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The AXB and BXA set of RI strains are useful in the genetic analysis of complex diseases. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin. AXB and BXA strains are derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains.


Strain Information

Former Names AXB-19/PgnJ    (Changed: 15-DEC-04 )
Type Recombinant Inbred (RI);
Additional information on Recombinant Inbred Mice.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   14-APR-15
Specieslaboratory mouse
RI progenitor A/J C57BL/6J
H2 Haplotypeb
GenerationF70+26 (04-MAY-15)
Generation Definitions

Related Genotype: a/a Tyrp1+/Tyrp1+ Tyr+/Tyr+

Through high density SNP analysis, some AXB and BXA recombinant inbred strains were shown to be the same or nearly the same genetically. AXB18/Pgn, AXB19/Pgn, and AXB20/Pgn were found to be highly similar in their overall genomes, but with particular Chromosomes differing between them. Two of these "sister" strains were renamed. AXB19/Pgn was designated the primary strain since it has the best traceable history, and therefore its name remained unchanged. AXB18/Pgn was renamed AXB19a/Pgn and AXB20/Pgn was renamed AXB19b/Pgn. In general, the "sister" strains (those with suffixes of a or b) should not be used for primary screening/QTL mapping. However, if a QTL is located in a region of difference in a sister recombinant inbred then this strain can serve as a "near congenic" for additional analysis.

The AXB and BXA set of RI strains are useful in the genetic analysis of several complex diseases including cardiovascular disease, diabetes, cancer, cleft palate, and hydrocephalus. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin.

The strain distribution pattern (SDP) for the AXB RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .

The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.

Related Strains

AXB Strains
001673   AXB1/PgnJ
001681   AXB10/PgnJ
001683   AXB12/PgnJ
001826   AXB13/PgnJ
001684   AXB13a/PgnJ
001685   AXB15/PgnJ
001686   AXB19a/PgnJ
001688   AXB19b/PgnJ
001674   AXB2/PgnJ
001690   AXB23/PgnJ
001691   AXB24/PgnJ
001676   AXB4/PgnJ
001677   AXB5/PgnJ
001678   AXB6/PgnJ
001679   AXB8/PgnJ
View AXB Strains     (15 strains)

Strains carrying   Nrg3ska allele
000646   A/J
001673   AXB1/PgnJ
001681   AXB10/PgnJ
001826   AXB13/PgnJ
001684   AXB13a/PgnJ
001688   AXB19b/PgnJ
001674   AXB2/PgnJ
001690   AXB23/PgnJ
001676   AXB4/PgnJ
001678   AXB6/PgnJ
001701   BXA13/PgnJ
001702   BXA14/PgnJ
001703   BXA16/PgnJ
001710   BXA24/PgnJ
001711   BXA25/PgnJ
001999   BXA26/PgnJ
001694   BXA4/PgnJ
001696   BXA7/PgnJ
001697   BXA8/PgnJ
View Strains carrying   Nrg3ska     (19 strains)

Additional Web Information

JAX® NOTES, Spring 1996; 465. AXB/BXA Recombinant Inbred Strains.
JAX® NOTES, Winter 2006; 504. AXB and BXA RI Strains Reclassified.


Phenotype Information

View Phenotypic Data

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Behavioral and Learning Defects
      genes regulating preferences to alcohol and stress

Research Tools
Cardiovascular Research
Diabetes and Obesity Research
Genetics Research
      Gene Mapping
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
Immunology, Inflammation and Autoimmunity Research
      genes regulating susceptibility to infectious disease and endotoxin

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Nrg3ska
Allele Name scaramanga
Allele Type Spontaneous
Common Name(s) ska;
Strain of OriginA/J
Gene Symbol and Name Nrg3, neuregulin 3
Chromosome 14
Gene Common Name(s) HRG3; RGD1559678; pro-NRG3; scaramanga; ska;
Molecular Note This allele maps to an interval between the microsatellite markers D14Mit14 and D14Mit80 located at 10.0 cM and 13.5 cM. The mutation identified is a microsatellite repeat within intron 7 of the gene. This simple sequence repeat (SSR) was found to completely cosegregate with the ska phenotype. [MGI Ref ID J:100495]


Genotyping Information

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Additional References

Brodkin ES; Carlezon WA Jr; Haile CN; Kosten TA; Heninger GR ; Nestler EJ. 1998. Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice. Brain Res 805(1-2):55-68. [PubMed: 9733917]  [MGI Ref ID J:50636]

Gill K; Desaulniers N; Desjardins P; Lake K. 1998. Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Mamm Genome 9(12):929-35. [PubMed: 9880655]  [MGI Ref ID J:52467]

Hamidi S; Aliesky HA; Williams RW; Rapoport B; McLachlan SM. 2013. Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function. Thyroid 23(3):360-70. [PubMed: 22988948]  [MGI Ref ID J:204730]

Llamas B; Belanger S; Picard S; Deschepper CF. 2007. Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31(2):176-82. [PubMed: 17566079]  [MGI Ref ID J:127219]

Marshall JD; Mu JL; Cheah YC; Nesbitt MN; Frankel WN; Paigen B. 1992. The AXB and BXA set of recombinant inbred mouse strains. Mamm Genome 3(12):669-80. [PubMed: 1477475]  [MGI Ref ID J:3516]

Martin MV; Dong H; Vallera D; Lee D; Lu L; Williams RW; Rosen GD; Cheverud JM; Csernansky JG. 2006. Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes Brain Behav 5(8):614-23. [PubMed: 17081266]  [MGI Ref ID J:117408]

McLachlan SM; Lu L; Aliesky HA; Williams RW; Rapoport B. 2011. Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. Endocrinology 152(3):1172-9. [PubMed: 21209025]  [MGI Ref ID J:173883]

Mu JL; Naggert JK; Nishina PM; Cheah YC; Paigen B. 1993. Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18. Mamm Genome 4(3):148-52. [PubMed: 8094988]  [MGI Ref ID J:4133]

Sampson SB; Higgins DC; Elliot RW; Taylor BA; Lueders KK; Koza RA; Paigen B. 1998. An edited linkage map for the AXB and BXA recombinant inbred mouse strains. Mamm Genome 9(9):688-94. [PubMed: 9716653]  [MGI Ref ID J:45463]

Nrg3ska related

Howard B; Panchal H; McCarthy A; Ashworth A. 2005. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev 19(17):2078-90. [PubMed: 16140987]  [MGI Ref ID J:100495]

Howard BA; Gusterson BA. 2000. Mammary gland patterning in the AXB/BXA recombinant inbred strains of mouse. Mech Dev 91(1-2):305-9. [PubMed: 10704854]  [MGI Ref ID J:61355]

Howard BA; Gusterson BA. 2000. The characterization of a mouse mutant that displays abnormal mammary gland development. Mamm Genome 11(3):234-7. [PubMed: 10723730]  [MGI Ref ID J:60708]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   14-APR-15
Diet Information New Diet as of March 2015: Lab Diet® 5K0Q (6% fat)

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

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Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

General Supply Notes

  • This strain is included in the Special Mutant Stock Resource collection.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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