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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6-Aw-J-EdaTa-6J.Cg-Tp(Y)1Ctsxr-b Hya- (Changed: 15-DEC-04 ) Type Chromosome Aberration; Transposition; Additional information on Mice with Chromosomal Aberrations. Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Donor Strain spontaneous deletion in Sxra , derived from Falconer strain via stock bearing Is(In7;X)1 Generation N23
Generation Definitions
Related Strains
Y Chromosomal Aberrations
000552 B6-Aw-J-EdaTa-6J.Cg-Sxr 002021 B6Ei.LT-Y(IsXPAR;Y)Ei/EiJ 000787 BALB/cByJ-Chr YMET/J 000908 C57BL/6J-Chr YMET/J View Y Chromosomal Aberrations (4 strains)
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 000552 B6-Aw-J-EdaTa-6J.Cg-Sxr 001809 B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J 000338 C57BL/6J Aw-J-EdaTa-6J/J
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 000552 B6-Aw-J-EdaTa-6J.Cg-Sxr 000841 B6-Aw-J.CBy-EdaTa-By/J 001809 B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J 000314 B6CBACa Aw-J/A-EdaTa/J-XO 000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 001232 C3H/HeJ-EdaTa-5J/J 000338 C57BL/6J Aw-J-EdaTa-6J/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J 003112 STOCK EdaTa-5J/J 000583 STOCK T(X;16)16H +/+ EdaTa
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 000552 B6-Aw-J-EdaTa-6J.Cg-Sxr
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tp(Y)1CtSxr-b/+
Background Not SpecifiedThis mouse can be used to support research in many areas including:
EdaTa-6J relatedReproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects
Research Tools
Genetics Research
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Developmental Biology Research
Eye Defects
Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia
Sensorineural Research
Eye Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | EdaTa-6J | ||
| Allele Name | tabby 6 Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Ta2; Ta6J; Tabby; | ||
| Strain of Origin | C57BL/6J-tp3J/J | ||
| Gene Symbol and Name | Eda, ectodysplasin-A | ||
| Chromosome | X | ||
| Gene Common Name(s) | ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; ODT1; RGD1563178; STHAGX1; Ta; XHED; XLHED; tabby; | ||
| Molecular Note | This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation. [MGI Ref ID J:42614] | ||
| Allele Symbol | Tp(Y)1CtSxr-b | ||
| Allele Name | Sex reversed, b variant | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | HY-; Sxr'; | ||
| Strain of Origin | T16H stock | ||
| Gene Symbol and Name | Tp(Y)1Ct, transposition, Chr Y, Cattanach 1 | ||
| Chromosome | Y | ||
| Gene Common Name(s) | Sxr; Tp1Ct; sex reversed, chromosomal aberration; | ||
| Associated Marker Note | Affected-Count: 2Af1-Gene: MGI:99212 Af2-Gene: MGI:96296 | ||
| Molecular Note | At least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy, Zfy1, and Zfy2. The Tp(Y)1CtSxr-b variant retained the testis determining gene, Sry, but lost the H-Y antigen-determining gene, Hya. This chromosomal variant also appears to lackone of the Y-linked zinc finger genes, Zfy1 but retains the other, Zfy2. The formation of Tp(Y)1CtSxr-b from Tp(Y)1CtSxr-a was later shown to be due to unequal crossing over between Zfy1 and Zfy2, resulting in a fusion gene and a small interstitial deletion. XX females carrying this transposition variant are sex-reversed but do not express Y Chromosome linked transplantation antigen, Hya. [MGI Ref ID J:9332] | ||
| Gene Symbol and Name | Hya, histocompatibility Y | ||
| Chromosome | Y | ||
| Gene Common Name(s) | H-Y; Sdma; Y linked serologically defined male antigen; | ||
References
References provided by MGI
Additional References
Aw-J relatedEdaTa-6J relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]
Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713] [MGI Ref ID J:145908]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]
Cunningham D; Spychala K; McLarren KW; Garza LA; Boerkoel CF; Herman GE. 2009. Developmental expression pattern of the cholesterogenic enzyme NSDHL and negative selection of NSDHL-deficient cells in the heterozygous Bpa(1H)/+ mouse. Mol Genet Metab 98(4):356-66. [PubMed: 19631568] [MGI Ref ID J:155028]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]
Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194] [MGI Ref ID J:32132]
Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738] [MGI Ref ID J:31403]
Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990] [MGI Ref ID J:61324]
Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442] [MGI Ref ID J:1295]
Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941] [MGI Ref ID J:101081]
Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031] [MGI Ref ID J:146365]
Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695] [MGI Ref ID J:126508]
Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869] [MGI Ref ID J:111363]
Martin LA; Goldowitz D; Mittleman G. 2010. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur J Neurosci 31(3):544-55. [PubMed: 20105240] [MGI Ref ID J:159466]
Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326] [MGI Ref ID J:5288]
Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460] [MGI Ref ID J:52138]
Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102] [MGI Ref ID J:52183]
Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]
Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]
O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570] [MGI Ref ID J:100906]
Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097] [MGI Ref ID J:119427]
Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086] [MGI Ref ID J:114943]
Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]
Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648] [MGI Ref ID J:138994]
Prtenjaca A; Hill KA. 2011. Mutation frequency is not elevated in the cerebellum of harlequin/Big Blue((R)) mice but Class II deletions occur preferentially in young harlequin cerebellum. Mutat Res 707(1-2):53-60. [PubMed: 21195094] [MGI Ref ID J:168461]
Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]
Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]
Zhang M; Su YQ; Sugiura K; Xia G; Eppig JJ. 2010. Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science 330(6002):366-9. [PubMed: 20947764] [MGI Ref ID J:164870]
van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]
Tp(Y)1CtSxr-b relatedCharles C; Pantalacci S; Peterkova R; Peterka M; Laudet V; Viriot L. 2007. Disruption of the palatal rugae pattern in Tabby (eda) mutant mice. Eur J Oral Sci 115(6):441-8. [PubMed: 18028050] [MGI Ref ID J:147677]
Cui CY; Durmowicz M; Ottolenghi C; Hashimoto T; Griggs B; Srivastava AK; Schlessinger D. 2003. Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet 12(22):2931-40. [PubMed: 14506134] [MGI Ref ID J:86628]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]
Cui CY; Smith JA; Schlessinger D; Chan CC. 2005. X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. Am J Pathol 167(1):89-95. [PubMed: 15972955] [MGI Ref ID J:99510]
Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]
Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. [PubMed: 9285798] [MGI Ref ID J:42614]
Kunisada M; Cui CY; Piao Y; Ko MS; Schlessinger D. 2009. Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet 18(10):1769-78. [PubMed: 19270025] [MGI Ref ID J:147576]
Sweet HO; Davisson MT. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313) Mouse Genome 93(4):1030-4. [MGI Ref ID J:30778]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Agulnik AI; Harrison WR; Bishop CE. 2001. Smcy transgene does not rescue spermatogenesis in sex-reversed mice. Mamm Genome 12(2):112-6. [PubMed: 11210179] [MGI Ref ID J:69107]
Clemente EJ; Furlong RA; Loveland KL; Affara NA. 2006. Gene expression study in the juvenile mouse testis: identification of stage-specific molecular pathways during spermatogenesis. Mamm Genome 17(9):956-75. [PubMed: 16964443] [MGI Ref ID J:112872]
Epplen JT; Studer R; McLaren A. 1988. Heterogeneity in the Sxr (sex-reversal) locus of the mouse as revealed by synthetic GATA-GACA probes. Genet Res 51(3):239-46. [PubMed: 3417145] [MGI Ref ID J:9360]
Lovell-Badge R; Robertson E. 1990. XY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy. Development 109(3):635-46. [PubMed: 2401216] [MGI Ref ID J:10734]
Mazeyrat S; Saut N; Grigoriev V; Mahadevaiah SK; Ojarikre OA; Rattigan A; Bishop C; Eicher EM; Mitchell MJ; Burgoyne PS. 2001. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet 29(1):49-53. [PubMed: 11528390] [MGI Ref ID J:71548]
McLaren A; Monk M. 1982. Fertile females produced by inactivation of an X chromosome of 'sex-reversed' mice. Nature 300(5891):446-8. [PubMed: 7144898] [MGI Ref ID J:160201]
McLaren A; Simpson E; Epplen JT; Studer R; Koopman P; Evans EP; Burgoyne PS. 1988. Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome. Proc Natl Acad Sci U S A 85(17):6442-5. [PubMed: 3261868] [MGI Ref ID J:9331]
McLaren A; Simpson E; Tomonari K; Chandler P; Hogg H. 1984. Male sexual differentiation in mice lacking H-Y antigen. Nature 312(5994):552-5. [PubMed: 6542174] [MGI Ref ID J:7662]
Nagamine CM; Capehart J; Carlisle C; Chang D. 1998. Ovotestes in B6-XXSxr sex-reversed mice. Dev Biol 196(1):24-32. [PubMed: 9527878] [MGI Ref ID J:47046]
Rabionet M; van der Spoel AC; Chuang CC; von Tumpling-Radosta B; Litjens M; Bouwmeester D; Hellbusch CC; Korner C; Wiegandt H; Gorgas K; Platt FM; Grone HJ; Sandhoff R. 2008. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 283(19):13357-69. [PubMed: 18308723] [MGI Ref ID J:137091]
Roberts C; Weith A; Passage E; Michot JL; Mattei MG; Bishop CE. 1988. Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm. Proc Natl Acad Sci U S A 85(17):6446-9. [PubMed: 3413106] [MGI Ref ID J:9332]
Simpson EM; Page DC. 1991. An interstitial deletion in mouse Y chromosomal DNA created a transcribed Zfy fusion gene. Genomics 11(3):601-8. [PubMed: 1774064] [MGI Ref ID J:11581]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.Colony Maintenance
Breeding & Husbandry Comments: This strain is maintained using EdaTa-6J as a phenotypic marker to expedite progeny testing at each of the two alternate generations. In the first generation a XEda-Ta-6JY? male is bred to a C57BL/6J-Aw-J female (Stock No. 000051); striped male offspring (genotype XXEda-Ta-6J sxrb) prove that the male parent is XEda-Ta-6JYsxrb. Four genotypically distinct offspring result from the breeding scheme C57BL/6J-Aw-J x XEda-Ta-6JYsxrb: XXEda-Ta-6J transversely striped females; XY normal males; XYsxrb phenotypically normal males; and XXEda-Ta-6J sxrb which are transversely striped, sterile males due to sex-reversion and which prove the paternal genotype. The phenotypically normal males are then bred with heterozygous C57BL/6J-Aw-J-EdaTa-6J females (Stock No. 000338) in the second generation of breeding. Again, transversely striped male offspring (genotype XXTa-6J sxrb) of these breeding pairs prove that the male parent is a carrier of Ysxrb. Eight genotypically distinct offspring result from the breeding scheme heterozygous C57BL/6J-Aw-J-EdaTa-6J x XYsxrb: XY normal males; XYsxrb phenotypically normal males; XEda-Ta-6JY tabby males; XEda-Ta-6JYsxrb tabby males; XX normal females; XEda-Ta-6JX transversely striped females; XXsxrb sterile males; and XEda-Ta-6JXsxrb transversely striped sterile males that prove the paternal genotype to be XYsxrb. The Tabby male progeny (XEda-Ta-6JY?) are then bred with C57BL/6J-Aw-J females for the first generation progeny test (C57BL/6J-Aw-J x XEda-Ta-6JYsxrb). XXsxrb sex-reversed males can be distinguished from XY and XYsxrb males by their small testes which are detectable by palpation at 6-8 weeks of age. C57BL/6J-Aw-J is used in breeding because the agouti coat color is necessary for viewing the EdaTa-6J phenotypes. It is important to note that only the Xsxrb carrying progeny of these breeding schemes will be sex reversed; XYsxrb mice a re male, not sex reversed. XXsxrb and XEda-Ta-6JXsxrb sex-reversed males are sterile.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery of Strains Needing Progeny Testing.
At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks.Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery of Strains Needing Progeny Testing.
At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks.Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.