Strain Name: |
STOCK a/a Tyrp1b sks/Tyrp1b +/J |
|---|---|
Stock Number: |
001432 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Tyrp1; Tyrp1b; a; sks; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Species laboratory mouse Strain Development
The mutation skeletal fusions with sterility (sks) arose spontaneously in 1982 at The Jackson Laboratory in strain A/J when that inbred was at generation F185. Two lines were developed. The first line was continued on this inbred background by simple sibling breeding keeping sks segregating. The second line was outcrossed at F185+4 to the B6C3Fe-a/a F1 hybrid and then maintained by cross-intercross matings using this F1 hybrid for the crosses. When the second line reached N6 it was crossed with the first line, then at F185+11, and the resulting strain was then maintained by sibling breeding with sks segregating. In 1992 this embryos were cryopreserved from matings of untested (+/?) females with heterozygous males with the generation of the last common parent being F5.
Gene & Allele Details
| Allele Symbol | Tyrp1b | ||
|---|---|---|---|
| Allele Name | brown | ||
| Strain of Origin | C57BL | ||
| Gene Symbol and Name | Tyrp1, tyrosinase-related protein 1 | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein; | ||
| General Note | Tyrp1b, brown, recessive. This type mutant of the brown locus is an old mutation of the mouse fancy. The eumelanin of the hair and eyes is brown rather than black. The pigment granules also appear brown rather than black and are spheroid rather than ovoid in shape (J:12970). The fine structure of the developing pigment granules is fibrillar, like that of wild type mice, but the appearance of the mature granule may be more coarsely granular (J:5346, J:5001, J:5068). The granules incorporate twice as much 14C-tyrosine as normal (J:12173). | ||
| Molecular Note | A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [J:44435] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Symbol | sks | ||
| Allele Name | skeletal fusions with sterility | ||
| Strain of Origin | A/J | ||
| General Note | Homozygous mutants can be classified visually shortly after birth by their shortened bodies and tail kinks. Skeletal anomalies are due to fusion of one or more cervical, thoracic, lumbar, and caudal vertebrae and bilateral or unilateral rib fusions. The appendicular skeleton and skull bones appear normal, and vertebral fusions were not seen in the sacrum. The sks mutation causes arrest during meiotic pachytene of virtually all spermatogenic cells. Although defects in chromosomal pairing and the synaptonemal complex are seen, defective pairing is thought not to be the cause of sterility. Oocytes are capable of undergoing maturation but can not be fertilized in vitro (J:9569). | ||
Related Strains
Strains carrying Tyrp1b allele
000004 ABP/LeJ 000571 B6.Cg-Whrnwi Tyrp1b/+ +/J 000027 B6.D-Tyrp1b m/J 000265 MY/HuLeJ 001045 SI/Col Tyrp1b Dnahc11iv/J 000064 STOCK a Tyrp1b Sisi/J 002238 STOCK a Tyrp1b shmy/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J 001101 STOCK T(3;4)5Rk Tyrp1b/J 000274 TSJ/LeJ View Strains carrying Tyrp1b (10 strains)
000068 C57BL/6J-Tyrp1b-J/J 000093 C57BL/6J-Tyrp1b-cJ/J 000671 DBA/2J 003588 LT/SvEi 006252 LT/SvEiJ 002142 STOCK 11R30m/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
Research Applications
This mouse can be used to support research in many areas including:Tyrp1b related
sks relatedDermatology Research
Color and White Spotting Defects
Mouse/Human Gene Homologs
oculocutaneous albinism type III
Developmental Biology Research
Skeletal Defects
Reproductive Biology Research
Fertility Defects
References
Selected Reference(s)
Additional ReferencesHandel MA; Lane PW; Schroeder AC; Davisson MT. 1988. New mutation causing sterility in the mouse. Gamete Res 21(4):409-23. [PubMed: 3220432] [J:9569]
Price and Supply Information
| Strain Name: | STOCK a/a Tyrp1b sks/Tyrp1b +/J |
| Stock Number: | 001432 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
*NO Shipping Destination selected!
Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryopreserved Embryos This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page. Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form