Strain Name:

B6C3Fe a/a-Col1a2oim/J

Stock Number:

001815

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Description

Strain Information

Former Names B6C3Fe-a/a-Col1a2oim/+    (Changed: 15-DEC-04 )
Type Mutant Strain;
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Mating SystemOutcross-Intercross         (Female x Male)   01-MAR-06
TJL Breeding Summary: homozygote x B6C3Fe a/a F1 or B6C3Fe a/a F1 x homozygote then heterozygote x heterozygote
Specieslaboratory mouse
GenerationN43F1 (21-DEC-11)
Generation Definitions

Appearance
black, skeletal defects
Related Genotype: a/a Col1a2oim/Col1a2oim

black, normal outward appearance
Related Genotype: a/a +/? or a/a Col1a2oim/+

Development
The mutation to osteogenesis imperfecta (oim) arose spontaneously in 1985 in the F2 generation of a C57BL/6J male bred with a C3H/HeJ-din ovarian transplant host which was itself a B6C3Fe-a/a F1 hybrid. In this F2 generation a pair of mice showing the abnormal leg development were mated and an affected offspring was outcrossed to a B6C3FeF1/J-a/a hybrid. The strain was subsequently maintained by cross-intercross, crossing a homozygote to a B6C3FeF1/J-a/a hybrid to maintain hybrid vigor then intercrossing the heterozygous offspring to produce affected homozygotes for the next cross to the F1 hybrid. In 1991 B6C3FeF1/J-a/a hybrid females were bred with N13 males homozygous for oim to generate embryos for cryopreservation.

Control Information

  Control
   Untyped from the colony
   001022 B6C3FeF1/J a/a
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Ces1ce/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (103 strains)

Strains carrying other alleles of Col1a2
007248   B6.129(FVB)-Col1a2tm1.1Mcbr/J
016237   B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J
View Strains carrying other alleles of Col1a2     (2 strains)

Strains carrying other alleles of a
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000001   B6.C3 A/a Mgrn1md/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
000231   B6;C3Fe a/a-Csf1op/J
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000785   B6;D2-a Ces1ce/EiJ
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000065   B6C3Fe a/a-we Pax1un at/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
003301   B6C3FeF1 a/A-Eya1bor/J
001022   B6C3FeF1/J a/a
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
001886   C3HeB/FeJLe a/a-gnd/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
000265   MY/HuLeJ
000308   SSL/LeJ
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying other alleles of a     (178 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
Osteogenesis Imperfecta, Type III - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Col1a2oim/Col1a2+

        B6C3Fe a/a-Col1a2oim/J
  • skeleton phenotype
  • abnormal compact bone morphology
    • cortical bone consists of areas of normal lamellar bone intermixed with hypercellular, highly vascularized bone, however cortical thickness is normal   (MGI Ref ID J:38013)
  • decreased bone strength
    • although heterozygotes do not exhibit fractures, they show reduced bone mechanical strength   (MGI Ref ID J:38013)
    • male and female femurs have a 21% and 18% reduction in maximum load, respectively   (MGI Ref ID J:38013)
    • male and female femurs have a 32% and 39% reduction in energy to failure, respectively, compared to wild-type   (MGI Ref ID J:38013)

Col1a2oim/Col1a2oim

        involves: C3H/HeJ * C57BL/6JLe
  • growth/size phenotype
  • decreased body size   (MGI Ref ID J:4348)
  • skeleton phenotype
  • abnormal bone mineralization
    • mineral crystals within cortical bone are thinner and less well aligned, probably contributing to the brittleness of bones   (MGI Ref ID J:31692)
  • abnormal caudal vertebrae morphology
    • periodically noticeable breaks in the tail vertebrae   (MGI Ref ID J:4348)
  • abnormal compact bone lamellar structure
    • lack of normal lamellar organization of the cortical bone   (MGI Ref ID J:4348)
  • abnormal joint morphology
    • joint subluxation   (MGI Ref ID J:4348)
    • sclerosis around the knee joints   (MGI Ref ID J:4348)
  • abnormal long bone morphology   (MGI Ref ID J:31692)
    • exhibit visible breaks in the long bones of the legs   (MGI Ref ID J:4348)
    • camptomelia
      • bowing of the long bones   (MGI Ref ID J:4348)
  • abnormal osteocyte morphology
    • increase in the number or density of cortical osteocytes   (MGI Ref ID J:4348)
  • decreased bone mineral density
    • generalized osteopenia   (MGI Ref ID J:4348)
  • decreased bone trabecula number
    • femurs at 7 months of age show fewer medullary trabeculae   (MGI Ref ID J:4348)
  • decreased compact bone thickness   (MGI Ref ID J:31692)
    • femurs at 7 months of age show cortical thinning and an increase in the number or density of cortical osteocytes   (MGI Ref ID J:4348)
  • decreased tendon stiffness
    • tendon collagen is less resistant to tensile stress than wild-type collagen indicating that tendons are weaker   (MGI Ref ID J:41509)
  • fragile skeleton   (MGI Ref ID J:31692)
    • homozygotes are born with bone fractures or develop them at an early age and mutants often show evidence of healed fractures   (MGI Ref ID J:4348)
  • kyphosis
    • older mice develop dorsal kyphosis   (MGI Ref ID J:4348)
  • scoliosis
    • in older mice   (MGI Ref ID J:4348)
  • behavior/neurological phenotype
  • abnormal gait
    • older animals develop an abnormal gait   (MGI Ref ID J:4348)
  • cardiovascular system phenotype
  • hemorrhage
    • hemorrhage into the joint cavities, sides of the body, or around the scapulas   (MGI Ref ID J:4348)
  • limbs/digits/tail phenotype
  • abnormal caudal vertebrae morphology
    • periodically noticeable breaks in the tail vertebrae   (MGI Ref ID J:4348)
  • abnormal forelimb morphology
    • drooping wrist appearance due to subluxation on one or both forepaws   (MGI Ref ID J:4348)
  • abnormal long bone morphology   (MGI Ref ID J:31692)
    • exhibit visible breaks in the long bones of the legs   (MGI Ref ID J:4348)
    • camptomelia
      • bowing of the long bones   (MGI Ref ID J:4348)
  • muscle phenotype
  • decreased tendon stiffness
    • tendon collagen is less resistant to tensile stress than wild-type collagen indicating that tendons are weaker   (MGI Ref ID J:41509)
  • integument phenotype
  • abnormal skin morphology
    • fibroblasts in the skin contain greatly dilated cisternae of the rough endoplasmic reticulum   (MGI Ref ID J:4348)
    • abnormal dermal layer morphology
      • dermal fibroblasts exhibit a rounded morphology instead of the typical elongated shape   (MGI Ref ID J:4348)

Col1a2oim/Col1a2oim

        B6C3Fe a/a-Col1a2oim/J
  • skeleton phenotype
  • abnormal compact bone morphology
    • cortical bone appears disorganized, very cellular, and highly vascularized   (MGI Ref ID J:38013)
    • abnormal compact bone lamellar structure
      • exhibit very little lamellar structure   (MGI Ref ID J:38013)
  • abnormal tendon morphology
    • higher than normal denaturation temperature of the tail tendon   (MGI Ref ID J:124000)
  • decreased bone strength
    • femurs have reduced biomechanical properties in bending   (MGI Ref ID J:38013)
    • male and female femurs have a 67% and 60% reduction in maximum load, respectively   (MGI Ref ID J:38013)
    • both male and female femurs have a 79% reduction in energy to failure compared to wild-type   (MGI Ref ID J:38013)
    • male and female femurs have a 64% and 40% reduction in stiffness, respectively   (MGI Ref ID J:38013)
  • muscle phenotype
  • abnormal tendon morphology
    • higher than normal denaturation temperature of the tail tendon   (MGI Ref ID J:124000)
  • cellular phenotype
  • *normal* cellular phenotype
    • normal hydroxylation of lysine in skin and tendon   (MGI Ref ID J:124000)
  • integument phenotype
  • abnormal skin morphology
    • thermogram assessment shows a 2.3 degree increase in skin denaturation temperature   (MGI Ref ID J:124000)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Col1a2oim related

Developmental Biology Research
Defects in Extracellular Matrix Molecules
Skeletal Defects

Mouse/Human Gene Homologs
osteogenesis imperfecta congenita, Ehlers-Danlos syndrome, type VII, autosomal dominant

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Col1a2oim
Allele Name osteogenesis imperfecta
Allele Type Spontaneous
Common Name(s) oim;
Strain of Origin(C3H/HeJ x C57BL/6JLe)F2
Gene Symbol and Name Col1a2, collagen, type I, alpha 2
Chromosome 6
Gene Common Name(s) AA960264; AI325291; Col1a-2; Cola-2; Cola2; OI4; expressed sequence AA960264; expressed sequence AI325291; oim; osteogenesis imperfecta; procollagen type I, alpha 2;
General Note Heterozygotes exhibit phenotypic similarity to human syndrome: mild form of osteogenesis imperfecta (J:38013).
Molecular Note A deletion of a single G residue at position 3983 is predicted to result in a frameshift mutation and an alteration of the last 48 amino acids in the encoded protein. [MGI Ref ID J:17202] [MGI Ref ID J:41994] [MGI Ref ID J:4348]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
Molecular Note Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. [MGI Ref ID J:16984] [MGI Ref ID J:24934]

Genotyping

Genotyping Information

Genotyping Protocols

Col1a2oim, Pyrosequencing


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Weis SM; Emery JL; Becker KD; McBride DJ Jr; Omens JH; McCulloch AD. 2000. Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim). Circ Res 87(8):663-9. [PubMed: 11029401]  [MGI Ref ID J:82592]

Col1a2oim related

Brodeur AC; Wirth DA; Franklin CL; Reneker LW; Miner JH; Phillips CL. 2007. Type I collagen glomerulopathy: postnatal collagen deposition follows glomerular maturation. Kidney Int 71(10):985-93. [PubMed: 17361118]  [MGI Ref ID J:136784]

Camacho NP; Hou L; Toledano TR; Ilg WA; Brayton CF; Raggio CL; Root L; Boskey AL. 1999. The material basis for reduced mechanical properties in oim mice bones. J Bone Miner Res 14(2):264-72. [PubMed: 9933481]  [MGI Ref ID J:54730]

Camacho NP; Landis WJ; Boskey AL. 1996. Mineral changes in a mouse model of osteogenesis imperfecta detected by Fourier transform infrared microscopy. Connect Tissue Res 35(1-4):259-65. [PubMed: 9084664]  [MGI Ref ID J:39178]

Carleton SM; McBride DJ; Carson WL; Huntington CE; Twenter KL; Rolwes KM; Winkelmann CT; Morris JS; Taylor JF; Phillips CL. 2008. Role of genetic background in determining phenotypic severity throughout postnatal development and at peak bone mass in Col1a2 deficient mice (oim). Bone 42(4):681-94. [PubMed: 18313376]  [MGI Ref ID J:136569]

Carleton SM; Whitford GM; Phillips CL. 2010. Dietary fluoride restriction does not alter femoral biomechanical strength in col1a2-deficient (oim) mice with type I collagen glomerulopathy. J Nutr 140(10):1752-6. [PubMed: 20724489]  [MGI Ref ID J:164391]

Chipman SD; Sweet HO; McBride DJ Jr; Davisson MT; Marks SC Jr; Shuldiner AR; Wenstrup RJ; Rowe DW; Shapiro JR. 1993. Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta. Proc Natl Acad Sci U S A 90(5):1701-5. [PubMed: 8446583]  [MGI Ref ID J:4348]

Dong XN; Zoghi M; Ran Q; Wang X. 2010. Collagen mutation causes changes of the microdamage morphology in bone of an OI mouse model. Bone 47(6):1071-5. [PubMed: 20736092]  [MGI Ref ID J:166371]

Fratzl P; Paris O; Klaushofer K; Landis WJ. 1996. Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering. J Clin Invest 97(2):396-402. [PubMed: 8567960]  [MGI Ref ID J:31692]

Grabner B; Landis WJ; Roschger P; Rinnerthaler S; Peterlik H; Klaushofer K; Fratzl P. 2001. Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim). Bone 29(5):453-7. [PubMed: 11704498]  [MGI Ref ID J:109416]

Guillot PV; Cook HT; Pusey CD; Fisk NM; Harten S; Moss J; Shore I; Bou-Gharios G. 2008. Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse. J Pathol 214(5):627-36. [PubMed: 18266309]  [MGI Ref ID J:133328]

Kalajzic I; Terzic J; Rumboldt Z; Mack K; Naprta A; Ledgard F; Gronowicz G; Clark SH; Rowe DW. 2002. Osteoblastic response to the defective matrix in the osteogenesis imperfecta murine (oim) mouse. Endocrinology 143(5):1594-601. [PubMed: 11956140]  [MGI Ref ID J:76321]

Li F; Wang X; Niyibizi C. 2010. Bone marrow stromal cells contribute to bone formation following infusion into femoral cavities of a mouse model of osteogenesis imperfecta. Bone 47(3):546-55. [PubMed: 20570757]  [MGI Ref ID J:165164]

Li H; Jiang X; Delaney J; Franceschetti T; Bilic-Curcic I; Kalinovsky J; Lorenzo JA; Grcevic D; Rowe DW; Kalajzic I. 2010. Immature osteoblast lineage cells increase osteoclastogenesis in osteogenesis imperfecta murine. Am J Pathol 176(5):2405-13. [PubMed: 20348238]  [MGI Ref ID J:160764]

Lopez Franco GE; Huang A; Pleshko Camacho N; Blank RD. 2005. Dental phenotype of the col1a2(oim) mutation: DI is present in both homozygotes and heterozygotes. Bone 36(6):1039-46. [PubMed: 15878701]  [MGI Ref ID J:105006]

McBride DJ Jr; Choe V; Shapiro JR; Brodsky B. 1997. Altered collagen structure in mouse tail tendon lacking the alpha 2(I) chain. J Mol Biol 270(2):275-84. [PubMed: 9236128]  [MGI Ref ID J:41994]

McBride DJ Jr; Shapiro JR. 1994. Confirmation of a G nucleotide deletion in the Cola-2 gene of mice with the osteogenesis imperfecta mutation. Genomics 20(1):135-7. [PubMed: 8020944]  [MGI Ref ID J:17202]

McBride DJ Jr; Shapiro JR; Dunn MG. 1998. Bone geometry and strength measurements in aging mice with the oim mutation. Calcif Tissue Int 62(2):172-6. [PubMed: 9437052]  [MGI Ref ID J:45596]

Mehrotra M; Rosol M; Ogawa M; Larue AC. 2010. Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies. Exp Hematol 38(7):593-602. [PubMed: 20417683]  [MGI Ref ID J:164084]

Miles CA; Sims TJ; Camacho NP; Bailey AJ. 2002. The role of the alpha2 chain in the stabilization of the collagen type I heterotrimer: a study of the type I homotrimer in oim mouse tissues. J Mol Biol 321(5):797-805. [PubMed: 12206762]  [MGI Ref ID J:124000]

Misof K; Landis WJ; Klaushofer K; Fratzl P. 1997. Collagen from the osteogenesis imperfecta mouse model (oim) shows reduced resistance against tensile stress. J Clin Invest 100(1):40-5. [PubMed: 9202055]  [MGI Ref ID J:41509]

Pfeiffer BJ; Franklin CL; Hsieh FH; Bank RA; Phillips CL. 2005. Alpha 2(I) collagen deficient oim mice have altered biomechanical integrity, collagen content, and collagen crosslinking of their thoracic aorta. Matrix Biol 24(7):451-8. [PubMed: 16095890]  [MGI Ref ID J:102262]

Phillips CL; Bradley DA; Schlotzhauer CL; Bergfeld M; Libreros-Minotta C; Gawenis LR; Morris JS; Clarke LL; Hillman LS. 2000. Oim mice exhibit altered femur and incisor mineral composition and decreased bone mineral density. Bone 27(2):219-26. [PubMed: 10913914]  [MGI Ref ID J:82589]

Phillips CL; Pfeiffer BJ; Luger AM; Franklin CL. 2002. Novel collagen glomerulopathy in a homotrimeric type I collagen mouse (oim). Kidney Int 62(2):383-91. [PubMed: 12109999]  [MGI Ref ID J:103946]

Roberts-Pilgrim AM; Makareeva E; Myles MH; Besch-Williford CL; Brodeur AC; Walker AL; Leikin S; Franklin CL; Phillips CL. 2011. Deficient degradation of homotrimeric type I collagen, alpha1(I)3 glomerulopathy in oim mice. Mol Genet Metab 104(3):373-82. [PubMed: 21855382]  [MGI Ref ID J:178244]

Saban J; Zussman MA; Havey R; Patwardhan AG; Schneider GB; King D. 1996. Heterozygous oim mice exhibit a mild form of osteogenesis imperfecta. Bone 19(6):575-9. [PubMed: 8968022]  [MGI Ref ID J:38013]

Sims TJ; Miles CA; Bailey AJ; Camacho NP. 2003. Properties of collagen in OIM mouse tissues. Connect Tissue Res 44 Suppl 1:202-5. [PubMed: 12952198]  [MGI Ref ID J:103112]

Vanleene M; Saldanha Z; Cloyd KL; Jell G; Bou-Gharios G; Bassett JH; Williams GR; Fisk NM; Oyen ML; Stevens MM; Guillot PV; Shefelbine SJ. 2011. Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties. Blood 117(3):1053-60. [PubMed: 21088133]  [MGI Ref ID J:168596]

Weis SM; Emery JL; Becker KD; McBride DJ Jr; Omens JH; McCulloch AD. 2000. Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim). Circ Res 87(8):663-9. [PubMed: 11029401]  [MGI Ref ID J:82592]

a related

Baba K; Sakakibara S; Setsu T; Terashima T. 2007. The superficial layers of the superior colliculus are cytoarchitectually and myeloarchitectually disorganized in the reelin-deficient mouse, reeler. Brain Res 1140:205-15. [PubMed: 17173877]  [MGI Ref ID J:120267]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Breeding & HusbandryThese mice may need to wait until 5 weeks of age to be phenotypically classified.
Mating SystemOutcross-Intercross         (Female x Male)   01-MAR-06
TJL Breeding Summary: homozygote x B6C3Fe a/a F1 or B6C3Fe a/a F1 x homozygote then heterozygote x heterozygote
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing
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Live Mice

Price (US dollars $)GenderGenotypes Provided
Individual Mouse $138.00Female or MaleHeterozygous for Col1a2oim
$225.00Female or MaleHomozygous for Col1a2oim
Pairs /Price (US dollars $)Pair Genotype
$276.00Heterozygous for Col1a2oim x Heterozygous for Col1a2oim

Standard Supply

Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.

Pricing for International shipping destinations View USA Canada and Mexico Pricing
Order this mouse

Live Mice

Price (US dollars $)GenderGenotypes Provided
Individual Mouse $179.40Female or MaleHeterozygous for Col1a2oim
$292.50Female or MaleHomozygous for Col1a2oim
Pairs /Price (US dollars $)Pair Genotype
$358.80Heterozygous for Col1a2oim x Heterozygous for Col1a2oim

Standard Supply

Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.

General Supply Notes

Control Information

  Control
   Untyped from the colony
   001022 B6C3FeF1/J a/a
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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