Strain Name: |
B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J |
|---|---|
Stock Number: |
001809 |
Availability: | Repository- Live |
General Terms and Conditions |
| Genes & Alleles | Aw-J; Ar; ArTfm; Eda; EdaTa-6J; a; |
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Mating System Other - see Strain Mating Scheme Text (Female x Male) For ArTfm: heterozygote x wildtype; for EdaTa-6J: heterozygote x hemizygote EdaTa-6J +/? ? x EdaTa-6J +/Y then proven EdaTa-6J +/? ArTfm x EdaTa-6J +/Y Species laboratory mouse Background Strain C57BL/6J Donor Strain EdaTa-6J , C57BL/6J-tp3J ; ArTfm, offspring of female carrying EdaTa and Atp7ablo Generation N3F23B6N30+F35 (29-NOV-06) Appearance
white-bellied agouti, males with female external genitalia (no vaginal opening)
Related Genotype: Aw-J/Aw-J + ArTfm/Y males
tabby (yellow coat, no hair on ears and tail, bald patch behind ears, no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J +/Y males
white bellied agouti with mosaic striped coat
Related Genotype: Aw-J/Aw-J EdaTa-6J +/+ ArTfm females
tabby (yellow coat, no hair on ears and tail, bald patch behind ears; no guard hairs)
Related Genotype: Aw-J/Aw-J EdaTa-6J +/EdaTa-6J + femalesStrain Description
Testicular feminization (ArTfm) is a dominant spontaneous mutation on the X chromosome. Hemizygous male mice are outwardly female in appearance except that the vagina does not open until 3 months of age if at all. Male reproductive development is abnormal leading to very small testes, and the absense of vas deferens, the epididymis, and male accessory glands. Spermatogonia and Sertoli cells are present in the testes, but spermatogenesis does not proceed past meiotic prophase. Leydig cells, which normally produce androgen in males, fail to develop normally. This strain is also segregating for the tabby 6J mutation (EdaTa-6J) that affects both the coat color and hair pattern growth. The tabby mutation is maintained in repulsion with the testicular feminization mutation and is used as a coat color marker to assist in identifying resulting genotypes obtained from matings.
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | ArTfm | ||
| Allele Name | testicular feminization | ||
| Common Name(s) | Tfm; | ||
| Strain of Origin | (STOCK Eda | ||
| Gene Symbol and Name | Ar, androgen receptor | ||
| Chromosome | X | ||
| Gene Common Name(s) | AIS; AW320017; Andr; DHTR; HUMARA; KD; NR3C4; SBMA; SMAX1; TFM; Tfm; expressed sequence AW320017; testicular feminization; | ||
| General Note | ArTfm acts by causing insensitivity to androgens due to a defect in androgen-binding receptor present in cytosol and nucleus. Most responses to androgens are absent or defective in ArTfm/Y males and are not inducible by administration of androgens (J:5221, J:5532). Androgen receptor is found in kidney, submandibular gland (J:5667) and brain (J:5927). ArTfm/Y males have about 20-25 percent of normal testosterone-binding activity in brain (J:6096) and 10-20 percent in kidney. | ||
| Molecular Note | A frameshift mutation resulting from the deletion of a single cytosine residue generated a premature stop codon at residue 412. The nonsenes mutation is expected to preclude the translation of both the DNA- and steroid-binding domains. [MGI Ref ID J:11219] [MGI Ref ID J:1264] [MGI Ref ID J:19598] [MGI Ref ID J:30797] [MGI Ref ID J:712] | ||
| Allele Symbol | EdaTa-6J | ||
| Allele Name | tabby 6 Jackson | ||
| Common Name(s) | Ta6J; Tabby; | ||
| Strain of Origin | C57BL/6J-tp3J/J | ||
| Gene Symbol and Name | Eda, ectodysplasin-A | ||
| Chromosome | X | ||
| Gene Common Name(s) | ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; RGD1563178; Ta; XHED; XLHED; tabby; | ||
| Molecular Note | This allele is defined by a base pair deletion (at position 1049) resulting in a frameshift mutation. [MGI Ref ID J:42614] | ||
| Allele | Control | |
|---|---|---|
| ArTfm | 000051 C57BL/6J-Aw-J/J | |
| Considerations for Choosing Controls | ||
Aw-J
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Strains carrying Aw-J allele
View Strains carrying Aw-J (31 strains)
Strains carrying ArTfm allele
000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J View Strains carrying ArTfm (1 strain)
Strains carrying EdaTa-6J allele
002016 B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ 000552 B6-Aw-J-EdaTa-6J.Cg-Sxr 001730 B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J 000338 C57BL/6J Aw-J-EdaTa-6J/J View Strains carrying EdaTa-6J (4 strains)
Strains carrying other alleles of Eda
000841 B6-Aw-J.CBy-EdaTa-By/J 000314 B6CBACa Aw-J/A-EdaTa/J-XO 000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 001232 C3H/HeJ-EdaTa-5J/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J 003112 STOCK EdaTa-5J/J 000583 STOCK T(X;16)16H +/+ EdaTa View Strains carrying other alleles of Eda (7 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (138 strains)
Congenic Nomenclature
JAX® NOTES, January 1990, 440. Tabby Stocks Available from The Jackson Laboratory.
JAX® NOTES, Summer 1994; 458. Tfm Strains at The Jackson Laboratory.
Room Number FGB29
ArTfm related
EdaTa-6J relatedEndocrine Deficiency Research
Gonad Defects
Mouse/Human Gene Homologs
testicular feminization
Reproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Developmental Biology Research
Eye Defects
Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia
Sensorineural Research
Eye Defects
Selected Reference(s)
Additional ReferencesCharest NJ; Zhou ZX; Lubahn DB; Olsen KL; Wilson EM; French FS. 1991. A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse. Mol Endocrinol 5(4):573-81. [PubMed: 1681426] [MGI Ref ID J:712]
Dulos GJ; Bagchus WM. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int Immunopharmacol 1(2):321-8. [PubMed: 11360932] [MGI Ref ID J:109877]
Gaspar ML; Bourgarel P; Meo T; Tosi M. 1991. [Structure of messenger RNA of androgen receptor in mice and molecular characterization in Tfm mutant] C R Seances Soc Biol Fil 185(6):510-9. [PubMed: 1822400] [MGI Ref ID J:1264]
Gaspar ML; Meo T; Bourgarel P; Guenet JL; Tosi M. 1991. A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation. Proc Natl Acad Sci U S A 88(19):8606-10. [PubMed: 1924321] [MGI Ref ID J:30797]
Johnston DS; Russell LD; Friel PJ; Griswold MD. 2001. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142(6):2405-8. [PubMed: 11356688] [MGI Ref ID J:109878]
Kurita T; Wang YZ; Donjacour AA; Zhao C; Lydon JP; O'Malley BW; Isaacs JT; Dahiya R; Cunha GR. 2001. Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ 8(2):192-200. [PubMed: 11313721] [MGI Ref ID J:109881]
Li-Hawkins J; Lund EG; Turley SD; Russell DW. 2000. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem 275(22):16536-42. [PubMed: 10748048] [MGI Ref ID J:62587]
Lyon MF; Hawkes SG. 1970. X-linked gene for testicular feminization in the mouse. Nature 227(5264):1217-9. [PubMed: 5452809] [MGI Ref ID J:5173]
Murphy L; Jeffcoate IA; O'Shaughnessy PJ. 1994. Abnormal Leydig cell development at puberty in the androgen-resistant Tfm mouse. Endocrinology 135(4):1372-7. [PubMed: 7925099] [MGI Ref ID J:20980]
| Strain Name: | B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J |
| Stock Number: | 001809 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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