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Former Names B6C3Fe-a/a-Lse (Changed: 15-DEC-04 ) Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N21p Description
Lse/+ pups can be identified at birth by the presence of an open auditory meatus, which in normal mice remains closed until approximately day 13, when the eyes also open. Fewer than the expected 50% affected pups are born, and about 50% of pups identified as Lse/+ fail to survive until weaning. Homozygotes either die prenatally or are indistinguishable from heterozygotes.The ears of Lse/+ mice are positioned lower and further forward than those of normal mice and are abnormally formed. These mice are not deaf. In addition to the ear abnormalities, Lse/+ mice are smaller than their normal littermates and have opaque corneas (Theiler and Sweet 1986).
Development
Low set ears, Lse, is a dominant mutation first observed in a male pup from a cross between the recipient of an ovary transplant from a Lmx1adr-J/Lmx1adr-J female and a C3HeB/FeJLe-a/a male. Lse has been maintained since its discovery by crossing affected male or female mice at each generation with B6C3Fe-a/a (C57BL/6J X C3HeB/FeJLe-a/a) F1 hybrid mice (Theiler and Sweet 1986).
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Strains carrying a allele
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Strains carrying other alleles of a
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View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
Lse/Lse
B6C3Fe a/a-Lse/J
- no phenotypic analysis
- *normal* no phenotypic analysis (MGI Ref ID J:8618)
- homozygotes either die in utero or have the same phenotype as heterozygotes
Lse/Lse+
B6C3Fe a/a-Lse/J
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:8618)
- 50% of heterozygotes do not survive to weaning
- hearing/vestibular/ear phenotype
- abnormal ear shape (MGI Ref ID J:8618)
- pinna is more rectangular than oval
- pinna is shapeless and thin and does not project upward over skull
- auricle is exposed
- anthelix is a slight elevation near the margin of the pinna rather than a distinct and sharp fold
- tragus and antitragus are farther apart then wildtype
- abnormal external auditory canal (MGI Ref ID J:8618)
- external auditory meatus remains open at birth
- lowered ear position (MGI Ref ID J:8618)
- ears appear lower and further forward on the head
- embryogenesis phenotype
- abnormal embryonic tissue morphology (MGI Ref ID J:8618)
- the shape of the bottom of the fossa angularis forms a shallow trough rather than a narrow furrow at E13
- in at least one E13 embryo, the distance between the edge of the pinna and the tragus is increased in comparison to wild-type
- abnormal branchial arch morphology (MGI Ref ID J:8618)
- abnormal low-set position of primitive pinna is first observed at E13
- rather than fusing, the lower end of the pinna is separate from the caudal rim of fossa angularis
- craniofacial phenotype
- abnormal branchial arch morphology (MGI Ref ID J:8618)
- abnormal low-set position of primitive pinna is first observed at E13
- rather than fusing, the lower end of the pinna is separate from the caudal rim of fossa angularis
- abnormal ear shape (MGI Ref ID J:8618)
- pinna is more rectangular than oval
- pinna is shapeless and thin and does not project upward over skull
- auricle is exposed
- anthelix is a slight elevation near the margin of the pinna rather than a distinct and sharp fold
- tragus and antitragus are farther apart then wildtype
- abnormal external auditory canal (MGI Ref ID J:8618)
- external auditory meatus remains open at birth
- lowered ear position (MGI Ref ID J:8618)
- ears appear lower and further forward on the head
- growth/size phenotype
- decreased body size (MGI Ref ID J:8618)
- heterozygotes are smaller than wild-type at birth
- vision/eye phenotype
- corneal opacity (MGI Ref ID J:8618)
- lethality-prenatal/perinatal
- prenatal lethality (MGI Ref ID J:8618)
- the number of heterozygotes born is less than the expected ratio
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:Lse related
Neurobiology Research
Vestibular and Hearing Defects
Sensorineural Research
Cataracts
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Vestibular and Hearing Defects
| Allele Symbol | Lse | ||
|---|---|---|---|
| Allele Name | low set ears | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | STOCK Lmx1a | ||
| Gene Symbol and Name | Lse, low set ears | ||
| Chromosome | UN | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Theiler K; Sweet HO. 1986. Low set ears (Lse), a new mutation of the house mouse. Anat Embryol (Berl) 175(2):241-6. [PubMed: 3103484] [MGI Ref ID J:8618]
Lse relatedTheiler K; Sweet HO. 1986. Low set ears (Lse), a new mutation of the house mouse. Anat Embryol (Berl) 175(2):241-6. [PubMed: 3103484] [MGI Ref ID J:8618]
Colony Maintenance
Breeding & Husbandry Comments: Culling normal littermates improves survival of Lse/+ pups (Theiler and Sweet 1986).
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Purchasing Information
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Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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