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Former Names CBy.RBF-Rb(8.12)5Bnr/J (Changed: 15-DEC-04 ) Rb5Bnr (Changed: 15-DEC-04 ) Type Chromosome Aberration; Robertsonian; Additional information on Mice with Chromosomal Aberrations. Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species Wild and outbred Swiss and M. m. domesticus Background Strain BALB/cByJ Donor Strain RBF/DnJ Generation F71 (23-AUG-10)
Generation DefinitionsAppearance
albino
Related Genotype: Tyrp1b/Tyrp1b Tyrc/TyrcDescription
Hybridomas are produced by fusing mouse meloma cells that are deficient in adenosine phosphoribosyltransferase (APRT) with spleen cells from mice immunized with specific antigens. A selection system using AAT (adenosine, aminopterin, and thymidine) medium eliminates all but the fusion cells that are APRT+ . Successful hybridomas must also retain the Igh heavy chain locus on chromosome 12 and one of the Igh light chain loci. The Robertsonian chromosome Rb(8.12)5Bnr can be used to produce hybridomas at a high frequency. Selecting for the Aprt locus on chromosome 8 also selects for the Igh locus on chromosome 12 because the two loci are "genetically linked" by the Robertsonian fusion chromosome. This chromosomal aberration congenic was created by backcrossing the Robertsonian chromosome Rb(8.12)5Bnr on the BALB/cByJ genetic background by Dr. Muriel Davisson at The Jackson Laboratory.
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| 001026 BALB/cByJ | ||
| Considerations for Choosing Controls | ||
Robertsonian Chromosome
View Robertsonian Chromosome (67 strains)
Strains carrying other alleles of Rb(8.12)5Bnr
000714 CByJ.RBF-Rb(8.12)5Bnr 000726 RBF/DnJ View Strains carrying other alleles of Rb(8.12)5Bnr (2 strains)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Research Tools
Cancer Research
hybridoma production
| Gene Symbol and Name | Rb(8.12)5Bnr, Robertsonian translocation, Chr 8 and 12, Universitat Bonn/Rhein 5 | ||
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| Chromosome | 12 | ||
| Gene Common Name(s) | Rb5Bnr; | ||
Taggart RT; Samloff IM. 1983. Stable antibody-producing murine hybridomas. Science 219(4589):1228-30. [PubMed: 6402815] [MGI Ref ID J:135139]
Animal Health Reports
Room Number AX11
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
| Pricing for USA, Canada and Mexico shipping destinations |
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Price (US dollars $) Gender Genotypes Provided Individual Mouse $99.00 Female or Male Homozygous for Rb(8.12)5Bnr
Pairs /Price (US dollars $) Pair Genotype $198.00 Homozygous for Rb(8.12)5Bnr x Homozygous for Rb(8.12)5Bnr Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Price (US dollars $) Gender Genotypes Provided Individual Mouse $128.70 Female or Male Homozygous for Rb(8.12)5Bnr
Pairs /Price (US dollars $) Pair Genotype $257.40 Homozygous for Rb(8.12)5Bnr x Homozygous for Rb(8.12)5Bnr Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Control | ||
|---|---|---|
| 001026 BALB/cByJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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