Strain Name:

STOCK Mgrn1md Igl-1b Igl1-rlo/J

Stock Number:

001277

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK md Igl-1b Igl1-rlo/md Igl-1b Igl1-rlo    (Changed: 15-DEC-04 )
Type Variant Allele;
Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationF28p
Generation Definitions

Development
Mahoganoid (Mgrn1md) arose spontaneously on strain C3H/HeJ at the Jackson Laboratory in 1957. The Igl-1b allele at the immunoglobulin lamba chain cluster 1 locus is found in strains SJL, YBR, BSVS and others and the Igl1-rlo allele occurs in strains SJL, BSVS and others. In 1972 Dr. M. C. Green received the fused phalanges (Fbn2fp) stock from Dr. Katrina Hummel. Fused phalanges arose spontaneously in strain C3HeB/FeHu. The stock Dr. Green received had been crossed once to C57BL/6J and it was then brother x sister bred to F20 in 1976. At F18 the stock was given to Dr. Muriel Davisson and it was continued to be inbred to F21 when a fused phalanges male was outcrossed to a homozygous mahoganoid (Mgrn1md) female. This mahoganoid female was the N2 offspring of a backcross that began with a mating of C57BL/6J x C3H/He-Mgrn1md/+ from which an F1 was bred back to a C3H/HeJ-Mgrn1md/Mgrn1md, which was at F69. The N2 homozygous female resulting from this breeding was bred with the F21 fused phalanges male and their offspring were bred brother x sister to F20. At that point, a mahoganoid male was outcrossed to an Lystbg homozygous female on a congenic SJL/J background at generation N12F4 from Dr. John Roths. The resulting stock was sibling mated and a homozygous mahoganoid female was backcrossed to an SJL/J male. The stock was then bred as homozygous for mahoganoid (Mgrn1md),Igl-1b and Igl1-rlo all on chromosome 16. It was cryopreserved in 1991 by mating homozygotes at F27 and F28.

Related Strains

Strains carrying   Mgrn1md allele
000001   B6.C3 A/a Mgrn1md/J
000309   B6.C3-Mgrn1md/J
000223   C3H/HeJ-Mgrn1md/J
View Strains carrying   Mgrn1md     (3 strains)

Strains carrying other alleles of Mgrn1
000809   C3H/HeJ-Mgrn1md-2J/J
View Strains carrying other alleles of Mgrn1     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Mgrn1md/Mgrn1md

        C3H/HeJ-Mgrn1md/J
  • pigmentation phenotype
  • darkened coat color
    • reduced amount of yellow pigment causing a dark brown appearance   (MGI Ref ID J:81466)
  • integument phenotype
  • darkened coat color
    • reduced amount of yellow pigment causing a dark brown appearance   (MGI Ref ID J:81466)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Igl-1b related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Mgrn1md related

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Igl-1b
Allele Name b variant
Allele Type Not Applicable
Gene Symbol and Name Igl-1, immunoglobulin lambda chain, cluster 1
Chromosome 16
 
Allele Symbol Mgrn1md
Allele Name mahoganoid
Allele Type Spontaneous
Common Name(s) md;
Strain of OriginC3H/HeJ
Gene Symbol and Name Mgrn1, mahogunin, ring finger 1
Chromosome 16
Gene Common Name(s) 2610042J20Rik; N28182; RGD1311862; RIKEN cDNA 2610042J20 gene; RNF156; expressed sequence N28182; mKIAA0544; mahoganoid; md; nc; non-agouti curly; non-agouti-curly;
General Note The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791).
Molecular Note The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. [MGI Ref ID J:80182]
 
Gene Symbol and Name Igl1-r, immunoglobulin lambda chain regulator
Chromosome 16
Gene Common Name(s) Igl-1r; Igl-Lo;

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Igl-1b related

Lieberman R; Humphrey W; Chien CC. 1977. Identification and genetics of lambda>1< light chain allotype in the mouse. Immunogenetics 5:515.  [MGI Ref ID J:12981]

Mgrn1md related

Bagher P; Jiao J; Owen Smith C; Cota CD; Gunn TM. 2006. Characterization of Mahogunin Ring Finger-1 expression in mice. Pigment Cell Res 19(6):635-43. [PubMed: 17083490]  [MGI Ref ID J:119125]

Concepcion D; Flores-Garcia L; Hamilton BA. 2009. Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. PLoS Genet 5(5):e1000484. [PubMed: 19436707]  [MGI Ref ID J:149430]

He L; Lu XY; Jolly AF; Eldridge AG; Watson SJ; Jackson PK; Barsh GS; Gunn TM. 2003. Spongiform degeneration in mahoganoid mutant mice. Science 299(5607):710-2. [PubMed: 12560552]  [MGI Ref ID J:81466]

Lane PW. 1960. mahoganoid, md Mouse News Lett 22:35.  [MGI Ref ID J:13379]

Miller KA; Gunn TM; Carrasquillo MM; Lamoreux ML; Galbraith DB ; Barsh GS. 1997. Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics 146(4):1407-15. [PubMed: 9258683]  [MGI Ref ID J:41964]

Overton JD; Leibel RL. 2011. Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem 286(21):18914-29. [PubMed: 21460229]  [MGI Ref ID J:174243]

Phan LK; Chung WK; Leibel RL. 2006. The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab 291(3):E611-20. [PubMed: 16638826]  [MGI Ref ID J:112364]

Phan LK; Lin F; LeDuc CA; Chung WK; Leibel RL. 2002. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest 110(10):1449-59. [PubMed: 12438443]  [MGI Ref ID J:80182]

Phillips RJS; Fisher G. 1979. Non-agouti curly: change of symbol. Mouse News Lett 60:46-47.  [MGI Ref ID J:13791]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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