Strain Name: |
STOCK Mgrn1md Igl-1b Igl1-rlo/J |
|---|---|
Stock Number: |
001277 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
STOCK md Igl-1b Igl1-rlo/md Igl-1b Igl1-rlo (Changed: 15-DEC-04
) |
| Genes & Alleles | Igl-1b; Igl1-r; Igl-1; Mgrn1; Mgrn1md; ; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Species laboratory mouse Generation F28p Strain Development
Mahoganoid (Mgrn1md) arose spontaneously on strain C3H/HeJ at the Jackson Laboratory in 1957. The Igl-1b allele at the immunoglobulin lamba chain cluster 1 locus is found in strains SJL, YBR, BSVS and others and the Igl1-rlo allele occurs in strains SJL, BSVS and others. In 1972 Dr. M. C. Green received the fused phalanges (Fbn2fp) stock from Dr. Katrina Hummel. Fused phalanges arose spontaneously in strain C3HeB/FeHu. The stock Dr. Green received had been crossed once to C57BL/6J and it was then brother x sister bred to F20 in 1976. At F18 the stock was given to Dr. Muriel Davisson and it was continued to be inbred to F21 when a fused phalanges male was outcrossed to a homozygous mahoganoid (Mgrn1md) female. This mahoganoid female was the N2 offspring of a backcross that began with a mating of C57BL/6J x C3H/He-Mgrn1md/+ from which an F1 was bred back to a C3H/HeJ-Mgrn1md/Mgrn1md, which was at F69. The N2 homozygous female resulting from this breeding was bred with the F21 fused phalanges male and their offspring were bred brother x sister to F20. At that point, a mahoganoid male was outcrossed to an Lystbg homozygous female on a congenic SJL/J background at generation N12F4 from Dr. John Roths. The resulting stock was sibling mated and a homozygous mahoganoid female was backcrossed to an SJL/J male. The stock was then bred as homozygous for mahoganoid (Mgrn1md),Igl-1b and Igl1-rlo all on chromosome 16. It was cryopreserved in 1991 by mating homozygotes at F27 and F28.
Gene & Allele Details
| Allele Symbol | Igl-1b | ||
|---|---|---|---|
| Allele Name | b variant | ||
| Gene Symbol and Name | Igl-1, immunoglobulin lambda chain, cluster 1 | ||
| Chromosome | 16 | ||
| Allele Symbol | Mgrn1md | ||
| Allele Name | mahoganoid | ||
| Common Name(s) | md; | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | Mgrn1, mahogunin, ring finger 1 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | 2610042J20Rik; KIAA0544; N28182; RGD1311862; RIKEN cDNA 2610042J20 gene; RNF156; expressed sequence N28182; mKIAA0544; mahoganoid; md; nc; non-agouti curly; non-agouti-curly; | ||
| General Note | The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791). | ||
| Molecular Note | The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. [MGI Ref ID J:80182] | ||
| Gene Symbol and Name | Igl1-r, immunoglobulin lambda chain regulator | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | Igl-1r; Igl-Lo; | ||
Related Strains
Strains carrying Mgrn1md allele
000001 B6.C3 A/a Mgrn1md/J 000309 B6.C3-Mgrn1md/J 000223 C3H/HeJ-Mgrn1md/J View Strains carrying Mgrn1md (3 strains)
Research Applications
This mouse can be used to support research in many areas including:Igl-1b related
Mgrn1md relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | STOCK Mgrn1md Igl-1b Igl1-rlo/J |
| Stock Number: | 001277 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
*NO Shipping Destination selected!
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form