Strain Name:

B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J

Stock Number:

001809

Availability:

Repository- Live

Description

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemFor ArTfm: heterozygote x wildtype; for EdaTa-6J: heterozygote x hemizygote EdaTa-6J +/? ? x EdaTa-6J +/Y then proven EdaTa-6J +/? ArTfm x EdaTa-6J +/Y
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain EdaTa-6J , C57BL/6J-tp3J ; ArTfm, offspring of female carrying EdaTa and Atp7ablo
GenerationN3F23B6N30+F37 (21-DEC-08)

Appearance
white-bellied agouti, males with female external genitalia (no vaginal opening)
Related Genotype: Aw-J/Aw-J + ArTfm/Y males

tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J +/Y males

white bellied agouti with mosaic striped coat
Related Genotype: Aw-J/Aw-J EdaTa-6J +/+ ArTfm females

tabby (yellow coat, no hair on ears and tail, bald patch behind ears; no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J +/EdaTa-6J + females

Description
Testicular feminization (ArTfm) is a dominant spontaneous mutation on the X chromosome. Hemizygous male mice are outwardly female in appearance except that the vagina does not open until 3 months of age if at all. Male reproductive development is abnormal leading to very small testes, and the absense of vas deferens, the epididymis, and male accessory glands. Spermatogonia and Sertoli cells are present in the testes, but spermatogenesis does not proceed past meiotic prophase. Leydig cells, which normally produce androgen in males, fail to develop normally. This strain is also segregating for the tabby 6J mutation (EdaTa-6J) that affects both the coat color and hair pattern growth. The tabby mutation is maintained in repulsion with the testicular feminization mutation and is used as a coat color marker to assist in identifying resulting genotypes obtained from matings.

Control Information

  Control
   000051 C57BL/6J-Aw-J/J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Aw-J     (31 strains)

Strains carrying   ArTfm allele
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
View Strains carrying   ArTfm     (1 strain)

Strains carrying   EdaTa-6J allele
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
View Strains carrying   EdaTa-6J     (4 strains)

Strains carrying other alleles of Eda
000841   B6-Aw-J.CBy-EdaTa-By/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
001232   C3H/HeJ-EdaTa-5J/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
003112   STOCK EdaTa-5J/J
000583   STOCK T(X;16)16H +/+ EdaTa
View Strains carrying other alleles of Eda     (7 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000769   B6.C/(HZ18)By-at-44J/J
000001   B6.C3 A/a Mgrn1md/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
000021   B6.Cg-Ay/J
000231   B6;C3Fe a/a-Csf1op/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000785   B6;D2-a Es1e/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
008425   C3FeLe.B6-a Trl/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying other alleles of a     (154 strains)

Additional Web Information

JAX® NOTES, January 1990, 440. Tabby Stocks Available from The Jackson Laboratory.
JAX® NOTES, Summer 1994; 458. Tfm Strains at The Jackson Laboratory.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms
Androgen Insensitivity Syndrome; AIS - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

ArTfm/Y

        Background Not Specified
  • reproductive system phenotype
  • abnormal spermatogenesis (MGI Ref ID J:65900)
    • germ cell development progressed to spermatocytes
  • abnormal testis morphology (MGI Ref ID J:65900)
    • an extra layer of parietal lymphatic cells was present, but these cells appeared to be normal; myoid cells were also normal
    • peritubular fibrosis was observed, as indicated by a few extra layers of fibroblastic-like cells around the seminiferous tubules, although this fibrosis was not as severe as that seen in Dhhtm1Amc feminized males
    • collagen and basal lamina material between Sertoli and myoid cells extended around the entire seminiferous tubule unlike that of the patchy basal lamina seen in Dhhtm1Amc feminized males
    • abnormal Leydig cell morphology (MGI Ref ID J:65900)
      • at 63 days of age, testes from adult male hemizygotes contained abundant adult-type Leydig cells which appeared relatively undifferentiated and lacked smooth endoplasmic reticulum
  • endocrine/exocrine gland phenotype
  • abnormal testis morphology (MGI Ref ID J:65900)
    • an extra layer of parietal lymphatic cells was present, but these cells appeared to be normal; myoid cells were also normal
    • peritubular fibrosis was observed, as indicated by a few extra layers of fibroblastic-like cells around the seminiferous tubules, although this fibrosis was not as severe as that seen in Dhhtm1Amc feminized males
    • collagen and basal lamina material between Sertoli and myoid cells extended around the entire seminiferous tubule unlike that of the patchy basal lamina seen in Dhhtm1Amc feminized males
    • abnormal Leydig cell morphology (MGI Ref ID J:65900)
      • at 63 days of age, testes from adult male hemizygotes contained abundant adult-type Leydig cells which appeared relatively undifferentiated and lacked smooth endoplasmic reticulum

ArTfm/Y

        involves: NMRI * STOCK EdaTa Atp7aMo-blo
  • reproductive system phenotype
  • abnormal seminiferous tubule morphology (MGI Ref ID J:140803)
    • mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
    • Leydig cell hyperplasia (MGI Ref ID J:140803)
      • unlike ArTfm male mice on the original stock background
    • enlarged seminiferous tubules (MGI Ref ID J:140803)
      • in 15 of 46 mice unlike ArTfm male mice on the original stock background
  • arrest of male meiosis (MGI Ref ID J:140803)
    • spermatogenesis does not proceed beyond meiosis prophase
  • cryptorchism (MGI Ref ID J:140803)
  • secondary sex reversal (MGI Ref ID J:140803)
    • male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts
  • tumorigenesis
  • testis tumor (MGI Ref ID J:140803)
    • 4 of 46 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
    • however, no germ cell tumors are observed
  • endocrine/exocrine gland phenotype
  • abnormal seminiferous tubule morphology (MGI Ref ID J:140803)
    • mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
    • Leydig cell hyperplasia (MGI Ref ID J:140803)
      • unlike ArTfm male mice on the original stock background
    • enlarged seminiferous tubules (MGI Ref ID J:140803)
      • in 15 of 46 mice unlike ArTfm male mice on the original stock background
  • cryptorchism (MGI Ref ID J:140803)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

ArTfm related

Endocrine Deficiency Research
Gonad Defects

Mouse/Human Gene Homologs
testicular feminization

Reproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects

EdaTa-6J related

Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects

Developmental Biology Research
Eye Defects

Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia

Sensorineural Research
Eye Defects

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Aw-J
Allele Name white bellied agouti Jackson
Allele Type Spontaneous
Common Name(s) AWJ;
Strain of OriginC57BL/6J
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
 
Allele Symbol ArTfm
Allele Name testicular feminization
Allele Type Spontaneous
Common Name(s) Tfm;
Strain of Origin(STOCK Eda x Atp7a)F1
Gene Symbol and Name Ar, androgen receptor
Chromosome X
Gene Common Name(s) AIS; AW320017; Andr; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; Tfm; expressed sequence AW320017; testicular feminization;
General Note ArTfm acts by causing insensitivity to androgens due to a defect in androgen-binding receptor present in cytosol and nucleus. Most responses to androgens are absent or defective in ArTfm/Y males and are not inducible by administration of androgens (J:5221, J:5532). Androgen receptor is found in kidney, submandibular gland (J:5667) and brain (J:5927). ArTfm/Y males have about 20-25 percent of normal testosterone-binding activity in brain (J:6096) and 10-20 percent in kidney.
Molecular Note A frameshift mutation resulting from the deletion of a single cytosine residue generated a premature stop codon at residue 412. The nonsenes mutation is expected to preclude the translation of both the DNA- and steroid-binding domains. [MGI Ref ID J:11219] [MGI Ref ID J:1264] [MGI Ref ID J:19598] [MGI Ref ID J:30797] [MGI Ref ID J:712]
 
Allele Symbol EdaTa-6J
Allele Name tabby 6 Jackson
Allele Type Spontaneous
Common Name(s) Ta2; Ta6J; Tabby;
Strain of OriginC57BL/6J-tp3J/J
Gene Symbol and Name Eda, ectodysplasin-A
Chromosome X
Gene Common Name(s) ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; RGD1563178; Ta; XHED; XLHED; tabby;
Molecular Note This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation. [MGI Ref ID J:42614]

Genotyping

Genotyping Information

Genotyping Protocols

EdaTa-6J +/+ ArTfm, Restriction Enzyme Digest

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Charest NJ; Zhou ZX; Lubahn DB; Olsen KL; Wilson EM; French FS. 1991. A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse. Mol Endocrinol 5(4):573-81. [PubMed: 1681426]  [MGI Ref ID J:712]

Dulos GJ; Bagchus WM. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int Immunopharmacol 1(2):321-8. [PubMed: 11360932]  [MGI Ref ID J:109877]

Gaspar ML; Bourgarel P; Meo T; Tosi M. 1991. [Structure of messenger RNA of androgen receptor in mice and molecular characterization in Tfm mutant] C R Seances Soc Biol Fil 185(6):510-9. [PubMed: 1822400]  [MGI Ref ID J:1264]

Gaspar ML; Meo T; Bourgarel P; Guenet JL; Tosi M. 1991. A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation. Proc Natl Acad Sci U S A 88(19):8606-10. [PubMed: 1924321]  [MGI Ref ID J:30797]

Johnston DS; Russell LD; Friel PJ; Griswold MD. 2001. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142(6):2405-8. [PubMed: 11356688]  [MGI Ref ID J:109878]

Kurita T; Wang YZ; Donjacour AA; Zhao C; Lydon JP; O'Malley BW; Isaacs JT; Dahiya R; Cunha GR. 2001. Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ 8(2):192-200. [PubMed: 11313721]  [MGI Ref ID J:109881]

Li-Hawkins J; Lund EG; Turley SD; Russell DW. 2000. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem 275(22):16536-42. [PubMed: 10748048]  [MGI Ref ID J:62587]

Lyon MF; Hawkes SG. 1970. X-linked gene for testicular feminization in the mouse. Nature 227(5264):1217-9. [PubMed: 5452809]  [MGI Ref ID J:5173]

Murphy L; Jeffcoate IA; O'Shaughnessy PJ. 1994. Abnormal Leydig cell development at puberty in the androgen-resistant Tfm mouse. Endocrinology 135(4):1372-7. [PubMed: 7925099]  [MGI Ref ID J:20980]

Additional References

Tullis KM; Krebs CJ; Leung JY; Robins DM. 2003. The regulator of sex-limitation gene, rsl, enforces male-specific liver gene expression by negative regulation. Endocrinology 144(5):1854-60. [PubMed: 12697692]  [MGI Ref ID J:83502]

Aw-J related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142]  [MGI Ref ID J:92174]

Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558]  [MGI Ref ID J:9799]

Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049]  [MGI Ref ID J:118430]

Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861]  [MGI Ref ID J:112546]

Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713]  [MGI Ref ID J:145908]

Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056]  [MGI Ref ID J:111051]

Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451]  [MGI Ref ID J:129949]

Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139]  [MGI Ref ID J:30922]

Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976]  [MGI Ref ID J:143603]

Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194]  [MGI Ref ID J:32132]

Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738]  [MGI Ref ID J:31403]

Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990]  [MGI Ref ID J:61324]

Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442]  [MGI Ref ID J:1295]

Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941]  [MGI Ref ID J:101081]

Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031]  [MGI Ref ID J:146365]

Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695]  [MGI Ref ID J:126508]

Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869]  [MGI Ref ID J:111363]

Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326]  [MGI Ref ID J:5288]

Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460]  [MGI Ref ID J:52138]

Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102]  [MGI Ref ID J:52183]

Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38.  [MGI Ref ID J:64104]

Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307]  [MGI Ref ID J:128256]

O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570]  [MGI Ref ID J:100906]

Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097]  [MGI Ref ID J:119427]

Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086]  [MGI Ref ID J:114943]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472]  [MGI Ref ID J:5519]

Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648]  [MGI Ref ID J:138994]

Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391]  [MGI Ref ID J:121345]

Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246]  [MGI Ref ID J:111491]

Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341]  [MGI Ref ID J:109469]

Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785]  [MGI Ref ID J:116953]

Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119]  [MGI Ref ID J:97010]

van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268]  [MGI Ref ID J:110278]

ArTfm related

Al-Attar L; Noel K; Dutertre M; Belville C; Forest MG; Burgoyne PS ; Josso N ; Rey R. 1997. Hormonal and cellular regulation of Sertoli cell anti-Mullerian hormone production in the postnatal mouse. J Clin Invest 100(6):1335-43. [PubMed: 9294098]  [MGI Ref ID J:43055]

Attardi B; Geller LN; Ohno S. 1976. Androgen and estrogen receptors in brain cytosol from male, female, and testicular feminized (tfm/y hermaphrodite) mice. Endocrinology 98(4):864-74. [PubMed: 179788]  [MGI Ref ID J:5655]

Attardi B; Ohno S. 1978. Physical properties of androgen receptors in brain cytosol from normal and testicular feminized (Tfm/y hermaphrodite) mice. Endocrinology 103(3):760-70. [PubMed: 744116]  [MGI Ref ID J:6096]

Baker PJ; Sha JH; O'Shaughnessy PJ. 1997. Localisation and regulation of 17beta-hydroxysteroid dehydrogenase type 3 mRNA during development in the mouse testis. Mol Cell Endocrinol 133(2):127-33. [PubMed: 9406858]  [MGI Ref ID J:44106]

Behringer RR; Finegold MJ; Cate RL. 1994. Mullerian-inhibiting substance function during mammalian sexual development. Cell 79(3):415-25. [PubMed: 7954809]  [MGI Ref ID J:21396]

Bodo C; Rissman EF. 2007. Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice. Eur J Neurosci 25(7):2182-90. [PubMed: 17419752]  [MGI Ref ID J:125039]

Clark AM; Garland KK; Russell LD. 2000. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type leydig cells and normal development of peritubular cells and seminiferous tubules Biol Reprod 63(6):1825-38. [PubMed: 11090455]  [MGI Ref ID J:65900]

Dev A; Nayernia K; Meins M; Adham I; Lacone F; Engel W. 2007. Mice deficient for RNA-binding protein brunol1 show reduction of spermatogenesis but are fertile. Mol Reprod Dev 74(11):1456-64. [PubMed: 17393433]  [MGI Ref ID J:128362]

Dofuku R; Tettenborn U; Ohno S. 1971. Testosterone-regulon in the mouse kidney. Nat New Biol 232(27):5-7. [PubMed: 5284427]  [MGI Ref ID J:5221]

Drews U. 1998. Direct and mediated effects of testosterone: analysis of sex reversed mosaic mice heterozygous for testicular feminization. Cytogenet Cell Genet 80(1-4):68-74. [PubMed: 9678337]  [MGI Ref ID J:48821]

Dunn JF; Wilson JD. 1975. Developmental study of androgen responsiveness in the submandibular gland of the mouse. Endocrinology 96(6):1571-8. [PubMed: 123850]  [MGI Ref ID J:5532]

He WW; Kumar MV; Tindall DJ. 1991. A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res 19(9):2373-8. [PubMed: 2041777]  [MGI Ref ID J:11219]

He WW; Lindzey JK; Prescott JL; Kumar MV; Tindall DJ. 1994. The androgen receptor in the testicular feminized (Tfm) mouse may be a product of internal translation initiation. Receptor 4(2):121-34. [PubMed: 7950980]  [MGI Ref ID J:19598]

Kraszucka K; Burfeind P; Nayernia K; Kohler M; Schmid M; Yaylaoglu M; Engel W. 1999. Developmental stage- and germ cell-regulated expression of a calcium-binding protein mRNA in mouse Sertoli cells. Mol Reprod Dev 54(3):232-43. [PubMed: 10497345]  [MGI Ref ID J:57920]

Lamm ML; Podlasek CA; Barnett DH; Lee J; Clemens JQ; Hebner CM; Bushman W. 2001. Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Dev Biol 232(2):301-14. [PubMed: 11401393]  [MGI Ref ID J:69382]

Le Goascogne C; Sannanes N; Gouezou M; Baulieu EE; Robel P. 1993. Suppressed expression of the cytochrome P45017 alpha protein in the testicular feminized (Tfm) mouse testes. J Endocrinol 139(1):127-30. [PubMed: 8254285]  [MGI Ref ID J:15718]

Lehraiki A; Racine C; Krust A; Habert R; Levacher C. 2009. Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism. Toxicol Sci 111(2):372-82. [PubMed: 19592451]  [MGI Ref ID J:152418]

Lindsey JS; Wilkinson MF. 1996. Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis. Dev Biol 179(2):471-84. [PubMed: 8903361]  [MGI Ref ID J:36481]

Lyon MF. 1969. Testicular feminization, proposed symbol Tfm Mouse News Lett 41:28.  [MGI Ref ID J:30664]

Lyon MF; Glenister PH. 1980. Reduced reproductive performance in androgen-resistant Tfm/Tfm female mice. Proc R Soc Lond B Biol Sci 208(1170):1-12. [PubMed: 6105650]  [MGI Ref ID J:6361]

Markova MS; Zeskand J; McEntee B; Rothstein J; Jimenez SA; Siracusa LD. 2004. A role for the androgen receptor in collagen content of the skin. J Invest Dermatol 123(6):1052-6. [PubMed: 15610513]  [MGI Ref ID J:120139]

Merlet J; Racine C; Moreau E; Moreno SG; Habert R. 2007. Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation. Proc Natl Acad Sci U S A 104(9):3615-20. [PubMed: 17360691]  [MGI Ref ID J:126078]

Meseguer A; Catterall JF. 1990. Cell-specific expression of kidney androgen-regulated protein messenger RNA is under multihormonal control. Mol Endocrinol 4(8):1240-8. [PubMed: 2293028]  [MGI Ref ID J:14636]

Meseguer A; Watson CS; Catterall JF. 1989. Nucleotide sequence of kidney androgen-regulated protein mRNA and its cell-specific expression in Tfm/Y mice. Mol Endocrinol 3(6):962-7. [PubMed: 2739660]  [MGI Ref ID J:36298]

Monks DA; Johansen JA; Mo K; Rao P; Eagleson B; Yu Z; Lieberman AP; Breedlove SM; Jordan CL. 2007. Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. Proc Natl Acad Sci U S A 104(46):18259-64. [PubMed: 17984063]  [MGI Ref ID J:127205]

Murphy L; O'Shaughnessy PJ. 1991. Testicular steroidogenesis in the testicular feminized (Tfm) mouse: loss of 17 alpha-hydroxylase activity. J Endocrinol 131(3):443-9. [PubMed: 1686053]  [MGI Ref ID J:155]

O'Shaughnessy PJ; Abel M; Charlton HM; Hu B; Johnston H; Baker PJ. 2007. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology 148(6):2914-24. [PubMed: 17332066]  [MGI Ref ID J:129602]

O'Shaughnessy PJ; Johnston H; Willerton L; Baker PJ. 2002. Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. J Cell Sci 115(Pt 17):3491-6. [PubMed: 12154079]  [MGI Ref ID J:78785]

Olsen NJ; Olson G; Viselli SM; Gu X; Kovacs WJ. 2001. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 142(3):1278-83. [PubMed: 11181545]  [MGI Ref ID J:68787]

Penatti CA; Porter DM; Henderson LP. 2009. Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. J Neurosci 29(40):12484-96. [PubMed: 19812324]  [MGI Ref ID J:153885]

Propst F; Rosenberg MP; Oskarsson MK; Russell LB; Nguyen-Huu MC; Nadeau J; Jenkins NA; Copeland NG; Vande Woude GF. 1988. Genetic analysis and developmental regulation of testis-specific RNA expression of Mos, Abl, actin and Hox-1.4. Oncogene 2(3):227-33. [PubMed: 2895445]  [MGI Ref ID J:9103]

Rizk A; Robertson J; Raber J. 2005. Behavioral performance of tfm mice supports the beneficial role of androgen receptors in spatial learning and memory. Brain Res 1034(1-2):132-8. [PubMed: 15713264]  [MGI Ref ID J:96211]

Rizk-Jackson A; Robertson J; Raber J. 2008. Tfm-AR modulates the effects of ApoE4 on cognition. J Neurochem 105(1):63-7. [PubMed: 18039320]  [MGI Ref ID J:135450]

Sawada K; Noumura T. 1992. Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y). Acta Anat (Basel) 143(3):241-5. [PubMed: 1632191]  [MGI Ref ID J:1403]

Schubert S; Kamino K; Bohm D; Adham I; Engel W; von Wasielewski R; Moharregh-Khiabani D; Mauceri G; Vaske B; Meinhardt A; Schoner A; Gonzalez-Fassrainer D; Schmidtke J. 2008. TSPY expression is variably altered in transgenic mice with testicular feminization. Biol Reprod 79(1):125-33. [PubMed: 18401008]  [MGI Ref ID J:140803]

Scordalakes EM; Rissman EF. 2004. Aggression and arginine vasopressin immunoreactivity regulation by androgen receptor and estrogen receptor alpha. Genes Brain Behav 3(1):20-6. [PubMed: 14960012]  [MGI Ref ID J:104808]

Scordalakes EM; Shetty SJ; Rissman EF. 2002. Roles of estrogen receptor alpha and androgen receptor in the regulation of neuronal nitric oxide synthase. J Comp Neurol 453(4):336-44. [PubMed: 12389206]  [MGI Ref ID J:113953]

Scott IS; Bennett MK; Porter-Goff AE; Harrison CJ; Cox BS; Grocock CA; O'Shaughnessy PJ; Clayton RN; Craven R; Furr BJA; Charlton HM.. 1992. Effects of the gonadotrophin-releasing hormone agonist 'Zoladex' upon pituitary and gonadal function in hypogonadal (hpg) male mice: a comparison with normal male and testicular feminized (tfm) mice. J Mol Endocrinol 8(3):249-58. [PubMed: 1385960]  [MGI Ref ID J:3443]

Shetty G; Weng CC; Porter KL; Zhang Z; Pakarinen P; Kumar TR; Meistrich ML. 2006. Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations. Endocrinology 147(7):3563-70. [PubMed: 16627582]  [MGI Ref ID J:110487]

Smithson G; Couse JF; Lubahn DB; Korach KS; Kincade PW. 1998. The role of estrogen receptors and androgen receptors in sex steroid regulation of B lymphopoiesis. J Immunol 161(1):27-34. [PubMed: 9647203]  [MGI Ref ID J:110923]

Sollars VE; McEntee BJ; Engiles JB; Rothstein JL; Buchberg AM. 2002. A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease. Hum Mol Genet 11(22):2777-86. [PubMed: 12374767]  [MGI Ref ID J:79618]

Tabibnia G; Cooke BM; Breedlove SM. 1999. Sex difference and laterality in the volume of mouse dentate gyrus granule cell layer. Brain Res 827(1-2):41-5. [PubMed: 10320691]  [MGI Ref ID J:54594]

Thomas PS Jr; Fraley GS; Damien V; Woodke LB; Zapata F; Sopher BL; Plymate SR; La Spada AR. 2006. Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy. Hum Mol Genet 15(14):2225-38. [PubMed: 16772330]  [MGI Ref ID J:112041]

Toda I; Sullivan BD; Wickham LA; Sullivan DA. 1999. Gender- and androgen-related influence on the expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice. J Steroid Biochem Mol Biol 71(1-2):49-61. [PubMed: 10619357]  [MGI Ref ID J:58967]

Tullis KM; Krebs CJ; Leung JY; Robins DM. 2003. The regulator of sex-limitation gene, rsl, enforces male-specific liver gene expression by negative regulation. Endocrinology 144(5):1854-60. [PubMed: 12697692]  [MGI Ref ID J:83502]

Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246]  [MGI Ref ID J:111491]

Verhoeven G; Wilson JD. 1976. Cytosol androgen binding in submandibular gland and kidney of the normal mouse and the mouse with testicular feminization. Endocrinology 99(1):79-92. [PubMed: 939201]  [MGI Ref ID J:5667]

Wieland SJ; Fox TO; Savakis C. 1978. DNA-binding of androgen and estrogen receptors from mouse brain: behavior of residual androgen receptor from Tfm mutant. Brain Res 140(1):159-64. [PubMed: 564230]  [MGI Ref ID J:5927]

Young CY; Johnson MP; Prescott JL; Tindall DJ. 1989. The androgen receptor of the testicular-feminized (Tfm) mutant mouse is smaller than the wild-type receptor. Endocrinology 124(2):771-5. [PubMed: 2912700]  [MGI Ref ID J:30796]

Zimmermann S; Steding G; Emmen JM; Brinkmann AO; Nayernia K; Holstein AF; Engel W; Adham IM. 1999. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol Endocrinol 13(5):681-91. [PubMed: 10319319]  [MGI Ref ID J:83429]

EdaTa-6J related

Charles C; Pantalacci S; Peterkova R; Peterka M; Laudet V; Viriot L. 2007. Disruption of the palatal rugae pattern in Tabby (eda) mutant mice. Eur J Oral Sci 115(6):441-8. [PubMed: 18028050]  [MGI Ref ID J:147677]

Cui CY; Durmowicz M; Ottolenghi C; Hashimoto T; Griggs B; Srivastava AK; Schlessinger D. 2003. Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet 12(22):2931-40. [PubMed: 14506134]  [MGI Ref ID J:86628]

Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056]  [MGI Ref ID J:111051]

Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451]  [MGI Ref ID J:129949]

Cui CY; Smith JA; Schlessinger D; Chan CC. 2005. X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. Am J Pathol 167(1):89-95. [PubMed: 15972955]  [MGI Ref ID J:99510]

Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976]  [MGI Ref ID J:143603]

Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. [PubMed: 9285798]  [MGI Ref ID J:42614]

Kunisada M; Cui CY; Piao Y; Ko MS; Schlessinger D. 2009. Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet 18(10):1769-78. [PubMed: 19270025]  [MGI Ref ID J:147576]

Sweet HO; Davisson MT. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313) Mouse Genome 93(4):1030-4.  [MGI Ref ID J:30778]

Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246]  [MGI Ref ID J:111491]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Mating SystemFor ArTfm: heterozygote x wildtype; for EdaTa-6J: heterozygote x hemizygote EdaTa-6J +/? ? x EdaTa-6J +/Y then proven EdaTa-6J +/? ArTfm x EdaTa-6J +/Y
Diet Information LabDiet® 5K52/5K67

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Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $141.00MaleWild-type for EdaTa-6J, Hemizygous for ArTfm (feminized Male)
Pairs /Price (US dollars $)Pair Genotype
$225.90Heterozygous for EdaTa-6J, Assumed Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm
$259.80Heterozygous for EdaTa-6J, Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $183.30MaleWild-type for EdaTa-6J, Hemizygous for ArTfm (feminized Male)
Pairs /Price (US dollars $)Pair Genotype
$293.70Heterozygous for EdaTa-6J, Assumed Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm
$337.80Heterozygous for EdaTa-6J, Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm

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Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
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   000051 C57BL/6J-Aw-J/J
 
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  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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