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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6.Cg-am-J/J (Changed: 11-SEP-08 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Donor Strain B6C3F1 Generation N6p
Related Strains
Strains carrying other alleles of a
View Strains carrying other alleles of a (179 strains)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
am-J/a
involves: C3H/HeJ * C57BL/6J
- pigmentation phenotype
- mottled coat (MGI Ref ID J:16570)
- found in both heterozygotes and homozygotes and ranges in color from almost extreme non-agouti with little ticking to full agouti with no mottling
- skin/coat/nails phenotype
- mottled coat (MGI Ref ID J:16570)
- found in both heterozygotes and homozygotes and ranges in color from almost extreme non-agouti with little ticking to full agouti with no mottling
am-J/am-J
involves: C3H/HeJ * C57BL/6J
- pigmentation phenotype
- mottled coat (MGI Ref ID J:16570)
- found in both heterozygotes and homozygotes and ranges in color from almost extreme non-agouti with little ticking to full agouti with no mottling
- skin/coat/nails phenotype
- mottled coat (MGI Ref ID J:16570)
- found in both heterozygotes and homozygotes and ranges in color from almost extreme non-agouti with little ticking to full agouti with no mottling
- cellular phenotype
- maternal imprinting (MGI Ref ID J:16570)
- variation in coat color is influenced by the genome of the dam
This mouse can be used to support research in many areas including:am-J related
Dermatology Research
Color and White Spotting Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | am-J | ||
|---|---|---|---|
| Allele Name | mottled agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | (C57BL/6J x C3H/HeJ)F1 | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | This allele is dominant to a. This mutation at the agouti locus arose in a C57BL/6J x C3H/HeJ F1 male. As with am the variation in color is influenced by the genome of the dam (J:16570). | ||
| Molecular Note | This mutation appears to represent a regulatory mutation that down-regulates agouti expression. [MGI Ref ID J:24934] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152] [MGI Ref ID J:3523]
Hustad CM; Perry WL; Siracusa LD; Rasberry C; Cobb L; Cattanach BM; Kovatch R; Copeland NG; Jenkins NA. 1995. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1):255-65. [PubMed: 7635290] [MGI Ref ID J:24934]
Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404] [MGI Ref ID J:4186]
Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545] [MGI Ref ID J:18750]
am-J relatedHustad CM; Perry WL; Siracusa LD; Rasberry C; Cobb L; Cattanach BM; Kovatch R; Copeland NG; Jenkins NA. 1995. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1):255-65. [PubMed: 7635290] [MGI Ref ID J:24934]
Lane PW. 1989. Mottled agouti-J (am-J) Mouse News Lett 84:89. [MGI Ref ID J:16570]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
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See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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