Strain Name: |
RHJ/LeJ |
|---|---|
Stock Number: |
001591 |
Availability: | Repository- Live |
General Terms and Conditions |
| Genes & Alleles | Hr; Hrrh-J; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Mating System Heterozygote x Homozygote (Female x Male) Species laboratory mouse Generation F155 (05-DEC-07) Appearance
unpigmented, without hair
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc Hrrh-J/Hrrh-J
albino, unaffected
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc Hrrh-J/+Strain Description
Rhino mice have spleen cells with a defective response to T-dependent antigens and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which occur in young mice and increase with age. These mice have increased numbers of Thy1 positive epidermal dendritic cells. Like homozygous hairless mice, rhino mice are hairless by 5 weeks and their skin becomes wrinkled and thickened.Strain Development
The rhino Jackson mutation (hrrh-J) was found at Carworth Farms (a New York commercial breeder) in a stock of undetermined genetic background and sent to The Jackson Laboratory in 1951. It was outcrossed to BALB/cHu for 6 generations and then sibling mated. At F15 in 1963 it was outcrossed to the albino hook (Hk) stock, which had C57BL/6J, AKR and A/Sn in its background, and was again sibling mated selecting away from hook. The stock was nonagouti (a/a), brown (Tyrp1b), albino (Tyrc) and carrying rhino Jackson (Hrrh-J). It was maintained by mating heterozygous (haired) females to rhino Jackson homozygous males and was cryopreserved as stock #000266 by mating heterozygous females to homozygous males at generation F76. The strain was maintained on the shelf in the production facility as JR#1591 and reached F148 in 2005.
Gene & Allele Details
| Allele Symbol | Hrrh-J | ||
|---|---|---|---|
| Allele Name | rhino Jackson | ||
| Gene Symbol and Name | Hr, hairless | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | ALUNC; AU; HSA277165; N; ba; baldy; bldy; rh; rh-bmh; rhino-bald Mill Hill; | ||
Control Information
| Control | ||
|---|---|---|
| Heterozygote from the colony | ||
| Considerations for Choosing Controls | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying Hrrh-J allele
000266 RHJ/Le View Strains carrying Hrrh-J (1 strain)
007621 B6.129S6-Hrtm1Cct/J 001737 B6.A-H2-T18a.HRS-Hrhr/J 007622 B6;SJL-Tg(KRT14-Hr)551Cct/J 000758 C57BL/6J-Hbbp Hrrh-7J/J 002922 D2.HRS-Hrhr/J 000673 HRS/J 001103 HRS/J-Hrhr Esdb/+ Esdb/J 002335 SKH2/J 000147 WLHR/LeJ
Additional Web Information
Genetic Quality Control Annual Report
JAX Notes, January 1989; 436. Phenotypic abnormalities in hr-locus mutants.
JAX Notes, January 1989; 436. References for the Rhino Allele.
JAX Notes, October 1988; 435. Introduction of Rhino (hrrh) into Jackson Laboratory Production Colonies.
Animal Health Reports
Room Number FGB29
Research Applications
This mouse can be used to support research in many areas including:Hrrh-J related
Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects
Research Tools
Toxicology Research
References
Selected Reference(s)
Additional ReferencesKawaji H; Tsukuda R; Nakaguchi T. 1980. Immunopathology of rhino mouse, an autosomal recessive mutant with murine lupus-like disease. Acta Pathol Jpn 30(4):515-30. [PubMed: 6968145] [J:6387]
Takaoki M; Kawaji H. 1980. Impaired antibody response against T-dependent antigens in rhino mice. Immunology 40(1):27-32. [PubMed: 6968290] [J:6391]
Price and Supply Information
| Strain Name: | RHJ/LeJ |
| Stock Number: | 001591 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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