Strain Name: |
BALB/cWtEiJ |
|---|---|
Stock Number: |
001311 |
Availability: | Repository-Cryopreserved |
Price and Supply Information | |
General Terms and Conditions |
| Strain Common Names | BALB Whitten; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Species laboratory mouse H2 Haplotype d Generation F234p (25-JAN-04) Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/TyrcStrain Description
Experimental allergic encephalitis (EAE) is an autoimmune disease of the nervous system induced by sensitization of experimental animals with homogenates of whole brain and/or spinal cord tissue, myelin, or myelin components. Many of the clinical and histologic aspects of EAE are similar to those of multiple sclerosis (MS), making EAE a useful MS model (Alvord et al., 1984). Mice of different sublines of the BALB/c inbred strain exhibit marked differences in the incidence and severity of EAE induced by immunization with spinal cord homogenate (Hickey et al., 1986) or with myelin proteolipid protein (PLP) (Tuohy et al., 1988). The most severe response to PLP was development in nine of ten BALB/cPt mice of rapid onset, severe clinical disease with limb paralysis accompanied histologically by meningeal and perivascular infiltration by mononuclear and polymorphonuclear lymphocytes, particularly of the spinal cord. At the opposite end of the spectrum, none of ten BALB/cORNL or of nine BALB/cWt mice developed clinical or histopathological symptoms. As all sublines of BALB/c share the H2d haplotype, it is proposed that PLP-induced EAE in these strains is influenced by the effects of genetic loci outside the major histocompatibility complex.
Related Strains
BALB Strains
000650 BALB/cBy 001026 BALB/cByJ 001905 BALB/cGaJ 000921 BALB/cGrRkJ 000651 BALB/cJ View BALB Strains (5 strains)
Phenotypic Data
Festing Inbred Strain Characteristics: BALB/c
Research Applications
This mouse can be used to support research in many areas including:
Developmental Biology Research
Early Mitotic Y-Chromosome Nondisjuction (Hermaphroditism: Sex Chromosome Chimerism)
Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
Neurobiology Research
Neurodevelopmental Defects (callosal agenesis, incomplete penetrance)
Research Tools
Cancer Research (monoclonal antibodies, myeloma and hybridoma production)
Neurobiology Research
Price and Supply Information
| Strain Name: | BALB/cWtEiJ |
| Stock Number: | 001311 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
International
| Price(s) in US dollars ($) | |||||
|---|---|---|---|---|---|
| Cryorecovery Fee | $2470.00 | ||||
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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