Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation F81+N1p

Appearance
agouti
Related Genotype: A/A

Important Note
This strain is homozygous for the retinal degeneration allele Pde6b^rd1.

Development
Osteochondrodystrophy (ocd) arose spontaneously in strain C3H/HeSn at the Jackson Laboratory in 1980. It has been maintained by inbreeding ever since and reached generation F74+4 in 2006.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying   Pde6b^rd1 allele

004202	B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002	B6.C3-Pde6brd1 Hps4le/J
001022	B6C3FeF1/J a/a
000652	BDP/J
000653	BUB/BnJ
002439	C3.129P2(B6)-B2mtm1Unc/J
005494	C3.129S1(B6)-Grm1rcw/J
000509	C3.Cg-Lystbg-2J/J
000480	C3.MRL-Faslpr/J
001957	C3A Pde6brd1.O20/A-Prph2Rd2/J
005973	C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326	C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968	C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906	C3Ga.Cg-Catb/J
001904	C3H-Atcayji-hes/J
000659	C3H/HeJ
000784	C3H/HeJ-Faslgld/J
002433	C3H/HeJ-Spnb4qv-lnd2J/J
005972	C3H/HeJBirLtJ
001824	C3H/HeJSxJ
000635	C3H/HeOuJ
000474	C3H/HeSn
000661	C3H/HeSnJ
002235	C3H/HeSnJ-Ctnna2cdf/J
002333	C3H/HeSnJ-gri/J
006435	C3HeB.SW-Soaa/MonJ
000658	C3HeB/FeJ
001576	C3HeB/FeJ-Atp7btx-J/J
002588	C3HeB/FeJ-Eya1bor/J
001533	C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886	C3HeB/FeJLe a/a-gnd/J
001908	C3HfB/BiJ
001502	C3Sn.B6-Epha4rb/EiGrsrJ
001547	C3Sn.Cg-Cm/J
000656	CBA/J
000813	CBA/J-Atp7aMo-pew/J
000660	DA/HuSnJ
000023	FL/1ReJ
000025	FL/4ReJ
003024	FVB.129P2(B6)-Fmr1tm1Cgr/J
002539	FVB.129P2-Abcb4tm1Bor/J
002935	FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953	FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170	FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078	FVB.Cg-Tg(WapIgf1)39Dlr/J
003257	FVB/N-Tg(GFAPGFP)14Mes/J
002374	FVB/N-Tg(MMTV-PyVT)634Mul/J
002856	FVB/N-Tg(TIE2-lacZ)182Sato/J
002384	FVB/N-Tg(UcpDta)1Kz/J
001800	FVB/NJ
003487	FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491	FVB/NMob
000734	MOLD/RkJ
000550	MOLF/EiJ
002423	NON/ShiLtJ
000679	P/J
000680	PL/J
100299	PLSJLF1/J
000269	SB/LeJ
005651	SJL.AK-Thy1a/TseJ
000686	SJL/J
000688	ST/bJ
004808	STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648	STOCK a/a Cln6nclf/J
000279	STOCK gr +/+ Ap3d1mh/J
005965	STOCK Tg(Pomc1-cre)16Lowl/J
004770	SW.B6-Soab/J
002023	SWR.M-Emv21 Emv22/J
000689	SWR/J
000939	SWR/J-Clcn1adr-mto/J
000692	WB/ReJ KitW/J
100410	WBB6F1/J-KitW/KitW-v/J
000693	WC/ReJ KitlSl/J
100401	WCB6F1/J KitlSl KitlSl-d

View Strains carrying   Pde6b^rd1     (74 strains)

Strains carrying other alleles of Pde6b

004297	B6.CXB1-Pde6brd10/J
005252	B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
003647	B6EiC3Sn.BLiAF1
002802	C3.BLiA Pde6b+-Krd/J
001979	C3A.BLiA-Pde6b+.O20-Prph2Rd2/J
001912	C3A.BLiA-Pde6b+/J
003648	C3Sn.BLiA-Pde6b+/Dn
004766	C57BL/6J-Pde6brd1-2J/J
004828	FVB.129P2-Pde6b+ Tyrc-ch/AntJ
004808	STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J

View Strains carrying other alleles of Pde6b     (10 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

ocd/ocd

        C3H/HeSnJ-ocd

• skeleton phenotype
• abnormal long bone epiphyseal plate proliferative zone (MGI Ref ID J:11111)
  • disorganized proliferative zone
• abnormal long bone epiphysis morphology (MGI Ref ID J:11111)
• decreased length of long bones (MGI Ref ID J:11111)
  • disproportionately shortened long bones
• decreased skull height (MGI Ref ID J:11111)
• domed skull (MGI Ref ID J:11111)
  • short, slightly domed head
• reproductive system phenotype
• male infertility (MGI Ref ID J:11111)
  • testes histology appears normal
• craniofacial phenotype
• abnormal craniofacial morphology (MGI Ref ID J:11111)
• decreased skull height (MGI Ref ID J:11111)
• domed skull (MGI Ref ID J:11111)
  • short, slightly domed head
• growth/size phenotype
• decreased body size (MGI Ref ID J:11111)
• limbs/digits/tail phenotype
• abnormal long bone epiphyseal plate proliferative zone (MGI Ref ID J:11111)
  • disorganized proliferative zone
• abnormal long bone epiphysis morphology (MGI Ref ID J:11111)
• abnormal paw/hand/foot morphology (MGI Ref ID J:11111)
  • supination of the forefeet
• abnormal tail morphology (MGI Ref ID J:11111)
• short tail (MGI Ref ID J:11111)
• thick tail (MGI Ref ID J:11111)
• decreased length of long bones (MGI Ref ID J:11111)
  • disproportionately shortened long bones

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Pde6b^rd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

ocd related

Developmental Biology Research
Growth Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		ocd
Allele Name		osteochondrodystrophy
Allele Type		Spontaneous
Strain of Origin		C3H/HeSnJ
Gene Symbol and Name		ocd, osteochondrodystrophy
Chromosome		19
General Note		This mutation is not an allele of Papss2 or Tcirg1, other mutations on Chr 19 that produce similar phenotypes (J:11111).
Allele Symbol		Pde6brd1
Allele Name		retinal degeneration 1
Allele Type		Spontaneous
Common Name(s)		Pdebrd1; rd; rd-1; rd1; rodless retina;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

ocd related

Sweet HO; Bronson RT. 1991. Osteochondrodystrophy (ocd): a new autosomal recessive mutation in the mouse. J Hered 82(2):140-4. [PubMed: 2013688]  [MGI Ref ID J:11111]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes	Cryopreserved Embryos This strain is also available as cryopreserved embryos. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page. Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Contact Information
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

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