|The AXB and BXA set of RI strains are useful in the genetic analysis of complex diseases. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin. AXB and BXA strains are derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains.|
Former Names AXB14/PgnJ (Changed: 14-SEP-06 ) AXB-14/Pgn (Changed: 15-DEC-04 ) AXB-14/PgnJ (Changed: 15-DEC-04 ) Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Species laboratory mouse RI progenitor A/J C57BL/6J H2 Haplotype b
Through high density SNP analysis, some AXB and BXA recombinant inbred strains were shown to be the same or nearly the same genetically. AXB13/PgnJ and AXB14/PgnJ are considered "sister strains" being identical throughout much of the genome but differing in large regions of Chromosomes 11, 12, 13, and in small regions of a few other Chromosomes. Because these two strains are "near congenics" a nomenclature change has been made to update AXB14/PgnJ to AXB13a/PgnJ. In general, "sister" strains (those with suffixes of a or b) should not be used for primary screening/QTL mapping. However, if a QTL is located in a region of difference in a sister recombinant inbred then this strain can serve as a "near congenic" for additional analysis.
The strain distribution pattern (SDP) for the AXB RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .
The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.
001673 AXB1/PgnJ 001681 AXB10/PgnJ 001683 AXB12/PgnJ 001826 AXB13/PgnJ 001685 AXB15/PgnJ 001687 AXB19/PgnJ 001686 AXB19a/PgnJ 001688 AXB19b/PgnJ 001674 AXB2/PgnJ 001690 AXB23/PgnJ 001691 AXB24/PgnJ 001676 AXB4/PgnJ 001677 AXB5/PgnJ 001678 AXB6/PgnJ 001679 AXB8/PgnJView AXB Strains (15 strains)Strains carrying Nrg3ska allele
000646 A/J 001673 AXB1/PgnJ 001681 AXB10/PgnJ 001826 AXB13/PgnJ 001687 AXB19/PgnJ 001688 AXB19b/PgnJ 001674 AXB2/PgnJ 001690 AXB23/PgnJ 001676 AXB4/PgnJ 001678 AXB6/PgnJ 001701 BXA13/PgnJ 001702 BXA14/PgnJ 001703 BXA16/PgnJ 001710 BXA24/PgnJ 001711 BXA25/PgnJ 001999 BXA26/PgnJ 001694 BXA4/PgnJ 001696 BXA7/PgnJ 001697 BXA8/PgnJView Strains carrying Nrg3ska (19 strains)
View Phenotypic DataPhenotypic DataView Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Behavioral and Learning Defects
genes regulating preferences to alcohol and stress
Diabetes and Obesity Research
Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
Immunology, Inflammation and Autoimmunity Research
genes regulating susceptibility to infectious disease and endotoxin
|Strain of Origin||A/J|
|Gene Symbol and Name||Nrg3, neuregulin 3|
|Gene Common Name(s)||HRG3; RGD1559678; pro-NRG3; scaramanga; ska;|
|Molecular Note||This allele maps to an interval between the microsatellite markers D14Mit14 and D14Mit80 located at 10.0 cM and 13.5 cM. The mutation identified is a microsatellite repeat within intron 7 of the gene. This simple sequence repeat (SSR) was found to completely cosegregate with the ska phenotype. [MGI Ref ID J:100495]|
Brodkin ES; Carlezon WA Jr; Haile CN; Kosten TA; Heninger GR ; Nestler EJ. 1998. Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice. Brain Res 805(1-2):55-68. [PubMed: 9733917] [MGI Ref ID J:50636]
Gill K; Desaulniers N; Desjardins P; Lake K. 1998. Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Mamm Genome 9(12):929-35. [PubMed: 9880655] [MGI Ref ID J:52467]
Hamidi S; Aliesky HA; Williams RW; Rapoport B; McLachlan SM. 2013. Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function. Thyroid 23(3):360-70. [PubMed: 22988948] [MGI Ref ID J:204730]
Llamas B; Belanger S; Picard S; Deschepper CF. 2007. Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31(2):176-82. [PubMed: 17566079] [MGI Ref ID J:127219]
Martin MV; Dong H; Vallera D; Lee D; Lu L; Williams RW; Rosen GD; Cheverud JM; Csernansky JG. 2006. Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes Brain Behav 5(8):614-23. [PubMed: 17081266] [MGI Ref ID J:117408]
McLachlan SM; Lu L; Aliesky HA; Williams RW; Rapoport B. 2011. Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. Endocrinology 152(3):1172-9. [PubMed: 21209025] [MGI Ref ID J:173883]
Mu JL; Naggert JK; Nishina PM; Cheah YC; Paigen B. 1993. Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18. Mamm Genome 4(3):148-52. [PubMed: 8094988] [MGI Ref ID J:4133]
Sampson SB; Higgins DC; Elliot RW; Taylor BA; Lueders KK; Koza RA; Paigen B. 1998. An edited linkage map for the AXB and BXA recombinant inbred mouse strains. Mamm Genome 9(9):688-94. [PubMed: 9716653] [MGI Ref ID J:45463]Nrg3ska related
Animal Health ReportsProduction of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
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Cryopreserved Mice - Ready for Recovery
Price (US dollars $) Cryorecovery* $2525.00
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Cryopreserved Mice - Ready for Recovery
Price (US dollars $) Cryorecovery* $3283.00
Cryorecovery - Standard.
Progeny testing is not required.
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