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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names C3Sn.B6-Epha4rb/J (Changed: 22-JUN-09 ) C3Sn.B6-rb (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C3H/HeSnJ Donor Strain C57BL/6J H2 Haplotype k Generation N27 Appearance
agouti, ataxic
Related Genotype: A/A Epha4rb/Epha4rb
agouti, unaffected
Related Genotype: A/A Epha4rb/+ or A/A +/?Important Note
The C3H/HeSnJ background strain is homozygous for the retinal degeneration mutation Pde6brd1.Description
Mice homozygous for the rb allele of Epha4 can be visibly identified by 2.5 - 3 weeks of age by a constant hopping gait of the hind limbs; the forelimbs may show a hopping gait or move normally. When picked up by the tail homozygotes clasp their hindlimbs and show reduced ability to hold on to an edge; forelimbs show normal strength.Development
The recessive rb mutation of Epha4 arose spontaneously on the C57BL/6J inbred strain at the Jackson Laboratory in 1964. The rb allele was transferred to the C3H/HeSnJ background and has been maintained for many generations by backcrossing mice homozygous for Epha4rb to C3H/HeSnJ mice, then intercrossing the progeny. In 2004 this strain reached N37.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| 000661 C3H/HeSnJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Epha4rb allele
000938 B6 x STOCK Epha4rb/J View Strains carrying Epha4rb (1 strain)
003129 C57BL/6J-Epha4rb-2J/GrsrJ
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Epha4rb/Epha4rb
C57BL/6J
- behavior/neurological phenotype
- abnormal gait (MGI Ref ID J:87289)
- mutant mice can be identified by 2.5-3 weeks of age by a constant hopping gait of the hindlimbs
- the forelimbs may show a hopping gait or move normally
- abnormal grip strength (MGI Ref ID J:87289)
- mutants show a reduced ability to hold onto an edge
- forelimbs show normal strength
- limb grasping (MGI Ref ID J:87289)
- mice grasp their hind limbs when picked up by the tail
- endocrine/exocrine gland phenotype
- cryptorchism (MGI Ref ID J:87289)
- males sometimes have undescended testes and fail to breed
- reproductive system phenotype
- cryptorchism (MGI Ref ID J:87289)
- males sometimes have undescended testes and fail to breed
- reduced male fertility (MGI Ref ID J:87289)
- due to undescended testes
This mouse can be used to support research in many areas including:Epha4rb related
Pde6brd1 relatedNeurobiology Research
Ataxia (Movement) Defects
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Epha4rb | ||
|---|---|---|---|
| Allele Name | rabbit | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Epha4, Eph receptor A4 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | 2900005C20Rik; AI385584; Cek8; HEK8; RGD1560587; RIKEN cDNA 2900005C20 gene; SEK; Sek; Sek1; TYRO1; expressed sequence AI385584; rabbit; rb; segmentation receptor tyrosine kinase; | ||
| Molecular Note | The rb mouse arose in 1964 at the Jackson Laboratory. This mouse was identified as an allele at the Epha4 locus based complementation analysis using the Epha4Gt(pGT1TM)38Wcs allele. The mutation at the level of the sequence has not been reported. [MGI Ref ID J:87289] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Cook SA; Eicher EM; Samples RM; Bronson RT; Davisson MT. 2004. Two spontaneous mutant alleles, rb and rb-2J, of the Epha4 gene on mouse Chromosome 1. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine (http://www.jax.org/mmr) MGI Direct Data Submission :. [MGI Ref ID J:87289]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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| Important Note | |
| The C3H/HeSnJ background strain is homozygous for the retinal degeneration mutation Pde6brd1. | |
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| 000661 C3H/HeSnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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