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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System For ArTfm: heterozygote x wildtype; for EdaTa-6J: heterozygote x hemizygote EdaTa-6J +/? ? x EdaTa-6J +/Y then proven EdaTa-6J +/? ArTfm x EdaTa-6J +/Y Species laboratory mouse Background Strain C57BL/6J Donor Strain EdaTa-6J , C57BL/6J-tp3J ; ArTfm, offspring of female carrying EdaTa and Atp7ablo Generation N3F23B6N30+F37 (21-DEC-08) Appearance
white-bellied agouti, males with female external genitalia (no vaginal opening)
Related Genotype: Aw-J/Aw-J + ArTfm/Y males
tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J +/Y males
white bellied agouti with mosaic striped coat
Related Genotype: Aw-J/Aw-J EdaTa-6J +/+ ArTfm females
tabby (yellow coat, no hair on ears and tail, bald patch behind ears; no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J +/EdaTa-6J + femalesDescription
Testicular feminization (ArTfm) is a dominant spontaneous mutation on the X chromosome. Hemizygous male mice are outwardly female in appearance except that the vagina does not open until 3 months of age if at all. Male reproductive development is abnormal leading to very small testes, and the absense of vas deferens, the epididymis, and male accessory glands. Spermatogonia and Sertoli cells are present in the testes, but spermatogenesis does not proceed past meiotic prophase. Leydig cells, which normally produce androgen in males, fail to develop normally. This strain is also segregating for the tabby 6J mutation (EdaTa-6J) that affects both the coat color and hair pattern growth. The tabby mutation is maintained in repulsion with the testicular feminization mutation and is used as a coat color marker to assist in identifying resulting genotypes obtained from matings.
Control Information
| Control | ||
|---|---|---|
| 000051 C57BL/6J-Aw-J/J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Aw-J allele
View Strains carrying Aw-J (31 strains)
000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 000552 B6-Aw-J-EdaTa-6J.Cg-Sxr 001730 B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J 000338 C57BL/6J Aw-J-EdaTa-6J/J
000841 B6-Aw-J.CBy-EdaTa-By/J 000314 B6CBACa Aw-J/A-EdaTa/J-XO 000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 001232 C3H/HeJ-EdaTa-5J/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J 003112 STOCK EdaTa-5J/J 000583 STOCK T(X;16)16H +/+ EdaTa
Additional Web Information
JAX® NOTES, January 1990, 440. Tabby Stocks Available from The Jackson Laboratory.
JAX® NOTES, Summer 1994; 458. Tfm Strains at The Jackson Laboratory.
Phenotype
Phenotype Information
Androgen Insensitivity Syndrome; AIS - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
ArTfm/Y
Background Not Specified
- reproductive system phenotype
- abnormal spermatogenesis (MGI Ref ID J:65900)
- germ cell development progressed to spermatocytes
- abnormal testis morphology (MGI Ref ID J:65900)
- an extra layer of parietal lymphatic cells was present, but these cells appeared to be normal; myoid cells were also normal
- peritubular fibrosis was observed, as indicated by a few extra layers of fibroblastic-like cells around the seminiferous tubules, although this fibrosis was not as severe as that seen in Dhhtm1Amc feminized males
- collagen and basal lamina material between Sertoli and myoid cells extended around the entire seminiferous tubule unlike that of the patchy basal lamina seen in Dhhtm1Amc feminized males
- abnormal Leydig cell morphology (MGI Ref ID J:65900)
- at 63 days of age, testes from adult male hemizygotes contained abundant adult-type Leydig cells which appeared relatively undifferentiated and lacked smooth endoplasmic reticulum
- endocrine/exocrine gland phenotype
- abnormal testis morphology (MGI Ref ID J:65900)
- an extra layer of parietal lymphatic cells was present, but these cells appeared to be normal; myoid cells were also normal
- peritubular fibrosis was observed, as indicated by a few extra layers of fibroblastic-like cells around the seminiferous tubules, although this fibrosis was not as severe as that seen in Dhhtm1Amc feminized males
- collagen and basal lamina material between Sertoli and myoid cells extended around the entire seminiferous tubule unlike that of the patchy basal lamina seen in Dhhtm1Amc feminized males
- abnormal Leydig cell morphology (MGI Ref ID J:65900)
- at 63 days of age, testes from adult male hemizygotes contained abundant adult-type Leydig cells which appeared relatively undifferentiated and lacked smooth endoplasmic reticulum
ArTfm/Y
involves: NMRI * STOCK EdaTa Atp7aMo-blo
- reproductive system phenotype
- abnormal seminiferous tubule morphology (MGI Ref ID J:140803)
- mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
- Leydig cell hyperplasia (MGI Ref ID J:140803)
- unlike ArTfm male mice on the original stock background
- enlarged seminiferous tubules (MGI Ref ID J:140803)
- in 15 of 46 mice unlike ArTfm male mice on the original stock background
- arrest of male meiosis (MGI Ref ID J:140803)
- spermatogenesis does not proceed beyond meiosis prophase
- cryptorchism (MGI Ref ID J:140803)
- secondary sex reversal (MGI Ref ID J:140803)
- male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts
- tumorigenesis
- testis tumor (MGI Ref ID J:140803)
- 4 of 46 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
- however, no germ cell tumors are observed
- endocrine/exocrine gland phenotype
- abnormal seminiferous tubule morphology (MGI Ref ID J:140803)
- mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
- Leydig cell hyperplasia (MGI Ref ID J:140803)
- unlike ArTfm male mice on the original stock background
- enlarged seminiferous tubules (MGI Ref ID J:140803)
- in 15 of 46 mice unlike ArTfm male mice on the original stock background
- cryptorchism (MGI Ref ID J:140803)
This mouse can be used to support research in many areas including:ArTfm related
EdaTa-6J relatedEndocrine Deficiency Research
Gonad Defects
Mouse/Human Gene Homologs
testicular feminization
Reproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Developmental Biology Research
Eye Defects
Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia
Sensorineural Research
Eye Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | ArTfm | ||
| Allele Name | testicular feminization | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Tfm; | ||
| Strain of Origin | (STOCK Eda | ||
| Gene Symbol and Name | Ar, androgen receptor | ||
| Chromosome | X | ||
| Gene Common Name(s) | AIS; AW320017; Andr; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; Tfm; expressed sequence AW320017; testicular feminization; | ||
| General Note | ArTfm acts by causing insensitivity to androgens due to a defect in androgen-binding receptor present in cytosol and nucleus. Most responses to androgens are absent or defective in ArTfm/Y males and are not inducible by administration of androgens (J:5221, J:5532). Androgen receptor is found in kidney, submandibular gland (J:5667) and brain (J:5927). ArTfm/Y males have about 20-25 percent of normal testosterone-binding activity in brain (J:6096) and 10-20 percent in kidney. | ||
| Molecular Note | A frameshift mutation resulting from the deletion of a single cytosine residue generated a premature stop codon at residue 412. The nonsenes mutation is expected to preclude the translation of both the DNA- and steroid-binding domains. [MGI Ref ID J:11219] [MGI Ref ID J:1264] [MGI Ref ID J:19598] [MGI Ref ID J:30797] [MGI Ref ID J:712] | ||
| Allele Symbol | EdaTa-6J | ||
| Allele Name | tabby 6 Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Ta2; Ta6J; Tabby; | ||
| Strain of Origin | C57BL/6J-tp3J/J | ||
| Gene Symbol and Name | Eda, ectodysplasin-A | ||
| Chromosome | X | ||
| Gene Common Name(s) | ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; RGD1563178; Ta; XHED; XLHED; tabby; | ||
| Molecular Note | This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation. [MGI Ref ID J:42614] | ||
Genotyping
Genotyping Information
Genotyping Protocols
EdaTa-6J +/+ ArTfm, Restriction Enzyme Digest
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Charest NJ; Zhou ZX; Lubahn DB; Olsen KL; Wilson EM; French FS. 1991. A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse. Mol Endocrinol 5(4):573-81. [PubMed: 1681426] [MGI Ref ID J:712]
Dulos GJ; Bagchus WM. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int Immunopharmacol 1(2):321-8. [PubMed: 11360932] [MGI Ref ID J:109877]
Gaspar ML; Bourgarel P; Meo T; Tosi M. 1991. [Structure of messenger RNA of androgen receptor in mice and molecular characterization in Tfm mutant] C R Seances Soc Biol Fil 185(6):510-9. [PubMed: 1822400] [MGI Ref ID J:1264]
Gaspar ML; Meo T; Bourgarel P; Guenet JL; Tosi M. 1991. A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation. Proc Natl Acad Sci U S A 88(19):8606-10. [PubMed: 1924321] [MGI Ref ID J:30797]
Johnston DS; Russell LD; Friel PJ; Griswold MD. 2001. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142(6):2405-8. [PubMed: 11356688] [MGI Ref ID J:109878]
Kurita T; Wang YZ; Donjacour AA; Zhao C; Lydon JP; O'Malley BW; Isaacs JT; Dahiya R; Cunha GR. 2001. Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ 8(2):192-200. [PubMed: 11313721] [MGI Ref ID J:109881]
Li-Hawkins J; Lund EG; Turley SD; Russell DW. 2000. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem 275(22):16536-42. [PubMed: 10748048] [MGI Ref ID J:62587]
Lyon MF; Hawkes SG. 1970. X-linked gene for testicular feminization in the mouse. Nature 227(5264):1217-9. [PubMed: 5452809] [MGI Ref ID J:5173]
Murphy L; Jeffcoate IA; O'Shaughnessy PJ. 1994. Abnormal Leydig cell development at puberty in the androgen-resistant Tfm mouse. Endocrinology 135(4):1372-7. [PubMed: 7925099] [MGI Ref ID J:20980]
Additional References
Tullis KM; Krebs CJ; Leung JY; Robins DM. 2003. The regulator of sex-limitation gene, rsl, enforces male-specific liver gene expression by negative regulation. Endocrinology 144(5):1854-60. [PubMed: 12697692] [MGI Ref ID J:83502]
Aw-J relatedArTfm relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]
Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713] [MGI Ref ID J:145908]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]
Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194] [MGI Ref ID J:32132]
Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738] [MGI Ref ID J:31403]
Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990] [MGI Ref ID J:61324]
Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442] [MGI Ref ID J:1295]
Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941] [MGI Ref ID J:101081]
Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031] [MGI Ref ID J:146365]
Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695] [MGI Ref ID J:126508]
Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869] [MGI Ref ID J:111363]
Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326] [MGI Ref ID J:5288]
Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460] [MGI Ref ID J:52138]
Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102] [MGI Ref ID J:52183]
Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]
Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]
O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570] [MGI Ref ID J:100906]
Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097] [MGI Ref ID J:119427]
Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086] [MGI Ref ID J:114943]
Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]
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Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]
Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]
van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]
EdaTa-6J relatedAl-Attar L; Noel K; Dutertre M; Belville C; Forest MG; Burgoyne PS ; Josso N ; Rey R. 1997. Hormonal and cellular regulation of Sertoli cell anti-Mullerian hormone production in the postnatal mouse. J Clin Invest 100(6):1335-43. [PubMed: 9294098] [MGI Ref ID J:43055]
Attardi B; Geller LN; Ohno S. 1976. Androgen and estrogen receptors in brain cytosol from male, female, and testicular feminized (tfm/y hermaphrodite) mice. Endocrinology 98(4):864-74. [PubMed: 179788] [MGI Ref ID J:5655]
Attardi B; Ohno S. 1978. Physical properties of androgen receptors in brain cytosol from normal and testicular feminized (Tfm/y hermaphrodite) mice. Endocrinology 103(3):760-70. [PubMed: 744116] [MGI Ref ID J:6096]
Baker PJ; Sha JH; O'Shaughnessy PJ. 1997. Localisation and regulation of 17beta-hydroxysteroid dehydrogenase type 3 mRNA during development in the mouse testis. Mol Cell Endocrinol 133(2):127-33. [PubMed: 9406858] [MGI Ref ID J:44106]
Behringer RR; Finegold MJ; Cate RL. 1994. Mullerian-inhibiting substance function during mammalian sexual development. Cell 79(3):415-25. [PubMed: 7954809] [MGI Ref ID J:21396]
Bodo C; Rissman EF. 2007. Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice. Eur J Neurosci 25(7):2182-90. [PubMed: 17419752] [MGI Ref ID J:125039]
Clark AM; Garland KK; Russell LD. 2000. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type leydig cells and normal development of peritubular cells and seminiferous tubules Biol Reprod 63(6):1825-38. [PubMed: 11090455] [MGI Ref ID J:65900]
Dev A; Nayernia K; Meins M; Adham I; Lacone F; Engel W. 2007. Mice deficient for RNA-binding protein brunol1 show reduction of spermatogenesis but are fertile. Mol Reprod Dev 74(11):1456-64. [PubMed: 17393433] [MGI Ref ID J:128362]
Dofuku R; Tettenborn U; Ohno S. 1971. Testosterone-regulon in the mouse kidney. Nat New Biol 232(27):5-7. [PubMed: 5284427] [MGI Ref ID J:5221]
Drews U. 1998. Direct and mediated effects of testosterone: analysis of sex reversed mosaic mice heterozygous for testicular feminization. Cytogenet Cell Genet 80(1-4):68-74. [PubMed: 9678337] [MGI Ref ID J:48821]
Dunn JF; Wilson JD. 1975. Developmental study of androgen responsiveness in the submandibular gland of the mouse. Endocrinology 96(6):1571-8. [PubMed: 123850] [MGI Ref ID J:5532]
He WW; Kumar MV; Tindall DJ. 1991. A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res 19(9):2373-8. [PubMed: 2041777] [MGI Ref ID J:11219]
He WW; Lindzey JK; Prescott JL; Kumar MV; Tindall DJ. 1994. The androgen receptor in the testicular feminized (Tfm) mouse may be a product of internal translation initiation. Receptor 4(2):121-34. [PubMed: 7950980] [MGI Ref ID J:19598]
Kraszucka K; Burfeind P; Nayernia K; Kohler M; Schmid M; Yaylaoglu M; Engel W. 1999. Developmental stage- and germ cell-regulated expression of a calcium-binding protein mRNA in mouse Sertoli cells. Mol Reprod Dev 54(3):232-43. [PubMed: 10497345] [MGI Ref ID J:57920]
Lamm ML; Podlasek CA; Barnett DH; Lee J; Clemens JQ; Hebner CM; Bushman W. 2001. Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Dev Biol 232(2):301-14. [PubMed: 11401393] [MGI Ref ID J:69382]
Le Goascogne C; Sannanes N; Gouezou M; Baulieu EE; Robel P. 1993. Suppressed expression of the cytochrome P45017 alpha protein in the testicular feminized (Tfm) mouse testes. J Endocrinol 139(1):127-30. [PubMed: 8254285] [MGI Ref ID J:15718]
Lehraiki A; Racine C; Krust A; Habert R; Levacher C. 2009. Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism. Toxicol Sci 111(2):372-82. [PubMed: 19592451] [MGI Ref ID J:152418]
Lindsey JS; Wilkinson MF. 1996. Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis. Dev Biol 179(2):471-84. [PubMed: 8903361] [MGI Ref ID J:36481]
Lyon MF. 1969. Testicular feminization, proposed symbol Tfm Mouse News Lett 41:28. [MGI Ref ID J:30664]
Lyon MF; Glenister PH. 1980. Reduced reproductive performance in androgen-resistant Tfm/Tfm female mice. Proc R Soc Lond B Biol Sci 208(1170):1-12. [PubMed: 6105650] [MGI Ref ID J:6361]
Markova MS; Zeskand J; McEntee B; Rothstein J; Jimenez SA; Siracusa LD. 2004. A role for the androgen receptor in collagen content of the skin. J Invest Dermatol 123(6):1052-6. [PubMed: 15610513] [MGI Ref ID J:120139]
Merlet J; Racine C; Moreau E; Moreno SG; Habert R. 2007. Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation. Proc Natl Acad Sci U S A 104(9):3615-20. [PubMed: 17360691] [MGI Ref ID J:126078]
Meseguer A; Catterall JF. 1990. Cell-specific expression of kidney androgen-regulated protein messenger RNA is under multihormonal control. Mol Endocrinol 4(8):1240-8. [PubMed: 2293028] [MGI Ref ID J:14636]
Meseguer A; Watson CS; Catterall JF. 1989. Nucleotide sequence of kidney androgen-regulated protein mRNA and its cell-specific expression in Tfm/Y mice. Mol Endocrinol 3(6):962-7. [PubMed: 2739660] [MGI Ref ID J:36298]
Monks DA; Johansen JA; Mo K; Rao P; Eagleson B; Yu Z; Lieberman AP; Breedlove SM; Jordan CL. 2007. Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. Proc Natl Acad Sci U S A 104(46):18259-64. [PubMed: 17984063] [MGI Ref ID J:127205]
Murphy L; O'Shaughnessy PJ. 1991. Testicular steroidogenesis in the testicular feminized (Tfm) mouse: loss of 17 alpha-hydroxylase activity. J Endocrinol 131(3):443-9. [PubMed: 1686053] [MGI Ref ID J:155]
O'Shaughnessy PJ; Abel M; Charlton HM; Hu B; Johnston H; Baker PJ. 2007. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology 148(6):2914-24. [PubMed: 17332066] [MGI Ref ID J:129602]
O'Shaughnessy PJ; Johnston H; Willerton L; Baker PJ. 2002. Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. J Cell Sci 115(Pt 17):3491-6. [PubMed: 12154079] [MGI Ref ID J:78785]
Olsen NJ; Olson G; Viselli SM; Gu X; Kovacs WJ. 2001. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 142(3):1278-83. [PubMed: 11181545] [MGI Ref ID J:68787]
Penatti CA; Porter DM; Henderson LP. 2009. Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. J Neurosci 29(40):12484-96. [PubMed: 19812324] [MGI Ref ID J:153885]
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Rizk-Jackson A; Robertson J; Raber J. 2008. Tfm-AR modulates the effects of ApoE4 on cognition. J Neurochem 105(1):63-7. [PubMed: 18039320] [MGI Ref ID J:135450]
Sawada K; Noumura T. 1992. Sexually dimorphic duct system of the submandibular gland in mouse with testicular feminization mutation (Tfm/Y). Acta Anat (Basel) 143(3):241-5. [PubMed: 1632191] [MGI Ref ID J:1403]
Schubert S; Kamino K; Bohm D; Adham I; Engel W; von Wasielewski R; Moharregh-Khiabani D; Mauceri G; Vaske B; Meinhardt A; Schoner A; Gonzalez-Fassrainer D; Schmidtke J. 2008. TSPY expression is variably altered in transgenic mice with testicular feminization. Biol Reprod 79(1):125-33. [PubMed: 18401008] [MGI Ref ID J:140803]
Scordalakes EM; Rissman EF. 2004. Aggression and arginine vasopressin immunoreactivity regulation by androgen receptor and estrogen receptor alpha. Genes Brain Behav 3(1):20-6. [PubMed: 14960012] [MGI Ref ID J:104808]
Scordalakes EM; Shetty SJ; Rissman EF. 2002. Roles of estrogen receptor alpha and androgen receptor in the regulation of neuronal nitric oxide synthase. J Comp Neurol 453(4):336-44. [PubMed: 12389206] [MGI Ref ID J:113953]
Scott IS; Bennett MK; Porter-Goff AE; Harrison CJ; Cox BS; Grocock CA; O'Shaughnessy PJ; Clayton RN; Craven R; Furr BJA; Charlton HM.. 1992. Effects of the gonadotrophin-releasing hormone agonist 'Zoladex' upon pituitary and gonadal function in hypogonadal (hpg) male mice: a comparison with normal male and testicular feminized (tfm) mice. J Mol Endocrinol 8(3):249-58. [PubMed: 1385960] [MGI Ref ID J:3443]
Shetty G; Weng CC; Porter KL; Zhang Z; Pakarinen P; Kumar TR; Meistrich ML. 2006. Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations. Endocrinology 147(7):3563-70. [PubMed: 16627582] [MGI Ref ID J:110487]
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Thomas PS Jr; Fraley GS; Damien V; Woodke LB; Zapata F; Sopher BL; Plymate SR; La Spada AR. 2006. Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy. Hum Mol Genet 15(14):2225-38. [PubMed: 16772330] [MGI Ref ID J:112041]
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Tullis KM; Krebs CJ; Leung JY; Robins DM. 2003. The regulator of sex-limitation gene, rsl, enforces male-specific liver gene expression by negative regulation. Endocrinology 144(5):1854-60. [PubMed: 12697692] [MGI Ref ID J:83502]
Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]
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Cui CY; Durmowicz M; Ottolenghi C; Hashimoto T; Griggs B; Srivastava AK; Schlessinger D. 2003. Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet 12(22):2931-40. [PubMed: 14506134] [MGI Ref ID J:86628]
Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Mating System For ArTfm: heterozygote x wildtype; for EdaTa-6J: heterozygote x hemizygote EdaTa-6J +/? ? x EdaTa-6J +/Y then proven EdaTa-6J +/? ArTfm x EdaTa-6J +/Y Diet Information LabDiet® 5K52/5K67
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Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $141.00 Male Wild-type for EdaTa-6J, Hemizygous for ArTfm (feminized Male)
Pairs /Price (US dollars $) Pair Genotype $225.90 Heterozygous for EdaTa-6J, Assumed Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm $259.80 Heterozygous for EdaTa-6J, Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $183.30 Male Wild-type for EdaTa-6J, Hemizygous for ArTfm (feminized Male)
Pairs /Price (US dollars $) Pair Genotype $293.70 Heterozygous for EdaTa-6J, Assumed Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm $337.80 Heterozygous for EdaTa-6J, Heterozygous for ArTfm x Hemizygous for EdaTa-6J, Wild-type for ArTfm
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
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| 000051 C57BL/6J-Aw-J/J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.