Strain Name:

C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J

Stock Number:

001533

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse

Appearance
dark black
Related Genotype: A/A Mc1rE-so/Mc1rE-so +/+

dark black with white belly spot and extra toes
Related Genotype: A/A Mc1rE-so/Mc1rE-so Gli3Xt-J/+

Important Note
This strain is homozygous for Mc1rE-so and Pde6brd1 and segregating for Gli3Xt-J.

Description
Mice heterozygous for the extra toes-J spontaneous mutation (Gli3Xt-J) have varying numbers of extra digits on preaxial side of feet. Homozygous mutant mice die in utero with multiple abnormalities. Excessively large pharyngeal arches and an open neural tube are evident at E9. Homologous to Grieg's cephalopoly-syndactyly, a rare multi-system syndrome in humans. This strain is homozygous for the sombre mutation (Mc1rE-so).

Control Information

  Control
   Wild-type from the colony Homozygous for MclrE-so and wild-type for Gli3Xt-J
   000658 C3HeB/FeJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Gli3Xt-J allele
000026   B6.C3-Gli3Xt-J/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
View Strains carrying   Gli3Xt-J     (2 strains)

Strains carrying   Mc1rE-so allele
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
View Strains carrying   Mc1rE-so     (1 strain)

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying   Pde6brd1     (73 strains)

Strains carrying other alleles of Gli3
008873   STOCK Gli3tm1Alj/J
013124   STOCK Gt(ROSA)26Sortm3(Gli3)Amc/J
View Strains carrying other alleles of Gli3     (2 strains)

Strains carrying other alleles of Mc1r
003625   B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J
000060   C57BL/6J-Mc1re/J
001000   RBD/DnJ
000726   RBF/DnJ
000807   RBJ/DnJ
000729   STOCK Rb(11.13)4Bnr/J
View Strains carrying other alleles of Mc1r     (6 strains)

View Strains carrying other alleles of Pde6b     (13 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Greig Cephalopolysyndactyly Syndrome; GCPS
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Oculocutaneous, Type II; OCA2   (MC1R)
Hypothalamic Hamartomas   (GLI3)
Melanoma, Cutaneous Malignant, Susceptibility to, 5; CMM5   (MC1R)
Pallister-Hall Syndrome 1; PHS1   (GLI3)
Polydactyly, Postaxial, Type A1; PAPA1   (GLI3)
Polydactyly, Preaxial IV   (GLI3)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Gli3Xt-J/Gli3Xt-J

        involves: C3H/HeJ
  • limbs/digits/tail phenotype
  • polydactyly
    • distal truncations of the forelimb skeleton and loss of the autopod at E14.5   (MGI Ref ID J:159210)

Mc1rE-so/Mc1r+

        C3H
  • pigmentation phenotype
  • abnormal skin pigmentation   (MGI Ref ID J:13077)
  • darkened coat color
    • at maturity flanks are flecked with yellow hairs and bellies may appear dark gray   (MGI Ref ID J:13077)
    • appearance is similar to homozygous non-agouti mice   (MGI Ref ID J:13077)
    • yellow perineal hairs are present in the first coat distinguishing heterozygotes from homozygotes by 12 days of age   (MGI Ref ID J:13077)
    • shows epistatic supression of light bellies in mice heterozygous for Aw. white bellied agouti   (MGI Ref ID J:13077)
  • hyperpigmentation
    • skin is dark, ears and nipples are especially obvious   (MGI Ref ID J:13077)
  • integument phenotype
  • abnormal skin pigmentation   (MGI Ref ID J:13077)
  • darkened coat color
    • at maturity flanks are flecked with yellow hairs and bellies may appear dark gray   (MGI Ref ID J:13077)
    • appearance is similar to homozygous non-agouti mice   (MGI Ref ID J:13077)
    • yellow perineal hairs are present in the first coat distinguishing heterozygotes from homozygotes by 12 days of age   (MGI Ref ID J:13077)
    • shows epistatic supression of light bellies in mice heterozygous for Aw. white bellied agouti   (MGI Ref ID J:13077)

Mc1rE-so/Mc1rE-so

        C3H
  • pigmentation phenotype
  • abnormal skin pigmentation
    • all skin surfaces are startlingly black   (MGI Ref ID J:13077)
  • darkened coat color
    • all black except for a few yellow hairs on the perineum   (MGI Ref ID J:13077)
  • hyperpigmentation   (MGI Ref ID J:13077)
  • integument phenotype
  • abnormal skin pigmentation
    • all skin surfaces are startlingly black   (MGI Ref ID J:13077)
  • darkened coat color
    • all black except for a few yellow hairs on the perineum   (MGI Ref ID J:13077)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Gli3Xt-J/Gli3+

        involves: C3H * CD-1
  • limbs/digits/tail phenotype
  • abnormal foot plate morphology
    • at day 12 of gestation, footpads are enlarged at the area destined to become digit 1   (MGI Ref ID J:4086)
  • polydactyly
    • display mild preaxial polydactyly in both fore- and hindlimbs   (MGI Ref ID J:38381)

Gli3Xt-J/Gli3+

        involves: 129/Sv * C3H/HeJ * C57BL/6
  • limbs/digits/tail phenotype
  • polyphalangy
    • there is an extra phalange in the first digit   (MGI Ref ID J:121609)
  • skeleton phenotype
  • polyphalangy
    • there is an extra phalange in the first digit   (MGI Ref ID J:121609)

Gli3Xt-J/Gli3+

        involves: C3H/HeJ * C57BL/6J * C57BL/6NHsd
  • limbs/digits/tail phenotype
  • polydactyly
    • 12% with unilateral anterior polydactyly involving the hind limbs only   (MGI Ref ID J:42445)

Gli3Xt-J/Gli3+

        involves: C3H/HeJ
  • limbs/digits/tail phenotype
  • polydactyly
    • in 4 of 17 forelimbs   (MGI Ref ID J:207959)

Gli3Xt-J/Gli3Xt-J

        involves: C3H * CD-1
  • mortality/aging
  • complete perinatal lethality
    • animals that survive to birth die within 2 days after birth   (MGI Ref ID J:4086)
  • partial prenatal lethality
    • many mutants die embryonically with a wide range of defects   (MGI Ref ID J:4086)
  • craniofacial phenotype
  • abnormal craniofacial development
    • enlarged maxillary arch   (MGI Ref ID J:4086)
    • reduced external nasal process   (MGI Ref ID J:4086)
    • abnormal tooth development
      • occurs in some mice   (MGI Ref ID J:38381)
  • abnormal cranium morphology
    • external nasal processes are reduced   (MGI Ref ID J:38381)
    • abnormal maxilla morphology
      • the maxillary region is enlarged   (MGI Ref ID J:38381)
    • abnormal neurocranium morphology
      • skull vault fails to form   (MGI Ref ID J:38381)
  • abnormal ear distance/ position
    • misplaced ears   (MGI Ref ID J:4086)
  • cleft palate
    • occurs in some mice   (MGI Ref ID J:38381)
  • skeleton phenotype
  • abnormal cranium morphology
    • external nasal processes are reduced   (MGI Ref ID J:38381)
    • abnormal maxilla morphology
      • the maxillary region is enlarged   (MGI Ref ID J:38381)
    • abnormal neurocranium morphology
      • skull vault fails to form   (MGI Ref ID J:38381)
  • abnormal long bone morphology   (MGI Ref ID J:38381)
    • increased diameter of humerus
      • slight thickening of the humerus   (MGI Ref ID J:38381)
    • increased diameter of radius
      • slight thickening of the radius   (MGI Ref ID J:38381)
    • increased diameter of ulna
      • slight thickening of the ulna   (MGI Ref ID J:38381)
    • short humerus
      • slight shortening of the humerus   (MGI Ref ID J:38381)
    • short radius
      • slight shortening of the radius   (MGI Ref ID J:38381)
    • short tibia
      • severe truncation of the tibia is observed   (MGI Ref ID J:38381)
    • short ulna
      • slight shortening of the ulna   (MGI Ref ID J:38381)
  • abnormal sternum morphology
    • sternum is unfused   (MGI Ref ID J:38381)
  • abnormal vertebral arch morphology
    • C1 and C2 neural arches are fused   (MGI Ref ID J:38381)
    • neural arches of other cervical vertebrae are expanded and have irregular shapes   (MGI Ref ID J:38381)
  • limbs/digits/tail phenotype
  • abnormal foot plate morphology
    • at E12, mutant embryos show a widening in the preaxial and postaxial areas of the footplates, resulting in a paddle-shaped foot with polydactyly   (MGI Ref ID J:4086)
  • increased diameter of humerus
    • slight thickening of the humerus   (MGI Ref ID J:38381)
  • increased diameter of radius
    • slight thickening of the radius   (MGI Ref ID J:38381)
  • increased diameter of ulna
    • slight thickening of the ulna   (MGI Ref ID J:38381)
  • polydactyly
    • forelimb exhibits severe polydactyly (7-8 digits) and hindlimb exhibits milder polydactyly (6 digits)   (MGI Ref ID J:38381)
    • present on all feet   (MGI Ref ID J:4086)
  • short humerus
    • slight shortening of the humerus   (MGI Ref ID J:38381)
  • short radius
    • slight shortening of the radius   (MGI Ref ID J:38381)
  • short tibia
    • severe truncation of the tibia is observed   (MGI Ref ID J:38381)
  • short ulna
    • slight shortening of the ulna   (MGI Ref ID J:38381)
  • syndactyly
    • present on all feet   (MGI Ref ID J:4086)
  • nervous system phenotype
  • abnormal brain morphology
    • gross malformations of the brain   (MGI Ref ID J:4086)
    • exencephaly
      • midbrain exencephaly   (MGI Ref ID J:4086)
  • incomplete rostral neuropore closure
    • neural tube closure is largely normal, although an opening around the midbrain region is seen   (MGI Ref ID J:4086)
  • hearing/vestibular/ear phenotype
  • abnormal ear distance/ position
    • misplaced ears   (MGI Ref ID J:4086)
  • homeostasis/metabolism phenotype
  • edema   (MGI Ref ID J:4086)
  • vision/eye phenotype
  • abnormal eye development
    • poorly developed eyes   (MGI Ref ID J:4086)
  • digestive/alimentary phenotype
  • cleft palate
    • occurs in some mice   (MGI Ref ID J:38381)
  • embryogenesis phenotype
  • incomplete rostral neuropore closure
    • neural tube closure is largely normal, although an opening around the midbrain region is seen   (MGI Ref ID J:4086)
  • integument phenotype
  • abnormal coat/ hair morphology
    • anomalous number and patterns of supra-orbital hair (eyelashes)   (MGI Ref ID J:4086)
  • abnormal vibrissa number
    • anomalous number and patterns of mystacial hair (vibrissae)   (MGI Ref ID J:4086)
  • growth/size/body phenotype
  • abnormal ear distance/ position
    • misplaced ears   (MGI Ref ID J:4086)
  • abnormal tooth development
    • occurs in some mice   (MGI Ref ID J:38381)
  • cleft palate
    • occurs in some mice   (MGI Ref ID J:38381)

Gli3Xt-J/Gli3Xt-J

        involves: 129/Sv * C3H/HeJ * C57BL/6J
  • limbs/digits/tail phenotype
  • polydactyly
    • similar to the phenotype seen in Gli3Xt-J Gas1tm2Fan double homozygotes   (MGI Ref ID J:121554)

Gli3Xt-J/Gli3Xt-J

        involves: 129/Sv * C3H/HeJ * C57BL/6
  • limbs/digits/tail phenotype
  • abnormal digit morphology
    • digits have lost their identity with some digits consisting of three phalanges that are usually undivided and longer than those in Gli3tm2Blnw homozygotes   (MGI Ref ID J:121609)
    • abnormal phalanx morphology
      • phalanges in some digits are undivided and longer than those in Gli3tm2Blnw homozygotes   (MGI Ref ID J:121609)
      • rarely extra phalanges element branch from the metatarsals   (MGI Ref ID J:121609)
      • however, ossification occurs at most proximal and distal phalanges   (MGI Ref ID J:121609)
    • polydactyly
      • at E16.5, some mice have 6 to 8 digits that lacked identity   (MGI Ref ID J:121609)
  • absent tibia
    • at E16.5, in some mice   (MGI Ref ID J:121609)
  • skeleton phenotype
  • abnormal phalanx morphology
    • phalanges in some digits are undivided and longer than those in Gli3tm2Blnw homozygotes   (MGI Ref ID J:121609)
    • rarely extra phalanges element branch from the metatarsals   (MGI Ref ID J:121609)
    • however, ossification occurs at most proximal and distal phalanges   (MGI Ref ID J:121609)
  • absent tibia
    • at E16.5, in some mice   (MGI Ref ID J:121609)

Gli3Xt-J/Gli3Xt-J

        involves: C3H/HeJ * CD-1
  • homeostasis/metabolism phenotype
  • edema
  • limbs/digits/tail phenotype
  • polydactyly
  • nervous system phenotype
  • exencephaly
  • skeleton phenotype
  • abnormal sternum morphology   (MGI Ref ID J:152259)
    • abnormal xiphoid process morphology
      • enlarged at E18.5   (MGI Ref ID J:152259)

Gli3Xt-J/Gli3Xt-J

        involves: C3H/HeJ * NMRI
  • limbs/digits/tail phenotype
  • polydactyly
    • additional anterior digits are formed but the anterior most digit 1 is lost   (MGI Ref ID J:184012)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Gli3Xt-J related

Developmental Biology Research
Neural Tube Defects
Skeletal Defects

Neurobiology Research
Neural Tube Defects

Sensorineural Research
Cataracts
      diffuse
Eye Defects

Mc1rE-so related

Dermatology Research
Color and White Spotting Defects
      red hair color

Pde6brd1 related

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Gli3Xt-J
Allele Name extra toes Jackson
Allele Type Spontaneous
Common Name(s) Gli3-; Gli3Xt; Gli3XtJ; Gli3delta; XtJ; XtJ; extra-toes J; xt;
Strain of OriginC3H/HeJ
Gene Symbol and Name Gli3, GLI-Kruppel family member GLI3
Chromosome 13
Gene Common Name(s) ACLS; AI854843; AU023367; Bph; GCPS; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV; Pdn; Xt; add; anterior digit pattern deformity; brachyphalangy; expressed sequence AI854843; expressed sequence AU023367; extra toes; polydactyly Nagoya;
General Note Genbank ID for this allele: AF418601
Phenotypic Similarity to Human Syndrome: lambdoid suture craniosynostosis in homozygous mice (J:163175)
Molecular Note Genomic sequencing and PCR analysis identified the mutation as a 51.5 kb deletion. The deleted region contains all Gli3 coding sequences 3' to exon 9, which includes sequences encoding some, but not all, of the zinc finger domains. This deletion resultsin the expression of an abnormal transcript that fuses Gli3 sequences to an exon belonging to an apparent LTR/MaLR repetitive element. However, this transcript lacks the sequences required for normal GLI3 activity. [MGI Ref ID J:4086] [MGI Ref ID J:48982] [MGI Ref ID J:76587]
 
Allele Symbol Mc1rE-so
Allele Name sombre
Allele Type Spontaneous
Common Name(s) Eso; So;
Strain of OriginC3H
Gene Symbol and Name Mc1r, melanocortin 1 receptor
Chromosome 8
Gene Common Name(s) CMM5; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening;
Molecular Note A T-to-C mutation in codon 96 is predicted to result in a leucine to proline alteration at this position. [MGI Ref ID J:4636]
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;
Strain of Originvarious
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
General Note The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Buttitta L; Mo R; Hui CC; Fan CM. 2003. Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130(25):6233-43. [PubMed: 14602680]  [MGI Ref ID J:87223]

Ernest S; Christensen B; Gilfix BM; Mamer OA; Hosack A; Rodier M; Colmenares C; McGrath J; Bale A; Balling R; Sankoff D; Rosenblatt DS; Nadeau JH. 2002. Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mamm Genome 13(5):259-67. [PubMed: 12016514]  [MGI Ref ID J:76559]

Johnson DR. 1967. Extra-toes: a new mutant gene causing multiple abnormalities in the mouse. J Embryol Exp Morphol 17(3):543-81. [PubMed: 6049666]  [MGI Ref ID J:5049]

Rallu M; Machold R; Gaiano N; Corbin JG; McMahon AP; Fishell G. 2002. Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development 129(21):4963-74. [PubMed: 12397105]  [MGI Ref ID J:79856]

Schimmang T; Lemaistre M; Vortkamp A; Ruther U. 1992. Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development 116(3):799-804. [PubMed: 1289066]  [MGI Ref ID J:3333]

Yada Y; Makino S; Chigusa-Ishiwa S; Shiroishi T. 2002. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol 46(7):975-82. [PubMed: 12455637]  [MGI Ref ID J:81331]

Gli3Xt-J related

Ahn S; Joyner AL. 2004. Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118(4):505-16. [PubMed: 15315762]  [MGI Ref ID J:92507]

Alt B; Elsalini OA; Schrumpf P; Haufs N; Lawson ND; Schwabe GC; Mundlos S; Gruters A; Krude H; Rohr KB. 2006. Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133(19):3797-804. [PubMed: 16968815]  [MGI Ref ID J:119563]

Anderson C; Williams VC; Moyon B; Daubas P; Tajbakhsh S; Buckingham ME; Shiroishi T; Hughes SM; Borycki AG. 2012. Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. Genes Dev 26(18):2103-17. [PubMed: 22987640]  [MGI Ref ID J:187740]

Aoto K; Shikata Y; Imai H; Matsumaru D; Tokunaga T; Shioda S; Yamada G; Motoyama J. 2009. Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol 327(1):106-20. [PubMed: 19103193]  [MGI Ref ID J:145732]

Aruga J; Mizugishi K; Koseki H; Imai K; Balling R; Noda T; Mikoshiba K. 1999. Zic1 regulates the patterning of vertebral arches in cooperation with Gli3. Mech Dev 89(1-2):141-50. [PubMed: 10559489]  [MGI Ref ID J:58623]

Bai CB; Joyner AL. 2001. Gli1 can rescue the in vivo function of Gli2. Development 128(24):5161-72. [PubMed: 11748151]  [MGI Ref ID J:73074]

Balaskas N; Ribeiro A; Panovska J; Dessaud E; Sasai N; Page KM; Briscoe J; Ribes V. 2012. Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell 148(1-2):273-84. [PubMed: 22265416]  [MGI Ref ID J:181293]

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Zeng HY; Lu QJ; Liu Q; Liu KG; Wang NL. 2011. The role of CCR1 expression in the retinal degeneration in rd mice. Curr Eye Res 36(3):264-9. [PubMed: 21275605]  [MGI Ref ID J:179793]

Zhang N; Kolesnikov AV; Jastrzebska B; Mustafi D; Sawada O; Maeda T; Genoud C; Engel A; Kefalov VJ; Palczewski K. 2013. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 123(1):121-37. [PubMed: 23221340]  [MGI Ref ID J:194158]

Zhu Y; Tu DC; Denner D; Shane T; Fitzgerald CM; Van Gelder RN. 2007. Melanopsin-dependent persistence and photopotentiation of murine pupillary light responses. Invest Ophthalmol Vis Sci 48(3):1268-75. [PubMed: 17325172]  [MGI Ref ID J:123259]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryGli3Xt-J/+ may have a white belly spot.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   Wild-type from the colony Homozygous for MclrE-so and wild-type for Gli3Xt-J
   000658 C3HeB/FeJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is homozygous for Mc1rE-so and Pde6brd1 and segregating for Gli3Xt-J.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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