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Strain Name:

B6C3Fe a/a-Cacng2stg/J

Stock Number:

001756

Availability:

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General Terms and Conditions

Former Name      B6C3Fe-a/a-Cacng2stg/+    (Changed: 15-DEC-04 )
Genes & Alleles   Cacng2;   Cacng2stg;   a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Mating SystemOutcross-Intercross         (Female x Male)
TJL Breeding Summary: homozygote x B6C3Fe a/a F1 then heterozygote x heterozygote
Specieslaboratory mouse
GenerationN43F2 (14-DEC-07)

Appearance
black, ataxic
Related Genotype: a/a Cacng2stg/Cacng2stg

black, unaffected
Related Genotype: a/a ?/+ or a/a Cacng2stg/+

Strain Description
Mice homozygous for the spontaneous mutation stargazer (Cacng2stg) are first recognizable at 14 days of age by their smaller body size and slightly ataxic gait. Female stargazer homozygous mutant mice are fertile, but most of the males are unable to breed. The mutation is named for the abnormal head movements resembling choreiform head tossing that is characteristic of these mice. The behavioral symptoms progressively worsen with age, but both males and females will live to over one year of age. Electrocorticographical recordings of stargazer mice reveal frequent, prolonged, generalized spike-wave cortical discharges with behavioral arrest. The abnormal brain wave patterns are similar to those seen in human beings with absence epilepsy. Waggler homozygotes (Cacng2stg-wag) manifest a less severe phenotype than stargazer homozygotes, but do display an ataxic gait and occasional seizures. In general, young stargazer mice are more healthy than waggler homozygotes, but if wagglers reach weaning age, they will usually live for 1 to 2 years. Homozygous waggler males and females will breed, and they display no gross neuroanatomical or histopathologic lesions.

Strain Development
Stargazer (Cacng2stg) arose spontaneously in strain A/J at the Jackson Laboratory in 1979. It was carried to N3F1 on the A/J strain and then outcrossed to a B6C3Fe-a/a F1 and continued on that background using the cross intercross system. It was cryopreserved in 1990 by mating heterozygotes at N20. The line that remained on the shelf readhed N40 in 2005.

Mammalian Phenotype Terms assigned by genotype

Cacng2stg/Cacng2stg

        B6C3Fe a/a-Cacng2stg/J
  • behavior/neurological phenotype
  • decreased startle reflex (MGI Ref ID J:91987)
    • mutants lack the acoustic startle reflex (ASR), but startle reflex to somatic sensory stimuli such as air puffs is intact
  • decreased vertical activity (MGI Ref ID J:91987)
  • hyperactivity (MGI Ref ID J:91987)
    • in photocell activity chambers, mutants display 3-4-fold higher activity compared to control mice while vestibular toxin-treated controls have 10-fold increased activity
  • impaired coordination (MGI Ref ID J:91987)
    • mutants can only stay on the grid for 60 seconds, coinciding with the turn to 90 degrees, in a cling test; control mice can hang on to the grid for ~180 seconds, including complete inversion of the grid
    • in the rotarod test, mutants and drug-treated control mice fall off the rod immediately, often before it begins to move, whereas normal controls can walk for ~the full 5 minute test period
  • impaired righting response (MGI Ref ID J:91987)
    • when mice are dropped supine from height of 50 cm, mutants show poor air-righting performance, whereas control mice land on their feet ~100% of the time and toxin-treated normal controls land feet-first on ~50% of tests
    • when placed inside a tube and inverted to supine position, mutants remain inverted for duration (60 s) of test whereas controls right themselves within a few seconds
    • after 30 minutes of intermittent horizontal rotation, control mice display a significant decrease in spontaneous movement, but mutants do not show a decrease
  • impaired swimming (MGI Ref ID J:91987)
    • mutants cannot keep their heads above water during swimming and rapidly begin a spiraling motion underwater and drown if not rescued
  • stereotypic behavior (MGI Ref ID J:91987)
    • stereotypic behaviors like circling or abnormal head movements, are evident in all mutants at 2-3 weeks of age, and persist throughout observation period (>1 year)
    • circling (MGI Ref ID J:91987)
      • in open field test, mice exhibit circling to the left or right; controls do not while in vestibular toxin-treated normal controls, circling is exacerbated compared to mutants
    • head bobbing (MGI Ref ID J:91987)
      • in open field tests, mutants display rapid vertical bobbing head movements
    • head shaking (MGI Ref ID J:91987)
      • mice show rapid sideways wagging movements of the head during open field tests
    • head tossing (MGI Ref ID J:91987)
      • mice show occasional episodes of exaggerated and sustained, elevation of the head, resembling retrocollis, during open field observations
  • hearing/vestibular/ear phenotype
  • abnormal brainstem auditory evoked potential (MGI Ref ID J:91987)
    • ABR thresholds for click as a stimulus are normal, with a trend toward increased thresholds for 8 and 16 kHz tone stimuli in mutants (not reaching significance, though)
  • abnormal crista ampullaris morphology (MGI Ref ID J:91987)
    • crista show a reduction density of hair cells compared to controls
  • abnormal vestibular hair cell morphology (MGI Ref ID J:91987)
    • vacuole-like defects measuring 15-25 um are seen in the vestibular epithelium
    • cells are disorganized in sensory epithelium; some supporting cell nuclei lose contact with the basement membrane and occupy locations higher in the epithelium
    • abnormal type I vestibular cell (MGI Ref ID J:91987)
      • afferent nerve calyces surrounding type I hair cells lack the fullness and rich mitochondrial content seen in controls; large vacuole-like defects appear to be localized inside afferent calyces
      • these vacuoles are surrounded by normal but small and crowded mitochondria and contain scanty debris like cytosol or mitochondria
  • circling (MGI Ref ID J:91987)
    • in open field test, mice exhibit circling to the left or right; controls do not while in vestibular toxin-treated normal controls, circling is exacerbated compared to mutants
  • decreased startle reflex (MGI Ref ID J:91987)
    • mutants lack the acoustic startle reflex (ASR), but startle reflex to somatic sensory stimuli such as air puffs is intact
  • head bobbing (MGI Ref ID J:91987)
    • in open field tests, mutants display rapid vertical bobbing head movements
  • head shaking (MGI Ref ID J:91987)
    • mice show rapid sideways wagging movements of the head during open field tests
  • head tossing (MGI Ref ID J:91987)
    • mice show occasional episodes of exaggerated and sustained, elevation of the head, resembling retrocollis, during open field observations
  • nervous system phenotype
  • abnormal CNS synapse formation (MGI Ref ID J:116541)
    • synaptic size appears smaller
    • decreased CNS synapse formation (MGI Ref ID J:116541)
      • mutants have lower synaptic density in the cerebellar cortex; there are 25% fewer synapses compared to wild type
  • abnormal Purkinje cell innervation (MGI Ref ID J:116541)
    • there are more parallel fiber- Purkinje spine synapses with smaller presynsaptic terminal compared to the postsynaptic spine
    • there is a 43% reduction in the mean area of the presynaptic terminals in mutants
    • synaptic profile in wild type shows >80% of synapses having larger parallel fiber varicosities than postsynaptic Purkinje cell spines, while in mutants there is ~equal distribution of synapses with larger parallel fiber area than postsynaptic Purkinje cell spine, those with equal pre- and postsynaptic areas, or with smaller parallel fiber varicosity than the postsynaptic Purkinje cell spine
  • abnormal brain wave pattern (MGI Ref ID J:91987)
    • saline-treated mutants display frequent abnormal polyspike discharges in the EEG; however, these do not correlate temporally with dyskinetic behaviors
    • after nifedipine treatment, polyspike discharges are increased while reducing dyskinesia scores in mutants; an inverse relationship is observed
  • abnormal synaptic vesicle morphology (MGI Ref ID J:116541)
    • presynaptic vesicles are less dense compared to wild type
    • abnormal synaptic vesicle number (MGI Ref ID J:116541)
      • presynaptic vesicles are reduced in number
      • there are fewer docked vesicles and fewer vesicles adjacent to the active zone ready to dock in mutants than in wild type
  • abnormal vestibular hair cell morphology (MGI Ref ID J:91987)
    • vacuole-like defects measuring 15-25 um are seen in the vestibular epithelium
    • cells are disorganized in sensory epithelium; some supporting cell nuclei lose contact with the basement membrane and occupy locations higher in the epithelium
    • abnormal type I vestibular cell (MGI Ref ID J:91987)
      • afferent nerve calyces surrounding type I hair cells lack the fullness and rich mitochondrial content seen in controls; large vacuole-like defects appear to be localized inside afferent calyces
      • these vacuoles are surrounded by normal but small and crowded mitochondria and contain scanty debris like cytosol or mitochondria

Cacng2stg/Cacng2stg

        B6C3Fe a/a-Cacng2stg
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:11008)
    • at 14 days, mutants are smaller than wild type littermates
  • behavior/neurological phenotype
  • absence seizures (MGI Ref ID J:15527)
    • adults exhibit spontaneous spike-wave seizures; seizures do not appear to increase in mean duration or mean incidence with age
  • ataxia (MGI Ref ID J:11008)
    • homozygotes can be identified at 14 days by mildly ataxic gait
    • males are usually more severely affected than females
  • head tossing (MGI Ref ID J:11008)
    • at 1 month of age, mice display abnormal head movements both at rest and during activity; frequency of movements increase progressively with age
    • movement resembles choreiform head tossing; mice elevate heads vertically and maintain an upward gaze for several seconds
    • males are usually more severely affected than females
  • impaired swimming (MGI Ref ID J:11008)
    • mice show severe disturbances in righting reflex during swimming, with wild underwater tumbling motions
  • nervous system phenotype
  • abnormal CNS synapse formation (MGI Ref ID J:15527)
    • the ectopic terminals that are seen do not appear to form synapses with dendrites of basket or granule cells
  • abnormal brain wave pattern (MGI Ref ID J:11008)
    • electrocorticographic (ECoG) recordings from young adults display prolonged high-amplitue (500uV-1mV), bilaterally symmetrical discharges from neocortex, accompanied by behavioral immobility for the duration of the discharge
    • paroxysmal spike bursts show 6-7 spikes/second frequencies, with discharge durations of 1-66 seconds; mean rate or discharge activity is 125/hr
    • adults show highly reproducible pattern of spontaneous bilaterally symmetrical 6-7/second spike-wave discharges in cortical and hippocampal regions
    • seizure rate ranges from 43-209 discharges/hour with durations ranging from 1-66 seconds with a mean of 4-6 seconds
    • patterned spike-wave synchronous discharges represent ~20% of total EEG activity in adult mice
    • no spike-wave discharges are recorded in P15 mice but are always present by P18; discharges in immature animals can display slightly slower spike frequency (4-5/sec) but are identical to those seen in adults
  • abnormal hippocampal mossy fiber morphology (MGI Ref ID J:15527)
  • abnormal innervation (MGI Ref ID J:15527)
    • mutants show dense mossy fiber staining along the full extent of the dentate gyrus inner molecular layer whereas wild type show no staining; this is consistently observed in mutants compared to wild type
    • a 48% increase in density of staining is seen within the inner molecular layer-granular cell layer of adult mutants
    • no mossy fiber sprouting is observed prior to seizure onset (at P15), but progressively increasing staining specific for mossy fibers is observed from P30-6 months of age
  • abnormal neurogenesis (MGI Ref ID J:15527)
    • sprouting of mossy fibers in inner molecular layer and granular cell layer of dentate gyrus increases in mutants compared to wild type
  • absence seizures (MGI Ref ID J:15527)
    • adults exhibit spontaneous spike-wave seizures; seizures do not appear to increase in mean duration or mean incidence with age
  • loss of hippocampal neurons (MGI Ref ID J:15527)
    • neuronal density of hilar neurons in hippocampus is reduced by 16% in adult mutants compared to wild type; this difference only becomes apparent after onset of seizure activity (P17<)
  • reproductive system phenotype
  • male infertility (MGI Ref ID J:11008)
    • males are infertile
  • hearing/vestibular/ear phenotype
  • head tossing (MGI Ref ID J:11008)
    • at 1 month of age, mice display abnormal head movements both at rest and during activity; frequency of movements increase progressively with age
    • movement resembles choreiform head tossing; mice elevate heads vertically and maintain an upward gaze for several seconds
    • males are usually more severely affected than females

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Cacng2stg/Cacng2stg

        involves: A/J * C3HeB/FeJ * C57BL/6J
  • nervous system phenotype
  • *normal* nervous system phenotype (MGI Ref ID J:121463)
    • synaptic electrophysiology including neurotransmitter release and end plate potentials, as well as responses to channel inhibitors is not different from wild-type NMJs
    • abnormal CNS synaptic transmission (MGI Ref ID J:106959)
      • peak current densities of low voltage-activated (LVA) calcium channels in thalamocortical neurons at membrane potential of -50 mV are increased by 45% compared to control
      • peak current densities of high voltage calcium channels (HVA) in TC neurons are increased compared to wild type
    • abnormal motor neuron morphology (MGI Ref ID J:121463)
      • fiber diameter at diaphragm NMJs (14.2 um) is slightly reduced compared with wild-type (15.8 um)
    • abnormal neuromuscular synapse morphology (MGI Ref ID J:121463)
      • neuromuscular junction area (area staining for acetylcholine receptors) in ~25% smaller relative to wild-type mice (333 um2 vs 446 um2)

Gene & Allele Details

Allele Symbol Cacng2stg
Allele Name stargazer
Common Name(s) gamma2stg; stg;
Strain of OriginA/J
Gene Symbol and Name Cacng2, calcium channel, voltage-dependent, gamma subunit 2
Chromosome 15
Gene Common Name(s) AW060990; B230105C07Rik; B930041E13Rik; Ipr328; MGC138502; MGC138504; RIKEN cDNA B230105C07 gene; RIKEN cDNA B930041E13 gene; TARP gamma 2; expressed sequence AW060990; stargazer; stargazin; stg; wag; waggler;
Molecular Note The phenotype of the stargazer mouse has been attributed to an early transposon (ETn) insertion into intron 2 of the Cacng2 gene. RT-PCR analysis demonstrated that in addition to aberrant transcripts generated by the insertion, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. [MGI Ref ID J:48966]
 
Allele Symbol a
Allele Name nonagouti

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (102 strains)

Strains carrying other alleles of Cacng2
001883   B6.MRL-Cacng2stg-wag/J
View Strains carrying other alleles of Cacng2     (1 strain)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (67 strains)

Additional Web Information

JAX Notes, Spring 2005, 497. Supression of Absence Epilepsy Seizures Dependent on Complex Balance of Proteins.

Animal Health Reports

Room Number           FGB29

Research Applications

This mouse can be used to support research in many areas including:

Cacng2stg related

Cell Biology Research
Channel and Transporter Defects (calcium)

Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
Channel and Transporter Defects (calcium)
Epilepsy
Vestibular and Hearing Defects

Sensorineural Research
Vestibular and Hearing Defects

References

Selected Reference(s)

Letts VA; Felix R; Biddlecome GH; Arikkath J; Mahaffey CL; Valenzuela A ; Bartlett FS 2nd ; Mori Y ; Campbell KP ; Frankel WN. 1998. The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit [see comments] Nat Genet 19(4):340-7. [PubMed: 9697694]  [MGI Ref ID J:48966]

Noebels JL; Qiao X; Bronson RT; Spencer C; Davisson MT. 1990. Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures [published erratum appears in Epilepsy Res 1992 Mar;11(1):72] Epilepsy Res 7(2):129-35. [PubMed: 2289471]  [MGI Ref ID J:11008]

Additional References

Price and Supply Information

Strain Name: B6C3Fe a/a-Cacng2stg/J
Stock Number: 001756

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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