Strain Name: |
B6C3Fe a/a-Glra1spd/J |
|---|---|
Stock Number: |
001278 |
Availability: | Repository-Cryopreserved |
Price and Supply Information | |
General Terms and Conditions |
| Former Name |
B6C3Fe-a/a-Glra1spd/+ (Changed: 15-DEC-04
) |
| Genes & Alleles | Glra1; Glra1spd; a; |
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Species laboratory mouse Generation N21F1 Appearance
black, tremors
Related Genotype: a/a Glraspd/Glraspd
black, unaffected
Related Genotype: a/a +/? or a/a Glraspd/+Strain Description
Mice homozygous for the spasmodic spontaneous mutation (Glra1spd) have rapid tremors, stiff posture, and difficulty in righting themselves. No differences have been observed in the levels of major CNS or PNS myelin proteins or lipids. As with the spastic mutation (Glrbspa) of the mouse, aminooxyacetic acid improves the behavioral abnormalities in spasmodic mice, but, unlike in spastic mice, no changes in the postsynaptic receptors for glycine, GABA, or benzodiazepines have been observed.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Glra1spd | ||
|---|---|---|---|
| Allele Name | spasmodic | ||
| Common Name(s) | spd; | ||
| Strain of Origin | A/HeJ | ||
| Gene Symbol and Name | Glra1, glycine receptor, alpha 1 subunit | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | B230397M16Rik; GLYRA1; MGC138878; MGC138879; RIKEN cDNA B230397M16 gene; STHE; neuroscience mutagenesis facility, 11; nmf11; oscillator; ot; spasmodic; spd; | ||
| General Note |
The spasmodic mutation arose in the A/HeJ inbred strain at The Jackson Laboratory (J:9027). Symptoms of the mutant resemble those of strychnine poisoning; strychnine, an alkaloid from the tropical plant Strychnos nuxvomica, is a glycine receptor antagonist (J:20373). The spasmodic mutation substitutes a single base pair in the Glra1 gene that alters the amino acid sequence of the gene product (J:18524). Homozygous spasmodic mice suffer an exaggerated acoustic startle reflex in response to loud noises or to handling, with rapid tremors, stiff posture, and difficulty in righting themselves (J:18524). No differences were observed in the levels of major central or peripheral nervous system myelin proteins or lipids. The spastic mouse, which has a phenotype similar to spasmodic, carries a mutation in Glrb, encoding the beta subunit of the glycine receptor (J:18530). Aminooxyacetic acid improves the behavioral abnormalities of both spastic and spasmodic homozygotes. However, there are no changes in the postsynaptic receptors for glycine, GABA, or benzodiazepines in spasmodic as there are in spastic mice (J:9027). | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele | Control | |
|---|---|---|
| Glra1spd | Untyped from the colony | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for JAX® GEMM® Strains | ||
Strains carrying a allele
View Strains carrying a (102 strains)
Strains carrying other alleles of Glra1
004109 C57BL/6J-Glra1nmf11/J 000536 C57BL/6J-Glra1spd-ot/J View Strains carrying other alleles of Glra1 (2 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (67 strains)
Glra1spd related
Cell Biology Research
Channel and Transporter Defects (chloride: glycine receptor)
Mouse/Human Gene Homologs
Kok disease-hyperexplexia, startle disease
Neurobiology Research
Channel and Transporter Defects (chloride: glycine receptor)
Neurotransmitter Receptor and Synaptic Vesicle Defects
Receptor Defects
Tremor Defects
Selected Reference(s)
Additional ReferencesLane PW; Ganser AL; Kerner AL; White WF. 1987. Spasmodic, a mutation on chromosome 11 in the mouse. J Hered 78(6):353-6. [PubMed: 3429842] [MGI Ref ID J:9027]
Ryan SG; Buckwalter MS; Lynch JW; Handford CA; Segura L; Shiang R; Wasmuth JJ; Camper SA; Schofield P; O'Connell P. 1994. A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse. Nat Genet 7(2):131-5. [PubMed: 7920629] [MGI Ref ID J:18524]
| Strain Name: | B6C3Fe a/a-Glra1spd/J |
| Stock Number: | 001278 |
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
| Price(s) in US dollars ($) | |||||
|---|---|---|---|---|---|
| Cryorecovery Fee | $1900.00 | ||||
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. View Control Pricing Information for JAX® Strains. |
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