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Strain Name:

C3Sn.Cg-Cm/J

Stock Number:

001547

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      C3H/HeSnJ-Cm/J    (Changed: 13-MAR-08 )
Genes & Alleles   Cm;   Pde6b;   Pde6brd1;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationN48F1pN1

Appearance
agouti, circling
Related Genotype: A/A Cm/+

agouti, normal behavior
Related Genotype: A/A +/+

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.

Strain Description
Mice heterozygous for the coloboma spontaneous mutation (Cm) show abnormal posture, head shaking or bobbing, and circling. Heterozygous mutant mice are extremely hyperactive, locomotor activity being three times that of normal mice.

Mammalian Phenotype Terms assigned by genotype

Cm/+

        C3Sn.Cg-Cm/J
  • vision/eye phenotype
  • coloboma (MGI Ref ID J:72108)
    • iris colobomas
  • hearing/vestibular/ear phenotype
  • abnormal cochlear hair cell morphology (MGI Ref ID J:72108)
    • decreased cochlear outer hair cell number (MGI Ref ID J:72108)
      • in the basal and middle regions of the cochleas, occasional short regions of only two rows of outer hair cells are present instead of the normal 3
    • increased cochlear inner hair cell number (MGI Ref ID J:72108)
      • extra hair cells in the inner hair cell row are seen in the base and apex
    • increased cochlear outer hair cell number (MGI Ref ID J:72108)
      • the very apical 10-35% of the cochlea, show an increase in outer hair cell rows, having 4-5 rows instead of the normal 3
  • abnormal semicircular canal (MGI Ref ID J:72108)
    • anterior and posterior canal truncations near the ampullae, however the lateral canal is normal, and the respective ampullae are small or absent
    • when the ampulla is present, the canal is still truncated
  • nervous system phenotype
  • abnormal cochlear hair cell morphology (MGI Ref ID J:72108)
    • decreased cochlear outer hair cell number (MGI Ref ID J:72108)
      • in the basal and middle regions of the cochleas, occasional short regions of only two rows of outer hair cells are present instead of the normal 3
    • increased cochlear inner hair cell number (MGI Ref ID J:72108)
      • extra hair cells in the inner hair cell row are seen in the base and apex
    • increased cochlear outer hair cell number (MGI Ref ID J:72108)
      • the very apical 10-35% of the cochlea, show an increase in outer hair cell rows, having 4-5 rows instead of the normal 3

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Cm/+

        involves: 101/H * C3H/HeH
  • behavior/neurological phenotype
  • abnormal head movements (MGI Ref ID J:13451)
  • abnormal posture (MGI Ref ID J:13451)
  • circling (MGI Ref ID J:13451)
  • hyperactivity (MGI Ref ID J:1371)
    • extremely hyperactive, locomotor activity being three times that of normal mice
  • vision/eye phenotype
  • abnormal choroid morphology (MGI Ref ID J:13451)
    • the ventral segment of the pigmented choroid, comprising about 25% of the whole, is absent
  • abnormal eye distance/ position (MGI Ref ID J:13451)
    • in adults the eyeballs are rotated ventrally so that the pupil may be partly hidden by the lower lid
  • microphthalmia (MGI Ref ID J:13451)
    • eyes of heterozygotes look smaller at birth
  • hearing/vestibular/ear phenotype
  • circling (MGI Ref ID J:13451)
  • head bobbing (MGI Ref ID J:13451)
  • head shaking (MGI Ref ID J:13451)

Cm/+

        involves: 101/H * C3H/He * C57BL/6J
  • vision/eye phenotype
  • abnormal eye morphology (MGI Ref ID J:54907)
    • abnormalities are similar to Jag1tm1Grid heterozygous mice

Cm/+

        Background Not Specified
  • vision/eye phenotype
  • abnormal cornea morphology (MGI Ref ID J:99768)
    • the cornea has a grayish spot of variable size
    • fused cornea and lens (MGI Ref ID J:99768)
      • at 14 days of gestation some heterozygotes display an adhesion of the anterior pole of the lens with the thinned cornea, while others display an anterior plug of lens fibers perforating the cornea
  • abnormal lens epithelium morphology (MGI Ref ID J:99768)
    • at 18 days of gestation the developing lens can have a cone-like thickening of the anterior lens epithelium or, in a more severe case, lens fibers are found to penetrate through a hole in the cornea into the conjunctival sac
  • abnormal lens vesicle development (MGI Ref ID J:99768)
    • first detected at day 11.5 of gestation when lenses are not detatched from the corneal ectoderm and there is epithelial continuity
  • coloboma (MGI Ref ID J:99768)
    • eyes of newborn heterozygotes are alsways smaller than normal and a coloboma is visible through the transparent eyelid
  • delayed eyelid opening (MGI Ref ID J:99768)
    • eyelids may remain closed in adults or may be opened slightly, and the pupil is often partly hidden behind the lower eyelid
  • eyelids fail to open (MGI Ref ID J:99768)
  • lenticonus (MGI Ref ID J:99768)
  • microphthalmia (MGI Ref ID J:99768)
  • behavior/neurological phenotype
  • head tossing (MGI Ref ID J:99768)
  • skin/coat/nails phenotype
  • abnormal coat appearance (MGI Ref ID J:99768)
    • the coat has a slightly abnormal texture, not as smooth as wildtype
  • hearing/vestibular/ear phenotype
  • head tossing (MGI Ref ID J:99768)

Cm/Cm

        involves: 101/H * C3H/HeH
  • lethality-prenatal/perinatal
  • prenatal lethality (MGI Ref ID J:13451)

Cm/Cm

        involves: 101/H * C3H/He * C57BL/6J
  • lethality-prenatal/perinatal
  • embryonic lethality during organogenesis (MGI Ref ID J:54907)
    • death occurs at approximately E10.5 from widespread hemorrhages due to vascular defects
  • cardiovascular system phenotype
  • hemorrhage (MGI Ref ID J:54907)
    • at E10.5, all homozygous embryos are hemorrhagic

Cm/Cm

        Background Not Specified
  • lethality-prenatal/perinatal
  • embryonic lethality before somite formation (MGI Ref ID J:99768)
    • homozygotes likely die before day 6 in pregnancy

Gene & Allele Details

Allele Symbol Cm
Allele Name coloboma
Strain of Origin(C3H/HeH x 101/H)F1
General Note This allele represents a deletion including Snap25, Plcb1
Molecular Note The deletion map of the Cm locus includes Snap25, Plcb, and some or all of Jag1, and numerous other DNA markers. [MGI Ref ID J:18309] [MGI Ref ID J:54907]
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Common Name(s) rd; rd-1; rd1; rodless retina;

Control Information

  Allele   Control
 Cm  000661 C3H/HeSnJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
005973   C3Bir.129P2(B6)-Il10C3Bir/LtJ
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
001906   C3Ga.Cg-Catb/J
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000784   C3H/HeJ-Faslgld/J
000509   C3H/HeJ-Lystbg-2J/J
002433   C3H/HeJ-Spnb4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002235   C3H/HeSnJ-Ctnna2cdf/J
002333   C3H/HeSnJ-gri/J
006435   C3HeB.SW-Soaa/MonJ
000658   C3HeB/FeJ
001576   C3HeB/FeJ-Atp7btx-J/J
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001886   C3HeB/FeJLe a/a-gnd/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/J
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002374   FVB/N-Tg(MMTV-PyVT)634Mul/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491   FVB/NMob
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
100299   PLSJLF1/J
000269   SB/LeJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying   Pde6brd1     (74 strains)

View Strains carrying other alleles of Pde6b     (8 strains)

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Cm related

Developmental Biology Research
Eye Defects

Neurobiology Research
Behavioral and Learning Defects
Vestibular and Hearing Defects

Sensorineural Research
Eye Defects
Vestibular and Hearing Defects

Pde6brd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

References

Additional References

Price and Supply Information

Strain Name: C3Sn.Cg-Cm/J
Stock Number: 001547

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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