Strain Name: |
FVB/NJ |
|---|---|
Stock Number: |
001800 |
Availability: | Level 1 |
General Terms and Conditions |
| Strain Common Names | FVB; Friend Virus B NIH Jackson; |
| Genes & Alleles | Fv1; Hc; Hc0; Pde6b; Pde6brd1; ; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Additional information on JAX® GEMM® Strains. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype q Generation F99 (03-JAN-08) Appearance
albino
Related Genotype: A/A Tyrc/TyrcImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX Notes Spring 2002, No. 485.Strain Description
FVB/NJ was inbred for the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection. Compared to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE. Despite having the H2q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis. This resistance stems from coding polymorphisms in Tcra-V11.1 and a genomic deletion of some Tcrb-V genes that includes Tcrb-V8.2. FVB/NJ have higher than average activity, anxiety, and basal body temperature, low stress-induced hyperthermia, and are homozygous for the Pde6brd1 allele, which results in early onset retinal degeneration. Although FVB/N typically do not develop spontaneous tumors, they are highly susceptible to chemically induced squamous cell carcinomas with a high rate of malignant conversion from papilloma to carcinoma. For more information, please refer to Michael Festing's Index of Inbred Strain Characteristics.Strain Development
In 1966, outbred Swiss mice at the National Institutes of Health were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination. At the eighth generation of inbreeding (in the early 1970s), the sensitive line, HSFS/N, was found to carry the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. The FVB/N strain resulted from inbreeding this line for the Fv1b allele. In 1988 FVB/N mice were imported from NIH to Dr. Taketo at The Jackson Laboratory and in 1991 these were re-derived at F50 into the foundation stocks facility at The Jackson Laboratory. In December 2002 this strain reached F87.
Gene & Allele Details
| Allele Symbol | Hc0 | ||
|---|---|---|---|
| Allele Name | deficient | ||
| Common Name(s) | C5-; C5-d; C5-def; C5-deficient; hco; | ||
| Gene Symbol and Name | Hc, hemolytic complement | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298; RGD1561905; | ||
| General Note |
This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211) | ||
| Molecular Note | A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [MGI Ref ID J:23983] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361] | ||
| Gene Symbol and Name | Fv1, Friend virus susceptibility 1 | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | Fv-1; Rauscher leukemia virus susceptibility 1; Rv-1; Rv1; | ||
Colony Maintenance
| Diet Information | JAX West and Bar Harbor Diets |
|---|
Related Strains
FVB Strains
001491 FVB/NMob View FVB Strains (1 strain)
000645 A/HeJ 000646 A/J 000647 A/WySnJ 000648 AKR/J 000460 B10.D2-Hc0 H2d H2-T18c/o2SnJ 000461 B10.D2-Hc0 H2d H2-T18c/oSnJ 000657 CE/J 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 001491 FVB/NMob 000674 I/LnJ 001303 NOD.CB17-Prkdcscid/J 001976 NOD/ShiLtJ 000684 NZB/BlNJ 000682 RF/J 000688 ST/bJ 000689 SWR/J
Phenotypic Data
Body Weight Information - JAX® Mice Strain FVB/NJ (001800)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - activity and motor function
Mouse Phenome Database - anxiety
Mouse Phenome Database - body weight
Mouse Phenome Database - cholesterol
Mouse Phenome Database - disease susceptibility
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Festing Inbred Strain Characteristics: FVB
JAX® Physiological Data Summary [pdf]
JAX® Physiological Data Protocol [pdf]
Additional Web Information
Genetic Quality Control Annual Report
JAX Notes, Fall 1991; 447. FVB/NJ Available from Production Colonies.
JAX Notes, Fall 2003; 491. JAX West Expansion
JAX Notes, Spring 2002; 485. Genetic Background Effects: Can Your Mice See?
JAX Notes, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
JAX® Physiological Data Protocol [pdf]
JAX® Physiological Data Summary [pdf]
Animal Health Reports
Room Number MP13
Room Number MP15
Room Number WR3
Research Applications
This mouse can be used to support research in many areas including:
Hc0 relatedResearch Tools
General Purpose
Genetics Research (Mutagenesis and Transgenesis: Production of Transgenic Mice, large pronuclei)
Sensorineural Research
Retinal Degeneration (Homozygous for Pde6brd1)
Pde6brd1 relatedImmunology and Inflammation Research
Immunodeficiency (specific complement deficiency)
Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
References
Selected Reference(s)
Additional ReferencesTaketo M; Schroeder AC; Mobraaten LE; Gunning KB; Hanten G; Fox RR; Roderick TH; Stewart CL; Lilly F; Hansen CT; Overbeek PA.. 1991. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci U S A 88(6):2065-9. [PubMed: 1848692] [MGI Ref ID J:11068]
Price and Supply Information
| Strain Name: | FVB/NJ |
| Stock Number: | 001800 |
Price Details
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Supply Details
| Standard Supply | JAX Ready Strain® (Level 1). Most popular strains. Readily available in any quantity you need. |
|---|---|
| Supply Notes |
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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