Description

Strain Information

Type Chromosome Aberration; Inversion; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Radiation Induced Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse

Appearance
brown
Related Genotype: a/a Tyrp1^b/Tyrp1^b

black
Related Genotype: a/a Tyrp1^b/+ or a/a +/+

Description
The Uoxⁱⁿ homozygous phenotype has incomplete penetrance. While 63% of Uoxⁱⁿ homozygotes die by 12-14 days of age, those that live to adulthood generally live a normal breeding life span. Homozygous adults display chronic polyuria, increased serum BUN and creatinine levels, and hydronephrosis with a concomitant inflammatory response that is followed by glomerular and tubular dilation. (Cook et al., 2001.)

Control Information

	Control
	None Available
Considerations for Choosing Controls

Related Strains

Inversions

001962	B6 x STOCK In(10)17Rk/J
002022	B6 x STOCK In(2)58Rk/J
000288	B6CBACa Aw-J/A-we a Mafbkr/J
000851	STOCK In(1)12Rk/J
000716	STOCK In(1)1Rk/J
000943	STOCK In(1)23Rk/J
001911	STOCK In(1)24Rk T(In1;13)2Rk/J
000946	STOCK In(1)24Rk/J
001032	STOCK In(1)38Rk/J
000730	STOCK In(1)46Rk/J
001031	STOCK In(1)49Rk/J
000724	STOCK In(10)42Rk/J
001635	STOCK In(10)57Rk/J
000719	STOCK In(10)6Rk/J
000834	STOCK In(11)20Rk/J
000982	STOCK In(12)25Rk/J
000890	STOCK In(13)31Rk/J
000727	STOCK In(13)43Rk/J
001375	STOCK In(13)50Rk/J
000931	STOCK In(14)22Rk/J
001024	STOCK In(14)36Rk/J
001377	STOCK In(14)54Rk/J
000620	STOCK In(15)18Rk/J
000920	STOCK In(15)21Rk/J
001023	STOCK In(15)35Rk/J
001376	STOCK In(16)51Rk/J
000721	STOCK In(19)37Rk/J
000830	STOCK In(2)19Rk/J
001637	STOCK In(2)3Dn/J
000723	STOCK In(2)40Rk/J
000715	STOCK In(2)5Rk/J
000850	STOCK In(3)11Rk/J
001564	STOCK In(4)1Dn/J
000877	STOCK In(4)28Rk/J
000897	STOCK In(4)32Rk/J
001379	STOCK In(4)56Rk Rd4/J
000717	STOCK In(5)2Rk/J
000852	STOCK In(5)30Rk/J
000907	STOCK In(5)33Rk/J
000718	STOCK In(5)9Rk/J
001029	STOCK In(6)47Rk/J
001030	STOCK In(6)48Rk/J
000853	STOCK In(7)13Rk/J
000854	STOCK In(8)14Rk/J
001020	STOCK In(8)34Rk/J
000855	STOCK In(9)26Rk/J
000722	STOCK In(9)39Rk/J
000919	STOCK In(X)1H/J

View Inversions     (48 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms

Hyperuricemic Nephropathy, Familial Juvenile; HNFJ - Models with phenotypic similarity to human disease where etiologies are distinct.2

2 Human genes are associated with this disease. Orthologs of those genes do not appear in the mouse genotype(s).

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Uoxⁱⁿ/Uoxⁱⁿ

        involves: C57BL/6J * DBA/2J

• lethality-postnatal
• postnatal lethality (MGI Ref ID J:70677)
  • 63% die postnatally at 12-14 days
• renal/urinary system phenotype
• abnormal kidney morphology (MGI Ref ID J:70677)
• abnormal renal glomerulus morphology (MGI Ref ID J:70677)
  • develop glomerular dilation
• dilated renal tubules (MGI Ref ID J:70677)
• hydronephrosis (MGI Ref ID J:70677)
  • develop hydronephrosis with a concomitant inflammatory response, followed by glomerular and tubular dilation
• abnormal urine chemistry (MGI Ref ID J:70677)
  • surviving adults show urine sediment containing ammonium and potassium urate calculi
• polyuria (MGI Ref ID J:70677)
  • surviving adults exhibit chronic polyuria, the urine sediment containing ammonium and potassium urate calculi
• homeostasis/metabolism phenotype
• abnormal urine chemistry (MGI Ref ID J:70677)
  • surviving adults show urine sediment containing ammonium and potassium urate calculi
• increased blood urea nitrogen level (MGI Ref ID J:70677)
• increased circulating creatinine level (MGI Ref ID J:70677)
• immune system phenotype
• chronic inflammation (MGI Ref ID J:70677)
  • develop hydronephrosis with a concomitant inflammatory response

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Uoxⁱⁿ related

Developmental Biology Research
Internal/Organ Defects (kidney)
Postnatal Mortality (Homozygous)

Internal/Organ Research
Kidney Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Uoxin
Allele Name		urate oxidase In(3)55Rk-induced
Allele Type		Radiation induced
Strain of Origin		DBA/2J
Gene Symbol and Name		Uox, urate oxidase
Chromosome		3
Gene Common Name(s)		AI663847; UOX-2; Uri; Uri2; expressed sequence AI663847;
General Note		See also In(3)55Rk-d and In(3)55Rk-p.
Molecular Note		PCR analysis on genomic DNA derived from mice carrying the In(3)55K inversion suggests that a disruption 3' to base 844 of exon 7 results in the mutation. Northern blot analysis on mRNA derived from liver RNA of homozygous mice confirmed that negligible amounts of encoded transcript was produced from this allele. [MGI Ref ID J:70677]
Gene Symbol and Name		In(3)55Rk-d, inversion, Chr 3, Roderick 55, distal
Chromosome		3
Gene Common Name(s)		In(3)55Rk; In55Rk;
Gene Symbol and Name		In(3)55Rk-p, inversion, Chr 3, Roderick 55, proximal
Chromosome		3
Gene Common Name(s)		In(3)55Rk; In55Rk;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Cook SA; Akeson EC; Calvano C; Johnson KR; Mandell J; Hawes NL; Bronson RT; Roderick TH; Davisson MT. 2001. Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet 93(1-2):77-82. [PubMed: 11474184]  [MGI Ref ID J:70677]

Additional References

Cook S; Johnson K; Davisson M. 1997. The mouse urate oxidase gene, Uox, maps to distal chromosome 3. Mamm Genome 8(8):623-4. [PubMed: 9250879]  [MGI Ref ID J:38316]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	None Available
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

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MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

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