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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names In56Rk (Changed: 15-DEC-04 ) STOCK Rd4/+ (Changed: 15-DEC-04 ) Type Chromosome Aberration; Inversion; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Appearance
black, retinal degeneration
Related Genotype: a/a Rd4/+
black, unaffected
Related Genotype: a/a +/+Important Note
This strain is segregating for Rd4, a dominant retinal degeneration allele.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Inversions
View Inversions (48 strains)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
In(4)56Rk/+ Rd4/Rd4+
involves: C57BL/6J * DBA/2J
- vision/eye phenotype
- abnormal eye electrophysiology
- in mutants, the electroretinogram is never normal (MGI Ref ID J:41514)
- abnormal ocular fundus morphology
- optic atrophy appears in the fundus by 4 weeks of age (MGI Ref ID J:41514)
- abnormal retinal outer nuclear layer morphology
- the outer nuclear layer begins to reduce at 10 days and is lost by 6 weeks of age (MGI Ref ID J:41514)
- abnormal retinal outer plexiform layer morphology
- layer begins to reduce at 10 days of age in mutants and is totally lost at 6 weeks (MGI Ref ID J:41514)
- abnormal retinal photoreceptor layer morphology
- by 2 weeks of age, the photoreceptor layer (MGI Ref ID J:41514)
- retinal photoreceptor degeneration
- by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors (MGI Ref ID J:41514)
- abnormal retinal pigmentation
- pigment spots appear in the fundus by 4 weeks of age (MGI Ref ID J:41514)
- abnormal retinal vasculature morphology
- retinal vessel attenuation appears in the fundus by 4 weeks of age (MGI Ref ID J:41514)
- nervous system phenotype
- retinal photoreceptor degeneration
- by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors (MGI Ref ID J:41514)
- pigmentation phenotype
- abnormal retinal pigmentation
- pigment spots appear in the fundus by 4 weeks of age (MGI Ref ID J:41514)
- cardiovascular system phenotype
- abnormal retinal vasculature morphology
- retinal vessel attenuation appears in the fundus by 4 weeks of age (MGI Ref ID J:41514)
In(4)56Rk/In(4)56Rk Rd4/Rd4
involves: C57BL/6J * DBA/2J
- mortality/aging
- prenatal lethality (MGI Ref ID J:41514)
This mouse can be used to support research in many areas including:Rd4 related
Sensorineural Research
Eye Defects
Retinal Degeneration
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | In(4)56Rk | ||
|---|---|---|---|
| Allele Name | inversion, Chr 4, Roderick 56 | ||
| Allele Type | Radiation induced | ||
| Strain of Origin | (DBA/2J x C57BL/6J)F1 | ||
| Gene Symbol and Name | In(4)56Rk, inversion, Chr 4, Roderick 56 | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | In56Rk; | ||
| General Note | This inversion is homozygous lethal. | ||
| Molecular Note | This is a large inversion on Chromosome 4 which arose in a DBA/2J male exposed to 1000R of radiation. It covers most of chromosome 4 with the breakpoints in G bands 4A1 and 4E2. The distal breakpoint of the inversion is in the second intron of the Gnb1gene and the proximal breakpoint lies within the centromere. [MGI Ref ID J:108450] [MGI Ref ID J:41514] | ||
| Allele Symbol | Rd4 | ||
| Allele Name | retinal degeneration 4 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | DBA/2J-In(4)56Rk | ||
| Gene Symbol and Name | Rd4, retinal degeneration 4 | ||
| Chromosome | 4 | ||
| General Note | The Rd4 mutation is an autosomal dominant retinal degeneration found in a stock carrying the large Chr 4 inversion In(4)56Rk. The inversion is homozygous lethal and in heterozygotes is always associated with retinal degeneration. The distal break point of In(4)56Rk is in Gnb1. | ||
| Molecular Note | Rd4 is an autosomal dominant retinal degeneration found in a stock carrying the large Chr 4 inversion In(4)56Rk. Rd4 did not recombine with the inversion in an outcross, suggesting that the Rd4 locus is located very close to or is disrupted by one of thebreakpoints of the inversion on Chr. 4, either near the centromere or near the telomere. | ||
References
References provided by MGI
Additional References
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Rd4 relatedIn(4)56Rk relatedChang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269] [MGI Ref ID J:156373]
Kitamura E; Danciger M; Yamashita C; Rao NP; Nusinowitz S; Chang B; Farber DB. 2006. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Invest Ophthalmol Vis Sci 47(4):1293-301. [PubMed: 16565360] [MGI Ref ID J:108450]
Roderick TH; Chang B; Hawes NL; Heckenlively JR. 1997. A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse. Genomics 42(3):393-6. [PubMed: 9205110] [MGI Ref ID J:41514]
Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544] [MGI Ref ID J:166679]
Beechey CV. 1994. List of Chromosome Anomalies Mouse Genome 92:336-47. [MGI Ref ID J:23392]
Kitamura E; Danciger M; Yamashita C; Rao NP; Nusinowitz S; Chang B; Farber DB. 2006. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Invest Ophthalmol Vis Sci 47(4):1293-301. [PubMed: 16565360] [MGI Ref ID J:108450]
Roderick TH; Chang B; Hawes NL; Heckenlively JR. 1997. A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse. Genomics 42(3):393-6. [PubMed: 9205110] [MGI Ref ID J:41514]
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $191.20 Female or Male Heterozygous for In(4)56Rk, Heterozygous for Rd4
Price per Pair (US dollars $) Pair Genotype $211.05 Heterozygous for In(4)56Rk, Heterozygous for Rd4 x C57BL/6J (000664) Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $248.60 Female or Male Heterozygous for In(4)56Rk, Heterozygous for Rd4
Price per Pair (US dollars $) Pair Genotype $274.40 Heterozygous for In(4)56Rk, Heterozygous for Rd4 x C57BL/6J (000664) Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
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Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
General Supply Notes
- This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Important Note
This strain is segregating for Rd4, a dominant retinal degeneration allele.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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