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Strain Name:

STOCK Tc/J

Stock Number:

001814

Availability:

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General Terms and Conditions

Genes & Alleles   T;   Tc;

Product Information

Strain Details

Type JAX® GEMM® Strain - Spontaneous Mutation
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
Generation?+F3+N1p
Mammalian Phenotype Terms assigned by genotype

Tc/T+

        mixed
  • limbs/digits/tail phenotype
  • abnormal tail bud morphology (MGI Ref ID J:106412)
    • by E 12, mutants show constriction at the base of the tail
    • later in development, the abnormalities observed are less severe and occur more posteriorly than in Tc/tw5 embryos
  • nervous system phenotype
  • abnormal neural tube morphology/development (MGI Ref ID J:106412)
    • at E12.5, one accessory neural tube is observed
    • spina bifida occulta (MGI Ref ID J:106412)
      • unlike T/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture
  • abnormal spinal cord morphology (MGI Ref ID J:106412)
    • embryos display ventral duplication of the spinal cord
  • embryogenesis phenotype
  • split notochord (MGI Ref ID J:106412)
    • some embryos show duplication or intermittent absence of the notochord
  • skeleton phenotype
  • absent vertebrae (MGI Ref ID J:106412)
    • embryos display partial or complete absence of bony vertebrae posterior to midliver level

Tc/Tc

        mixed
  • lethality-prenatal/perinatal
  • embryonic lethality during organogenesis (MGI Ref ID J:106412)
    • embryos die around E10-11 due to failure of establishment of placental connections
  • embryogenesis phenotype
  • abnormal limb bud morphology (MGI Ref ID J:106412)
  • abnormal rostral-caudal axis patterning (MGI Ref ID J:106412)
    • posterior portion of the body is severely reduced
  • abnormal somite development (MGI Ref ID J:106412)
    • embryos lack externally visible somites
  • nervous system phenotype
  • abnormal neural tube morphology/development (MGI Ref ID J:106412)
    • neural tube bulges anteriorly and is uneven in width with larger than normal spaces between cells
  • limbs/digits/tail phenotype
  • abnormal limb bud morphology (MGI Ref ID J:106412)
  • abnormal tail bud morphology (MGI Ref ID J:106412)
    • tail bud is absent

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tc/T+

        Background Not Specified
  • limbs/digits/tail phenotype
  • abnormal tail morphology (MGI Ref ID J:64262)
    • tail is reduced to a very short curly filament without skeleton and in some instances the tail is altogether absent
    • while approximately 5% of heterozygotes have a short tail not more than 20% normal length, most have no normal tail but a short boneless caudal filament
    • absent tail (MGI Ref ID J:5003)
    • short tail (MGI Ref ID J:5003)
  • skeleton phenotype
  • abnormal bone ossification (MGI Ref ID J:5003)
    • the centra of cervical vertebrae are wider than normal, the axis tends to ossify from twin centers, and distortion and fusion is found in some throacic centra
  • abnormal cervical vertebrae morphology (MGI Ref ID J:5003)
    • abnormal cervical atlas morphology (MGI Ref ID J:5003)
      • the neural arch is partially double in some heterozygotes
    • abnormal odontoid process (MGI Ref ID J:5003)
      • the axis odontoid process is absent resulting in a horseshoe-shaped articulation between the atlas and axis
    • cervical vertebral fusion (MGI Ref ID J:5003)
      • between the second and third vertebrae
  • abnormal nucleus pulposus morphology (MGI Ref ID J:5003)
    • aside from slight traces in the lower thoracic and lumbar regions, the intervertebral nuclei pulposi are absent at 3 weeks of age
  • abnormal vertebral arch development (MGI Ref ID J:5003)
  • decreased presacral vertebrae number (MGI Ref ID J:5003)
  • rib fusion (MGI Ref ID J:5003)
    • often extensive in the thoracic region
  • short ribs (MGI Ref ID J:5003)
  • vertebral fusion (MGI Ref ID J:5003)
    • cervical vertebral fusion (MGI Ref ID J:5003)
      • between the second and third vertebrae
    • fusion of vertebral arches (MGI Ref ID J:5003)
    • thoracic vertebral fusion (MGI Ref ID J:5003)
  • lethality-prenatal/perinatal
  • neonatal lethality (MGI Ref ID J:5003)
    • ratio of mutant to wild type is less than 1 to 1 at birth
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:5003)
    • 32% of curtailed mice die between birth and weaning

Tc/Tc

        Background Not Specified
  • lethality-prenatal/perinatal
  • embryonic lethality during organogenesis (MGI Ref ID J:5003)
    • between embryonic day 9 and 11, 31% of embryos from intercrosses of heterozygotes are dead or malformed and the abnormalities are more extreme than in T homozygotes
  • embryogenesis phenotype
  • abnormal allantois morphology (MGI Ref ID J:5003)
    • at embryonic day 10 to 11 the normal allantoic outgrowth is lacking
  • absent somites (MGI Ref ID J:5003)
    • at embryonic day 10 to 11 externally visible somites are absent
  • caudal body truncation (MGI Ref ID J:5003)
    • at embryonic day 10 to 11 the posterior part of the body, including hind-limb buds and tail have failed to develop
  • nervous system phenotype
  • abnormal neural fold formation (MGI Ref ID J:5003)
    • at embryonic day 10 to 11 the nerual folds remain open in the trunk region and there are kinks in the spinal cord on each side of the open neural folds
  • kinked neural tube (MGI Ref ID J:5003)
  • cardiovascular system phenotype
  • distended pericardial sacs (MGI Ref ID J:5003)
    • at embryonic day 10 to 11 the pericardium is distended

Gene & Allele Details

Allele Symbol Tc
Allele Name curtailed
Gene Symbol and Name T, brachyury
Chromosome 17
Gene Common Name(s) Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75;
General Note Tc, curtailed, semidominant. Found among offspring of an irradiated (C3H/He x 101/H)F1 male mated to females of a multiple recessive stock. Heterozygotes have complete or near-complete absence of the tail, absence of the odontoid process of the axis, absence of the nucleus pulposi of the intervertebral discs, a tendency for rib and vertebral fusions, and a slight decrease in average number of presacral vertebrae. They occasionally show paralysis of the hindlimbs and atresia ani. Homozygotes die at the same time as T/T embryos and are similar to them but more severely affected. Tc/T embryos are variable and intermediate between T/T and T c/T c (J:5003).
Molecular Note Southern analysis of genomic DNA showed that this allele does not comprise a deletion of flanking loci, D17Leh119II and D17RP17, as found for alleles Thp and TOrl. Sequencing genomic DNA from the open reading frame revealed a G to A transition that would result in a protein truncated at the carboxyl-terminal end. [MGI Ref ID J:85398]

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of T
003879   B10;TFLe-a/a T tf/+ tf/J
000405   B10ScSn.Cg-T/J
004591   B6 x B6Ei.Cg-TWis/EiJ
000953   B6 x BALB/cBy-T4J/J
001518   B6 x STOCK T tf/th45 tf/J
000567   B6.Cg-T2J +/+ Qkqk/J
001015   B6.Cg-T4Or/J
001054   B6.Cg-TOrl/EiJ
000350   B6By.Cg-KitW-v MitfMi-wh T/J
002282   BTBR T+ tf/J
001053   C3Sn.AK-Thp/EiJ
000545   C57BL/6J-T2J/J
001199   C57BL/6J-T5J/J
001961   C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei
View Strains carrying other alleles of T     (14 strains)

Research Applications

This mouse can be used to support research in many areas including:

Tc related

Developmental Biology Research
Neural Tube Defects

Neurobiology Research
Neural Tube Defects

References

Selected Reference(s)

Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493]  [MGI Ref ID J:5003]

Additional References

Price and Supply Information

Strain Name: STOCK Tc/J
Stock Number: 001814

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Request Form Strain from the Neural Tube Defect Resource. First time use requires submission of a Request Form, please inquire.
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Control InformationView Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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