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Type Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation ?+F3+N1p
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Strains carrying other alleles of T
003879 B10;TFLe-a/a T tf/+ tf/J 000405 B10ScSn.Cg-T/J 004591 B6 x B6Ei.Cg-TWis/EiJ 000953 B6 x BALB/cBy-T4J/J 001518 B6 x STOCK T tf/th45 tf/J 000567 B6.Cg-T2J +/+ Qkqk/J 001015 B6.Cg-T4Or/J 001054 B6.Cg-TOrl/EiJ 000350 B6By.Cg-KitW-v MitfMi-wh T/J 002282 BTBR T+ tf/J 001053 C3Sn.AK-Thp/EiJ 000545 C57BL/6J-T2J/J 001199 C57BL/6J-T5J/J 001961 C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei View Strains carrying other alleles of T (14 strains)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
Tc/T+
mixed
- limbs/digits/tail phenotype
- abnormal tail bud morphology (MGI Ref ID J:106412)
- by E 12, mutants show constriction at the base of the tail
- later in development, the abnormalities observed are less severe and occur more posteriorly than in Tc/tw5 embryos
- nervous system phenotype
- abnormal neural tube morphology/development (MGI Ref ID J:106412)
- at E12.5, one accessory neural tube is observed
- spina bifida occulta (MGI Ref ID J:106412)
- unlike T
/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture - abnormal spinal cord morphology (MGI Ref ID J:106412)
- embryos display ventral duplication of the spinal cord
- embryogenesis phenotype
- abnormal neural tube morphology/development (MGI Ref ID J:106412)
- at E12.5, one accessory neural tube is observed
- spina bifida occulta (MGI Ref ID J:106412)
- unlike T
/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture - split notochord (MGI Ref ID J:106412)
- some embryos show duplication or intermittent absence of the notochord
- skeleton phenotype
- absent vertebrae (MGI Ref ID J:106412)
- embryos display partial or complete absence of bony vertebrae posterior to midliver level
- spina bifida occulta (MGI Ref ID J:106412)
- unlike T
/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture Tc/Tc
mixed
- lethality-prenatal/perinatal
- embryonic lethality during organogenesis (MGI Ref ID J:106412)
- embryos die around E10-11 due to failure of establishment of placental connections
- embryogenesis phenotype
- abnormal limb bud morphology (MGI Ref ID J:106412)
- abnormal neural tube morphology/development (MGI Ref ID J:106412)
- neural tube bulges anteriorly and is uneven in width with larger than normal spaces between cells
- abnormal rostral-caudal axis patterning (MGI Ref ID J:106412)
- posterior portion of the body is severely reduced
- abnormal somite development (MGI Ref ID J:106412)
- embryos lack externally visible somites
- nervous system phenotype
- abnormal neural tube morphology/development (MGI Ref ID J:106412)
- neural tube bulges anteriorly and is uneven in width with larger than normal spaces between cells
- limbs/digits/tail phenotype
- abnormal limb bud morphology (MGI Ref ID J:106412)
- abnormal tail bud morphology (MGI Ref ID J:106412)
- tail bud is absent
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tc/T+
Background Not Specified
- limbs/digits/tail phenotype
- abnormal tail morphology (MGI Ref ID J:64262)
- tail is reduced to a very short curly filament without skeleton and in some instances the tail is altogether absent
- while approximately 5% of heterozygotes have a short tail not more than 20% normal length, most have no normal tail but a short boneless caudal filament
- skeleton phenotype
- abnormal bone ossification (MGI Ref ID J:5003)
- the centra of cervical vertebrae are wider than normal, the axis tends to ossify from twin centers, and distortion and fusion is found in some throacic centra
- abnormal cervical vertebrae morphology (MGI Ref ID J:5003)
- abnormal cervical atlas morphology (MGI Ref ID J:5003)
- the neural arch is partially double in some heterozygotes
- abnormal odontoid process (MGI Ref ID J:5003)
- the axis odontoid process is absent resulting in a horseshoe-shaped articulation between the atlas and axis
- cervical vertebral fusion (MGI Ref ID J:5003)
- between the second and third vertebrae
- abnormal nucleus pulposus morphology (MGI Ref ID J:5003)
- aside from slight traces in the lower thoracic and lumbar regions, the intervertebral nuclei pulposi are absent at 3 weeks of age
- abnormal vertebral arch development (MGI Ref ID J:5003)
- decreased presacral vertebrae number (MGI Ref ID J:5003)
- rib fusion (MGI Ref ID J:5003)
- often extensive in the thoracic region
- short ribs (MGI Ref ID J:5003)
- vertebral fusion (MGI Ref ID J:5003)
- cervical vertebral fusion (MGI Ref ID J:5003)
- between the second and third vertebrae
- fusion of vertebral arches (MGI Ref ID J:5003)
- thoracic vertebral fusion (MGI Ref ID J:5003)
- lethality-prenatal/perinatal
- neonatal lethality (MGI Ref ID J:5003)
- ratio of mutant to wild-type is less than 1 to 1 at birth
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:5003)
- 32% of curtailed mice die between birth and weaning
Tc/Tc
Background Not Specified
- lethality-prenatal/perinatal
- embryonic lethality during organogenesis (MGI Ref ID J:5003)
- between embryonic day 9 and 11, 31% of embryos from intercrosses of heterozygotes are dead or malformed and the abnormalities are more extreme than in T homozygotes
- embryogenesis phenotype
- abnormal allantois morphology (MGI Ref ID J:5003)
- at embryonic day 10 to 11 the normal allantoic outgrowth is lacking
- absent somites (MGI Ref ID J:5003)
- at embryonic day 10 to 11 externally visible somites are absent
- caudal body truncation (MGI Ref ID J:5003)
- at embryonic day 10 to 11 the posterior part of the body, including hind-limb buds and tail have failed to develop
- kinked neural tube (MGI Ref ID J:5003)
- nervous system phenotype
- abnormal neural fold formation (MGI Ref ID J:5003)
- at embryonic day 10 to 11 the nerual folds remain open in the trunk region and there are kinks in the spinal cord on each side of the open neural folds
- kinked neural tube (MGI Ref ID J:5003)
- cardiovascular system phenotype
- distended pericardium (MGI Ref ID J:5003)
- at embryonic day 10 to 11 the pericardium is distended
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:Tc related
Developmental Biology Research
Neural Tube Defects
Neurobiology Research
Neural Tube Defects
| Allele Symbol | Tc | ||
|---|---|---|---|
| Allele Name | curtailed | ||
| Allele Type | Radiation induced | ||
| Gene Symbol and Name | T, brachyury | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75; | ||
| General Note | Tc, curtailed, semidominant. Found among offspring of an irradiated (C3H/He x 101/H)F1 male mated to females of a multiple recessive stock. Heterozygotes have complete or near-complete absence of the tail, absence of the odontoid process of the axis, absence of the nucleus pulposi of the intervertebral discs, a tendency for rib and vertebral fusions, and a slight decrease in average number of presacral vertebrae. They occasionally show paralysis of the hindlimbs and atresia ani. Homozygotes die at the same time as T/T embryos and are similar to them but more severely affected. Tc/T embryos are variable and intermediate between T/T and T c/T c (J:5003). | ||
| Molecular Note | Southern analysis of genomic DNA showed that this allele does not comprise a deletion of flanking loci, D17Leh119II and D17RP17, as found for alleles Thp and TOrl. Sequencing genomic DNA from the open reading frame revealed a G to A transition that would result in a protein truncated at the carboxyl-terminal end. [MGI Ref ID J:85398] | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493] [MGI Ref ID J:5003]
Dietrich S; Schubert FR; Gruss P. 1993. Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev 44(2-3):189-207. [PubMed: 8155581] [MGI Ref ID J:16484]
Tc relatedDietrich S; Schubert FR; Gruss P. 1993. Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev 44(2-3):189-207. [PubMed: 8155581] [MGI Ref ID J:16484]
Dietrich S; Schubert FR; Gruss P; Lumsden A. 1999. The role of the notochord for epaxial myotome formation in the mouse. Cell Mol Biol (Noisy-le-grand) 45(5):601-16. [PubMed: 10512192] [MGI Ref ID J:59749]
Herrmann BG; Kispert A. 1994. The T genes in embryogenesis. Trends Genet 10(8):280-6. [PubMed: 7940757] [MGI Ref ID J:85398]
Inman KE; Downs KM. 2006. Brachyury is required for elongation and vasculogenesis in the murine allantois. Development 133(15):2947-59. [PubMed: 16835439] [MGI Ref ID J:119027]
MacMurray A; Shin HS. 1988. The antimorphic nature of the Tc allele at the mouse T locus. Genetics 120(2):545-50. [PubMed: 3197959] [MGI Ref ID J:9490]
Park CH; Pruitt JH; Bennett D. 1989. A mouse model for neural tube defects: the curtailed (Tc) mutation produces spina bifida occulta in Tc/+ animals and spina bifida with meningomyelocele in Tc/t. Teratology 39(3):303-12. [PubMed: 2658196] [MGI Ref ID J:106412]
Schubert FR; Fainsod A; Gruenbaum Y; Gruss P. 1995. Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev 51(1):99-114. [PubMed: 7669696] [MGI Ref ID J:26182]
Searle AG. 1960. T<c> - curtailed Mouse News Lett 22:29. [MGI Ref ID J:64262]
Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292] [MGI Ref ID J:3956]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
| Request Form |
Strain from the Neural Tube Defect Resource. First time use requires submission of a Request Form, please inquire. |
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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Contact Information
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Fax: 1-207-288-6150
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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