Strain Name:

CXB10/HiAJ

Stock Number:

001631

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Availability:

Cryopreserved - Ready for recovery

The CXB set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease) and pulmonary inflammation as well as behavioral phenotypes including avoidance, exploration and locomotor activity. The CXB set is derived from the BALBc/ByJ (Stock No. 001026) and C57BL/6ByJ (Stock No. 001139) progenitor strains.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names CXB-10/HiAJ    (Changed: 15-DEC-04 )
Type Recombinant Inbred (Ri);
Additional information on Recombinant Inbred Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
RI progenitor BALB/cBy C57BL/6By
H2 Haplotypeb
GenerationF47
Generation Definitions

Appearance
albino
Related Genotype: Tyrc/Tyrc

Description
The CXB set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease) and pulmonary inflammation as well as behavioral phenotypes including avoidance, exploration and locomotor activity. The CXB set is so small that markers on different chromosomes occasionally have almost precisely the same SDP. This produces high non-syntenic association and false linkage between variance in phenotypes and genotypes. Please examine the correlation coefficients of markers close to interest loci with ALL other markers to evaluate the risk of non-syntenic association.

The strain distribution pattern (SDP) for the CXB RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network.

Development
The original 11 CXB recombinant inbred (RI) lines were generated at the National Institutes of Health by Dr. Donald Bailey (labcode By) starting in 1959. After moving to The Jackson Laboratory in 1967, an additional set of 6 strains was created with the help of Jo Hilgers (Labcode Hi). The CXB set is derived from the BALBc/ByJ (Stock No. 001026) and C57BL/6ByJ (Stock No. 001139) progenitor strains. CXB1 through CXB7 originally were designated using letters. Several of the original strains are extinct. The Jackson Laboratory currently distributes 7 of the original By strains and 6 of the Hi strains.

Related Strains

CXB HiA Strains
001632   CXB11/HiAJ
001633   CXB12/HiAJ
001634   CXB13/HiAJ
001629   CXB8/HiAJ
001630   CXB9/HiAJ
View CXB HiA Strains     (5 strains)

CXB Strains
000351   CXB1/ByJ
001632   CXB11/HiAJ
001633   CXB12/HiAJ
001634   CXB13/HiAJ
000352   CXB2/ByJ
000353   CXB3/ByJ
000354   CXB4/ByJ
000355   CXB5/ByJ
000356   CXB6/ByJ
000357   CXB7/ByJ
001629   CXB8/HiAJ
001630   CXB9/HiAJ
View CXB Strains     (12 strains)

Phenotype

Phenotype Information

View Phenotypic Data

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Behavioral and Learning Defects

Research Tools
Genetics Research
      Gene Mapping
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bailey DW. 1971. Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation 11(3):325-7. [PubMed: 5558564]  [MGI Ref ID J:17649]

Williams RW; Gu J; Qi S; Lu L. 2001. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 2(11):1-18. [PubMed: 11737945]  [MGI Ref ID J:73062]

Additional References

Aliesky HA; Pichurin PN; Chen CR; Williams RW; Rapoport B; McLachlan SM. 2006. Probing the genetic basis for thyrotropin receptor antibodies and hyperthyroidism in immunized CXB recombinant inbred mice. Endocrinology 147(6):2789-800. [PubMed: 16543368]  [MGI Ref ID J:109467]

Hamidi S; Aliesky HA; Williams RW; Rapoport B; McLachlan SM. 2013. Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function. Thyroid 23(3):360-70. [PubMed: 22988948]  [MGI Ref ID J:204730]

McLachlan SM; Lu L; Aliesky HA; Williams RW; Rapoport B. 2011. Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. Endocrinology 152(3):1172-9. [PubMed: 21209025]  [MGI Ref ID J:173883]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • This strain is included in the Special Mutant Stock Resource collection.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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