Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation F26

Development
Acromelanic (Tyr^c-a), an allele at the albino locus, arose spontaneously in C3H/HeJ at the Jackson Laboratory in 1985 when that inbred was at generaton F183. It was sibling mated by forced heterozygosis (heterozygote x homozygote). It reached at F26 in 1991. In 1990 embryos were generated for cryopreservation by mating homozygous males to heterozygous females or vice versa at generation F25 or more.

Related Strains

Strains carrying other alleles of Tyr

000090	129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
000091	129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
001279	129T1/Sv-Oca2+ Tyrc-ch-Aft/J
005445	A.B6 Tyr+-Cybanmf333/J
005012	A.B6 Tyr+-Myo5ad-l31J/J
002565	A.B6-Tyr+/J
001017	AKXD10/TyJ
000765	AKXD13/TyJ
000954	AKXD15/TyJ
000958	AKXD16/TyJ
001093	AKXD18/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000969	AKXD24/TyJ
000777	AKXD6/TyJ
000763	AKXD9/TyJ
000409	B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418	B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432	B10.C-H1b Hbbd Tyrc/(41N)SnJ
000580	B10.D2/nSn-Tyrc-4J/J
000822	B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
000578	B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000058	B6(Cg)-Tyrc-2J/J
000383	B6.C-Tyrc H1b Hbbd/ByJ
007484	B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035	B6.Cg-Tyrc-J/J
000104	B6.Cg-Tyrc-h/J
000054	B6.D2-Tyrc-p/J
000899	C.B6-Tyr+ Hbbs/J
000339	C3H/HeJ-Tyrc-9J/J
001002	C57BL/10SnJ-Tyrc-11J/J
001006	CBA/J-Tyrc-10J/J
000657	CE/J
000619	FS/EiJ
004828	FVB.129P2-Pde6b+ Tyrc-ch/AntJ
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000494	J.Cg-Oca2+ Tyr+ Lystbg/J
002281	NFS.C58-Tyr+/J
004304	NOD.CBALs-Tyr+/LtJ
005115	NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ
005114	NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ
000271	SH1/LeJ
001759	STOCK A Tyrc Sha/J
000306	STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
000006	STOCK Hk Tyrc/J
000206	STOCK a/a Tyrc-h/J

View Strains carrying other alleles of Tyr     (46 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Tyr^c-a/Tyr^c-a

        C3H/HeJ-Tyr^c-a/J

• homeostasis/metabolism phenotype
• *normal* homeostasis/metabolism phenotype (MGI Ref ID J:29151)
  • no aberrant bleeding time after tail vein nick

Tyr^c-a/Tyr^c-a

        C3H/HeJ

• pigmentation phenotype
• abnormal coat/hair pigmentation (MGI Ref ID J:14994)
  • young and adult have an off-white coat color and eyes, ears, tail and anal regions are pigmented
  • in the albino series, coat appearance is between chinchilla and extreme dilution
• skin/coat/nails phenotype
• abnormal coat/hair pigmentation (MGI Ref ID J:14994)
  • young and adult have an off-white coat color and eyes, ears, tail and anal regions are pigmented
  • in the albino series, coat appearance is between chinchilla and extreme dilution

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Tyr^c-a related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
albinism, tyrosine negative

Genes & Alleles

Gene & Allele Information

Allele Symbol		Tyrc-a
Allele Name		acromelanic
Allele Type		Spontaneous
Strain of Origin		C3H/HeJ
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Tyr^c-a related

Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53.  [MGI Ref ID J:22600]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Swank RT; Reddington M; Howlett O; Novak EK. 1991. Platelet storage pool deficiency associated with inherited abnormalities of the inner ear in the mouse pigment mutants muted and mocha. Blood 78(8):2036-44. [PubMed: 1912584]  [MGI Ref ID J:29151]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

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Contact information

General inquiries

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fax:	207-288-6655

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