Description

Strain Information

Former Names BXA-16/PgnJ    (Changed: 15-DEC-04 ) Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse RI progenitor C57BL/6J A/J H2 Haplotype b Generation F44p+28 (21-DEC-10) Generation Definitions

Appearance
albino
Related Genotype: a/a Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c

Description
The AXB and BXA set of RI strains are useful in the genetic analysis of several complex diseases including cardiovascular disease, diabetes, cancer, cleft palate, and hydrocephalus. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin. The strain distribution pattern (SDP) for both the AXB and BXA RI strains is available through the Mouse Genome Informatics Recombinant Inbred Strain Distribution Patterns Query Form.

Development
The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.

Related Strains

BXA Strains

001692	BXA1/PgnJ
001699	BXA11/PgnJ
001700	BXA12/PgnJ
001701	BXA13/PgnJ
001702	BXA14/PgnJ
001693	BXA2/PgnJ
001710	BXA24/PgnJ
001711	BXA25/PgnJ
001999	BXA26/PgnJ
001694	BXA4/PgnJ
001696	BXA7/PgnJ
001697	BXA8/PgnJ

View BXA Strains     (12 strains)

Strains carrying   Nrg3^ska allele

000646	A/J
001673	AXB1/PgnJ
001681	AXB10/PgnJ
001826	AXB13/PgnJ
001684	AXB13a/PgnJ
001687	AXB19/PgnJ
001688	AXB19b/PgnJ
001674	AXB2/PgnJ
001690	AXB23/PgnJ
001676	AXB4/PgnJ
001678	AXB6/PgnJ
001701	BXA13/PgnJ
001702	BXA14/PgnJ
001710	BXA24/PgnJ
001711	BXA25/PgnJ
001999	BXA26/PgnJ
001694	BXA4/PgnJ
001696	BXA7/PgnJ
001697	BXA8/PgnJ

View Strains carrying   Nrg3^ska     (19 strains)

Strains carrying other alleles of Nrg3

000646	A/J
001673	AXB1/PgnJ
001681	AXB10/PgnJ
001826	AXB13/PgnJ
001684	AXB13a/PgnJ
001687	AXB19/PgnJ
001688	AXB19b/PgnJ
001674	AXB2/PgnJ
001690	AXB23/PgnJ
001676	AXB4/PgnJ
001678	AXB6/PgnJ
001701	BXA13/PgnJ
001702	BXA14/PgnJ
001710	BXA24/PgnJ
001711	BXA25/PgnJ
001999	BXA26/PgnJ
001694	BXA4/PgnJ
001696	BXA7/PgnJ
001697	BXA8/PgnJ

View Strains carrying other alleles of Nrg3     (19 strains)

Additional Web Information

JAX^® NOTES, Spring 1996; 465. AXB/BXA Recombinant Inbred Strains.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for BXA RI Line

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Behavioral and Learning Defects
      genes regulating preferences to alcohol and stress

Research Tools
Cardiovascular Research
Diabetes and Obesity Research
Genetics Research
      Gene Mapping
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
Immunology and Inflammation Research
      genes regulating susceptibility to infectious disease and endotoxin

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Nrg3ska
Allele Name		scaramanga
Allele Type		Spontaneous
Common Name(s)		ska;
Strain of Origin		A/J
Gene Symbol and Name		Nrg3, neuregulin 3
Chromosome		14
Gene Common Name(s)		HRG3; RGD1559678; pro-NRG3; scaramanga; ska;
Molecular Note		This allele maps to an interval between the microsatellite markers D14Mit14 and D14Mit80 located at 10.0 cM and 13.5 cM. The mutation identified is a microsatellite repeat within intron 7 of the gene. This simple sequence repeat (SSR) was found to completely cosegregate with the ska phenotype. [MGI Ref ID J:100495]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Brodkin ES; Carlezon WA Jr; Haile CN; Kosten TA; Heninger GR ; Nestler EJ. 1998. Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice. Brain Res 805(1-2):55-68. [PubMed: 9733917]  [MGI Ref ID J:50636]

Gill K; Desaulniers N; Desjardins P; Lake K. 1998. Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Mamm Genome 9(12):929-35. [PubMed: 9880655]  [MGI Ref ID J:52467]

Marshall JD; Mu JL; Cheah YC; Nesbitt MN; Frankel WN; Paigen B. 1992. The AXB and BXA set of recombinant inbred mouse strains. Mamm Genome 3(12):669-80. [PubMed: 1477475]  [MGI Ref ID J:3516]

Mu JL; Naggert JK; Nishina PM; Cheah YC; Paigen B. 1993. Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18. Mamm Genome 4(3):148-52. [PubMed: 8094988]  [MGI Ref ID J:4133]

Sampson SB; Higgins DC; Elliot RW; Taylor BA; Lueders KK; Koza RA; Paigen B. 1998. An edited linkage map for the AXB and BXA recombinant inbred mouse strains. Mamm Genome 9(9):688-94. [PubMed: 9716653]  [MGI Ref ID J:45463]

Nrg3^ska related

Howard B; Panchal H; McCarthy A; Ashworth A. 2005. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev 19(17):2078-90. [PubMed: 16140987]  [MGI Ref ID J:100495]

Howard BA; Gusterson BA. 2000. Mammary gland patterning in the AXB/BXA recombinant inbred strains of mouse. Mech Dev 91(1-2):305-9. [PubMed: 10704854]  [MGI Ref ID J:61355]

Howard BA; Gusterson BA. 2000. The characterization of a mouse mutant that displays abnormal mammary gland development. Mamm Genome 11(3):234-7. [PubMed: 10723730]  [MGI Ref ID J:60708]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Special Mutant Stock Resource collection.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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