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Strain Name:

C57BL/6JEi-Chr YWSB/Ei/EiJ

Stock Number:

001574

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Former Name      C57BL/6JEi-Chr YWSB/EiJ    (Changed: 06-JUN-08 )
      C57BL/6JEi-Chr YWSB    (Changed: 27-NOV-07 )
      C57BL/6JEi-YWSB    (Changed: 15-DEC-04 )
Strain Common Names      B6.YWSB;      B6JEi-YWSB;

Product Information

Strain Details

Type Consomic
Additional information on Consomic Mice.
Specieslaboratory mouse
Donating Investigator Eva Eicher,   The Jackson Laboratory
GenerationN11

Strain Description
This consomic is valuable in the study of sex determination. The TOrl /+ XYWSB offspring, from the cross of B6.Cg-TOrl /+ females with C57BL/6JEi-Chr YWSB/EiJ males, are sex reversed, with ovarian tissue development.

Strain Development
The Y Chromosome was backcrossed from WSB/Ei onto C57BL/6JEi through repeated backcrossing. In 1990 embryos were cryopreserved from C57BL/6JEi females bred with consomic males at generation N10 or beyond.

Mammalian Phenotype Terms assigned by genotype

  • reproductive system phenotype
  • *normal* reproductive system phenotype (MGI Ref ID J:44538)
    • this consomic does not have sex reversal

    • Research Applications

    This mouse can be used to support research in many areas including:

    Developmental Biology Research
    Internal/Organ Defects (gonads)

    Reproductive Biology Research
    Developmental Defects Affecting Gonads

    Research Tools
    Reproductive Biology Research

    References

    Selected Reference(s)

    Albrecht KH; Eicher EM. 1997. DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit. Genetics 147(3):1267-77. [PubMed: 9383069]  [MGI Ref ID J:44538]

    Washburn LL; Albrecht KH; Eicher EM. 2001. C57BL/6J-T-Associated Sex Reversal in Mice Is Caused by Reduced Expression of a Mus domesticus Sry Allele. Genetics 158(4):1675-81. [PubMed: 11514455]  [MGI Ref ID J:71077]

    Price and Supply Information

    Strain Name: C57BL/6JEi-Chr YWSB/Ei/EiJ
    Stock Number: 001574

    Price Details

    IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

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    Supply Details

    Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
    Supply Notes Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.

    LicensingSee General Terms and Conditions below  

    General Terms and Conditions

    View JAX® Mice & Services Conditions of Use.

    The Jackson Laboratory's Genotype Promise

    The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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