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Strain Name:

C3H/HeJ-Tyrc-a/J

Stock Number:

001294

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Genes & Alleles   Tyr;   Tyrc-a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Coisogenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationF26

Strain Development
Acromelanic (Tyrc-a), an allele at the albino locus, arose spontaneously in C3H/HeJ at the Jackson Laboratory in 1985 when that inbred was at generaton F183. It was sibling mated by forced heterozygosis (heterozygote x homozygote). It reached at F26 in 1991. In 1990 embryos were generated for cryopreservation by mating homozygous males to heterozygous females or vice versa at generation F25 or more.

Mammalian Phenotype Terms assigned by genotype

Tyrc-a/Tyrc-a

        C3H/HeJ-Tyrc-a/J
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype (J:29151)
    • no aberrant bleeding time after tail vein nick

Gene & Allele Details

Allele Symbol Tyrc-a
Allele Name acromelanic
Strain of OriginC3H/HeJ
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
General Note Tyrc-a, acromelanic. The acromelanic mutation arose in the C3H/HeJ strain at The Jackson Laboratory. Homozygotes are distinguishable from albino at birth by pigmented eyes. Both young and adult Tyrc-a homozygotes have an off-white coat color, pigmented eyes, ears, tail, and anal region. Unlike Tyrc-h homozygotes, no dark hairs appear on the nose. With respect to coat color, acromelanic is between chinchilla and extreme dilution in the albino series of phenotypes.Tyrc-a is fully recessive to wild type and completely dominant to Tyrc. Tyrc/Tyr/c-a heterozygotes have a slightly off-white coat color, dark eyes, and slightly sooty ears and tail. Tyrc-a/Tyrc-ch heterozygotes have a coat color intermediate between chinchilla and acromelanic homozygotes, with a very darkly pigmented anal region. Tyrc-a/Tyrc-e heterozygotes have a lighter coat but darker ears and tail than extreme dilution homozygotes and are indistinguishable from acromelanic homozygotes. In combination with Tyrc-h, the coat is lighter and again indistinguishable from acromelanic homozygotes, but the eyes are pigmented in addition to the dark ears and tail (J:14994).

Related Strains

View Strains carrying other alleles of Tyr     (36 strains)

Research Applications

This mouse can be used to support research in many areas including:

Tyrc-a related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
albinism, tyrosine negative

References

Additional References

Price and Supply Information

Strain Name: C3H/HeJ-Tyrc-a/J
Stock Number: 001294

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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