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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names In56Rk (Changed: 15-DEC-04 ) STOCK Rd4/+ (Changed: 15-DEC-04 ) Type Chromosome Aberration; Inversion; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Appearance
black, retinal degeneration
Related Genotype: a/a Rd4/+
black, unaffected
Related Genotype: a/a +/+Important Note
This strain is segregating for Rd4, a dominant retinal degeneration allele.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Inversions
View Inversions (48 strains)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
In(4)56Rk/+ Rd4/Rd4+
involves: C57BL/6J * DBA/2J
- vision/eye phenotype
- abnormal eye electrophysiology (MGI Ref ID J:41514)
- in mutants, the electroretinogram is never normal
- abnormal retina morphology (MGI Ref ID J:41514)
- optic atrophy appears in the fundus by 4 weeks of age
- abnormal retinal outer nuclear layer morphology (MGI Ref ID J:41514)
- the outer nuclear layer begins to reduce at 10 days and is lost by 6 weeks of age
- abnormal retinal outer plexiform layer morphology (MGI Ref ID J:41514)
- layer begins to reduce at 10 days of age in mutants and is totally lost at 6 weeks
- abnormal retinal photoreceptor layer (MGI Ref ID J:41514)
- by 2 weeks of age, the photoreceptor layer
- retinal photoreceptor degeneration (MGI Ref ID J:41514)
- by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors
- abnormal retinal pigmentation (MGI Ref ID J:41514)
- pigment spots appear in the fundus by 4 weeks of age
- abnormal retinal vasculature (MGI Ref ID J:41514)
- retinal vessel attenuation appears in the fundus by 4 weeks of age
- nervous system phenotype
- retinal photoreceptor degeneration (MGI Ref ID J:41514)
- by 3 weeks of age, only cones are detected in mutants; by 6 weeks, there are no photoreceptors
- pigmentation phenotype
- abnormal retinal pigmentation (MGI Ref ID J:41514)
- pigment spots appear in the fundus by 4 weeks of age
- cardiovascular system phenotype
- abnormal retinal vasculature (MGI Ref ID J:41514)
- retinal vessel attenuation appears in the fundus by 4 weeks of age
In(4)56Rk/In(4)56Rk Rd4/Rd4
involves: C57BL/6J * DBA/2J
- lethality-prenatal/perinatal
- prenatal lethality (MGI Ref ID J:41514)
This mouse can be used to support research in many areas including:Rd4 related
Sensorineural Research
Eye Defects
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | In(4)56Rk | ||
|---|---|---|---|
| Allele Name | inversion, Chr 4, Roderick 56 | ||
| Allele Type | Radiation induced | ||
| General Note | This inversion is homozygous lethal. | ||
| Molecular Note | This is a large inversion on Chromosome 4 which arose in a DBA/2J male exposed to 1000R of radiation. It covers most of chromosome 4 with the breakpoints in G bands 4A1 and 4E2. The distal breakpoint of the inversion is in the second intron of the Gnb1gene and the proximal breakpoint lies within the centromere. [MGI Ref ID J:108450] [MGI Ref ID J:41514] | ||
| Allele Symbol | Rd4 | ||
| Allele Name | retinal degeneration 4 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | DBA/2J-In(4)56Rk | ||
| General Note | The Rd4 mutation is an autosomal dominant retinal degeneration found in a stock carrying the large Chr 4 inversion In(4)56Rk. The inversion is homozygous lethal and in heterozygotes is always associated with retinal degeneration. The distal break point of In(4)56Rk is in Gnb1. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Rd4 relatedIn(4)56Rk relatedChang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Kitamura E; Danciger M; Yamashita C; Rao NP; Nusinowitz S; Chang B; Farber DB. 2006. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Invest Ophthalmol Vis Sci 47(4):1293-301. [PubMed: 16565360] [MGI Ref ID J:108450]
Roderick TH; Chang B; Hawes NL; Heckenlively JR. 1997. A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse. Genomics 42(3):393-6. [PubMed: 9205110] [MGI Ref ID J:41514]
Beechey CV. 1994. List of Chromosome Anomalies Mouse Genome 92:336-47. [MGI Ref ID J:23392]
Kitamura E; Danciger M; Yamashita C; Rao NP; Nusinowitz S; Chang B; Farber DB. 2006. Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse. Invest Ophthalmol Vis Sci 47(4):1293-301. [PubMed: 16565360] [MGI Ref ID J:108450]
Roderick TH; Chang B; Hawes NL; Heckenlively JR. 1997. A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse. Genomics 42(3):393-6. [PubMed: 9205110] [MGI Ref ID J:41514]
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $127.90 Female or Male Heterozygous for In(4)56Rk, Heterozygous for Rd4 *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $143.40 Heterozygous for In(4)56Rk, Heterozygous for Rd4 x C57BL/6J (000664)
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $166.30 Female or Male Heterozygous for In(4)56Rk, Heterozygous for Rd4 *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $186.50 Heterozygous for In(4)56Rk, Heterozygous for Rd4 x C57BL/6J (000664)
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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| Important Note | This strain is segregating for Rd4, a dominant retinal degeneration allele. |
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
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