Strain Name: |
CByJ.RBF-Rb(8.12)5Bnr/J |
|---|---|
Stock Number: |
001802 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
CBy.RBF-Rb(8.12)5Bnr/J (Changed: 15-DEC-04
) |
|
Rb5Bnr (Changed: 15-DEC-04
) | |
| Genes & Alleles | Rb(8.12)5Bnr; ; |
Product Information
Strain Details
Type Chromosome Aberration Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type Robertsonian Additional information on Mice with Chromosomal Aberrations. Mating System Homozygote x Homozygote (Female x Male) Species Wild and outbred Swiss and M. m. domesticus Background Strain BALB/cByJ Donor Strain RBF/DnJ Generation F65 (11-DEC-07) Appearance
albino
Related Genotype: Tyrp1b/Tyrp1b Tyrc/TyrcStrain Description
Hybridomas are produced by fusing mouse meloma cells that are deficient in adenosine phosphoribosyltransferase (APRT) with spleen cells from mice immunized with specific antigens. A selection system using AAT (adenosine, aminopterin, and thymidine) medium eliminates all but the fusion cells that are APRT+ . Successful hybridomas must also retain the Igh heavy chain locus on chromosome 12 and one of the Igh light chain loci. The Robertsonian chromosome Rb(8.12)5Bnr can be used to produce hybridomas at a high frequency. Selecting for the Aprt locus on chromosome 8 also selects for the Igh locus on chromosome 12 because the two loci are "genetically linked" by the Robertsonian fusion chromosome. This chromosomal aberration congenic was created by backcrossing the Robertsonian chromosome Rb(8.12)5Bnr on the BALB/cByJ genetic background by Dr. Muriel Davisson at The Jackson Laboratory.
Gene & Allele Details
| Gene Symbol and Name | Rb(8.12)5Bnr, Robertsonian translocation, Chr 8 and 12, Universitat Bonn/Rhein 5 | ||
|---|---|---|---|
| Chromosome | 12 | ||
| Gene Common Name(s) | Rb5Bnr; | ||
Control Information
| Control | ||
|---|---|---|
| 001026 BALB/cByJ | ||
| Considerations for Choosing Controls | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Robertsonian Chromosome
View Robertsonian Chromosome (69 strains)
Additional Web Information
Congenic Nomenclature
Genetic Quality Control Annual Report
Animal Health Reports
Room Number AX11
Research Applications
This mouse can be used to support research in many areas including:
Research Tools
Cancer Research (hybridoma production)
References
Selected Reference(s)
Taggart RT; Samloff IM. 1983. Stable antibody-producing murine hybridomas. Science 219(4589):1228-30. [PubMed: 6402815] [J:135139]
Price and Supply Information
| Strain Name: | CByJ.RBF-Rb(8.12)5Bnr/J |
| Stock Number: | 001802 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
*NO Shipping Destination selected!
Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form