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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Stock; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation F35p
Related Strains
Strains carrying Aw allele
000427 B10.CE-H13b Aw/(30NX)SnJ 000420 B10.LP-H13b Aw/Sn View Strains carrying Aw (2 strains)
000319 STOCK a us/J
Phenotype
Phenotype Information
Currently there is no phenotype information for this strain.This mouse can be used to support research in many areas including:us related
Developmental Biology Research
Internal/Organ Defects (urogenital)
Skeletal Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Aw | ||
|---|---|---|---|
| Allele Name | white bellied agouti | ||
| Allele Type | Spontaneous | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | The Aw allele produces a phenotype like A except that the belly is white or cream. Aw is dominant to A and to all alleles with lower case symbols. Since mutations to this allele are common, the Aw alleles found in many laboratory stocks may not be of common origin. | ||
| Molecular Note | The mutation is a 0.6 kB insertion in the first intron consisting of a single LTR of a VL30 family retrovirus-like transposable element. This results in the expression of alternatively spliced transcripts that are not present in the wild-type allele. [MGI Ref ID J:16984] | ||
| Allele Symbol | us | ||
| Allele Name | urogenital syndrome | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | STOCK a we Atrnmg | ||
| General Note | This mutation occurred in a linkage cross in 1966, and resembles the extinct mutation ur (urogenital). Homozygotes are small at birth and have a kinky tail. Skeletal abnormalities include split arches and fusions of cervical vertebrae, fusions of thoracic and lumbar vertebrae, and unilateral and bilateral fusions of one or more ribs. Delayed growth, sterility, and urogenital abnormalities also occur. Affected mice have a thinner coat with fewer zigzags and narrower awls than wild-type, and slightly abnormal behavior (J:13631). The mutation has been proposed as a model for human nail-patella-syndrome (OMIM 161200; J:14466). | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Aw relatedus relatedBultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. [PubMed: 8125260] [MGI Ref ID J:16984]
Chen Y; Duhl DM; Barsh GS. 1996. Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics 144(1):265-77. [PubMed: 8878692] [MGI Ref ID J:35710]
Dickie MM. 1969. A<w> - white-bellied agouti Mouse News Lett 40:29. [MGI Ref ID J:64108]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53. [MGI Ref ID J:22600]
Enshell-Seijffers D; Lindon C; Morgan BA. 2008. The serine protease Corin is a novel modifier of the Agouti pathway. Development 135(2):217-25. [PubMed: 18057101] [MGI Ref ID J:130426]
Fragioudaki K; Kouvelas ED; Cristiani R; Giompres P; Bagnoli P; Mitsacos A. 2007. Expression of amino acid receptors and neural peptides in the weaver mouse brain. Brain Res 1140:132-52. [PubMed: 16626633] [MGI Ref ID J:120619]
Galbraith DB; Wolff GL; Brewer NL. 1980. Hair pigment patterns in different integumental environments of the mouse. Influence of the agouti suppressor (A<s>) mutation on expression of agouti locus alleles. J Hered 71:229-234. [MGI Ref ID J:12033]
Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404] [MGI Ref ID J:4186]
Poole TW. 1982. The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. J Exp Zool 220(1):57-64. [PubMed: 7077265] [MGI Ref ID J:6763]
SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791] [MGI Ref ID J:13013]
Sandulache R; Neuhauser-Klaus A; Favor J. 1994. Genetic instability at the agouti locus of the mouse (Mus musculus). I. Increased reverse mutation frequency to the Aw allele in A/a heterozygotes. Genetics 137(4):1079-87. [PubMed: 7982562] [MGI Ref ID J:19319]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Tanaka S; Nishimura M; Matsuzawa A. 1994. Genetic association between agouti locus and adrenal X zone morphology in SM/J mice. Acta Anat (Basel) 149(3):170-3. [PubMed: 7976166] [MGI Ref ID J:19308]
Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545] [MGI Ref ID J:18750]
Lane PW. 1973. Urogenital syndrome (us). Mouse News Lett 49:32. [MGI Ref ID J:13631]
Lane PW; Birkenmeier CS. 1993. Urogenital syndrome (us): a developmental mutation on chromosome 2 of the mouse. Mamm Genome 4(9):481-4. [PubMed: 7906966] [MGI Ref ID J:14466]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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General Terms and Conditions
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