Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD/Lt    (Changed: 05-FEB-08 ) NOD/Lt    (Changed: 23-FEB-07 ) Non-obese Diabetic    (Changed: 15-DEC-04 ) Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Species laboratory mouse H2 Haplotype g7 Generation F96p

Appearance
albino
Related Genotype: A/A/Tyr^c/Tyr^c

Related Strains

NOD Strains

006778	NOD/ShiLt-Tg(GFAP-Cd80)9Mdos/MdosJ
001976	NOD/ShiLtJ
004939	NOD/ShiLtJ-Leprdb-5J/LtJ

View NOD Strains     (3 strains)

Strains carrying   Il2^m1 allele

000486	MRL/MpJ
001976	NOD/ShiLtJ
000686	SJL/J

View Strains carrying   Il2^m1     (3 strains)

Strains carrying other alleles of Il2

006102	B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
002252	B6.129P2-Il2tm1Hor/J
006098	B6.Cg-Tg(Il2/NFAT-luc)83Rinc/J
002229	C.129P2(B6)-Il2tm1Hor/J
002228	C3.129P2(B6)-Il2tm1Hor/J
002573	NOD.129P2(B6)-Il2tm1Hor/DvsJ
003852	NOD.B6-Il2C57BL/6/Lt

View Strains carrying other alleles of Il2     (7 strains)

Phenotype

Phenotype Information

Currently there is no phenotype information for this strain.

Genes & Alleles

Gene & Allele Information

Allele Symbol		Il2m1
Allele Name		mutation 1
Allele Type		Spontaneous
Strain of Origin		multiple strains
Gene Symbol and Name		Il2, interleukin 2
Chromosome		3
Gene Common Name(s)		IL-2; Il-2; TCGF; lymphokine;
Molecular Note		This hypoactive polymorphism, found in MRL/MpJ, SJL/J, and NOD/ShiLtJ inbred strains, includes a smaller polyglutamine tract predicted to shorten the first alpha helix, which forms part of the IL2 receptor binding site. [MGI Ref ID J:75331]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Il2^m1 related

Choi Y; Simon-Stoos K; Puck J. 2002. Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. Eur J Immunol 32(3):677-85. [PubMed: 11857342]  [MGI Ref ID J:75331]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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