Strain Name:

A.BY H2bc H2-T18f/SnJ-Dstncorn1/J

Stock Number:

001649

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Research Strain

Mice homozygous for the recessive Dstncorn1 mutation have abnormally proliferative basal corneal epithelial cells. Focal areas of corneal epithelial hyperplasia are found by one week of age, and neovascularization is found by 14 days of age when the eyes open. Corneal epithelial cells show increased levels and altered organizational pattern of filamentous actin. The areas of thickened cortical epithelia yield a roughened, opaque corneal surface. Homozygotes develop hemangiogenesis at 4 weeks of age; onset of lymphangiogenesis is delayed, less intense and regresses earlier compared with hemangiogenesis.

Description

Strain Information

Former Names A.BY-H2b H2-T18b/SnJ-Dstncorn1/J    (Changed: 15-DEC-04 )
A.BY-H2b H2-T18b/SnJ-corn1    (Changed: 15-DEC-04 )
A.BY/SnJ-corn1    (Changed: 15-DEC-04 )
Type Congenic; Major Histocompatibility Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationF?+F16 (27-JUN-14)
Generation Definitions

Appearance
albino, vascularized cornea, cataract
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc Dstncorn1/Dstncorn1

Description
Mice homozygous for the recessive Dstncorn1 mutation have abnormally proliferative basal corneal epithelial cells. Focal areas of corneal epithelial hyperplasia are found by one week of age, and neovascularization is found by 14 days of age when the eyes open. This neovascularization, which progresses during the first two months of age, is not found in mice homozygous for the Dstncorn-2J allele (which is a point mutation leading to a change in a single amino acid residue). In both mutants the corneal epithelial cells show increased levels and altered organizational pattern of filamentous actin. The areas of thickened cortical epithelia yield a roughened, opaque corneal surface.

At 4 weeks of age in Dstncorn1 homozygotes, expression of keratin 14 and involucrin extend into the suprabasal layer in the areas of hyperplastic corneal epithelia. There is also an increase in the levels of expression of cofilin 1, lumican and keratocan with lumican showing abnormal expression in epithelial cells. (Smith et al., 1996; Wang et al., 2001; Ikeda et al., 2003.) Homozygotes develop hemangiogenesis at 4 weeks of age; onset of lymphangiogenesis is delayed, less intense and regresses earlier compared with hemangiogenesis. (Cursiefen et al., 2005).

Development
The Dstncorn1 mutation was observed in 1987 in the A.BY/Sn congenic strain (#000140). The mutation was identified as a 35 kb deletion encompassing the entire coding region of the gene.

Control Information

  Control
   000646 A/J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Dstn
002623   C57BL/6JSmn-Dstncorn1-2J/J
View Strains carrying other alleles of Dstn     (1 strain)

View Strains carrying other alleles of H2-T18     (32 strains)

Strains carrying other alleles of H2
006500   129.NOD-(D17Mit175-H2)/J
000140   A.BY-H2bc H2-T18f/SnJ
000472   A.CA-H2f H2-T18a/SnJ
000471   A.SW-H2s H2-T18b/SnJ
001066   A.TH-H2t2/SfDvEgMobJ
001067   A.TL-H2t1/SfDvEgMobJ
002089   AK.B6-H2b Fv1b/J
002090   AK.B6-H2b/J
001094   AK.L-H2b/1CyTyJ
001095   AK.L-H2oz2/CyJ
001096   AK.L-H2oz3/CyJ
000470   AK.M-H2m H2-T18a/nSnJ
003851   ALR.NOD-(D17Mit30-D17Mit123)/Lt
000469   B10.A-H2a H2-T18a/SgSnJ
000468   B10.A-H2h2/(2R)SgSnJ
001150   B10.A-H2h4/(4R)SgDvEgJ
001149   B10.A-H2i3/(3R)SgDvEgJ
000467   B10.A-H2i5 H2-T18a/(5R)SgSnJ
000466   B10.AKM-H2m H2-T18a/SnJ
001954   B10.AQR-H2y1/KljMcdJ
000465   B10.BR-H2k2 H2-T18a/SgSnJ
004804   B10.BR-H2k2 H2-T18a/SgSnJJrep
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534   B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ
010514   B10.Cg-H2g Tg(Cd4-Klra1)6295Dl/J
006446   B10.Cg-H2h4 Sh3pxd2bnee/GrsrJ
006102   B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100   B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002024   B10.D1-H2q/SgJ
001163   B10.D2-H2bm23/EgJ
000462   B10.D2-H2d/n2SnJ
001164   B10.D2-H2dm1/EgJ
001151   B10.D2-H2g3/(103R)EgJ
001153   B10.D2-H2i7/(107R)EgJ
001152   B10.D2-H2ia/(106R)EgJ
000460   B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461   B10.D2-Hc0 H2d H2-T18c/oSnJ
000463   B10.D2-Hc1 H2d H2-T18c/nSnJ
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
000464   B10.DA-H2qp1 H2-T18b/(80NS)SnJ
001823   B10.F-H2bp5/(14R)J
001818   B10.F-H2pb1/(13R)J
001012   B10.HTG-H2g/2CyJ
000999   B10.HTG-H2g/3CyJ
001894   B10.LG-H2ar1/J
000459   B10.M-H2f H2-T18a?/SnJ
002225   B10.M-H2f/nMob Fmn1ld-2J/J
001068   B10.M-H2f/nMobJ
000739   B10.M-H2fm2/MobJ
001154   B10.MBR-H2bq1/SxEgJ
010972   B10.NOD-(rs13459151-rs13483054)/1107MrkJ
001825   B10.P-H2kp1/(10R)SgJ
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
003200   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
000458   B10.PL-H2u H2-T18a/(73NS)SnJ
000457   B10.RIII-H2r H2-T18b/(71NS)SnJ
001069   B10.RIII-H2r/(71NS)nMobJ
001760   B10.S-H2as1/(8R)/J
001953   B10.S-H2s/SgMcdJ
001817   B10.S-H2sm1/(12R)SgJ
001650   B10.S-H2t4/(9R)/J
000456   B10.SM H2v H2-T18b/(70NS)Sn-cw/J
001155   B10.T-H2y2/(6R)SgDvEgJ
000445   B10.WB-H2j H2-T18b/SnJ
000444   B10.Y-H2pa H2-T18c/SnJ
003483   B6 x B10.D1-H2q/SgJ-Nox3het-2J/J
003561   B6 x B10.PL-H2u/(73NS)Sn-Hxl/J
002995   B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J
003584   B6.129S2-H2dlAb1-Ea/J
001148   B6.AK-H2k/FlaEgJ
001895   B6.AK-H2k/J
001160   B6.C-H2bm10/KhEgJ
001161   B6.C-H2bm11/KhEgJ
000364   B6.C-H2bm2/ByJ
000369   B6.C-H2bm4/ByJ
001158   B6.C-H2bm7/KhEgJ
000360   B6.C-H2d Mdmg1BALB/cBy/aByJ
000359   B6.C-H2d/bByJ
001429   B6.C-H2g6/J
005715   B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ
007958   B6.Cg-H2b3/FlaCmwJ
007959   B6.Cg-H2b4/FlaCmwJ
005717   B6.Cg-Sostdc1shk H2g7/GrsrJ
003068   B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
004555   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ
003300   B6.NOD-(D17Mit21-D17Mit10)/LtJ
003069   B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ
003071   B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J
003067   B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J
003066   B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J
024949   B6.NOD-(D11Mit167) H2g7/DvsJ
025223   B6.NOD-(D11Mit167-D11Mit48) H2g7/DvsJ
000944   B6.SJL-H2b C3c/2CyJ
000966   B6.SJL-H2s C3c/1CyJ
000945   B6.SW/1CyJ
003374   B6;129S2-H2dlAb1-Ea/J
003240   B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J
002844   BALB.5R-H2i5/LilJ
001165   BALB/c-H2dm2/KhEgJ
001041   BKS.B6-H2b/J
001892   BRVR.B10-H2b/J
001893   BRVR.D2-H2d/J
002845   C.B-H2b Tg(H2-Dd)D8Gja/LilJ
001952   C.B10-H2b/LilMcdJ
001768   C3.Cg-Irs1Sml H2b/GrsrJ
000443   C3.HTG-H2g H2-T18b?/SnJ
000441   C3.JK-H2j H2-T18b/SnJ
000440   C3.LG-H2ar1/CkcCyJ
000439   C3.NB-H2p H2-T18c?/SnJ
000438   C3.SW-H2b/SnJ
000473   C3H-H2o2 C4bb/SfSnJ
001156   C57BL/6J-H2bm3/EgJ
001157   C57BL/6Kh-H2bm5/KhEgJ
000437   D1.C-H2d H2-T18c/SnJ
000436   D1.DA-H2qp1/SnJ
000435   D1.LP-H2b H2-T18b?/SnJ
000434   LP.RIII-H2r H2-T18b/SnJ
001382   LT.MA-Glo1b H2d/J
001383   LT.MA-Glo1b H2k/J
002591   NOD.B10Sn-H2b/J
006935   NOD.Cg-H2b thnh/J
004447   NOD.Cg-H2h4/DilTacUmmJ
001626   NOD.NON-H2nb1/LtJ
002032   NOD.SW-H2q/J
001976   NOD/ShiLtJ
001627   NON.NOD-H2g7/LtJ
002974   STOCK Ces1ce H2d/J
001308   STOCK H2473a/J
003154   WLC.C-H2d/MorJ
003153   WLC.Cg-H2d Mtv2a/MorJ
View Strains carrying other alleles of H2     (132 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Dstncorn1/Dstncorn1

        A.BY H2bc H2-T18f/SnJ-Dstncorn1/J
  • vision/eye phenotype
  • abnormal cornea morphology
    • neutrophil and macrophage infiltration of the cornea   (MGI Ref ID J:139239)
    • infiltration by neutrophils is seen by P12 and persists through P28   (MGI Ref ID J:139239)
    • neutrophils and macrophages are most abundant in the periphery at P14   (MGI Ref ID J:139239)
  • immune system phenotype
  • *normal* immune system phenotype
    • no significant difference is detected in the peripheral blood populations of neutrophils or macrophages compared to controls   (MGI Ref ID J:139239)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Dstncorn1/Dstncorn1

        A.By-H2b/SnJ
  • vision/eye phenotype
  • abnormal corneal epithelium morphology   (MGI Ref ID J:114973)
    • focal areas ~1 mm in diameter are elevated above corneal surface   (MGI Ref ID J:31798)
    • epithelium has "dry", white appearance   (MGI Ref ID J:31798)
    • at 12 days of age, mice show mild edema of basal epithelial layers and corneal surface shows irregularities with focal areas ~1 mm in diameter elevated above corneal surface; corneal surface is increasingly roughened and irregular, until 70 days of age when irregularity stabilizes   (MGI Ref ID J:31798)
    • at 21 and 30 days of age, thickening of epithelium increases   (MGI Ref ID J:31798)
    • surface epithelial cell nuclei are pyknotic and cytoplasm has granular appearance   (MGI Ref ID J:31798)
    • eosinophilia is seen in superficial epithelial cells at 12 days of age, but is decreased by 60 days of age   (MGI Ref ID J:31798)
    • at 4 weeks of age the hyperplastic corneal epithelium has altered expression of keratin 14, involucrin, and lumican   (MGI Ref ID J:83043)
  • cataracts
    • bilateral cataracts develop by 45-50 days of age; progressive lenticular opacification is observed to 8 months of age   (MGI Ref ID J:31798)
    • cataracts are manifested by liquefaction of lens fibers and posterior migration of lens epithelial nuclei   (MGI Ref ID J:31798)
  • corneal vascularization
    • mice exhibit spontaneous corneal vascularization   (MGI Ref ID J:114973)
    • corneal injection of sflt-1 (secreted isoform of the cell surface receptor membrane-bound Flt1) protein reduces the area of vascularization compared to untreated mutants   (MGI Ref ID J:114973)
    • neovascularization is present in limbus at E18; vascularization grows and reaches center of cornea at 45 days   (MGI Ref ID J:31798)
    • hemangiogenesis in the normally avascular cornea is first seen as single sprouts around 2 weeks of age, by 3 weeks of age slit-lamp examination shows outgrowth of limbal blood vessels, and blood vessels cover the corneal surface by approximately 6 weeks of age.   (MGI Ref ID J:98465)
    • corneal hemangiogenesis precedes lymphangiogenesis by approximately one week, and there is no corneal blood vessel regression in the first year.   (MGI Ref ID J:98465)
    • Corneal hemangiogenesis and lymphangiogenesis can be inhibited by treatment with an antibody blocking vascular enothelial growht factor receptor 3   (MGI Ref ID J:98465)
  • cellular phenotype
  • increased cell proliferation
    • in homozygotes, there are 10-fold more proliferating corneal epithelial cells than in wild-type or heterozygous mice   (MGI Ref ID J:31798)
  • cardiovascular system phenotype
  • corneal vascularization
    • mice exhibit spontaneous corneal vascularization   (MGI Ref ID J:114973)
    • corneal injection of sflt-1 (secreted isoform of the cell surface receptor membrane-bound Flt1) protein reduces the area of vascularization compared to untreated mutants   (MGI Ref ID J:114973)
    • neovascularization is present in limbus at E18; vascularization grows and reaches center of cornea at 45 days   (MGI Ref ID J:31798)
    • hemangiogenesis in the normally avascular cornea is first seen as single sprouts around 2 weeks of age, by 3 weeks of age slit-lamp examination shows outgrowth of limbal blood vessels, and blood vessels cover the corneal surface by approximately 6 weeks of age.   (MGI Ref ID J:98465)
    • corneal hemangiogenesis precedes lymphangiogenesis by approximately one week, and there is no corneal blood vessel regression in the first year.   (MGI Ref ID J:98465)
    • Corneal hemangiogenesis and lymphangiogenesis can be inhibited by treatment with an antibody blocking vascular enothelial growht factor receptor 3   (MGI Ref ID J:98465)
  • increased angiogenesis
    • in the cornea   (MGI Ref ID J:98465)
  • immune system phenotype
  • *normal* immune system phenotype
    • the aqueous humor has a normal protein and leukocyte count indicating that the corneal neovascularization and lymphangiogenesis are not mediated primarily by inflammation   (MGI Ref ID J:98465)
    • abnormal lymphangiogenesis
      • Corneal lymphangiogenesis begins with small sprouts around 3 weeks of age, a week after corneal hemangiogenesis begins, and lymphatic vessels are clearly visible by 4 to 6 weeks of age. Vessel fragmentation is seen as early as 2 months of age. Thus, corneal lymphangiogenesis is less severe than hemangiogenesis and comparatively delayed.   (MGI Ref ID J:98465)
      • This corneal lymphangiogenesis occurs in a low inflammatory context in which there are only slightly more CD45 positive cells at 4 weeks of age than in controls.   (MGI Ref ID J:98465)

Dstncorn1/Dstncorn1

        involves: A/WySn * brachy stock * C57BL/6JSmn
  • vision/eye phenotype
  • abnormal corneal epithelium morphology
    • severe epithelial proliferation   (MGI Ref ID J:83125)
  • corneal vascularization   (MGI Ref ID J:83125)
  • cardiovascular system phenotype
  • corneal vascularization   (MGI Ref ID J:83125)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Dstncorn1 related

Cancer Research
Other
      tumor metastasis

Cardiovascular Research
Vascular Defects

Cell Biology Research
Cell Cycle Regulation
Genes Regulating Growth and Proliferation
Post-translational Processing
Signal Transduction

Developmental Biology Research
Eye Defects

Sensorineural Research
Cataracts
      cortical
Eye Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Dstncorn1
Allele Name corneal disease 1
Allele Type Spontaneous
Common Name(s) corn1;
Strain of OriginA.BY-H2bc H2-T18f/SnJ
Gene Symbol and Name Dstn, destrin
Chromosome 2
Gene Common Name(s) 2610043P17Rik; ACTDP; ADF; AU042046; HEL32; RIKEN cDNA 2610043P17 gene; bA462D18.2; corn1; corneal disease 1; expressed sequence AU042046; sid23p;
Molecular Note The mutation in the corn1 mouse was identified as a 35 kb deletion encompassing the entire coding region of the gene. [MGI Ref ID J:83125]
 
Gene Symbol and Name H2, histocompatibility-2, MHC
Chromosome 17
Gene Common Name(s) H-2; MHC-II;
 
Gene Symbol and Name H2-T18, histocompatibility 2, T region locus 18
Chromosome 17
Gene Common Name(s) H-2T18; TL Ag; Tla; thymus leukemia antigen;

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Ikeda S; Cunningham LA; Boggess D; Hobson CD; Sundberg JP; Naggert JK; Smith RS; Nishina PM. 2003. Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet 12(9):1029-37. [PubMed: 12700171]  [MGI Ref ID J:83125]

Wang I; Kao CW; Liu C; Saika S; Nishina PM; Sundberg JP; Smith RS; Kao WW. 2001. Characterization of Corn1 mice: Alteration of epithelial and stromal cell gene expression. Mol Vis 7:20-6. [PubMed: 11182022]  [MGI Ref ID J:83043]

Dstncorn1 related

Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. [PubMed: 17051153]  [MGI Ref ID J:114973]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Cursiefen C; Ikeda S; Nishina PM; Smith RS; Ikeda A; Jackson D; Mo JS; Chen L; Dana MR; Pytowski B; Kruse FE; Streilein JW. 2005. Spontaneous Corneal Hem- and Lymphangiogenesis in Mice with Destrin-Mutation Depend on VEGFR3 Signaling. Am J Pathol 166(5):1367-77. [PubMed: 15855638]  [MGI Ref ID J:98465]

Ikeda S; Cunningham LA; Boggess D; Hobson CD; Sundberg JP; Naggert JK; Smith RS; Nishina PM. 2003. Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet 12(9):1029-37. [PubMed: 12700171]  [MGI Ref ID J:83125]

Kawakami-Schulz SV; Sattler SG; Doebley AL; Ikeda A; Ikeda S. 2013. Genetic modification of corneal neovascularization in Dstn (corn1) mice. Mamm Genome 24(9-10):349-57. [PubMed: 23929036]  [MGI Ref ID J:201614]

Kawakami-Schulz SV; Verdoni AM; Sattler SG; Ikeda A; Ikeda S. 2012. Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background. Mol Vis 18:606-16. [PubMed: 22419854]  [MGI Ref ID J:191621]

Kawakami-Schulz SV; Verdoni AM; Sattler SG; Jessen E; Kao WW; Ikeda A; Ikeda S. 2014. Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea. Physiol Genomics 46(8):277-89. [PubMed: 24550211]  [MGI Ref ID J:208758]

Kousaka K; Kiyonari H; Oshima N; Nagafuchi A; Shima Y; Chisaka O; Uemura T. 2008. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. Genesis 46(5):246-55. [PubMed: 18442045]  [MGI Ref ID J:136245]

Mahaffey JP; Grego-Bessa J; Liem KF Jr; Anderson KV. 2013. Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development 140(6):1262-71. [PubMed: 23406901]  [MGI Ref ID J:194042]

Smith RS; Hawes NL; Kuhlmann SD; Heckenlively JR; Chang B; Roderick TH; Sundberg JP. 1996. Corn1: a mouse model for corneal surface disease and neovascularization. Invest Ophthalmol Vis Sci 37(2):397-404. [PubMed: 8603845]  [MGI Ref ID J:31798]

Verdoni AM; Aoyama N; Ikeda A; Ikeda S. 2008. Effect of destrin mutations on the gene expression profile in vivo. Physiol Genomics 34(1):9-21. [PubMed: 18381839]  [MGI Ref ID J:145310]

Verdoni AM; Schuster KJ; Cole BS; Ikeda A; Kao WW; Ikeda S. 2010. A pathogenic relationship between a regulator of the actin cytoskeleton and serum response factor. Genetics 186(1):147-57. [PubMed: 20610412]  [MGI Ref ID J:164255]

Verdoni AM; Smith RS; Ikeda A; Ikeda S. 2008. Defects in actin dynamics lead to an autoinflammatory condition through the upregulation of CXCL5. PLoS ONE 3(7):e2701. [PubMed: 18628996]  [MGI Ref ID J:139239]

Wang I; Kao CW; Liu C; Saika S; Nishina PM; Sundberg JP; Smith RS; Kao WW. 2001. Characterization of Corn1 mice: Alteration of epithelial and stromal cell gene expression. Mol Vis 7:20-6. [PubMed: 11182022]  [MGI Ref ID J:83043]

Zhang W; Zhao J; Chen L; Urbanowicz MM; Nagasaki T. 2008. Abnormal epithelial homeostasis in the cornea of mice with a destrin deletion. Mol Vis 14:1929-39. [PubMed: 18958303]  [MGI Ref ID J:144053]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $125.45Female or MaleHomozygous for Dstncorn1  
Price per Pair (US dollars $)Pair Genotype
$250.85Homozygous for Dstncorn1 x Homozygous for Dstncorn1  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $163.10Female or MaleHomozygous for Dstncorn1  
Price per Pair (US dollars $)Pair Genotype
$326.20Homozygous for Dstncorn1 x Homozygous for Dstncorn1  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

General Supply Notes

Control Information

  Control
   000646 A/J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use


General Terms and Conditions


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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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