Strain Name:

NON.NOD-H2g7/LtJ

Stock Number:

001627

Availability:

Under Development for Cryopreservation Repository

To register your interest in this strain go to the Strain Interest Form.
This histocompatibility congenic strain carries the diabetogenic MHC from NOD/ShiLtJ mice. These mice exhibit some but not all of the immune dysfunctions of NOD/ShiLtJ mice. These mice are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.

Description

Strain Information

Former Names NOD.NON-H2g    (Changed: 15-DEC-04 )
Type Congenic; Major Histocompatibility Congenic; Mutant Strain;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain NON/ShiLt
Donor Strain NOD/ShiLt
GenerationN21F55 (05-DEC-07)

Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc

Description
This histocompatibility congenic strain carries the diabetogenic MHC from NOD/ShiLtJ mice and is used as a comparison strain for NOD/ShiLtJ (Stock No. 001976) and NON/ShiLtJ (Stock No. 002423). These mice exhibit some but not all of the immune dysfunctions of NOD/ShiLtJ mice. These mice are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.

Control Information

  Control
   002423 NON/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   H2g7     (9 strains)

Strains carrying other alleles of H2
000471   A.SW-H2s H2-T18b/SnJ
002089   AK.B6-H2b Fv1b/J
002090   AK.B6-H2b/J
001094   AK.L-H2b/1CyTyJ
000469   B10.A-H2a H2-T18a/SgSnJ
000468   B10.A-H2h2/(2R)SgSnJ
001150   B10.A-H2h4/(4R)SgDvEgJ
000467   B10.A-H2i5 H2-T18a/(5R)SgSnJ
000465   B10.BR-H2k H2-T18a/SgSnJ
004804   B10.BR-H2k H2-T18a/SgSnJJrep
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534   B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ
006102   B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100   B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002024   B10.D1-H2q/SgJ
000462   B10.D2-H2d/n2SnJ
001153   B10.D2-H2i7/(107R)EgJ
000460   B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461   B10.D2-Hc0 H2d H2-T18c/oSnJ
000463   B10.D2-Hc1 H2d H2-T18c/nSnJ
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
001953   B10.S-H2s/SgMcdJ
002995   B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J
003584   B6.129S2-H2dlAb1-Ea/J
001148   B6.AK-H2k/FlaEgJ
001895   B6.AK-H2k/J
000360   B6.C-H2d Mdmg1BALB/cBy/aByJ
000359   B6.C-H2d/bByJ
000944   B6.SJL-H2b C3c/2CyJ
000966   B6.SJL-H2s C3c/1CyJ
000945   B6.SW/1CyJ
003374   B6;129S2-H2dlAb1-Ea/J
003240   B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J
002844   BALB.5R-H2i5/LilJ
001041   BKS.B6-H2b/J
001892   BRVR.B10-H2b/J
001893   BRVR.D2-H2d/J
001952   C.B10-H2b/LilMcdJ
001951   C.C3-H2k/LilMcdJ
000438   C3.SW-H2b/SnJ
000437   D1.C-H2d H2-T18c/SnJ
000435   D1.LP-H2b H2-T18b?/SnJ
001383   LT.MA-Glo1b H2k/J
002591   NOD.B10Sn-H2b/J
004447   NOD.Cg-H2h4/DilTacUmmJ
002032   NOD.SW-H2q/J
003153   WLC.C-H2d.GR-Mtv2/MorJ
003154   WLC.C-H2d/MorJ
View Strains carrying other alleles of H2     (49 strains)

Additional Web Information

Congenic Nomenclature
Genetic Quality Control Annual Report
JAX® NOTES, Spring 1999; 477. Control Strains for NOD/LtJ Mice in Diabetes Research.

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ MHC Congenics)

H2g7 related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information

Allele Symbol H2g7
Allele Name g7 variant
Allele Type Not Applicable
Gene Symbol and Name H2, histocompatibility-2, MHC
Chromosome 17
Gene Common Name(s) H-2; MHC-II;
General Note The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2g7

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

H2g7 related

Carrasco-Marin E; Shimizu J; Kanagawa O; Unanue ER. 1996. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol 156(2):450-8. [PubMed: 8543793]  [MGI Ref ID J:30538]

Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. [PubMed: 10449528]  [MGI Ref ID J:108724]

Gray D; Abramson J; Benoist C; Mathis D. 2007. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204(11):2521-8. [PubMed: 17908938]  [MGI Ref ID J:126040]

Jasinski JM; Yu L; Nakayama M; Li MM; Lipes MA; Eisenbarth GS; Liu E. 2006. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 55(7):1978-84. [PubMed: 16804066]  [MGI Ref ID J:111874]

Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984]  [MGI Ref ID J:7097]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin.  [MGI Ref ID J:110093]

Levisetti MG; Lewis DM; Suri A; Unanue ER. 2008. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57(7):1852-60. [PubMed: 18398138]  [MGI Ref ID J:138230]

Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. [PubMed: 9449718]  [MGI Ref ID J:108722]

Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. [PubMed: 9530156]  [MGI Ref ID J:46553]

Martin-Orozco N; Chen Z; Poirot L; Hyatt E; Chen A; Kanagawa O; Sharpe A; Mathis D; Benoist C. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 171(12):6954-60. [PubMed: 14662903]  [MGI Ref ID J:86926]

Pearson T; Markees TG; Serreze DV; Pierce MA; Marron MP; Wicker LS; Peterson LB; Shultz LD; Mordes JP; Rossini AA; Greiner DL. 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol 171(1):185-95. [PubMed: 12816997]  [MGI Ref ID J:109845]

Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054]  [MGI Ref ID J:14178]

Serreze DV; Gallichan WS; Snider DP; Croitoru K; Rosenthal KL; Leiter EH; Christianson GJ; Dudley ME; Roopenian DC. 1996. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes 45(7):902-8. [PubMed: 8666141]  [MGI Ref ID J:33688]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068]  [MGI Ref ID J:104385]

Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. [PubMed: 15983204]  [MGI Ref ID J:109830]

Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. [PubMed: 18299579]  [MGI Ref ID J:132764]

Zhang C; Todorov I; Lin CL; Atkinson M; Kandeel F; Forman S; Zeng D. 2007. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A 104(7):2337-42. [PubMed: 17267595]  [MGI Ref ID J:119749]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

 

This strain is currently Under Development for Cryopreservation Repository.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development and On Hold

Supply Details

Standard SupplyUnder Development for Cryopreservation Repository
Supply Notes

Control Information

  Control
   002423 NON/ShiLtJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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