Strain Name: |
C3Sn.Cg-KitlSl-con/J |
|---|---|
Stock Number: |
001380 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
MgfSl-con (Changed: 15-DEC-04
) |
| Genes & Alleles | Kitl; KitlSl-con; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Species laboratory mouse Background Strain C3H/HeSnJ Donor Strain (C3H/HeH x 101/H)F1 Generation N12p Strain Description
Both homozygous and heterozygous mice with the contrasted induced mutation (KitlSl-con) are viable. Male homozygous mutant mice are fertile but females are usually sterile. Mice heterozygous for the contrasted mutation are recognizable soon after birth by dark pigmentation of the genital papilla with the adult coat being slightly lighter than normal. Homozygous mutant mice also have dark genitalia and a markedly diluted coat and mild macrocytic anemia.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | KitlSl-con | ||
|---|---|---|---|
| Allele Name | contrasted | ||
| Common Name(s) | Mgf; | ||
| Gene Symbol and Name | Kitl, kit ligand | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | Clo; Con; DKFZp686F2250; Gb; KL-1; Kl1; Kl2; MGF; Mgf; SCF; SF; SHEP7; SLF; Sl; Steel; Steel factor; cloud gray; contrasted; grizzle-belly; mast cell growth factor; steel; stem cell factor; | ||
| General Note |
The contrasted mutation was found in a neutron irradiation experiment. Heterozygotes are recognizable soon after birth by dark pigmentation of the genital papilla. The adult coat is slightly lighter than normal. Homozygotes also have dark external genitalia but a markedly diluted coat; they have a mild macrocytic anemia. Males are fertile but females are usually sterile (J:20215). The mutation was shown to be allelic to steel by linkage and complementation tests (J:13654). The cause of the Kitl | ||
| Molecular Note | Pulse field gel electrophoresis using cDNA and genomic clones showed that this allele comprises an undefined rearrangement between 90 and 2.2Mb 5' to Kitl. Northern analysis showed that the mRNA transcript is of normal size but this allele exerts tissue-specific effects on transcript abundance. [MGI Ref ID J:23593] | ||
Control Information
| Allele | Control | |
|---|---|---|
| KitlSl-con | Wild-type from the colony | |
| KitlSl-con | 000661 C3H/HeSnJ | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Kitl
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 002993 B6.Cg-KitlSl-18H/EiJ 000124 B6.Cg-KitlSl Krt71Ca/J 000160 B6.D2-KitlSl-d/J 000291 C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J 003252 C57BL/6J-KitlSl-20J/J 006839 C57BL/6J-KitlSl-22J/J 000979 STOCK KitlSl-16J/J 000161 WB.D2-KitlSl-d/J 000693 WC/ReJ KitlSl/J 100401 WCB6F1/J KitlSl KitlSl-d View Strains carrying other alleles of Kitl (11 strains)
Additional Web Information
Congenic Nomenclature
JAX® NOTES, February 2001; 481. Mgf Gene Name Changes to Kitl.
Research Applications
This mouse can be used to support research in many areas including:KitlSl-con related
Cancer Research
Growth Factors/Receptors/Cytokines
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neural Crest Defects
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Hypothalamus/Pituitary Defects
Skin Defects
Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency (Mast Cell Deficiency)
Neurobiology Research
Vestibular and Hearing Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (testicular teratomas)
Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)
Sensorineural Research
Vestibular and Hearing Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | C3Sn.Cg-KitlSl-con/J |
| Stock Number: | 001380 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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