Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation ?+F3+N1p

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of T

003879	B10;TFLe-a/a T tf/+ tf/J
000405	B10ScSn.Cg-T/J
004591	B6 x B6Ei.Cg-TWis/EiJ
000953	B6 x BALB/cBy-T4J/J
001518	B6 x STOCK T tf/th45 tf/J
000567	B6.Cg-T2J +/+ Qkqk/J
001015	B6.Cg-T4Or/J
001054	B6.Cg-TOrl/EiJ
000350	B6By.Cg-KitW-v MitfMi-wh T/J
002282	BTBR T+ tf/J
001053	C3Sn.AK-Thp/EiJ
000545	C57BL/6J-T2J/J
001199	C57BL/6J-T5J/J
001961	C57BL/6JEi x STOCK T T(16;17)43H/+ T(16;17)43H/Ei

View Strains carrying other alleles of T     (14 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

T^c/T⁺

        mixed

• limbs/digits/tail phenotype
• abnormal tail bud morphology (MGI Ref ID J:106412)
  • by E 12, mutants show constriction at the base of the tail
  • later in development, the abnormalities observed are less severe and occur more posteriorly than in T^c/t^w5 embryos
• nervous system phenotype
• abnormal neural tube morphology/development (MGI Ref ID J:106412)
  • at E12.5, one accessory neural tube is observed
• spina bifida occulta (MGI Ref ID J:106412)
  • unlike T/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture
• abnormal spinal cord morphology (MGI Ref ID J:106412)
  • embryos display ventral duplication of the spinal cord
• embryogenesis phenotype
• abnormal neural tube morphology/development (MGI Ref ID J:106412)
  • at E12.5, one accessory neural tube is observed
• spina bifida occulta (MGI Ref ID J:106412)
  • unlike T/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture
• split notochord (MGI Ref ID J:106412)
  • some embryos show duplication or intermittent absence of the notochord
• skeleton phenotype
• absent vertebrae (MGI Ref ID J:106412)
  • embryos display partial or complete absence of bony vertebrae posterior to midliver level
• spina bifida occulta (MGI Ref ID J:106412)
  • unlike T/t<25> mutants, the dermis over the bony defect of the spinal cord does not become attenuated and rupture

T^c/T^c

        mixed

• lethality-prenatal/perinatal
• embryonic lethality during organogenesis (MGI Ref ID J:106412)
  • embryos die around E10-11 due to failure of establishment of placental connections
• embryogenesis phenotype
• abnormal limb bud morphology (MGI Ref ID J:106412)
• abnormal neural tube morphology/development (MGI Ref ID J:106412)
  • neural tube bulges anteriorly and is uneven in width with larger than normal spaces between cells
• abnormal rostral-caudal axis patterning (MGI Ref ID J:106412)
  • posterior portion of the body is severely reduced
• abnormal somite development (MGI Ref ID J:106412)
  • embryos lack externally visible somites
• nervous system phenotype
• abnormal neural tube morphology/development (MGI Ref ID J:106412)
  • neural tube bulges anteriorly and is uneven in width with larger than normal spaces between cells
• limbs/digits/tail phenotype
• abnormal limb bud morphology (MGI Ref ID J:106412)
• abnormal tail bud morphology (MGI Ref ID J:106412)
  • tail bud is absent

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

T^c/T⁺

        Background Not Specified

• limbs/digits/tail phenotype
• abnormal tail morphology (MGI Ref ID J:64262)
  • tail is reduced to a very short curly filament without skeleton and in some instances the tail is altogether absent
  • while approximately 5% of heterozygotes have a short tail not more than 20% normal length, most have no normal tail but a short boneless caudal filament
• absent tail (MGI Ref ID J:5003)
• short tail (MGI Ref ID J:5003)
• skeleton phenotype
• abnormal bone ossification (MGI Ref ID J:5003)
  • the centra of cervical vertebrae are wider than normal, the axis tends to ossify from twin centers, and distortion and fusion is found in some throacic centra
• abnormal cervical vertebrae morphology (MGI Ref ID J:5003)
• abnormal cervical atlas morphology (MGI Ref ID J:5003)
  • the neural arch is partially double in some heterozygotes
• abnormal odontoid process (MGI Ref ID J:5003)
  • the axis odontoid process is absent resulting in a horseshoe-shaped articulation between the atlas and axis
• cervical vertebral fusion (MGI Ref ID J:5003)
  • between the second and third vertebrae
• abnormal nucleus pulposus morphology (MGI Ref ID J:5003)
  • aside from slight traces in the lower thoracic and lumbar regions, the intervertebral nuclei pulposi are absent at 3 weeks of age
• abnormal vertebral arch development (MGI Ref ID J:5003)
• decreased presacral vertebrae number (MGI Ref ID J:5003)
• rib fusion (MGI Ref ID J:5003)
  • often extensive in the thoracic region
• short ribs (MGI Ref ID J:5003)
• vertebral fusion (MGI Ref ID J:5003)
• cervical vertebral fusion (MGI Ref ID J:5003)
  • between the second and third vertebrae
• fusion of vertebral arches (MGI Ref ID J:5003)
• thoracic vertebral fusion (MGI Ref ID J:5003)
• lethality-prenatal/perinatal
• neonatal lethality (MGI Ref ID J:5003)
  • ratio of mutant to wild-type is less than 1 to 1 at birth
• lethality-postnatal
• postnatal lethality (MGI Ref ID J:5003)
  • 32% of curtailed mice die between birth and weaning

T^c/T^c

        Background Not Specified

• lethality-prenatal/perinatal
• embryonic lethality during organogenesis (MGI Ref ID J:5003)
  • between embryonic day 9 and 11, 31% of embryos from intercrosses of heterozygotes are dead or malformed and the abnormalities are more extreme than in T homozygotes
• embryogenesis phenotype
• abnormal allantois morphology (MGI Ref ID J:5003)
  • at embryonic day 10 to 11 the normal allantoic outgrowth is lacking
• absent somites (MGI Ref ID J:5003)
  • at embryonic day 10 to 11 externally visible somites are absent
• caudal body truncation (MGI Ref ID J:5003)
  • at embryonic day 10 to 11 the posterior part of the body, including hind-limb buds and tail have failed to develop
• kinked neural tube (MGI Ref ID J:5003)
• nervous system phenotype
• abnormal neural fold formation (MGI Ref ID J:5003)
  • at embryonic day 10 to 11 the nerual folds remain open in the trunk region and there are kinks in the spinal cord on each side of the open neural folds
• kinked neural tube (MGI Ref ID J:5003)
• cardiovascular system phenotype
• distended pericardium (MGI Ref ID J:5003)
  • at embryonic day 10 to 11 the pericardium is distended

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

T^c related

Developmental Biology Research
Neural Tube Defects

Neurobiology Research
Neural Tube Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Tc
Allele Name		curtailed
Allele Type		Radiation induced
Gene Symbol and Name		T, brachyury
Chromosome		17
Gene Common Name(s)		Bra; Low; Lr; MGC104817; T1; TFT; Tl2; Tl3; brachyury-like 2; brachyury-like 3; cou; coupe; low ratio; me75;
General Note		Tc, curtailed, semidominant. Found among offspring of an irradiated (C3H/He x 101/H)F1 male mated to females of a multiple recessive stock. Heterozygotes have complete or near-complete absence of the tail, absence of the odontoid process of the axis, absence of the nucleus pulposi of the intervertebral discs, a tendency for rib and vertebral fusions, and a slight decrease in average number of presacral vertebrae. They occasionally show paralysis of the hindlimbs and atresia ani. Homozygotes die at the same time as T/T embryos and are similar to them but more severely affected. Tc/T embryos are variable and intermediate between T/T and T c/T c (J:5003).
Molecular Note		Southern analysis of genomic DNA showed that this allele does not comprise a deletion of flanking loci, D17Leh119II and D17RP17, as found for alleles Thp and TOrl. Sequencing genomic DNA from the open reading frame revealed a G to A transition that would result in a protein truncated at the carboxyl-terminal end. [MGI Ref ID J:85398]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Searle AG. 1966. Curtailed, a new dominant T-allele in the house mouse. Genet Res 7(1):86-95. [PubMed: 5906493]  [MGI Ref ID J:5003]

Additional References

Dietrich S; Schubert FR; Gruss P. 1993. Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev 44(2-3):189-207. [PubMed: 8155581]  [MGI Ref ID J:16484]

T^c related

Dietrich S; Schubert FR; Gruss P. 1993. Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev 44(2-3):189-207. [PubMed: 8155581]  [MGI Ref ID J:16484]

Dietrich S; Schubert FR; Gruss P; Lumsden A. 1999. The role of the notochord for epaxial myotome formation in the mouse. Cell Mol Biol (Noisy-le-grand) 45(5):601-16. [PubMed: 10512192]  [MGI Ref ID J:59749]

Herrmann BG; Kispert A. 1994. The T genes in embryogenesis. Trends Genet 10(8):280-6. [PubMed: 7940757]  [MGI Ref ID J:85398]

Inman KE; Downs KM. 2006. Brachyury is required for elongation and vasculogenesis in the murine allantois. Development 133(15):2947-59. [PubMed: 16835439]  [MGI Ref ID J:119027]

MacMurray A; Shin HS. 1988. The antimorphic nature of the Tc allele at the mouse T locus. Genetics 120(2):545-50. [PubMed: 3197959]  [MGI Ref ID J:9490]

Park CH; Pruitt JH; Bennett D. 1989. A mouse model for neural tube defects: the curtailed (Tc) mutation produces spina bifida occulta in Tc/+ animals and spina bifida with meningomyelocele in Tc/t. Teratology 39(3):303-12. [PubMed: 2658196]  [MGI Ref ID J:106412]

Schubert FR; Fainsod A; Gruenbaum Y; Gruss P. 1995. Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev 51(1):99-114. [PubMed: 7669696]  [MGI Ref ID J:26182]

Searle AG. 1960. T<c> - curtailed Mouse News Lett 22:29.  [MGI Ref ID J:64262]

Stott D; Kispert A; Herrmann BG. 1993. Rescue of the tail defect of Brachyury mice. Genes Dev 7(2):197-203. [PubMed: 8436292]  [MGI Ref ID J:3956]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). Genomic DNA is available for this strain from the Mouse DNA Resource.
Request Form	Strain from the Neural Tube Defect Resource. First time use requires submission of a Request Form, please inquire.

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

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