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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N1p
Generation Definitions
Related Strains
Strains carrying T allele
003879 B10;TFLe-a/a T tf/+ tf/J 000405 B10ScSn.Cg-T/J 000350 B6By.Cg-KitW-v MitfMi-wh T/J 001961 C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei View Strains carrying T (4 strains)
003879 B10;TFLe-a/a T tf/+ tf/J 016926 BTBR T+ tf-Fbxl3Ovtm/J 002282 BTBR T+ tf/J 001874 STOCK tw82 tf/J 000588 TF/GnLe-T(1;17)190Ca +/+ tf/J
003879 B10;TFLe-a/a T tf/+ tf/J 000405 B10ScSn.Cg-T/J 004591 B6 x B6Ei.Cg-TWis/EiJ 000953 B6 x BALB/cBy-T4J/J 000567 B6.Cg-T2J +/+ Qkqk-v/J 001015 B6.Cg-T4Or/J 001054 B6.Cg-TOrl/EiJ 000350 B6By.Cg-KitW-v MitfMi-wh T/J 016926 BTBR T+ tf-Fbxl3Ovtm/J 002282 BTBR T+ tf/J 001053 C3Sn.AK-Thp/EiJ 000545 C57BL/6J-T2J/J 001199 C57BL/6J-T5J/J 001961 C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei 001814 STOCK Tc/J
000906 B6Ei.Cg-Rb(16.17)8Lub-tw3Lub/+ +/J 001874 STOCK tw82 tf/J
003879 B10;TFLe-a/a T tf/+ tf/J 016926 BTBR T+ tf-Fbxl3Ovtm/J 002282 BTBR T+ tf/J 001874 STOCK tw82 tf/J 000588 TF/GnLe-T(1;17)190Ca +/+ tf/J
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:T related
th45 relatedDevelopmental Biology Research
Skeletal Defects
tf relatedDermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | T | ||
|---|---|---|---|
| Allele Name | brachyury | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | T1; | ||
| Strain of Origin | Laboratory stock | ||
| Gene Symbol and Name | T, brachyury | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Bra; Low; Lr; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; | ||
| Molecular Note | Pulsed-field gel electrophoresis revealed an altered restriction fragment size consistent with a deletion of 160-200kb. [MGI Ref ID J:126311] [MGI Ref ID J:21263] | ||
| Allele Symbol | th45 | ||
| Allele Name | t, Harwell 45 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | STOCK ttf/T t | ||
| Gene Symbol and Name | t, t-complex | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | brachyury interacting tail length modifier; brachyury-interacting tail length modifier; btm; | ||
| Molecular Note | This t-haplotype allele arose by homologous recombination between DNA markers T119I and T66E in wild-type and t6 haplotype chromatin. th45 carries t DNA that extends over Tcp-1 and includes the t-specific form of RP17. This represents recombination between wild-type and t haplotype chromosomes across the proximal inversion. [MGI Ref ID J:20080] [MGI Ref ID J:8163] | ||
| Allele Symbol | tf | ||
| Allele Name | tufted | ||
| Allele Type | Spontaneous | ||
| Gene Symbol and Name | tf, tufted | ||
| Chromosome | 17 | ||
| General Note | This allele was recovered from a Harwell testing stock carrying multiple recessive markers in an undefined background. (J:273) | ||
References
References provided by MGI
Additional References
T relatedth45 relatedBabiarz B; Garrisi GJ; Bennett D. 1982. Genetic analysis of the tw73 haplotype of the mouse using deletion mutations: evidence for a parasitic lethal mutation. Genet Res 39(2):111-20. [PubMed: 7084665] [MGI Ref ID J:175674]
Bennett D. 1975. The T-locus of the mouse. Cell 6:441-454. [MGI Ref ID J:11933]
Bucan M; Herrmann BG; Frischauf AM; Bautch VL; Bode V; Silver LM; Martin GR; Lehrach H. 1987. Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Genes Dev 1(4):376-85. [PubMed: 3678828] [MGI Ref ID J:8922]
Chesley P. 1935. Development of the short-tailed mutant in the house mouse. J Exp Zool 70:429-459. [MGI Ref ID J:13018]
Dobrovolskaia-Zavadskaia N. 1927. Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable" C R Seances Soc Biol Fil 97:114-16. [MGI Ref ID J:14909]
Dunn LC; Bennett D. 1971. Lethal alleles near locus T in the house mouse population on the Jutland Peninsula, Denmark Evolution 25(3):451-53. [MGI Ref ID J:175677]
Dunn LC; Gluecksohn-Waelsch S. 1953. Genetic Analysis of Seven Newly Discovered Mutant Alleles at Locus T in the House Mouse. Genetics 38(3):261-71. [PubMed: 17247438] [MGI Ref ID J:36683]
Fujimoto A; Baba N; Wakasugi N. 1991. A tail length modifier gene discovered in the Japanese wild mice (Mus musculus molossinus). Jpn J Genet 66(2):141-54. [PubMed: 1859671] [MGI Ref ID J:14919]
Fujimoto A; Wakasugi N; Tomita T. 1994. The developmental and morphological studies on the neural and skeletal abnormalities in the t/btm tailless mice. Dev Growth Differ 36(4):409-417. [MGI Ref ID J:21054]
GRUNEBERG H. 1958. Genetical studies on the skeleton of the mouse. XXIII. The development of brachyury and anury. J Embryol Exp Morphol 6(3):424-43. [PubMed: 13575656] [MGI Ref ID J:15081]
Guenet JL; Condamine H; Gaillard J; Jacob F. 1980. twPa-1, twPa-2, twPa-3: three new t-haplotypes in the mouse. Genet Res 36(2):211-7. [PubMed: 7461454] [MGI Ref ID J:6461]
Harrison SM; Houzelstein D; Dunwoodie SL; Beddington RS. 2000. Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury Dev Biol 227(2):358-72. [PubMed: 11071760] [MGI Ref ID J:65743]
Herrmann BG; Labeit S; Poustka A; King TR; Lehrach H. 1990. Cloning of the T gene required in mesoderm formation in the mouse [see comments] Nature 343(6259):617-22. [PubMed: 2154694] [MGI Ref ID J:21263]
Kinder SJ; Tsang TE; Ang SL; Behringer RR; Tam PP. 2001. Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol 45(1 Spec No):347-55. [PubMed: 11291865] [MGI Ref ID J:74124]
King T; Beddington RS; Brown NA. 1998. The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev 79(1-2):29-37. [PubMed: 10349618] [MGI Ref ID J:52218]
Le Saux F; Besson MJ; Maurin Y. 2002. Abnormal postnatal ontogeny of the locus coeruleus in the epileptic mutant mouse quaking. Brain Res Dev Brain Res 136(2):197-205. [PubMed: 12101037] [MGI Ref ID J:109168]
Lyon MF. 1984. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37(2):621-8. [PubMed: 6722884] [MGI Ref ID J:7443]
Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. [PubMed: 924142] [MGI Ref ID J:5889]
Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068] [MGI Ref ID J:88013]
Rennebeck GM; Lader E; Chen Q; Bohm RA; Cai ZS; Faust C; Magnuson T; Pease LR; Artzt K. 1995. Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol 172(1):206-17. [PubMed: 7589801] [MGI Ref ID J:29666]
Ruvinsky A; Polyakov A; Agulnik A; Tichy H; Figueroa F; Klein J. 1991. Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. Genetics 127(1):161-8. [PubMed: 2016041] [MGI Ref ID J:32745]
Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493] [MGI Ref ID J:5003]
Silver LM; Artzt K. 1981. Recombination suppression of mouse t-haplotypes due to chromatin mismatching. Nature 290(5801):68-70. [PubMed: 7207588] [MGI Ref ID J:6478]
Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292] [MGI Ref ID J:3956]
Styrna J; Klein J. 1981. Evidence for two regions in the mouse t complex controlling transmission ratios. Genet Res 38(3):315-25. [PubMed: 7333459] [MGI Ref ID J:6700]
Vojtiskova M; Viklicky V; Voracova B; Lewis SE; Gluecksohn-Waelsch S. 1976. The effects of a t-allele (tAE5) in the mouse on the lymphoid system and reproduction. J Embryol Exp Morphol 36(2):443-51. [PubMed: 1003081] [MGI Ref ID J:83862]
Wittler L; Shin EH; Grote P; Kispert A; Beckers A; Gossler A; Werber M; Herrmann BG. 2007. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8(8):784-9. [PubMed: 17668009] [MGI Ref ID J:129900]
Wu JI; Centilli MA; Vasquez G; Young S; Scolnick J; Durfee LA; Spearow JL; Schwantz SD; Rennebeck G; Artzt K. 2007. tint Maps to Mouse Chromosome 6 and May Interact With a Notochordal Enhancer of Brachyury. Genetics 177(2):1151-61. [PubMed: 17954925] [MGI Ref ID J:126311]
Yamaguchi TP; Takada S; Yoshikawa Y; Wu N; McMahon AP. 1999. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13(24):3185-90. [PubMed: 10617567] [MGI Ref ID J:59271]
tf relatedHerrmann B; Bucan M; Mains PE; Frischauf AM; Silver LM; Lehrach H. 1986. Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Cell 44(3):469-76. [PubMed: 3455895] [MGI Ref ID J:8163]
Herrmann BG; Barlow DP; Lehrach H. 1987. A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversion. Cell 48(5):813-25. [PubMed: 2880670] [MGI Ref ID J:20080]
Lyon MF. 1986. Male sterility of the mouse t-complex is due to homozygosity of the distorter genes. Cell 44(2):357-63. [PubMed: 3943128] [MGI Ref ID J:8162]
Lyon MF. 1984. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37(2):621-8. [PubMed: 6722884] [MGI Ref ID J:7443]
Neufeld E; Vincek V; Figueroa F; Klein J. 1991. Limits of the distal inversion in the t complex of the house mouse: evidence from linkage disequilibria. Mamm Genome 1(4):242-8. [PubMed: 1794053] [MGI Ref ID J:11625]
Crabbe JC; Cotnam CJ; Cameron AJ; Schlumbohm JP; Rhodes JS; Metten P; Wahlsten D. 2003. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav 2(4):201-13. [PubMed: 12953786] [MGI Ref ID J:104878]
Kusek GK; Wahlsten D; Herron BJ; Bolivar VJ; Flaherty L. 2007. Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse. Genes Brain Behav 6(4):359-63. [PubMed: 16899052] [MGI Ref ID J:137289]
Lyon MF. 1956. Hereditary hair loss in the tufted mutant of the house mouse J Hered 47:101-3. [MGI Ref ID J:273]
Lyon MF; Bechtol KB. 1977. Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30(1):63-76. [PubMed: 924142] [MGI Ref ID J:5889]
MacPherson P; McGaffigan R; Wahlsten D; Nguyen PV. 2008. Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice. Brain Res 1210:179-88. [PubMed: 18417102] [MGI Ref ID J:136821]
Silver LM; Cisek L; Jackson C; Lukralle D. 1985. A new spontaneous mutation at the tufted locus within a mouse t haplotype. Genet Res 45(1):107-12. [PubMed: 3996911] [MGI Ref ID J:7861]
Yang M; Clarke AM; Crawley JN. 2009. Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability. Eur J Neurosci 29(8):1663-77. [PubMed: 19419429] [MGI Ref ID J:148483]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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