MGI Ref ID J:5046)
  • unlike Mitf^Mi homozygotes no skeletal abnormalities are seen
• homeostasis/metabolism phenotype
• decreased bleeding time (MGI Ref ID J:7327)
  • bleed time of only 1 minute after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls

Wnt7a^px/Wnt7a^px

        involves: STOCK Sox18^Ra

• limbs/digits/tail phenotype
• abnormal forelimb morphology (MGI Ref ID J:112)
  • forelimbs are regularly affected
• abnormal ulna morphology (MGI Ref ID J:112)
  • reduction or absence of the ulna
• abnormal hindlimb morphology (MGI Ref ID J:112)
  • hindlimbs are usually normal, but digit 5 may be absent, and occasionally the fibula is reduced
• short fibula (MGI Ref ID J:112)
  • occasionally the fibula is reduced
• oligodactyly (MGI Ref ID J:112)
  • there may be absence of digits 5, 4, and sometimes 3 on the forelimbs
  • digit 5 may be absent on the hindlimbs
• reproductive system phenotype
• abnormal reproductive system morphology (MGI Ref ID J:112)
  • anomalies of the Mullerian ducts in both sexes
• female infertility (MGI Ref ID J:112)
• male infertility (MGI Ref ID J:112)
• skeleton phenotype
• abnormal ulna morphology (MGI Ref ID J:112)
  • reduction or absence of the ulna
• decreased presacral vertebrae number (MGI Ref ID J:112)
  • mice with more severely affected limbs tend to have a slight reduction in the number of presacral vertebrae
• increased rib number (MGI Ref ID J:112)
  • mice with more severely affected limbs tend to have an extra pair of ribs
• scapular bone foramen (MGI Ref ID J:112)
  • a large oval foramen is present in the scapula
• short fibula (MGI Ref ID J:112)
  • occasionally the fibula is reduced

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Mitf^Mi-wh related

Dermatology Research
Color and White Spotting Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects

Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects

Mouse/Human Gene Homologs
Waardenburg syndrome, type IIA

Neurobiology Research
Vestibular and Hearing Defects

Sensorineural Research
Eye Defects
Vestibular and Hearing Defects

Wnt7a^px related

Developmental Biology Research
Skeletal Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		MitfMi-wh
Allele Name		white
Allele Type		Spontaneous
Common Name(s)		Miwh;
Strain of Origin		(C57BL x DBA)F1
Gene Symbol and Name		Mitf, microphthalmia-associated transcription factor
Chromosome		6
Gene Common Name(s)		MI; WS2A; bHLHe32; black eyed white; bw; mi; microphthalmia; vit; vitiligo; wh;
General Note		Combination heterozygotes of MitfMi-wh/MitfMi, MitfMi-wh/MitfMi-b, and MitfMi-wh/MitfMi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearlynormal than either homozygote (J:12967, J:19656). MitfMi-b/MitfMi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).
Molecular Note		T to A transversion at bp 764, which leads to an isoleucine to asparagine substitution at the corresponding amino acid (212) in the encoded protein. This mutation is in the basic region of the protein. [MGI Ref ID J:19656] [MGI Ref ID J:21366]
Allele Symbol		Wnt7apx
Allele Name		postaxial hemimelia
Allele Type		Spontaneous
Common Name(s)		px;
Strain of Origin		STOCK Sox18
Gene Symbol and Name		Wnt7a, wingless-related MMTV integration site 7A
Chromosome		6
Gene Common Name(s)		AI849442; Wnt-7a; expressed sequence AI849442; foot-twist; postaxial hemimelia; px; tw;
Molecular Note		A 515 bp deletion at the end of exon 3. This results in utilization of a cryptic splice site in exon 3. This alteration in the mRNA is predicted to create a shift in the reading frame and the introduction of a stop codon at the beginning of the fourth exon. [MGI Ref ID J:50461]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Deol MS. 1967. The neural crest and the acoustic ganglion. J Embryol Exp Morphol 17(3):533-41. [PubMed: 6049665]  [MGI Ref ID J:5048]

Hodgkinson CA; Moore KJ; Nakayama A; Steingrimsson E; Copeland NG; Jenkins NA; Arnheiter H. 1993. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74(2):395-404. [PubMed: 8343963]  [MGI Ref ID J:13562]

Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20. [PubMed: 7852195]  [MGI Ref ID J:21682]

Raisz LG; Simmons HA; Gworek SC; Eilon G. 1977. Studies on congenital osteopetrosis in microphthalmic mice using organ cultures: impairment of bone resorption in response to physiologic stimulators. J Exp Med 145(4):857-65. [PubMed: 870607]  [MGI Ref ID J:5804]

Steingrimsson E; Moore KJ; Lamoreux ML; Ferre-D'Amare AR; Burley SK; Zimring DC; Skow LC; Hodgkinson CA; Arnheiter H; Copeland NG; Jenkins NA. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments] Nat Genet 8(3):256-63. [PubMed: 7874168]  [MGI Ref ID J:21366]

Tachibana M; Perez-Jurado LA; Nakayama A; Hodgkinson CA; Li X; Schneider M; Miki T; Fex J; Francke U; Arnheiter H. 1994. Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3. Hum Mol Genet 3(4):553-7. [PubMed: 8069297]  [MGI Ref ID J:17853]

Mitf^Mi-wh related

Beechey CV. 2004. A reassessment of imprinting regions and phenotypes on mouse chromosome 6: Nap1l5 locates within the currently defined sub-proximal imprinting region. Cytogenet Genome Res 107(1-2):108-14. [PubMed: 15305064]  [MGI Ref ID J:93134]

Boissy RE; Lamoreux ML. 1995. In vivo and in vitro morphological analysis of melanocytes homozygous for the misp allele at the murine microphthalmia locus. Pigment Cell Res 8(6):294-301. [PubMed: 8789737]  [MGI Ref ID J:31402]

Diwakar G; Zhang D; Jiang S; Hornyak TJ. 2008. Neurofibromin as a regulator of melanocyte development and differentiation. J Cell Sci 121(Pt 2):167-77. [PubMed: 18089649]  [MGI Ref ID J:130856]

Grobman AB; Charles DR. 1947. Mutant white mice. A new dominant autosomal mutant affecting coat color in Mus musculus. J Hered 38:381-384.  [MGI Ref ID J:13058]

Gruneberg H. 1953. The relations of microphthalmia and white in the mouse. J Genet 51:359-362.  [MGI Ref ID J:13042]

Hollander WF. 1968. Complementary alleles at the mi-locus in the mouse. Genetics 60:189.  [MGI Ref ID J:12967]

Ito A; Jippo T; Wakayama T; Morii E; Koma Y; Onda H; Nojima H; Iseki S; Kitamura Y. 2003. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood 101(7):2601-8. [PubMed: 12456501]  [MGI Ref ID J:115530]

Jippo T; Morii E; Ito A; Kitamura Y. 2003. Effect of anatomical distribution of mast cells on their defense function against bacterial infections: demonstration using partially mast cell-deficient tg/tg mice. J Exp Med 197(11):1417-25. [PubMed: 12771178]  [MGI Ref ID J:83732]

Kim DK; Morii E; Ogihara H; Lee YM; Jippo T; Adachi S; Maeyama K; Kim HM; Kitamura Y. 1999. Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells. Blood 93(12):4179-86. [PubMed: 10361115]  [MGI Ref ID J:55734]

Konyukhov BV; Kindyakov BN; Malinina NA. 1994. Effects of the white allele of the mi locus on coat pigmentation in chimeric mice. Genet Res 63(3):175-81. [PubMed: 8082834]  [MGI Ref ID J:19656]

Konyukhov BV; Osipov VV. 1968. Interallelic complementation of microphthalmia and white genes in mice. Sov Genet 4(11):1457-1465.  [MGI Ref ID J:12001]

Larsen M. 1966. Microphthalmia-brownish, Mi<b> Mouse News Lett 34:41.  [MGI Ref ID J:15061]

Moller A; Eysteinsson T; Steingrimsson E. 2004. Electroretinographic assessment of retinal function in microphthalmia mutant mice. Exp Eye Res 78(4):837-48. [PubMed: 15037118]  [MGI Ref ID J:88541]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Munford RE. 1965. Mutation at mi locus Mouse News Lett 33:52.  [MGI Ref ID J:83501]

Nakayama A; Nguyen MT; Chen CC; Opdecamp K; Hodgkinson CA; Arnheiter H. 1998. Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently. Mech Dev 70(1-2):155-66. [PubMed: 9510032]  [MGI Ref ID J:46130]

Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991]  [MGI Ref ID J:7327]

Packer SO. 1967. The eye and skeletal effects of two mutant alleles at the microphthalmia locus of Mus musculus. J Exp Zool 165(1):21-45. [PubMed: 4963367]  [MGI Ref ID J:5046]

Pratt BM. 1982. Site of gene action of the white allele (Miwh) of the microphthalmia locus: a dermal-epidermal recombination study. J Exp Zool 220(1):93-101. [PubMed: 7042901]  [MGI Ref ID J:6764]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Steingrimsson E; Arnheiter H; Hallsson JH; Lamoreux ML; Copeland NG; Jenkins NA. 2003. Interallelic complementation at the mouse mitf locus. Genetics 163(1):267-76. [PubMed: 12586714]  [MGI Ref ID J:82600]

Steingrimsson E; Moore KJ; Lamoreux ML; Ferre-D'Amare AR; Burley SK; Zimring DC; Skow LC; Hodgkinson CA; Arnheiter H; Copeland NG; Jenkins NA. 1994. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences [see comments] Nat Genet 8(3):256-63. [PubMed: 7874168]  [MGI Ref ID J:21366]

Steingrimsson E; Tessarollo L; Pathak B; Hou L; Arnheiter H; Copeland NG; Jenkins NA. 2002. Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A 99(7):4477-82. [PubMed: 11930005]  [MGI Ref ID J:89821]

Zanjani HS; Vogel MW; Martinou JC; Delhaye-Bouchaud N; Mariani J. 1998. Postnatal expression of Hu-bcl-2 gene in Lurcher mutant mice fails to rescue Purkinje cells but protects inferior olivary neurons from target-related cell death. J Neurosci 18(1):319-27. [PubMed: 9412510]  [MGI Ref ID J:119889]

Wnt7a^px related

Cox S; Smith L; Bogani D; Cheeseman M; Siggers P; Greenfield A. 2006. Sexually dimorphic expression of secreted frizzled-related (SFRP) genes in the developing mouse Mullerian duct. Mol Reprod Dev 73(8):1008-16. [PubMed: 16700072]  [MGI Ref ID J:119228]

Parr BA; Avery EJ; Cygan JA; McMahon AP. 1998. The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene. Dev Biol 202(2):228-34. [PubMed: 9769174]  [MGI Ref ID J:50461]

Searle AG. 1964. The genetics and morphology of two 'luxoid' mutants in the house mouse Genet Res 5:171-197.  [MGI Ref ID J:112]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.