Strain Name: |
STOCK A Tyrc Sha/J |
|---|---|
Stock Number: |
001759 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | A; Sha; Tyr; Tyrc; a; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Species laboratory mouse Generation +N1p Strain Development
Shaven (Sha) arose in a stock in the Endocrinology Department at Edinburgh, Scotland. It was imported to the Jackson Laboratory from Welcome Research Animal Laboratories at the University of Dublin, Ireland in 1988. Welcome Research had received it as an inbred line from Edinburgh in the mid 1970’s. It was inbred until the early 1980’s and was then random bred within stock. At the Jackson Laboratory it was inbred homozygote x homozygote. It was cryopreserved in 1990 by mating homozygous males at F5 or F6 to C57BL/6J females.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | Sha | ||
| Allele Name | shaven | ||
| Strain of Origin | STOCK Sgk3fz | ||
| General Note | Arose in a stock of the Endocrinology Department, Edinburgh. Heterozygotes have a greasy coat and some waviness of the vibrissae. Homozygotes do not grow a first coat during the preweaning period and thereafter show cyclic growth and loss of very short sparse furry hairs. The vibrissae are short and wavy at birth and throughout life. Hairs are of normal size in heterozygotes, but the air spaces in the medulla are smaller than normal and filled with sudanophilic fluid. In homozygotes the hairs are thin and uneven in diameter, and the air spaces are very small and irregular and filled with sudanophilic fluid. Sha is closely linked to naked (N). The skin histology of homozygous shaven mice is similar to that of homozygous naked mice. Keratinization of the hairs is defective, and they fail to penetrate the epidermis (J:4425). | ||
| Allele Symbol | Tyrc | ||
| Allele Name | albino | ||
| Common Name(s) | c; | ||
| Strain of Origin | old mutant of the mouse fancy | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
| General Note | Tyrc, albino. This very old mutant was already known in Greek and Roman times. Hair and eyes are completely devoid of pigment (J:5436, J:5001, J:30725). The albino mutation affects the amount of tyrosinase, and thus of melanin, in pigment cells, but does not interfere with the production of pigment cells themselves (J:12173, J:13092). Melanocytes with melanosomes showing normal fine structure occur in the retina and hair follicles. Pigment granules are smaller and fewer than normal and completely lack melanin (J:5346, J:5001, J:30725). Tyrosinase is almost absent (J:12173).Although Tyr is the structural gene for tyrosinase, some albino mutations may affect tyrosinase enzyme regulation rather than structure (J:6611), suggesting that these mutations affect tyrosinase inhibition (J:5346), presumably via control regions of the gene. All the mutant alleles are recessive to wild type in phenotype, but heterozygotes with wild type produce intermediate amounts of tyrosinase (J:12173).Albino-locus mutants with lightly pigmented eyes have a reduced number of fibers of the optic nerve going to the ipsilateral lateral geniculate nucleus of the brain. This is probably a secondary effect of reduced tyrosinase activity or amount of pigment in the pigmentepithelium, since genes at other loci that reduce eye pigmentation also cause the same anomaly (J:5436, J:6064).Abnormal retinal pathways disrupted at the optic chiasm that occur in albinism can be corrected with a Tyr normal transgene (J:22320).Lipofuscin is a terminal oxidation product pigment that accumulates with age. In a cross of C57BL/6J and BALB/cJ, which differ in cardiac deposition of the pigment, this trait segregated with albinism, and is controlled by the Tyr locus (J:15460).Tyrc homozygotes do not perform as well as normal in a number of behavioral tests. It is likely that this effect is mediated, at least in part, by defective vision resulting from lack of retinal pigment (J:5470, J:5360, J:5378). | ||
| Molecular Note | The specific mutation in the albino allele is a G to C transversion causing an amino acid change from cysteine to serine. This mutation introduces a DdeI enzyme restriction site. [J:10889] [J:40223] | ||
Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying A allele
003301 (C57BL/6J x C3H-Eya1bor)F1/J 002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/J 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 001752 B6CBCa Aw-J/A-T(7;15)9H/J 006450 B6EiC3 a/A-Vss/J 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 001923 B6EiC3Sn a/A-Ts(417)2Lws Tim/J 000200 C3FeB6 A/Aw-J-Ankank/J 000638 C3FeB6 A/Aw-J-Spnb4qv-J/J 000283 LT.CAST-A/J View Strains carrying A (17 strains)
000409 B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ 000418 B10.129P-H1b Tyrc Hbbd/(5M)nSnJ 000432 B10.C-H1b Hbbd Tyrc/(41N)SnJ 000383 B6.C-Tyrc H1b Hbbd/ByJ 000006 STOCK Hk Tyrc/J
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 000091 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J 001279 129T1/Sv-Oca2+ Tyrc-ch-Aft/J 005445 A.B6 Tyr+-Cybanmf333/J 005012 A.B6 Tyr+-Myo5ad-l31J/J 002565 A.B6-Tyr+/J 000580 B10.D2/nSn-Tyrc-4J/J 000822 B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J 000578 B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 000058 B6(Cg)-Tyrc-2J/J 007484 B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ 000035 B6.Cg-Tyrc-J/J 000104 B6.Cg-Tyrc-h/J 000054 B6.D2-Tyrc-p/J 000899 C.B6-Tyr+ Hbbs/J 000339 C3H/HeJ-Tyrc-9J/J 001294 C3H/HeJ-Tyrc-a/J 001002 C57BL/10SnJ-Tyrc-11J/J 001006 CBA/J-Tyrc-10J/J 000657 CE/J 000619 FS/EiJ 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 002281 NFS.C58-Tyr+/J 004304 NOD.CBALs-Tyr+/LtJ 005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ 005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ 000271 SH1/LeJ 000306 STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J 000206 STOCK a/a Tyrc-h/J
Research Applications
This mouse can be used to support research in many areas including:Sha related
Tyrc relatedDermatology Research
Skin and Hair Texture Defects
Color and White Spotting Defects (oculocutaneous albinism, type I)
Mouse/Human Gene Homologs
albinism, tyrosine negative
References
Additional ReferencesPrice and Supply Information
| Strain Name: | STOCK A Tyrc Sha/J |
| Stock Number: | 001759 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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