Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N17F4N1p (29-FEB-04)

Appearance
agouti
Related Genotype: A/A

Description
Mice homozygous for the vestibulomotor degeneration spontaneous mutation (wl^vmd) can be identified at 20 days of age by their small size, shaky behavior, ungroomed coat, and emaciation. Homozygous mutant mice tend to sit hunched with rear feet and limbs tucked in towards the body and exhibit a generalized tremor. When startled, they jump sideways. They clasp their hind feet when picked up by the tail. Most mutants die by 30 days of age, probably from inability to feed and starvation. There is no apparent difference between the wabbler lethal (wl) and vestibulomotor degeneration mutant phenotypes.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of wl

004835	B6 x B6JCu.Cg-wl/J
002457	CBA/J-wl3J/J
000147	WLHR/LeJ

View Strains carrying other alleles of wl     (3 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

wl^vmd/wl^vmd

        C3H/HeSnJ-wl^vmd/J

• life span-post-weaning/aging
• premature death (MGI Ref ID J:11718)
  • few survive longer than 30 days of age, presumably due to starvation as homozygotes are unable to feed themselves
• growth/size phenotype
• decreased body size (MGI Ref ID J:11718)
  • smaller size is identifiable at 20 days of age
• cachexia (MGI Ref ID J:11718)
  • seen by 20 days of age
• nervous system phenotype
• axonal dystrophy (MGI Ref ID J:11718)
  • dystrophic axons are concentrated in the ventral funiculus of the cervical segments of the spinal cord and are particularly numerous in ventro-medial aspects of the medulla dorsal to the pyramids and ventral to the medial lemniscus in the area of the vestibulospinal tract
  • axons in the vestibular spinal tract and some axons projecting from the vestibular ganglion to the lateral vestibular nucleus are dystrophic
• chromatolysis (MGI Ref ID J:11718)
  • neurons in both the vestibular ganglion and nucleus have central chromatolysis
• motor neuron degeneration (MGI Ref ID J:11718)
  • vestibulo-motor degeneration
• behavior/neurological phenotype
• abnormal involuntary movement (MGI Ref ID J:11718)
  • when startled, jump sideways with legs splay out from the body
• limb grasping (MGI Ref ID J:11718)
  • when picked up by tail, clasp hind legs and the entire body shakes violently
• tremors (MGI Ref ID J:11718)
  • exhibit a generalized tremor
• decreased eating behavior (MGI Ref ID J:11718)
  • unable to feed themselves leading to starvation
• hunched posture (MGI Ref ID J:11718)
  • tend to sit hunched over with rear feet and legs tucked in towards the body
• skin/coat/nails phenotype
• disheveled coat (MGI Ref ID J:11718)
  • ungroomed hair coat

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

wl^vmd related

Neurobiology Research
Ataxia (Movement) Defects
Myelination Defects
Neurodegeneration
Tremor Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		wlvmd
Allele Name		vestibulomotor degeneration
Allele Type		Spontaneous
Common Name(s)		vmd;
Strain of Origin		C3H/HeSnJ
Gene Symbol and Name		wl, wabbler-lethal
Chromosome		14
Gene Common Name(s)		vestibulomotor degeneration; vmd;
General Note		This allele of wl arose in the C3H/HeSnJ strain at The Jackson Laboratory.(J:11718). No lesions have been found in somatic organs (J:2856). There is no apparent difference between the wl/wl and wlvmd/wlvmd phenotypes (J:28233).

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Bronson RT; Sweet HO; Spencer CA; Davisson MT. 1992. Genetic and age related models of neurodegeneration in mice: dystrophic axons. J Neurogenet 8(2):71-83. [PubMed: 1634998]  [MGI Ref ID J:11718]

wl^vmd related

Bronson RT; Sweet HO; Spencer CA; Davisson MT. 1992. Genetic and age related models of neurodegeneration in mice: dystrophic axons. J Neurogenet 8(2):71-83. [PubMed: 1634998]  [MGI Ref ID J:11718]

Carroll EW; Curtis RL; Sullivan DA; Melvin JL. 1992. Wallerian degeneration in the optic nerve of the wabbler-lethal (wl/wl) mouse. Brain Res Bull 29(3-4):411-8. [PubMed: 1382814]  [MGI Ref ID J:2856]

Sweet HO. 1993. Vestibulo-motor degeneration Mouse Genome 91(4):860.  [MGI Ref ID J:28233]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

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In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.