Description

Strain Information

Type Mutant Stock; Additional information on Genetically Engineered Mutant Mice. Mating System Progeny Tested         (Female x Male) TJL Breeding Scheme: progeny tested then heterozygote x heterozygote TJL Breeding Summary: +/? x ?/+ then heterozygote x heterozygote Species laboratory mouse Generation ?+F68 (14-DEC-07)

Appearance
grey, small body size
Related Genotype: A/A dwg/dwg

agouti, normal size
Related Genotype: A/A dwg/+ or A/A +/+ or A/A +/?

Description
Mice homozgyous for the dwarf grey spontaneous mutation (dwg) are viable but do not breed. Homozygous mutant mice have grey coats, are smaller than littermates, and develop cataracts by 3-4 weeks of age. Additional characteristics include increased numbers of osteoclasts, reduced bone mass, reduced red pulp area of the spleen, and slightly reduced thyroxin levels.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of dwg

003100

STOCK dwgBayer/J

View Strains carrying other alleles of dwg     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

dwg/dwg

        (STOCK Pou1f1^dw x T(8;16)17H)F1

• pigmentation phenotype
• diluted coat color (MGI Ref ID J:14281)
  • appear grey
• growth/size phenotype
• disproportionate dwarf (MGI Ref ID J:14281)
• hematopoietic system phenotype
• decreased spleen red pulp amount (MGI Ref ID J:14281)
• increased osteoclast cell number (MGI Ref ID J:14281)
  • increased numbers of osteoclasts
• immune system phenotype
• decreased spleen red pulp amount (MGI Ref ID J:14281)
• increased osteoclast cell number (MGI Ref ID J:14281)
  • increased numbers of osteoclasts
• reproductive system phenotype
• infertility (MGI Ref ID J:14281)
  • mice are unable to breed
• skeleton phenotype
• decreased bone mass (MGI Ref ID J:14281)
• increased osteoclast cell number (MGI Ref ID J:14281)
  • increased numbers of osteoclasts
• skin/coat/nails phenotype
• diluted coat color (MGI Ref ID J:14281)
  • appear grey
• vision/eye phenotype
• cataracts (MGI Ref ID J:14281)
  • obvious at 3-4 weeks of age
• homeostasis/metabolism phenotype
• decreased thyroxine level (MGI Ref ID J:14281)
  • slightly reduced thyroxin levels

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

dwg related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Growth Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Spleen Defects
Thyroid Defects

Internal/Organ Research
Spleen Defects
Thyroid Defects

Sensorineural Research
Eye Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		dwg
Allele Name		dwarf grey
Allele Type		Spontaneous
Strain of Origin		(STOCK Pou1f1dw x T(8;16)17H)F1

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

dwg related

Harris B; Davisson MT. 1990. Dwarf grey (dwg). Mouse Genome 86:238.  [MGI Ref ID J:14281]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Mating System	Progeny Tested         (Female x Male)
	TJL Breeding Scheme: progeny tested then heterozygote x heterozygote TJL Breeding Summary: +/? x ?/+ then heterozygote x heterozygote

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.